1

   AS FILED WITH THE SECURITIES AND EXCHANGE COMMISSION ON SEPTEMBER 25, 1997

   
                                                      REGISTRATION NO. 333-31481
    
================================================================================
 
                       SECURITIES AND EXCHANGE COMMISSION
                             WASHINGTON, D.C. 20549
                            ------------------------
   
                                AMENDMENT NO. 1

                                       TO

                                   FORM SB-2
                             REGISTRATION STATEMENT
                                     UNDER
                           THE SECURITIES ACT OF 1933
 
                       INTEGRATED SURGICAL SYSTEMS, INC.
                 (NAME OF SMALL BUSINESS ISSUER IN ITS CHARTER)

                                                                  
              DELAWARE                              3841                             68-0232575
  (STATE OR OTHER JURISDICTION OF       (PRIMARY STANDARD INDUSTRIAL              (I.R.S. EMPLOYER
   INCORPORATION OR ORGANIZATION)       CLASSIFICATION CODE NUMBER)             IDENTIFICATION NO.)

                             829 WEST STADIUM LANE
                          SACRAMENTO, CALIFORNIA 95834
                           TELEPHONE: (916) 646-3487
                           TELECOPIER: (916) 646-4075
         (ADDRESS AND TELEPHONE NUMBER OF PRINCIPAL EXECUTIVE OFFICES)
                            ------------------------
                             DR. RAMESH C. TRIVEDI
                     CHIEF EXECUTIVE OFFICER AND PRESIDENT
                       INTEGRATED SURGICAL SYSTEMS, INC.
                             829 WEST STADIUM LANE
                          SACRAMENTO, CALIFORNIA 95834
                           TELEPHONE: (916) 646-3487
                           TELECOPIER: (916) 646-4075
           (NAME, ADDRESS AND TELEPHONE NUMBER OF AGENT FOR SERVICE)
                            ------------------------
                                   COPIES TO:

                               JACK BECKER, ESQ.

                            SNOW BECKER KRAUSS P.C.

                                605 THIRD AVENUE

                         NEW YORK, NEW YORK 10158-0125

                           TELEPHONE: (212) 687-3860

                           TELECOPIER: (212) 949-7052

                            ------------------------

                APPROXIMATE DATE OF PROPOSED SALE TO THE PUBLIC:

As soon as practicable after the effective date of this registration statement.

   
    If this Form is filed to register additional securities for an offering
pursuant to Rule 462(b) under the Securities Act, please check the following box
and list the Securities Act registration statement number of the earlier
effective registration statement for the same offering.  [ ]

   
    If this Form is a post-effective amendment filed pursuant to Rule 462(c)
under the Securities Act, check the following box and list the Securities Act
registration statement number of the earlier effective registration statement
for the same offering.  [ ]

   
    If delivery of the prospectus is expected to be made pursuant to Rule 434,
please check the following box.  [ ]

   
    If any of the securities on this form are to be offered on a delayed or
continuous basis pursuant to Rule 415 under the Securities Act please check the
following box.  [X]
    
                        CALCULATION OF REGISTRATION FEE

===========================================================================================================================
                                                                       PROPOSED           PROPOSED
              TITLE OF EACH CLASS                    AMOUNT             MAXIMUM            MAXIMUM           AMOUNT OF
                 OF SECURITIES                        TO BE         OFFERING PRICE        AGGREGATE        REGISTRATION
               TO BE REGISTERED                    REGISTERED       PER SECURITY(1)   OFFERING PRICE(1)         FEE
- ---------------------------------------------------------------------------------------------------------------------------
                                                                                            
Common Stock, $.01 par value...................      1,833,790          $ 7.25         $13,294,977.50        $4,028.78
                                                  1,903,710(2)         $7.50(3)        $14,277,825.00        $4,711.68
Advisors' Warrants to purchase shares of Common
  Stock........................................       325,000             --            $       10.00           (4)
Common Stock issuable upon exercise of
  Advisors' Warrants...........................     159,460(5)          $ 7.25         $ 1,156,085.00        $ 350.33
                                                   165,540(5)           $ 9.00         $ 1,489,860.00        $ 491.65
                                                                                                             ---------
         Total Registration Fee................                                                            $9,582.44(6)
===========================================================================================================================

 
(1) Estimated solely for the purpose of calculating the registration fee
    pursuant to Rule 457 promulgated under the Securities Act of 1933.
   
(2) Includes 487,500 shares of Common Stock which may be purchased by the Lead
    Manager to cover over-allotments, if any.

(3) Calculated on the basis of the closing bid price of the Common Stock on the
    Nasdaq SmallCap Market on September 23, 1997.

(4) Pursuant to Rule 457(g) promulgated under the Securities Act of 1933, no
    filing fee is required.

(5) Pursuant to Rule 416, there are also being registered such indeterminate
    number of additional shares as may become issuable pursuant to the
    anti-dilution provisions the Advisors' Warrants.

(6) A fee of $4,379.10 was previously paid on or about July 17, 1997.
    
                            ------------------------

    THE REGISTRANT HEREBY AMENDS THIS REGISTRATION STATEMENT ON SUCH DATE OR
DATES AS MAY BE NECESSARY TO DELAY ITS EFFECTIVE DATE UNTIL THE
REGISTRANT SHALL FILE A FURTHER AMENDMENT WHICH SPECIFICALLY STATES THAT THIS
REGISTRATION STATEMENT SHALL THEREAFTER BECOME EFFECTIVE IN ACCORDANCE WITH
SECTION 8(a) OF THE SECURITIES ACT OF 1933 OR UNTIL THE REGISTRATION STATEMENT
SHALL BECOME EFFECTIVE ON SUCH DATE AS THE SECURITIES AND EXCHANGE COMMISSION,
ACTING PURSUANT TO SAID SECTION 8(a), MAY DETERMINE.

- --------------------------------------------------------------------------------
    
- --------------------------------------------------------------------------------
   2
 
                       INTEGRATED SURGICAL SYSTEMS, INC.
 
                     CROSS REFERENCE SHEET SHOWING LOCATION
                          IN PROSPECTUS OF INFORMATION
 
              REQUIRED BY ITEMS 1 THROUGH 23, PART I OF FORM SB-2

                  ITEM AND HEADING                          LOCATION IN PROSPECTUS
     -------------------------------------------  -------------------------------------------
                                            
  1. Forepart of the Registration Statement and
     Outside Front Cover Page of Prospectus.....  Outside Front Cover Page
  2. Inside Front and Outside Back Cover Pages
     of Prospectus..............................  Inside Front and Outside Back Cover Pages
                                                  of Prospectus; Description of
                                                    Securities -- Reports to Stockholders
  3. Summary Information, Risk Factors..........  Prospectus Summary; Risk Factors
  4. Use of Proceeds............................  Use of Proceeds
  5. Determination of Offering Price............  Outside Front Cover Page; Risk Factors;
                                                  Market for Common Stock and Related
                                                    Stockholder Matters; Underwriting
  6. Dilution...................................  Dilution
  7. Selling Security Holders...................  Not Applicable
  8. Plan of Distribution.......................  Underwriting
  9. Legal Proceedings..........................  Business -- Litigation
 10. Directors, Executive Officers Promoters
     and/Control Persons........................  Management
 11. Security Ownership of Certain Beneficial
     Owners and Management......................  Security Ownership of Certain Beneficial
                                                  Owners and Management
 12. Description of the Securities..............  Description of Securities
 13. Interest of Named Experts and Counsel......  Not Applicable
 14. Disclosure of Commission Position on
     Indemnification for Securities Act
     Liabilities................................  Management -- Indemnification of Officers
                                                  and Directors and Limitation on Director
                                                    Liability
 15. Organization Within Last Five Years........  Not Applicable
 16. Description of Business....................  Prospectus Summary; Business
 17. Management's Discussion and Analysis or
     Plan of Operation..........................  Management's Discussion and Analysis of
                                                    Financial Condition and Results of
                                                    Operations
 18. Description of Property....................  Business -- Facilities
 19. Certain Relationships and Related
     Transactions...............................  Certain Transactions
 20. Market for Common Equity and Related
     Stockholder Matters........................  Market for Common Stock and Related
                                                    Stockholder Matters; Description of
                                                    Securities
 21. Executive Compensation.....................  Management
 22. Financial Statements.......................  Consolidated Financial Statements
 23. Changes in and Disagreements with
     Accountants on Accounting and Financial
     Disclosure.................................  Not Applicable

   3
 
     INFORMATION CONTAINED HEREIN IS SUBJECT TO COMPLETION OR AMENDMENT. A
     REGISTRATION STATEMENT RELATING TO THESE SECURITIES HAS BEEN FILED WITH THE
     SECURITIES AND EXCHANGE COMMISSION. THESE SECURITIES MAY NOT BE SOLD NOR
     MAY OFFERS TO BUY BE ACCEPTED PRIOR TO THE TIME THE REGISTRATION STATEMENT
     BECOMES EFFECTIVE. THIS PROSPECTUS SHALL NOT CONSTITUTE AN OFFER TO SELL OR
     THE SOLICITATION OF AN OFFER TO BUY NOR SHALL THERE BE ANY SALE OF THESE
     SECURITIES IN ANY STATE IN WHICH SUCH OFFER, SOLICITATION OR SALE WOULD BE
     UNLAWFUL PRIOR TO REGISTRATION OR QUALIFICATION UNDER THE SECURITIES LAWS
     OF ANY SUCH STATE.

                SUBJECT TO COMPLETION, DATED SEPTEMBER 25, 1997
    
                       INTEGRATED SURGICAL SYSTEMS, INC.
   
                        3,171,771 SHARES OF COMMON STOCK

   
     This Prospectus relates to an offering (the "Offering") by Integrated
Surgical Systems, Inc. (the "Company") of 3,171,771 shares of common stock, par
value $.01 per share (the "Common Stock"), in Europe through a group of managers
(the "Managers") for whom Investmentbank Austria Aktiengesellschaft
("Investmentbank Austria"), Vienna, Austria, will act as Lead Manager.

   
     The Common Stock is quoted on The Nasdaq SmallCap Market under the symbol
"RDOC" and is listed on the Pacific Stock Exchange Incorporated under the symbol
"ROB". Application will be made for the admission of the Common Stock to the
European Association of Securities Dealers' Automated Quotation ("EASDAQ")
System under the symbol "RDOC". Prior to the Offering, there has been no public
market for the Common Stock on EASDAQ, and there can be no assurance that any
such market will develop after the closing of the Offering or that, if
developed, it will be sustained. On September 23, 1997, the closing bid price of
the Common Stock on the Nasdaq Smallcap Market was $7 1/2 per share. See "Price
Range of Common Stock."

   
     THE SECURITIES OFFERED HEREBY ARE SPECULATIVE AND INVOLVE A HIGH DEGREE OF
RISK. ONLY INVESTORS WHO CAN BEAR THE RISK OF LOSS OF THEIR ENTIRE INVESTMENT
SHOULD INVEST. FOR A DESCRIPTION OF CERTAIN RISKS REGARDING AN INVESTMENT IN THE
COMPANY, SEE "RISK FACTORS" COMMENCING ON PAGE 8 AND "DILUTION" ON PAGE 21.

  THESE SECURITIES HAVE NOT BEEN APPROVED OR DISAPPROVED BY THE SECURITIES AND
EXCHANGE COMMISSION OR ANY STATE SECURITIES COMMISSION NOR HAS THE COMMISSION OR
  ANY STATE SECURITIES COMMISSION PASSED UPON THE ACCURACY OR ADEQUACY OF THIS
     PROSPECTUS. ANY REPRESENTATION TO THE CONTRARY IS A CRIMINAL OFFENSE.
================================================================================

                                                                     UNDERWRITING
                                                  PRICE TO           DISCOUNTS AND         PROCEEDS TO
                                                   PUBLIC           COMMISSIONS(1)        COMPANY(2)(3)
- -----------------------------------------------------------------------------------------------------------
                                                                             
Per Share...................................           $                   $                    $
- -----------------------------------------------------------------------------------------------------------
Total(3)....................................           $                   $                    $
===========================================================================================================

 
   
(1) Underwriting discounts and commissions are anticipated to be 6% of the gross
    proceeds of the Offering. Does not include (i) a fee of 3.5% of the gross
    proceeds of the Offering payable to Value Management & Research GmbH ("VMR"
    or the "Placement Coordinator"), placement coordinator for the Offering,
    (ii) a non-accountable expense allowance payable to Investmentbank Austria
    and VMR equal to 2% and 0.75%, respectively, of the gross proceeds of the
    Offering, of which $25,000 has been paid to VMR by the Company to date, and
    (iii) a consulting fee of $2,000 per month payable to VMR for 12 months
    following the closing of the Offering, or a total of $24,000, and (iv)
    warrants (the "Advisors' Warrants") entitling each of Investmentbank Austria
    and VMR to purchase up to 5% of the shares of Common Stock sold in the
    Offering (exclusive of the over-allotment option referred to in note(3)
    below). The Company has also agreed to indemnify the Managers against
    certain civil liabilities, including those arising under the Securities Act.
    See "Underwriting."

   
(2) The gross proceeds of the Offering will be the U.S. Dollar equivalent of
    40,000,000 Deutsche Marks, after deducting discounts and commissions payable
    to the Managers, but before payment of the fee payable to the Placement
    Coordinator, the non-accountable expense allowance ($        , or $
    if the Over-Allotment Option is exercised in full) and the other expenses of
    the Offering (estimated at $        ) payable by the Company. See
    "Underwriting."

   
(3) The Company has granted Investmentbank Austria an option, exercisable for a
    period of 30 days after the closing of the Offering, to purchase up to an
    additional 15% of the Common Stock offered hereby, upon the same terms and
    conditions solely for the purpose of covering over-allotments, if any (the
    "Over-Allotment Option"). If the Over-Allotment Option is exercised in full,
    the Total Price to Public, Underwriting Discounts and Commissions and
    Proceeds to Company will be $        , $        and $        , respectively.
    See "Underwriting."

   
     The Common Stock is being offered by the Managers on a firm commitment
basis, subject to prior sale, when, as and if delivered to the Managers and
subject to certain conditions. Subject to the provisions of the purchase
agreement between the Managers and the Company, the Managers reserve the right
to withdraw, cancel or modify the Offering and to reject any order in whole or
in part. It is expected that ownership of shares of Common Stock may be credited
to the accounts of investors with financial institutions that have direct or
indirect access to INTERSETTLE, the Swiss-based clearing and settlement system
("INTERSETTLE"). The term financial institution includes the Euroclear System
("Euroclear") and Cedel Bank, societe anonyme ("Cedel Bank"), which have each
made arrangements with INTERSETTLE to have shares of the Common Stock credited
to accounts with Euroclear or Cedel Bank through intermediaries.

                             INVESTMENTBANK AUSTRIA

                THE DATE OF THIS PROSPECTUS IS           , 1997
    
   4

                       CAUTIONARY STATEMENT FOR PURPOSES
    
                     OF THE "SAFE HARBOR" PROVISIONS OF THE
   
                PRIVATE SECURITIES LITIGATION REFORM ACT OF 1995

     THIS DOCUMENT SPECIFIES FORWARD-LOOKING STATEMENTS OF MANAGEMENT OF THE
COMPANY, INCLUDING REVENUE PROJECTIONS. FORWARD-LOOKING STATEMENTS ARE
STATEMENTS THAT ESTIMATE THE HAPPENING OF FUTURE EVENTS, ARE NOT BASED ON
HISTORICAL FACT AND ARE "FORWARD-LOOKING STATEMENTS" WITHIN THE MEANING OF THE
PRIVATE SECURITIES LITIGATION REFORM ACT OF 1995. FORWARD-LOOKING STATEMENTS MAY
BE IDENTIFIED BY THE USE OF FORWARD-LOOKING TERMINOLOGY SUCH AS "MAY", "WILL",
"EXPECT", "ESTIMATE", "ANTICIPATE", "PROBABLE", "CONTINUE", OR SIMILAR TERMS,
VARIATIONS OF THOSE TERMS OR THE NEGATIVE OF THOSE TERMS. THE "RISK FACTORS" SET
FORTH IN THIS DOCUMENT CONSTITUTE CAUTIONARY STATEMENTS IDENTIFYING IMPORTANT
FACTORS THAT COULD CAUSE ACTUAL RESULTS TO DIFFER MATERIALLY FROM THOSE IN THE
FORWARD-LOOKING STATEMENT IDENTIFYING IMPORTANT FACTORS THAT COULD CAUSE ACTUAL
RESULTS TO DIFFER MATERIALLY FROM THOSE IN THE FORWARD-LOOKING STATEMENTS. THE
FORWARD-LOOKING STATEMENTS SPECIFIED IN THIS DOCUMENT HAVE BEEN COMPILED BY
MANAGEMENT OF THE COMPANY ON THE BASIS OF ASSUMPTIONS MADE BY MANAGEMENT AND
CONSIDERED BY MANAGEMENT TO BE REASONABLE. FUTURE OPERATING RESULTS OF THE
COMPANY, HOWEVER, ARE IMPOSSIBLE TO PREDICT AND NO REPRESENTATION, GUARANTY, OR
WARRANTY IS TO BE INFERRED FROM THOSE FORWARD-LOOKING STATEMENTS. THEREFORE,
PROSPECTIVE PURCHASERS OF THE SHARES OF COMMON STOCK ARE URGED TO CONSULT WITH
THEIR ADVISORS (THE OPINIONS OF WHICH MAY DIFFER FROM THOSE SPECIFIED IN THOSE
FORWARD-LOOKING STATEMENTS) WITH RESPECT TO THOSE ASSUMPTIONS OR HYPOTHESES.
 
     THE ASSUMPTIONS USED FOR PURPOSES OF THE FORWARD-LOOKING STATEMENTS
SPECIFIED IN THIS DOCUMENT, INCLUDING THOSE REVENUE PROJECTIONS, REPRESENT
ESTIMATES OF FUTURE EVENTS AND ARE SUBJECT TO UNCERTAINTY AS TO POSSIBLE CHANGES
IN ECONOMIC, LEGISLATIVE, INDUSTRY, AND OTHER CIRCUMSTANCES. AS A RESULT, THE
IDENTIFICATION AND INTERPRETATION OF DATA AND OTHER INFORMATION AND THEIR USE IN
DEVELOPING AND SELECTING ASSUMPTIONS FROM AND AMONG REASONABLE ALTERNATIVES
REQUIRE THE EXERCISE OF JUDGMENT. TO THE EXTENT THAT THE ASSUMED EVENTS DO NOT
OCCUR, THE OUTCOME MAY VARY SUBSTANTIALLY FROM ANTICIPATED OR PROJECTED RESULTS,
AND ACCORDINGLY, NO OPINION IS EXPRESSED ON THE ACHIEVABILITY OF THOSE
FORWARD-LOOKING STATEMENTS, INCLUDING THOSE REVENUE PROJECTIONS.
 
     THESE FORWARD-LOOKING STATEMENTS, INCLUDING THESE REVENUE PROJECTIONS, HAVE
BEEN COMPILED AS OF THE DATE OF THIS DOCUMENT AND SHOULD BE EVALUATED WITH
CONSIDERATION OF ANY CHANGES OCCURRING AFTER THE DATE OF THIS DOCUMENT. NO
ASSURANCE CAN BE GIVEN THAT ANY OF THE ASSUMPTIONS RELATING TO THE
FORWARD-LOOKING STATEMENTS SPECIFIED IN THIS DOCUMENT, INCLUDING THOSE REVENUE
PROJECTIONS, ARE ACCURATE OR THAT THEY WILL PROVIDE TO BE APPLICABLE TO A
PARTICULAR PURCHASER OF THE SHARES OF COMMON STOCK. IT IS THE RESPONSIBILITY OF
THE PURCHASERS OF THE COMMON STOCK AND THEIR ADVISORS TO REVIEW THOSE
FORWARD-LOOKING STATEMENTS, INCLUDING THOSE REVENUE PROJECTIONS TO CONSIDER THE
ASSUMPTIONS ON WHICH THOSE FORWARD-LOOKING STATEMENTS ARE BASED AND TO ASCERTAIN
THEIR REASONABLENESS.
 
                                        2
   5

     NO DEALER, SALESMAN OR OTHER PERSON HAS BEEN AUTHORIZED TO GIVE ANY
INFORMATION OR TO MAKE ANY REPRESENTATION IN CONNECTION WITH THIS OFFERING OTHER
THAN THOSE CONTAINED IN THIS PROSPECTUS AND, IF GIVEN OR MADE, SUCH OTHER
INFORMATION AND REPRESENTATIONS MUST NOT BE RELIED UPON AS HAVING BEEN
AUTHORIZED BY THE COMPANY, THE MANAGERS OR THE PLACEMENT COORDINATOR. NEITHER
THE DELIVERY OF THIS PROSPECTUS NOR ANY SALE MADE HEREUNDER SHALL UNDER ANY
CIRCUMSTANCES CREATE ANY IMPLICATION THAT THERE HAD BEEN NO CHANGE IN THE
AFFAIRS OF THE COMPANY SINCE THE DATE HEREOF. THIS PROSPECTUS DOES NOT
CONSTITUTE AN OFFER TO SELL OR THE SOLICITATION OF AN OFFER TO BUY ANY
SECURITIES OFFERED HEREBY BY ANYONE IN JURISDICTIONS IN WHICH SUCH OFFER OR
SOLICITATION IS NOT AUTHORIZED OR IN WHICH THE PERSON MAKING SUCH OFFER OR
SOLICITATION IS NOT QUALIFIED TO DO SO OR TO ANYONE TO WHOM IT IS UNLAWFUL TO
MAKE SUCH OFFER OR SOLICITATION.

                               TABLE OF CONTENTS

                                                                                        PAGE
                                                                                        -----
                                                                                     
Prospectus Summary....................................................................      4
Risk Factors..........................................................................      8
Use of Proceeds.......................................................................     18
Market for Common Stock and Related Stockholder Matters...............................     19
Capitalization........................................................................     20
Dilution..............................................................................     21
Dividend Policy.......................................................................     21
Selected Consolidated Financial Information...........................................     22
Management's Discussion and Analysis of Financial Condition and Results of
  Operations..........................................................................     23
Glossary..............................................................................     27
Business..............................................................................     28
Management............................................................................     45
Certain Transactions..................................................................     52
Security Ownership of Certain Beneficial Owners and Management........................     54
Description of Securities.............................................................     56
Underwriting..........................................................................     61
Legal Matters.........................................................................     62
Experts...............................................................................     62
Additional Information................................................................     62
Index to Consolidated Financial Statements............................................    F-1

 
   
     The Company is subject to the reporting requirements of the Securities
Exchange Act of 1934 (the "Exchange Act"), and, in accordance therewith, files,
reports, proxy and information statements and other information with the
Securities and Exchange Commission (the "Commission"). The Company has filed a
Registration Statement on Form SB-2 under the Securities Act with the Commission
in Washington, D.C. with respect to the shares of Common Stock offered hereby.
This Prospectus, which is part of the Registration Statement, does not contain
all of the information set forth in the Registration Statement and the exhibits
thereto. For further information with respect to the Company and the shares
offered hereby, reference is made to the Registration Statement and such
exhibits as well as the reports, proxy and information statements and other
information filed under the Exchange Act, which may be inspected and copied at
the Public Reference Section of the Commission at Room 1024, Judiciary Plaza,
450 Fifth Street, N.W., Washington, D.C. 20549 and at the following regional
offices: New York Regional Office, Suite 1300, 7 World Trade Center, New York,
New York 10048, and Chicago Regional Office, 500 West Madison Street, Suite
1400, Chicago, Illinois 60661-2511, and copies of such material may also be
obtained from the Public Reference Section of the Commission at prescribed
rates. The Commission maintains a Web site (http://www.sec.gov) that contains
reports, proxy and information statements and other information regarding
registrants that file electronically. The Company distributes to its
stockholders annual reports containing audited financial statements and such
other reports as the Company deems appropriate or as may be required by law or
by the rules or regulations of any exchange on which the Company's Common Stock
is listed.

                                        3
   6

                               PROSPECTUS SUMMARY

   
     The following summary is qualified in its entirety by the more detailed
information, financial statements and the notes thereto appearing elsewhere in
this Prospectus. Unless otherwise indicated or the context otherwise requires,
(i) all references to the Company in this Prospectus include Integrated Surgical
Systems, Inc., a Delaware corporation, and its wholly owned subsidiaries, except
that information concerning the Company prior to September 5, 1997, does not
include Innovative Medical Machines International, S.A. ("IMMI"), acquired by
the Company on that date, and (ii) all share and per share data and information
in this Prospectus relating to the number of shares of Common Stock outstanding
give effect to a one-for-five reverse stock split with respect to the Company's
capital stock effected on December 20, 1995, and a one-for-1.479586 reverse
stock split with respect to the Common Stock effected on November 6, 1996, and
assumes that the Over-Allotment Option is not exercised. See the "Glossary"
appearing at page 27 of this Prospectus for the definitions of certain technical
terms used herein.

   
     The Purchase Agreement pursuant to which the Managers will purchase the
shares of Common Stock offered hereby contemplates that the gross proceeds to
the Company will be 40,000,000 Deutsche Marks ("DM"). Information in this
Prospectus concerning the U.S. Dollar equivalent of DM 40,000,000 assumes an
exchange rate between the U.S. Dollar and the Deutsche Mark of DM 1 = $1.7680,
the representative exchange rate as of September 16, 1997, as reported by the
Federal Reserve Bank. The number of shares of Common Stock offered hereby is
based upon an assumed offering price per share of $7.125, the closing bid price
per share of Common Stock on the Nasdaq SmallCap Market on September 16, 1997
and an exchange rate of $1.00 = DM .5650, the representative exchange rate as of
that date, as reported by The New York Times.

   
                                  THE COMPANY

   
     Integrated Surgical Systems, Inc. develops, manufactures, markets and
services image-directed, computer-controlled robotic products for surgical
applications. The Company's principal products are the ROBODOC(R) Surgical
Assistant System (the "ROBODOC System"), consisting of a computer-controlled
surgical robot and the Company's ORTHODOC(R) Presurgical Planner (the
"ORTHODOC"), and as a result of the acquisition of IMMI, the NeuroMate System,
consisting of a computer controlled robotic arm, head stabilizer and monitor
(the ROBODOC System and the NeuroMate System are sometimes referred to
collectively as the "Systems").

   
     The ROBODOC System has been used for primary total hip replacement ("THR")
surgery on over 1,500 patients in Europe and the United States. The Company
believes its "active" robotic system is the only available system that can
accurately perform key segments of surgical procedures with precise tolerances
generally not attainable by traditional manual surgical techniques. The ROBODOC
System also allows the surgeon to prepare a preoperative plan specifically
designed for the characteristics of the individual patient's anatomy. The
technology for the ROBODOC System was initially developed at the University of
California, Davis, in collaboration with International Business Machines
Corporation ("IBM"). Upon completion of the Offering, IBM will retain rights to
acquire approximately 20% of the Common Stock on a fully diluted basis.

     The ORTHODOC is a computer workstation that utilizes the Company's
proprietary software for preoperative surgical planning. The ORTHODOC is
included as part of the ROBODOC System, but is also planned to be marketed
separately by the Company. The ORTHODOC converts computerized tomography ("CT")
scan data of a patient's femur (i.e., thigh bone) into three-dimensional images,
and through a graphical user interface allows the surgeon to examine the bone
more thoroughly and to select the optimal implant for the patient using a
built-in library of available implants. A tape of the planned surgical
procedure, developed by the ORTHODOC, guides the surgical robot arm of the
ROBODOC System to accurately mill a cavity in the bone, thus allowing the
surgeon to properly orient and align the implant. Non-clinical scientific data
published by scientists from the Company and IBM demonstrate that as a result of
the precise milling of a cavity, the ROBODOC System achieves over 95%
bone-to-implant contact, as compared to an average of 20% bone-to-implant
contact when surgery is performed manually.
 
     THR surgery involves the insertion of an implant or metal prosthesis into a
cavity created in the patient's femur. The Company believes that precise fit and
correct alignment of the implant within the femoral cavity are key factors in
the long-term success of THR surgery. In conventional THR surgery, a bone cavity
is cut in the shape of the implant manually with metal tools, and the surgical
plan, including the selection of the size
 
                                        4
   7

and shape of the implant, is generally formulated based upon patient data
obtained from two-dimensional x-ray images of the patient's femur. Based upon
clinical experience with the ROBODOC System to date in Europe, patients
generally have become weight-bearing in a shorter period than generally
experienced by patients who have had this surgery performed manually. In
addition, clinical data obtained from trials in Europe and the United States
indicates that intraoperative fractures have been dramatically reduced in THR
surgeries performed with the ROBODOC System (no intraoperative fractures have
resulted from THR surgeries performed with the ROBODOC System to date). The
Company also believes fewer hip revision surgeries (implant replacements) may be
necessary for patients who have had primary THR surgery performed with the
ROBODOC System, as compared to patients who have had this surgery performed
manually.

   
     The NeuroMate System has been used to perform over 1,500 neurosurgical
procedures in Europe and Japan. The Company believes that the NeuroMate System,
which uses its proprietary robotic arm design and control systems designed
specifically for use in the operating room, is the only image-guided, computer-
controlled stereotactic robot currently in use to precisely position and hold
critical tools used in the performance of neurosurgical procedures. Stereotactic
neurosurgery involves the registration of the patient's cranium and brain to
external anatomical references such as standard population atlases or, as
currently implemented, to the patient's presurgical CT and magnetic resonance
images (MRI). By registering certain key anatomical features common to both the
images and the patient, the images are used to guide the surgeon to specific
sites within the brain through small openings (i.e., not necessitating a
craniotomy).

   
     The Company is seeking to establish itself as a leading provider of
innovative image-directed, computer-controlled robotic technologies worldwide,
initially for orthopaedic and neurosurgical applications and subsequently for
other surgical applications. The Company's business strategy over the next two
years is to concentrate its marketing and sales efforts on selling the ROBODOC
System throughout Europe and then Japan, subject to obtaining the requisite
approval from the Japanese Ministry of Health, and selling the NeuroMate System
throughout Europe, Japan and the United States. The Company will thereby attempt
to establish an installed customer base in the United States, Europe, Japan and
other foreign markets through the sale of its systems, and offer its customers
separate software packages for each new application if, as and when developed by
the Company. Consequently, the Company's customers would be able to use the
ROBODOC System as the platform for performing a variety of orthopaedic surgical
procedures, and the NeuroMate System as the platform for performing a variety of
neurosurgical procedures, without incurring significant additional hardware
costs. The Company also plans to further exploit its image-directed robotics
technology by incorporating additional imaging modalities for presurgical
planning, including ultrasound (which is less expensive than CT) and MRI (which,
unlike CT, does not involve the risk of radiation).

   
     The Company markets the ROBODOC System in Europe through direct marketing
and arrangements with implant companies. The ROBODOC System satisfies the
appropriate international standards for medical equipment and meets the
requirements for the "CE Mark". The Company markets the NeuroMate through direct
marketing in Europe and through its distributor in Japan. It is anticipated that
marketing of the NeuroMate in the United States will commence in early 1998
through a combination of direct marketing and select distributors/agents. During
the six months ended June 30, 1997, the Company realized revenues of
approximately $1,380,000 from the commercial sales of the ROBODOC System
(including related consumables) in Europe.

   
     The Company has developed a software package, in collaboration with IBM and
Johns Hopkins University, for surgery to replace loose or otherwise failed hip
implants (the "hip revision application") using the ROBODOC System. The Company
has completed clinical trials of the hip revision application in Europe and
plans to commence marketing the software for the hip revision application to its
customers in Europe in early 1998. The development of the hip revision
application has been funded in part by a grant from the National Institute for
Standards and Technology (Advanced Technology Program) of the United States
Department of Commerce.

     The ROBODOC System cannot be marketed in the United States until clearance
or approval is obtained from the U.S. Food and Drug Administration ("FDA"). The
Company intends to submit a pre-market approval application ("PMA") to the FDA
in late 1997 for approval to market the ROBODOC System in the
 
                                        5
   8

United States. The Company has received clearance from the FDA to sell the
ORTHODOC in the United States, and intends to commence marketing the ORTHODOC in
the United States in early 1998. See "Risk Factors -- Available Clinical Data;
Risk Versus Benefit Issues" and "Risk Factors -- Government Regulation."

     The Company was incorporated under the laws of the State of Delaware on
October 1, 1990. The Company's offices are located at 829 West Stadium Lane,
Sacramento, California 95834, and its telephone number is (916) 646-3487.
 
                                  THE OFFERING

Securities Offered.........  3,171,771 shares of Common Stock.
                             "See "Description of Securities" and
                             "Underwriting."

   
Common Stock Outstanding:
  Prior to the
  Offering(1)..............  3,986,311 shares of Common Stock.

  After the
Offering(1)(2).............  7,158,082 shares of Common Stock.

   
Use of Proceeds............  The net proceeds of this Offering will be used (i)
                             for product development, (ii) for sales and
                             marketing, (iii) for investment in a clinic located
                             in Spain to train surgeons in the use of the ROBOC
                             System, and (iv) for working capital and general
                             corporate purposes. See "Use of Proceeds."

Risk Factors...............  The securities offered hereby involve a high degree
                             of risk and immediate substantial dilution to new
                             investors. Only investors who can bear the loss of
                             their entire investment should invest. See "Risk
                             Factors" and "Dilution."

Nasdaq SmallCap Market
  Symbol...................  RDOC

   
Pacific Stock Exchange
Symbol.....................  ROB

   
Proposed EASDAQ Symbol.....  RDOC

   
CUSIP No. .................  45812 Y 10 8

- ---------------
   
(1) Includes 619,355 shares of Common Stock issued in connection with the
    acquisition of IMMI on September 5, 1997. See "Business -- Acquisition of
    IMMI." Does not include (i) 4,332,816 shares of Common Stock issuable upon
    the exercise of warrants at exercise prices ranging from $.01 to $8.25 or
    (ii) 1,168,313 shares of Common Stock issuable upon exercise of outstanding
    options granted pursuant to the Company's stock option plans at exercise
    prices ranging from $0.07 to $8.75 per share, including options to purchase
    53,398 shares granted subsequent to June 30, 1997. See "Management -- Stock
    Option Plan," "Certain Transactions" and "Description of Securities.

   
(2) Does not include (i) 475,766 shares of Common Stock reserved for issuance
    upon exercise of the Over-Allotment Option, and (ii) 317,177 shares reserved
    for issuance upon exercise of the Advisors' Warrants. See "Underwriting."

                                        6
   9
 
                 SUMMARY OF CONSOLIDATED FINANCIAL INFORMATION

     The summary financial information set forth below is derived from and
should be read in conjunction with the Company's consolidated financial
statements and unaudited pro forma combined condensed financial statements,
including the notes thereto, appearing elsewhere in this Prospectus. The
historical summary financial information set forth below does not include data
regarding the separate results of operations or financial position of IMMI for
the periods and at the dates indicated.

STATEMENT OF OPERATIONS DATA:

                                                                                                                   PRO FORMA
                                                                   PRO FORMA                                       COMBINED
                                          YEAR ENDED               COMBINED            SIX MONTHS ENDED           SIX MONTHS
                                         DECEMBER 31,             YEAR ENDED               JUNE 30,                  ENDED
                                  ---------------------------      DECEMBER       ---------------------------      JUNE 30,
                                     1995            1996         31, 1996(2)        1996            1997           1997(2)
                                  -----------     -----------     -----------     -----------     -----------     -----------
                                                                                                
  Net sales.....................  $   174,521     $ 2,280,311     $ 2,727,621     $ 1,064,206     $ 1,379,696     $ 1,997,276
  Gross profit..................      104,342       1,396,159       1,642,587         605,723         848,003       1,180,463
  Operating loss................   (3,925,730)     (3,495,861)     (5,175,998)     (1,505,176)     (1,809,112)     (2,270,394)
  Net loss......................   (4,053,528)     (3,448,829)     (5,134,440)     (1,490,594)     (1,687,591)     (2,102,058)
  Net loss applicable to common
    stockholders................   (4,989,853)     (3,448,829)     (5,134,440)     (1,490,594)     (1,687,591)     (2,102,058)
  Net loss per common and common
    share equivalent............       $(1.19)         $(0.79)         $(1.03)         $(0.34)         $(0.50)         $(0.53)
  Shares used in per share
    calculations(1).............    4,178,877       4,373,947       4,993,302       4,377,643       3,364,567       3,983,922

 
BALANCE SHEET DATA:

                                                                   JUNE 30, 1997
                                                   ----------------------------------------------
                                                                                      PRO FORMA
                                                                                       COMBINED
                                                                     PRO FORMA       AS ADJUSTED
                                                      ACTUAL        COMBINED(2)         (2)(3)
                                                   ------------     ------------     ------------
                                                                            
  Working capital................................  $  4,367,685     $  4,030,805     $ 23,560,918
  Total assets...................................     6,663,357       11,330,541       30,860,654
  Accumulated deficit............................   (20,788,402)     (21,096,948)     (21,096,948)
  Stockholders' equity...........................     4,654,512        8,235,515       27,765,628

 
- ---------------
(1) See Note 2 of notes to consolidated financial statements for an explanation
    of the determination of the number of shares used in computing net loss per
    share.

(2) Gives effect to the acquisition of IMMI using the purchase method of
    accounting as of January 1, 1996 for statement of operations data and as of
    June 30, 1997 for balance sheet data. The pro forma information is presented
    for illustrative purposes only and may not be indicative of the results that
    would have been obtained had the transaction actually occurred on the dates
    assumed nor is it necessarily indicative of the future combined results of
    operations. See the unaudited Pro Forma Combined Condensed Financial
    Statements appearing elsewhere in this Prospectus.

   
(3) Gives effect to the issuance and sale of 3,171,771 shares of Common Stock
    offered hereby and the application of the estimated net proceeds from the
    sale thereof. See "Use of Proceeds." Does not include 4,332,816 shares of
    Common Stock issuable upon exercise of outstanding warrants at exercise
    prices ranging from $0.01 to $8.25 per share, (ii) 1,168,313 shares of
    Common Stock issuable upon exercise of outstanding options granted pursuant
    to the Company's stock option plans, at exercise prices ranging from $0.07
    to $8.75 per share, including options to purchase 53,398 shares granted
    subsequent to June 30, 1997, or (iii) Common Stock issuable upon exercise of
    the Over-Allotment Option.

                                        7
   10
 
                                  RISK FACTORS
 
     The securities offered hereby are speculative and involve a high degree of
risk, including, but not limited to, the risk factors described below. Each
prospective investor should carefully consider the following risk factors before
making an investment decision.

     History of Losses; Accumulated Deficit; Anticipated Future Losses.  Since
its inception, the Company has incurred losses. The Company incurred a net loss
of approximately $3,449,000 (on net sales of approximately $2,280,000) for its
fiscal year ended December 31, 1996 and a net loss of approximately $4,054,000
(on net sales of approximately $175,000) for its fiscal year ended December 31,
1995. In addition, the Company incurred a net loss of approximately $1,688,000
(on net sales of approximately $1,380,000) for the six months ended June 30,
1997, as compared to a net loss of approximately $1,491,000 (on net sales of
approximately $1,064,000), for the six months ended June 30, 1996. IMMI also has
incurred losses since its inception, including a net loss of approximately
$910,000 (on net sales of approximately $447,000) for its fiscal year ended
December 31, 1996, and a net loss of approximately $27,000 (on net sales of
approximately $618,000) for the six months ended June 30, 1997, as compared to a
net loss of approximately $423,000 (on net sales of approximately $147,000) for
the six months ended June 30, 1996. At June 30, 1997, the Company's accumulated
deficit was approximately $20,788,000 and IMMI's accumulated deficit was
approximately $1,605,000, in each case as a result of continuing losses. The
Company expects to continue to incur operating losses until such time, if ever,
as it derives significant revenues from the sale of its products. The Company's
ability to operate profitably depends upon market acceptance of its orthopaedic
and neurosurgical products, the development of an effective sales and marketing
organization, and the development of new products and improvements to existing
products. There can be no assurance that the Company will obtain FDA approval to
market the ROBODOC System in the United States or that its products will achieve
market acceptance in the United States, Europe and other foreign markets to
generate sufficient revenues to become profitable.

   
     Limited Operating History.  Although the Company commenced operations in
October 1990, its operations have consisted primarily of the development and
clinical testing of the ORTHODOC and the ROBODOC System, the organization of its
manufacturing facility, the hiring of key personnel and the formulation of a
plan for marketing the ROBODOC System in Europe. Although commercial sales of
the ROBODOC System have been made in Europe, the Company has engaged only in
clinical testing of the ROBODOC System in the United States, and the Company's
ability to market the ROBODOC System in the United States is dependent upon FDA
approval. See "Risk Factors -- Government Regulation." Accordingly, the Company
must be evaluated in light of the uncertainties, delays, difficulties and
expenses commonly experienced by companies in the early operating stage, which
generally include unanticipated problems and additional costs relating to the
development and testing of products, regulatory compliance, commencement of
production, product introduction and marketing, and competition. Many of these
factors may be beyond the Company's control, including but not limited to
unanticipated results of product tests requiring modification in product design,
changes in applicable government regulations or the interpretation thereof,
market acceptance of the Company's products and development of competing
products by others. In addition, the Company's future performance also will be
subject to other factors beyond the Company's control, including general
economic conditions and conditions in the healthcare industry or targeted
commercial markets.

   
     Lengthy Sales Cycle.  Since the purchase of a ROBODOC System or NeuroMate
System represents a significant capital expenditure for a customer, the
placement of orders may be delayed due to customers' internal procedures to
approve large capital expenditures. The Company anticipates that the period
between initial contact of a customer for a System and submission of a purchase
order by that customer could be as long as 9 to 12 months. Furthermore, the
current lead time required by the supplier of the robot for either the ROBODOC
System or the NeuroMate System is approximately four months after receipt of the
order. Although the Company generally intends to require a deposit upon receipt
of an order for a System, the Company may be required to expend significant cash
resources to fund its operations until the balance of the purchase price is
paid. Accordingly, a significant portion of the sales price of a System may not
be recognized until a fiscal quarter subsequent to the fiscal quarter in which
the Company incurred marketing and sales

                                        8
   11
 
expenses associated with that order. See "Management's Discussion and Analysis
of Financial Condition and Results of Operations" and the Company's consolidated
financial statements appearing elsewhere herein.

     Challenges of Growth.  The Company intends to use a portion of the net
proceeds of this Offering to hire and retain sales and marketing, research and
development and technical personnel to increase and support sales of Systems and
to develop additional surgical applications for its orthopaedic and
neurosurgical systems. See "Use of Proceeds." The anticipated growth of the
Company will likely result in new and increased responsibilities for management
personnel and place significant strain upon the Company's management, operating
and financial systems and resources. To accommodate such growth and compete
effectively, the Company must continue to implement and improve its operational,
financial, management and information systems, procedures and controls, and to
expand, train, motivate and manage its personnel. There can be no assurance that
the Company's personnel, systems, procedures and controls will be adequate to
support the Company's future operations. Any failure to implement and improve
the Company's operational, financial, management and information systems,
procedures or controls, or to expand, train, motivate or manage employees, could
materially and adversely affect the Company's business, financial condition and
results of operations. See "Risk Factors -- Dependence on Key Personnel,"
"Business -- Employees" and "Management -- Directors, Executive Officers and Key
Employees."

   
     Available Clinical Data; Risk Versus Benefit Issues.  The Company has
conducted a randomized clinical trial for the ROBODOC System in the United
States at three centers. Of the 120 patients enrolled in the U.S. clinical
study, 71 hips received treatment with the ROBODOC System and 65 hips in a
control group received conventional THR surgery. In addition, at least 1,400
patients have received treatment with the ROBODOC System in Europe, although not
as a part of the formal U.S. clinical study.

   
     In communications with the Company, the FDA has indicated a strong
"preference" for two year post-operative data from patients participating in the
U.S. clinical trial, although in a late 1996 meeting the FDA indicated that it
may accept a PMA application for filing with only two year post-operative data
on some patients and permit the Company to submit the additional post-operative
data while the PMA application is under review. However, there can be no
assurance that the FDA will not require complete two-year post-operative data on
all patients participating in the U.S. clinical trial before accepting a PMA
application for filing. The last patient who has received surgery in the U.S.
clinical trial will reach the two year post-operative mark in February 1998. The
number of patients enrolled in the U.S. clinical study is less than the 300
patients (150 ROBODOC System; 150 control group) initially requested to be
studied by the Company in its Investigational Device Exemption ("IDE")
application to the FDA. Nonetheless, there have been at least 1,500 primary THR
surgeries performed with the ROBODOC System in the combined U.S. clinical trial
and the European study (without a control group). If the FDA concludes that the
existing clinical data is insufficient to establish the safety and efficacy of
the ROBODOC System, the FDA could require the Company to obtain additional
clinical data, which could significantly delay completion of the PMA review
process, and which could accordingly have a material adverse effect on the
Company's business, financial condition and results of operations.

     No assurance can be given that the FDA will agree that the data indicates
that the ROBODOC System achieves better implant fit and alignment, that better
fit and alignment are significant surgical endpoints or that ROBODOC reduces
intraoperative fractures compared to conventional THR surgery, nor can assurance
be given that the FDA will agree that the greater surgery time and blood loss
associated with the ROBODOC System does not pose a significant safety concern or
create an unfavorable risk/benefit ratio. Further, no assurance can be given
that the FDA would not require the Company to obtain additional clinical data to
resolve any concern about the risk/benefit ratio offered by the ROBODOC System.
If the Company were required to obtain such additional data, the FDA review
process could be prolonged by several years.
 
     In February 1995, a law firm specializing in FDA regulatory matters
examined an interim report of preliminary data and concluded that it was
doubtful that the FDA would find that the device was safe and effective for its
intended use, or provided a therapeutic benefit, sufficient to permit PMA
approval, if the FDA were presented with the then existing preliminary data or
future data qualitatively similar to the preliminary data. The Company believes
that the currently available data, which have not been reviewed by an
 
                                        9
   12
 
independent third party, address many of the concerns identified in the law
firm's report. However, there can be no assurance that the FDA would agree that
the Company's current clinical data show that the ROBODOC System is safe and
effective for its intended use, provides a therapeutic benefit, or has an
acceptable risk/benefit ratio in light of increased surgery time and
intraoperative blood loss. In addition, the Company's Director of Regulatory
Affairs and Quality Assurance resigned in September 1996 and subsequently has
asserted that one of the reasons for his resignation was his concern about the
adequacy of the Company's clinical data. See "Business -- Available Clinical
Data; Risk Versus Benefit Issues."
 
  GOVERNMENT REGULATION.
 
     Summary.  The Company's products are subject to continued and pervasive
regulation by the FDA and foreign and state regulatory authorities. In the
United States, the Company must comply with food and drug laws and with
regulations promulgated by the FDA. These laws and regulations require the
Company's products to obtain various authorizations prior to being marketed in
the United States, and there is no assurance the Company's products will receive
these authorizations. The Company's manufacturing facilities and practices will
also be subject to FDA regulations. In each foreign market, the Company's
products may be subject to substantially different regulations. Failure to
comply with U.S. or applicable foreign regulations could have a material adverse
effect on the Company. See "Business -- Government Regulation."
 
  U.S. REGULATION.
 
     General.  Pursuant to the Federal Food, Drug, and Cosmetic Act, as amended,
and regulations thereunder (collectively, the "FDC Act"), the FDA regulates the
clinical testing, manufacture, labeling, sale, distribution and promotion of
medical devices in the United States. Noncompliance with applicable requirements
can result in, among other things, fines, injunctions, civil penalties, recall
or seizure of products, total or partial suspension of production, failure of
the government to grant pre-market clearance or pre-market approval for devices,
withdrawal of marketing clearances or approvals, and criminal prosecution. The
FDA also has the authority to request recall, repair, replacement or refund of
the cost of any device manufactured or distributed by the Company. Failure to
comply with regulatory requirements, including any future changes to such
requirements, could have a material adverse effect on the Company's business,
financial condition and results of operation. See "Business -- Government
Regulation."

     Lengthy "Pre-Market" Approval Process for ROBODOC System.  Before a new
device can be introduced into the U.S. market, the manufacturer must obtain FDA
permission to market through either the 510(k) pre-market notification process
for medical devices which are substantially similar to other approved medical
devices or the costlier, lengthier and less certain pre-market approval ("PMA")
application process. The Company intends to submit a PMA in late 1997 for
approval to market the ROBODOC System in the United States. The Company intends
to make an informal pre-PMA submission of the clinical data to the FDA prior to
the submission of a formal PMA application. Depending upon the FDA's review of
this informal submission, the target date for submitting a PMA application could
be delayed for a significant period. There can be no assurance that the PMA
application, once submitted, will be accepted for filing, found approvable, or,
if found approvable, will not take longer than expected to obtain approval, or
will not include unfavorable post-approval restrictions (for example,
limitations on the indicated patient population). See "Risk Factors -- Available
Clinical Data; Risk Versus Benefit Issues."

     New surgical applications for the ROBODOC System generally will require FDA
approval of a PMA supplement or, possibly, a new PMA. The Company is also likely
to require additional FDA approvals, supported by additional clinical data,
before incorporating new imaging modalities such as ultrasound and MRI or other
new technologies in the ROBODOC System. See "Business -- Government Regulation."
 
     No Assurance of Approvals; Subsequent Review of Approvals, Etc.  There can
be no assurance that any of the Company's current or future products will obtain
required FDA approvals on a timely basis, or at all, or that the Company will
have the necessary resources to obtain such approvals. If any of the Company's
products are not approved for use in the United States, the Company will be
limited to marketing them in foreign countries. Furthermore, approvals that have
been or may be granted are subject to continual review,
 
                                       10
   13
 
and later discovery if previously unknown problems result in product labeling
restrictions or withdrawal of the product from the market. See
"Business -- Government Regulation."
 
     Requirement to Follow Good Manufacturing Practices.  Assuming the Company
obtains the necessary FDA approvals and clearances for its products, in order to
maintain such approvals and clearances the Company will be required, among other
things, to register its establishment and list its devices with the FDA and with
certain state agencies, maintain extensive records, report any adverse
experiences on the use of its products and submit to periodic inspections by the
FDA and certain state agencies. The FDC Act also requires devices to be
manufactured in accordance with the Quality System Regulation ("QSR"), which
sets forth good manufacturing practices ("GMP") requirements with respect to
manufacturing and quality assurance activities. The QSR revises the previous GMP
regulation and imposes certain enhanced requirements that are likely to increase
the cost of compliance, including design controls. See "Business -- Government
Regulation."

     Foreign Regulation.  The introduction of the Company's products in foreign
markets has subjected and will continue to subject the Company to foreign
regulatory clearances, which may be unpredictable and uncertain, and which may
impose substantial additional costs and burdens. The ROBODOC and NeuroMate
Systems satisfy the appropriate international electromedical safety standards
and comply with the requirements of the Electromagnetic Compatibility Directive,
thus allowing the Company to apply the CE Mark under the European Directives and
to distribute the ROBODOC and NeuroMate Systems throughout the European Union.
Outside the European Union, international sales of medical devices are subject
to the regulatory requirements of each country. The regulatory review process
varies from country to country. Many countries also impose product standards,
packaging requirements, labeling requirements and import restrictions on
devices. No assurance can be given that any additional necessary approvals or
clearances for the Company's products will be granted on a timely basis, or at
all. See "Business -- Government Regulation."

     Adverse Effect of Delays or Loss of Approvals.  Delays in the receipt of,
or failure to receive, FDA approvals or clearances, or the loss of any
previously received approvals or clearances, or limitations on intended use
imposed as a condition of such approvals or clearances, would have a material
adverse effect on the business, financial condition and results of operations of
the Company. See "Business -- Government Regulation."

     Dependence on Principal Product.  For the near term, the Company expects to
derive most of its revenues from sales of the ROBODOC System. Accordingly, the
Company's potential future success and financial performance will depend almost
entirely on its ability to successfully market its ROBODOC System. If the
Company is unable to obtain the requisite regulatory approvals or to achieve
commercial acceptance of its ROBODOC System, the Company's business, financial
condition and results of operations will be materially and adversely affected.
See "Management's Discussion and Analysis of Financial Condition and Results of
Operations."

   
     Uncertainty of Market Acceptance.  The Company's ability to successfully
commercialize its Systems will require substantial marketing efforts and the
expenditure of significant funds to inform potential customers, including
hospitals and physicians, of its distinctive characteristics and the advantages
of using the Systems instead of traditional surgical tools and procedures. Since
the Systems employ innovative technology, rather than being an improvement of
existing technology, and represents a substantial capital expenditure, the
Company expects to encounter resistance to change, which it must overcome to
successfully market its products. Failure of the Systems to achieve significant
market acceptance would materially and adversely affect the Company's business,
financial condition and results of operations.

     Competition.  The principal competition for the ROBODOC System is manual
surgery performed by orthopaedic surgeons, using surgical power tools and manual
devices. The providers of these instruments are the major orthopaedic companies,
which include Howmedica, Inc. (a subsidiary of Pfizer, Inc.), located in New
York; Zimmer, Inc. (a subsidiary of Bristol-Myers Squibb Company), located in
Indiana; Johnson & Johnson Orthopaedics, Inc. (a subsidiary of Johnson &
Johnson), located in New Jersey; DePuy, Inc. located in Indiana; Biomet, Inc.,
located in Indiana; and Osteonics, Inc. (a subsidiary of the Stryker
Corporation), located in New Jersey. MAQUET, a manufacturer of operating tables
located in Germany, has recently
 
                                       11
   14

announced that it intends to market a device similar to ROBODOC System in mid
1998. The principal competition for the NeuroMate System are frame-based and
frameless navigators, which are manually operated. Approximately twenty
navigator models have been introduced, including those by Radionics,
Sofamor-Danek and Ohio Medical Surgical products, all located in the United
States; Elekta, located in Sweden; and Fischer Leibingher and Brain Lab, both
located in Germany. In general, there are companies in the medical products
industry capable of developing and marketing computer-controlled robotic systems
for surgical applications, many of whom have significantly greater financial,
technical, manufacturing, marketing and distribution resources than the Company,
and have established reputations in the medical device industry. Furthermore,
there can be no assurance that IBM or the University of California, which
developed the technology embodied in the ROBODOC System and hold patents
relating thereto, will not enter the market or license the technology to other
companies.

   
     There can be no assurance that future competition will not have a material
adverse effect on the Company's business. The cost of the Systems represents a
significant capital expenditure for a customer and accordingly may discourage
purchases by certain customers. See "Business -- Competition."

  UNCERTAINTY REGARDING PATENTS AND PROTECTION OF PROPRIETARY TECHNOLOGY.

     Summary.  Certain technology underlying the Company's products is the
subject of one United States patent issued to IBM, which IBM has agreed not to
enforce against the manufacture and sale of the Company's products, and five
patent applications by the Company, the outcome of which applications is
uncertain. Third party claims to the technology used in the Company's products
could, if valid, require the Company to obtain licenses to the technology; those
licenses may not be available on acceptable terms. The technology used in the
Company's products could be (a) disclosed by Company employees despite their
confidentiality obligations to the Company or (b) independently developed or
otherwise acquired by potential competitors. See "Business -- Patents and
Proprietary Rights."

   
     General.  The Company's ability to compete successfully may depend, in
part, on its ability to obtain and protect patents, protect trade secrets and
operate without infringing the proprietary rights of others. The Company's
policy is to seek to protect its proprietary position by, among other methods,
filing U.S. and foreign patent applications relating to its technology,
inventions and improvements that are important to the development of its
business. The Company has filed four patent applications, and is preparing for
filing additional patent applications covering various aspects of its
technology. In addition, IBM has agreed not to assert infringement claims
against the Company with respect to an IBM patent relating to robotic medical
technology, to the extent such technology is used in the Company's products.
Significant portions of the ROBODOC System and ORTHODOC software are protected
by copyrights. IBM has granted the Company a royalty-free license for the
underlying software code for the ROBODOC System. See "Business -- Patents and
Proprietary Rights."

     There can be no assurance that the Company's pending or future patent
applications will mature into issued patents, or that the Company will continue
to develop its own patentable technologies. Further, there can be no assurance
that any patents that may be issued in the future will effectively protect the
Company's technology or provide a competitive advantage for the Company's
products or will not be challenged, invalidated, or circumvented in the future.
In addition, there can be no assurance that competitors, many of which have
substantially more resources than the Company and have made substantial
investments in competing technologies, will not obtain patents that will
prevent, limit or interfere with the Company's ability to make, use or sell its
products either in the United States or internationally. See
"Business -- Patents and Proprietary Rights."

     Secrecy of Patent Applications Until Patents Issued.  Patent applications
in the United States are maintained in secrecy until patents' issue, and patent
applications in foreign countries are maintained in secrecy for a period after
filing. Publication of discoveries in the scientific or patent literature tends
to lag behind actual discoveries and the filing of related patent applications.
Patents issued and patent applications filed relating to medical devices are
numerous and there can be no assurance that current and potential competitors
and other third parties have not filed or in the future will not file
applications for, or have not

                                       12
   15
 
received or in the future will not receive, patents or obtain additional
proprietary rights relating to products or processes used or proposed to be used
by the Company. See "Business -- Patents and Proprietary Rights."

     Lack of Infringement Study.  The Company's patent counsel has not
undertaken any infringement study to determine if the Company's products and
pending patent applications infringe on other existing patents due to the
Company's belief that an infringement study would not be cost-effective, nor
offer sufficient protection against potential infringement claims, if and when
made. The medical device industry has been characterized by substantial
competition and litigation regarding patent and other proprietary rights. The
Company intends to vigorously protect and defend its patents and other
proprietary rights relating to its proprietary technology. Litigation alleging
infringement claims against the Company (with or without merit), or instituted
by the Company to enforce patents and to protect trade secrets or know-how owned
by the Company or to determine the enforceability, scope and validity of the
proprietary rights of others, is costly and time consuming. If any relevant
claims of third-party patents are upheld as valid and enforceable in any
litigation or administrative proceedings, the Company could be prevented from
practicing the subject matter claimed in such patents, or could be required to
obtain licenses from the patent owners of each patent, or to redesign its
products or processes to avoid infringement. There can be no assurance that such
licenses would be available or, if available, would be available on terms
acceptable to the Company or that the Company would be successful in any attempt
to redesign its products or processes to avoid infringement. Accordingly, an
adverse determination in a judicial or administrative proceeding or failure to
obtain necessary licenses could prevent the Company from manufacturing and
selling its products, which would have a material adverse effect on the
Company's business, financial condition and results of operations. See
"Business -- Patents and Proprietary Rights."

     Possibility of Disclosure or Discovery of Proprietary
Information.  Although the Company requires each of its employees, consultants,
and advisors to execute confidentiality and assignment of inventions and
proprietary information agreements in connection with their employment,
consulting or advisory relationships with the Company, there can be no assurance
that these agreements will provide effective protection for the Company's
proprietary information in the event of unauthorized use or disclosure of such
information. Furthermore, no assurance can be given that competitors will not
independently develop substantially equivalent proprietary information and
techniques or otherwise gain access to the Company's proprietary technology, or
that the Company can meaningfully protect its rights in unpatented proprietary
technology. See "Business -- Patents and Proprietary Rights."
 
     Limited Manufacturing Experience.  The Company's success will depend in
part on its ability to manufacture its products in a timely, cost-effective
manner and in compliance with GMP, and manufacturing requirements of other
countries, including the International Standards Organization ("ISO") 9000
standards and other regulatory requirements. The manufacture of the Company's
products is a complex operation involving a number of separate processes and
components. The Company's manufacturing activities to date have consisted
primarily of manufacturing limited quantities of systems for use in clinical
trials and a limited number of systems for commercial sale. The Company does not
have experience in manufacturing its products in the commercial quantities that
might be required. Furthermore, as a condition to receipt of PMA approval, the
Company's facilities, procedures and practices will be subject to pre-approval
and ongoing GMP inspections by FDA.
 
     Manufacturers often encounter difficulties in scaling up manufacturing of
new products, including problems involving product yields, quality control and
assurance, component and service availability, adequacy of control policies and
procedures, lack of qualified personnel, compliance with FDA regulations, and
the need for further FDA approval of new manufacturing processes and facilities.
There can be no assurance that manufacturing yields, costs or quality will not
be adversely affected as the Company seeks to increase production, and any such
adverse effect could have a material adverse effect on the Company's business,
financial condition and results of operations. See "Business -- Manufacturing."

     Dependence On Supplier for Robot.  Although the Company has multiple
sources for most of the components, parts and assemblies used in the ROBODOC and
NeuroMate Systems, the Company is dependent on Sankyo Seiki of Japan for the
ROBODOC System robot and Audemars-Piguet of Switzerland for the supply of the
customized NeuroMate robot. The robot for either the ROBODOC System or the

                                       13
   16

NeuroMate System can be obtained from other suppliers with appropriate
modifications and engineering effort. If the Company were no longer able to
obtain the robot from its supplier, there can be no assurance that the delays
resulting from the required modifications or engineering effort to adapt
alternative components would not have a material adverse effect on the Company's
business, financial condition and results of operations. See
"Business -- Manufacturing."

   
     Reliance on Foreign Sales.  From inception through June 30, 1997,
substantially all of the Company's sales (other than clinical sales in the
United States pursuant to an exemption in the rules and regulations of the FDA
for investigational devices) have been to customers in Germany, Austria, France
and Japan. The Company believes that until such time, if ever, as it receives
approval from the FDA to market the ROBODOC System in the United States,
substantially all of its sales for the ROBODOC System will be derived from
customers in foreign markets. Foreign sales are subject to certain risks,
including economic or political instability, shipping delays, fluctuations in
foreign currency exchange rates, changes in regulatory requirements, custom
duties and export quotas and other trade restrictions, any of which could have a
material adverse effect on the Company's business. To date, payment for
substantially all ROBODOC Systems in Europe has been fixed in U.S. Dollars.
However, there can be no assurance that in the future the customers will be
willing to make payment to the Company for its products in U.S. Dollars. If the
U.S. Dollar strengthens substantially against the foreign currency of a country
in which the Company sells its products, the cost of purchasing the Company's
products in U.S. Dollars would increase and may inhibit purchases of the
Company's products by customers in that country. The Company is unable to
predict the nature of future changes in foreign markets or the effect, if any,
they might have on the Company. See "Business -- Sales and Marketing."

   
     Dependence on Key Personnel.  The Company's business and marketing plan was
formulated by, and is to be implemented under the direction of, Dr. Ramesh C.
Trivedi, the Chief Executive Officer and President of the Company. Dr. Trivedi
is employed by the Company pursuant to an employment agreement terminable by the
Company or Dr. Trivedi at any time. The Company has obtained key-man insurance
on the life of Dr. Trivedi in the amount of $1,000,000. The Company's growth and
future success also will depend in large part on the continued contributions of
its key technical and senior management personnel, as well as its ability to
attract, motivate and retain highly qualified personnel generally and, in
particular, trained and experienced professionals capable of developing, selling
and installing the Systems and training surgeons in their use. Competition for
such personnel is intense, and there can be no assurance that the Company will
be successful in hiring, motivating or retaining such qualified personnel. None
of the Company's executive or key technical personnel, other than Dr. Trivedi,
is employed by the Company pursuant to an employment agreement with the Company.
The loss of the services of Dr. Trivedi or other senior management or key
technical personnel, or the inability to hire or retain qualified personnel,
could have a material adverse effect on the Company's business, financial
condition and results of operations. "See Management."

   
     Control of the Company; Ownership of Shares by Current Management and
Principal Securityholders. Upon completion of this Offering, the current
executive officers, directors and other significant securityholders of the
Company will continue to own or have rights to acquire 4,335,626 shares of
Common Stock (or approximately 38% of the shares of Common Stock on a fully
diluted basis). Although these securityholders may or may not agree on any
particular matter that is the subject of a vote of the stockholders, these
securityholders may be effectively able to control the outcome of any issues
which may be subject to a vote of securityholders, including the election of
directors, proposals to increase the authorized capital stock, or the approval
of mergers, acquisitions, or the sale of all or substantially all of the
Company's assets. See "Security Ownership of Certain Beneficial Owners and
Management."

   
     Need for Additional Financing.  Although the Company anticipates that the
net proceeds of this Offering, together with cash flow from operations, will be
sufficient to finance its operations for at least 24 months following the date
of this Prospectus, there can be no assurance that the Company will not require
additional financing at an earlier date. This will depend upon the Company's
ability to generate sufficient sales of its products, and the timing of required
expenditures. If the Company is required to obtain financing in the future,
there can be no assurance that such financing will be available on terms
acceptable to the Company, if

                                       14
   17
 
at all. See "Management's Discussion and Analysis of Financial Condition and
Results of Operations -- Liquidity and Capital Resources."

     Product Liability.  The manufacture and sale of medical products exposes
the Company to the risk of significant damages from product liability claims.
The Company maintains product liability insurance against product liability
claims in the amount of $5 million per occurrence and $5 million in aggregate.
In addition, in connection with the sale of ROBODOC Systems, the Company enters
into indemnification agreements with its customers pursuant to which the
customers indemnify the Company against any claims against it arising from
improper use of the ROBODOC System. There can be no assurance, however, that the
coverage limits of the Company's insurance coverage, that such insurance can be
maintained at acceptable costs, or that customers will be able to satisfy
indemnification claims. Although the Company has not experienced any product
liability claims to date, a successful claim brought against the Company in
excess of its insurance coverage could have a materially adverse effect on the
Company's business, financial condition, and results of operations.

     Limitation on Director Liability.  The Company's certificate of
incorporation provides that a director of the Company shall not be personally
liable to the Company or its stockholders for monetary damages for breach of
fiduciary duty as a director, with certain exceptions under Delaware law. This
may discourage stockholders from bringing suit against a director for breach of
fiduciary duty and may reduce the likelihood of derivative litigation brought by
stockholders on behalf of the Company against a director. In addition, the
Company's By-laws provide for mandatory indemnification of directors and
officers. See "Management -- Indemnification of Officers and Directors and
Limitation on Director Liability."
 
     Absence of Dividends.  Since inception, the Company has not paid any
dividends on its Common Stock and it does not anticipate paying such dividends
in the foreseeable future. The Company intends to retain earnings, if any, to
finance its operations. See "Dividend Policy."

     Possible Volatility of Market Price for the Common Stock.  Since the
completion of the Company's initial public offering in November 1996, the market
price of the Common Stock has fluctuated significantly. The Company believes
that factors such as announcement of developments related to the Company's
business, announcements of technological innovations or new products by the
Company or its competitors, sales of the Company's Common Stock in the public
market, and shortfalls or changes in the Company's financial results from
analysts' expectations could cause the price of the Common Stock to fluctuate
substantially. The Company's operating results and various factors affecting the
medical device industry generally also may significantly impact the market price
of the Company's securities. In addition, the stock market generally, and the
securities of technology companies in particular, have experienced a high level
of price and volume volatility, and market prices for the securities of many
companies have experienced wide price fluctuations not necessarily related to
the operating performance of such companies. There can be no assurance that the
market price of the Common Stock will not experience significant fluctuations or
decline below the public offering price.

   
     Possible Volatility of Market Price for Common Stock Due to Dual Listing in
Different Currencies.  Following the completion of the Offering, the Common
Stock will be quoted on the Nasdaq SmallCap Market in US dollars, and quoted on
EASDAQ in Deutsche Marks. Fluctuations in the value of the US dollar against the
Deutsche Mark may affect the market value of the Common Stock and result in
trading therein by currency speculators or otherwise, which may cause further
volatility in the price of the Common Stock.

   
     Shares Eligible for Future Sale.  No assurance can be given as to the
effect, if any, that future sales of Common Stock, or the availability of shares
of Common Stock for future sales, will have on the market price of the Common
Stock from time to time. Sales of substantial amounts of Common Stock (including
shares issued upon the exercise of warrants or stock options), or the
possibility of such sales, could adversely affect the market price of the Common
Stock and also impair the Company's ability to raise capital through an offering
of its equity securities in the future. Upon completion of this Offering, the
Company will have 7,158,082 shares of Common Stock outstanding, of which only
4,712,989 shares of Common Stock will be transferable without restriction under
the Securities Act of 1933 (the "Securities Act"). The remaining 2,445,093
shares, issued in private transactions, will be "restricted securities" (as that
term is defined in Rule

                                       15
   18

144 promulgated under the Securities Act) which may be publicly sold only if
registered under the Securities Act or if sold in accordance with an applicable
exemption from registration, such as Rule 144. In general, under Rule 144 as
currently in effect, subject to the satisfaction of certain other conditions, a
person, including an affiliate of the Company, who has beneficially owned
restricted securities for at least one year, is entitled to sell (together with
any person with whom such individual is required to aggregate sales), within any
three-month period, a number of shares that does not exceed the greater of 1% of
the total number of outstanding shares of the same class or, if the Common Stock
is quoted on Nasdaq or a national securities exchange, the average weekly
trading volume during the four calendar weeks preceding the sale. A person who
has not been an affiliate of the Company for at least three months and who has
beneficially owned restricted securities for at least two years is entitled to
sell such restricted securities under Rule 144 without regard to any of the
limitations described above. Officers, directors and the other existing
securityholders of the Company, owning or having rights to acquire in the
aggregate 5,129,759 shares of Common Stock constituting restricted securities,
have agreed not to sell or otherwise dispose of any shares of Common Stock prior
to May 21, 1998 ("Lock-Up Agreements"), without the prior written consent of
Rickel & Associates, Inc., managing underwriter of the Company's initial public
offering. Following expiration of the term of the Lock-Up Agreements, 1,828,778
shares of Common Stock will become eligible for resale pursuant to Rule 144
commencing in the second quarter of 1998, subject to the volume limitations and
compliance with the other provisions of Rule 144. In addition, securityholders
of the Company owning or having rights to acquire in the aggregate 4,030,649
shares of Common Stock granted certain registration rights with respect to those
shares have agreed that they will not exercise such registration rights prior to
May 21, 1998. The Company has agreed to file a registration statement for the
resale in the United States of the 619,355 shares of Common Stock ("the IMMI
Shares") issued in connection with the acquisition of IMMI, on or about November
21, 1997. The shareholders of IMMI have agreed not to sell their IMMI Shares
prior to March 5, 1999, except as follows: (i) prior to December 5, 1997, an
aggregate of 50,000 shares; (ii) from December 6, 1997 through March 5, 1998, an
aggregate of 50,000 shares plus 1% of the total number of shares of Common Stock
traded on Nasdaq during the preceding three month period; (iii) from March 6,
1998 through June 5, 1998, an aggregate of 75,000 shares plus 1% of the total
number of shares of Common Stock traded on Nasdaq during the preceding three
month period; (iv) from June 6, 1998 through September 5, 1998, an aggregate of
100,000 shares plus 1% of the total number of shares of Common Stock traded on
Nasdaq during the preceding three month period; (v) from September 6, 1998
through December 5, 1998, an aggregate of 100,000 shares plus 1% of the total
number of shares of Common Stock traded on Nasdaq during the preceding three
month period; and (vi) from December 6, 1998 through March 5, 1999, an aggregate
of 100,000 shares plus 1% of the total number of shares of Common Stock traded
on Nasdaq during the preceding three month period. Thereafter, the IMMI Shares
must be resold in compliance with the volume limitation and other conditions of
Rule 144. The Company also has granted the former shareholders of IMMI piggyback
registration rights (other than in connection with the Offering and certain
other types of offerings) for resales of the IMMI Shares. The Company granted
Rickel & Associates, Inc. certain registration rights with respect to the shares
of Common Stock and warrants issuable upon exercise of the underwriter's
warrants issued in connection with that offering. Furthermore, the holders of
the Advisors' Warrants have demand and piggyback registration rights with
respect to the shares of Common Stock issuable upon exercise thereof. See
"Description of Securities -- Shares Eligible for Future Sale," "Description of
Securities -- Registration Rights," "Certain Transactions" and "Underwriting."

   
     Effect of Issuance of Common Stock Upon Exercise of Warrants and Options;
Possible Issuance of Additional Options.  Immediately after the Offering, the
Company will have an aggregate of 1,942,855 shares of Common Stock authorized
but unissued and not reserved for specific purposes and an additional 5,899,063
shares of Common Stock unissued but reserved for issuance pursuant to (i) the
Company's stock option plans, (ii) outstanding warrants, and (iii) exercise of
the Advisors' Warrants . All of such shares may be issued without any action or
approval by the Company's stockholders. Although there are no present plans,
agreements, commitments or undertakings with respect to the issuance of
additional shares or securities convertible into any such shares by the Company,
any shares issued would further dilute the percentage ownership of the Company
held by the public stockholders. The Company has agreed with Rickel &
Associates, Inc. that it will not issue any securities, or rights thereto,
without its consent until November 21,

                                       16
   19

1999. Rickel & Associates, Inc. has consented to the issuance of the securities
specifically described herein. The Company also has agreed with Investmentbank
Austria that for a period of six months following the closing of this Offering,
it will not issue or sell, offer or contract to issue or sell, grant any option
for issuance or sale of, or otherwise dispose of, directly or indirectly, any
Common Stock or any securities convertible into, exchangeable for, or
representing the right to receive Common Stock without, in each case, the prior
written consent of Investmentbank Austria, which consent will not be
unreasonably withheld.

     The exercise of warrants or options and the sale of the underlying shares
of Common Stock (or even the potential of such exercise or sale) may have a
depressive effect on the market price of the Company's securities. Moreover, the
terms upon which the Company will be able to obtain additional equity capital
may be adversely affected since the holders of outstanding warrants and options
can be expected to exercise them, to the extent they are able, at a time when
the Company would, in all likelihood, be able to obtain any needed capital on
terms more favorable to the Company than those provided in the warrants and
options. See "Management -- Stock Option Plan," "Description of Securities" and
"Underwriting."
 
     Possible Adverse Effect of Issuance of Preferred Stock.  The Company's
certificate of incorporation authorizes the issuance of 1,000,000 shares of
"blank check" preferred stock, with designations, rights and preferences
determined from time to time by the Company's Board of Directors. Accordingly,
the Company's Board of Directors is empowered, without further stockholder
approval, to issue preferred stock with dividend, liquidation, conversion,
voting or other rights that could adversely affect the voting power or other
rights of the holders of the Common Stock. In the event of issuance, the
preferred stock could be used, under certain circumstances, as a method of
discouraging, delaying or preventing a change in control of the Company, since
the terms of the preferred stock that might be issued could effectively restrict
the Company's ability to consummate a merger, reorganization, sale of all or
substantially all of its assets, liquidation or other extraordinary corporate
transaction without the approval of the holders of the preferred stock. The
Company has no current plans to issue any shares of preferred stock. However,
there can be no assurance that preferred stock will not be issued at some time
in the future. The Company has agreed with Rickel & Associates, Inc. that it
will not issue any securities, or rights thereto, without its consent until
November 21, 1999, Rickel & Associates, Inc. has consented to the issuance of
the securities specifically described herein. See "Description of
Securities -- Preferred Stock."
 
     Antitakeover Provisions of Delaware Business Combination Statute.  The
Company is subject to Section 203 of the Delaware General Corporation Law
("DGCL"), which limits transactions between a publicly held company and
"interested stockholders" (generally, those stockholders who, together with
their affiliates and associates, own 15% or more of a company's outstanding
capital stock). This provision of the DGCL also may have the effect of deterring
certain potential acquisitions of the Company. See "Description of Securities --
Statutory Provisions Affecting Stockholders."

     Risks Associated with Forward-Looking Statements Included in this
Prospectus.  This Prospectus contains certain forward-looking statements
regarding, among other items, the Company's expansion strategy. The
forward-looking statements included herein are based on current expectations
that involve numerous risks and uncertainties. Assumptions relating to the
foregoing involve judgments with respect to, among other things, future
economic, competitive and market conditions and future business decisions, all
of which are difficult or impossible to predict accurately and many of which are
beyond the control of the Company. Although the Company believes that its
assumptions underlying the forward-looking statements are reasonable, any of the
assumptions could prove inaccurate and, therefore, there can be no assurance
that the forward-looking statements included in this Prospectus will prove to be
accurate. In light of the significant uncertainties inherent in the
forward-looking statements included herein, the inclusion of such information
should not be regarded as a representation by the Company or any other person
    
that the objectives and plans of the Company will be achieved.
 
                                       17
   20

                                USE OF PROCEEDS

   
     The net proceeds to the Company from the sale of the shares of Common Stock
offered hereby, after deducting underwriting discounts and other expenses of the
Offering, are estimated to be $19,530,113 ($22,507,862 if the Over-Allotment
Option is exercised in full). The Company expects to use the net proceeds of the
Offering as follows:

   

                                                                 APPROXIMATE
                                                                   AMOUNT        PERCENT
                                                                 -----------     -------
                                                                           
        Product development(1).................................  $ 7,910,000       40.5%
        Sales and marketing(2).................................    7,735,000       39.6%
        Investment in clinic(3)................................      290,000        1.5%
        Working capital and general corporate purposes.........    3,595,000       18.4%
                                                                  ----------        ---
          Total................................................  $19,530,000      100.0%
                                                                  ==========        ===

 
- ---------------
   
(1) Includes development of software packages for total knee replacement and
    acetabulum surgeries, as well as neurosurgical applications and product
    design improvements.

   
(2) Represents costs associated with marketing and sales activities with respect
    to the Company's products, including advertising and promotional activities,
    as well as participation in trade shows. Also includes costs associated with
    market development and sales activities.

(3) Represents costs associated with an investment to be made in a clinic
    located in Spain which is intended to be a training center for use of the
    ROBODOC System for surgeons from Southern Europe, Latin America and the
    Middle East.

     Additional proceeds from the exercise of the Over-Allotment Option will be
added to the Company's working capital and be available for general corporate
purposes. Pending application, the Company will invest the net proceeds of this
Offering in United States government securities and investment-grade commercial
paper.

     The Company has not determined the specific allocation of the net proceeds
among the various uses described above. Specific allocations of such net
proceeds will ultimately depend on the development of the Company's products and
the related technology, the adaptation of its products to additional surgical
applications and commercial acceptance of its products. The Company anticipates,
based on currently proposed plans and assumptions relating to its operations,
that the net proceeds of this Offering will be sufficient to satisfy the
Company's anticipated cash requirements for at least 24 months following the
date of this Prospectus.
 
                                       18
   21

                            MARKET FOR COMMON STOCK
    
                        AND RELATED STOCKHOLDER MATTERS

     Since November 21, 1996, the Company's Common Stock and Warrants have
traded on the Nasdaq SmallCap Market under the symbols "RDOC" and "RDOCW",
respectively. The Company's Common Stock and Warrants also are listed on the
Pacific Stock Exchange under the symbols "ROB" and "ROBWS", respectively.*

   
     Set forth below are the high and low bid prices for the Common Stock and
Warrants on the Nasdaq SmallCap Market for each quarter since November 21, 1996.
Nasdaq SmallCap quotations reflect inter-dealer prices, without retail mark-up,
mark-down or commission, and may not represent actual transactions.

                             NASDAQ SMALLCAP MARKET

                                                           COMMON STOCK           WARRANTS
                                                             ("RDOC")             ("RDOCW")
                                                          --------------       ---------------
    QUARTER ENDED                                         HIGH      LOW        HIGH       LOW
    ----------------------------------------------------  ----      ----       ----      -----
                                                                             
    December 31, 1996...................................  $5 3/4    $  5       $  1      $ 1/2
    March 31, 1997......................................  $6 3/4    $  5       $1 1/2    $ 5/8
    June 30, 1997.......................................  $7 5/8    $  5       $2 1/4    $7/16
    September 30, 1997 (through September 18, 1997).....  $9 1/4    $6 5/8     $3 1/8    $1 5/8

 
   
     On September 23, 1997, the closing bid price of the Common Stock and
Warrants on the Nasdaq SmallCap Market was $7 1/2 and $2 1/8, respectively.

   
     As of September 1, 1997, there were 64 holders of record of the Common
Stock and 7 holders of record of the Warrants.
    
- ---------------

* No trading activity has been reported by the Pacific Stock Exchange.

                                       19
   22
 
                                 CAPITALIZATION

     The following table sets forth the capitalization of the Company (i) as of
June 30, 1997, (ii) as of June 30, 1997 Pro Forma Combined to reflect the
acquisition of IMMI on September 5, 1997 and (iii) such pro forma capitalization
on an as adjusted basis to give effect to the sale of the 3,171,771 shares of
Common Stock offered hereby, and the application of the estimated net proceeds
thereof. The information set forth below should be read in conjunction with the
consolidated financial statements, unaudited pro forma combined condensed
financial statements, and notes thereto appearing elsewhere in this Prospectus,
"Management's Discussion and Analysis of Financial Condition and Results of
Operations" and "Use of Proceeds."

   

                                                            PRO FORMA         PRO FORMA COMBINED
                                          ACTUAL(1)       COMBINED(1)(2)     AS ADJUSTED(1)(2)(3)
                                         ------------     --------------     --------------------
                                                                    
    Long-term debt.....................  $         --      $    184,727          $    184,727
                                         ------------      ------------
    Stockholders' equity:
      Preferred stock, $0.01 par value,
         1,000,000 shares authorized,
         no shares issued or
         outstanding...................            --                --                    --
      Common stock, $0.01 par value,
         15,000,000 shares authorized;
         Actual 3,366,956 shares issued
         and outstanding; 3,986,311
         shares issued and outstanding
         pro forma combined; 7,158,082
         shares issued and outstanding
         pro forma combined as
         adjusted......................        33,669            39,863                71,581
      Additional paid-in capital.......    25,775,656        29,659,011            49,159,269
      Deferred stock compensation......      (336,417)         (336,417)             (336,417)
      Accumulated translation
         adjustment....................       (29,994)          (29,994)              (29,994)
      Accumulated deficit..............   (20,788,402)      (21,096,948)          (21,096,948)
                                         ------------      ------------
    Total stockholders' equity.........     4,654,512         8,235,515            27,767,491
                                         ------------      ------------
              Total capitalization.....  $  4,654,512      $  8,420,242          $ 27,952,218
                                         ============      ============

 
- ---------------
   
(1) Does not include (i) 4,332,816 shares of Common Stock issuable upon exercise
    of outstanding warrants at exercise prices ranging from $0.01 to $8.25 per
    share, and (ii) 1,168,313 shares of Common Stock issuable upon exercise of
    outstanding options granted pursuant to the Company's stock option plans, at
    exercise prices ranging from $0.07 to $8.25 per share, including options to
    purchase 53,398 shares granted subsequent to June 30, 1997. See "Certain
    Transactions."

   
(2) See the unaudited Pro Forma Combined Condensed Financial Statements
    appearing elsewhere in this prospectus.

   
(3) Does not include shares of Common Stock reserved for issuance upon exercise
    of the Over-Allotment Option or the Advisors' Warrants, or the proceeds
    therefrom.

                                       20
   23
 
                                    DILUTION

     The pro forma combined net tangible book value of the Company as of June
30, 1997 was $4,391,273 or approximately $1.10 per share of Common Stock. The
pro forma combined net tangible book value of the Company as of June 30, 1997
includes the effect of the acquisition of IMMI on September 5, 1997. The net
tangible book value of the Company is the tangible assets less total
liabilities. Dilution per share to new investors represents the difference
between the amount paid per share of Common Stock by purchasers in the Offering,
and the pro forma combined adjusted net tangible book value per share after the
Offering.

   
     After giving effect to the sale by the Company of the 3,171,771 shares of
Common Stock offered hereby, the pro forma combined adjusted net tangible book
value of the Company as of June 30, 1997, would have been $23,921,386 or $3.34
per share. This represents an increase in net tangible book value per share of
$2.24 to the Company's existing stockholders and an immediate dilution of $3.79
per share (or approximately 53% of the offering price) to new stockholders
purchasing shares of Common Stock in the Offering. The following table
illustrates this dilution on a per share basis:

   

            Public offering price per share.....................            $ 7.13
            Pro forma combined net tangible book value before
              Offering..........................................  $1.10
            Increase attributable to new investors..............   2.24
                                                                  -----
            Pro forma combined adjusted net tangible book value
              after Offering....................................              3.34
                                                                             -----
            Dilution to new investors...........................            $ 3.79
                                                                             =====

 
   
     The above table does not include the possible exercise of outstanding stock
options or warrants. As of June 30, 1997, there were outstanding options to
purchase an aggregate of 1,114,915 shares of Common Stock having exercise prices
from $0.07 per share to $7.84 per share and outstanding warrants to purchase an
aggregate of 4,332,816 shares of Common Stock having exercise prices from $0.01
per share to $8.25 per share. To the extent that stock options or warrants are
exercised at prices below the public offering price per share, there will be
further dilution to new investors. See "Certain Transactions," "Description of
Securities" and "Underwriting."

   
     The information in the following table summarizes the number and
percentages of shares of Common Stock, purchased from the Company through June
30, 1997, the amount and percentage of consideration paid and the average price
per share paid to the Company by existing stockholders and by new investors
pursuant to the Offering. The information also includes 619,355 shares of Common
Stock issued by the Company on September 5, 1997 in connection with the
acquisition of IMMI.

   

                                                            TOTAL CONSIDERATION      AVERAGE PRICE
                                    SHARES PURCHASED               PAID                PER SHARE
                                   -------------------     ---------------------     -------------
                                                                      
    Existing Stockholders........  3,986,311      55.7%    $24,551,043      52.0%       $  6.16
    New Investors................  3,171,771      44.3%     22,624,434      48.0%          7.13
                                   ---------     -----     -----------     -----
                                   7,158,082     100.0%    $47,175,477     100.0%
                                   =========     =====     ===========     =====

 
   
     The information in the foregoing table excludes 1,168,313 shares of Common
Stock issuable upon the exercise of outstanding options (including options to
purchase 53,398 shares granted subsequent to June 30, 1997), 4,332,816 shares of
Common Stock issuable upon exercise of outstanding warrants, 475,765 shares of
Common Stock reserved for issuance upon exercise of the Over-Allotment Option
and 317,177 shares of Common Stock reserved for issuance pursuant to the
Advisors' Warrants. See "Capitalization" and "Underwriting."

                                DIVIDEND POLICY
 
     The payment of dividends by the Company is within the discretion of its
Board of Directors and depends in part upon the Company's earnings, capital
requirements and financial condition. Since its inception, the Company has not
paid any dividends on its Common Stock and does not anticipate paying such
dividends in the foreseeable future. The Company intends to retain earnings, if
any, to finance its operations.
 
                                       21
   24
 
                  SELECTED CONSOLIDATED FINANCIAL INFORMATION

     The following table sets forth selected consolidated financial information
regarding the results of operations and financial position of the Company for
the periods and at the dates indicated. The financial statements of the Company
as of December 31, 1996 and for the years ended December 31, 1995 and 1996 have
been audited by Ernst & Young LLP, independent auditors, as set forth in their
report thereon included elsewhere in this Prospectus. The selected financial
information as of June 30, 1997 and for the six months ended June 30, 1996 and
1997 are derived from the unaudited interim consolidated financial statements of
the Company set forth elsewhere in this Prospectus and include, in the opinion
of management, all adjustments (consisting only of normal recurring adjustments)
necessary for the fair presentation of its results of operations for such
periods. The results of operations for the six months ended June 30, 1997 are
not necessarily indicative of the results to be expected for the full year. The
historical selected consolidated financial information set forth below does not
include data regarding the results of operations or financial position of IMMI
for the periods and at the dates indicated. This data should be read in
conjunction with the Company's consolidated financial statements (including the
notes thereto) and the Company's unaudited interim consolidated financial
statements appearing elsewhere in this Prospectus, and "Management's Discussion
and Analysis of Financial Condition and Results of Operations."

STATEMENT OF OPERATIONS DATA:

                                                                              SIX MONTHS ENDED
                                              YEAR ENDED DECEMBER 31,             JUNE 30,
                                             -------------------------   --------------------------
                                                1995          1996          1996           1997
                                             -----------   -----------   -----------   ------------
                                                                           
Net sales................................... $   174,521   $ 2,280,311   $ 1,064,206   $  1,379,696
Cost of sales...............................      70,179       884,152       458,483        531,693
                                             -----------   -----------    ----------   ------------
                                                 104,342     1,396,159       605,723        848,003
Operating expenses:
  Selling, general and administrative.......   1,668,947     2,066,236       887,283      1,383,596
  Research and development..................   2,361,125     2,468,535       977,616      1,183,519
  Stock compensation........................          --       357,249       246,000         90,000
                                             -----------   -----------    ----------   ------------
                                               4,030,072     4,892,020     2,110,899      2,657,115
Other income (expense):
  Interest income...........................     107,306        87,933        38,723        125,147
  Interest expense..........................    (287,792)           --            --             --
  Other.....................................      55,801       (30,635)      (20,958)        14,374
                                             -----------   -----------    ----------   ------------
Loss before provision for income taxes......  (4,050,415)   (3,438,563)   (1,487,411)    (1,669,591)
Provision for income taxes..................       3,113        10,266         3,183         18,000
                                             -----------   -----------    ----------   ------------
Net loss....................................  (4,053,528)   (3,448,829)   (1,490,594)    (1,687,591)
Preferred stock dividends...................    (936,325)           --            --             --
                                             -----------   -----------    ----------   ------------
Net loss applicable to common
  stockholders.............................. $(4,989,853)  $(3,448,829)  $(1,490,594)  $ (1,687,591)
                                             ===========   ===========    ==========   ============
Net loss per common and common share
  equivalent................................ $     (1.19)  $     (0.79)  $     (0.34)  $      (0.50)
                                             ===========   ===========    ==========   ============
Shares used in per share calculations(1)....   4,178,877     4,373,947     4,377,643      3,364,567
                                             ===========   ===========    ==========   ============

 
BALANCE SHEET DATA:

                                                                DECEMBER 31, 1996     JUNE 30, 1997
                                                                -----------------     --------------
                                                                                
Working capital...............................................     $ 6,053,430         $  4,367,685
Total assets..................................................       8,029,431            6,663,357
Accumulated deficit...........................................     (19,100,811)         (20,788,402)
Stockholders' equity..........................................       6,322,304            4,654,512

 
- ---------------
(1) See Note 2 of notes to consolidated financial statements for an explanation
    of the determination of the number of shares used in computing net loss per
    share.
 
                                       22
   25
 
                    MANAGEMENT'S DISCUSSION AND ANALYSIS OF
                 FINANCIAL CONDITION AND RESULTS OF OPERATIONS
 
GENERAL

     The following discussion and analysis, which relates solely to the
operations of Integrated Surgical Systems, Inc. and does not include the
operations of IMMI which it acquired on September 5, 1997, should be read in
conjunction with the consolidated financial statements of Integrated Surgical
Systems, Inc., including the notes thereto, appearing elsewhere in this
Prospectus.

     From its inception in October 1990, the Company has been primarily engaged
in the development and clinical evaluation of the ROBODOC System. Net sales are
derived from the sale of ROBODOC Systems and related consumables. Prior to 1996,
sales of the ROBODOC System were limited to sales for clinical evaluation. The
ROBODOC System satisfies the appropriate international standards for medical
electrical equipment and the Electromagnetic Compatibility Directive ("CE
Mark"), and complies with the relevant provisions of the Medical Device
Directive for a Class IIb Medical Device, thus allowing the Company to
distribute the ROBODOC System throughout the European Union. The Company sold
its first commercial ROBODOC System to a clinic in Germany in March 1996. The
Company intends to use a significant portion of the net proceeds of this
Offering for marketing and sales in Europe. See "Use of Proceeds."
 
     In the United States, the Company's products are subject to regulation by
the FDA. The Company intends to file an application for pre-market approval with
the FDA in late 1997 for approval to market the ROBODOC System in the United
States. See "Risk Factors -- Government Regulation" and "Business -- Government
Regulation."
 
     Until the commercial introduction of the ROBODOC System in the first
quarter of 1996, the Company operated as a development stage enterprise, and
incurred a net loss for each period since its inception. The Company intends to
develop additional surgical applications for the ROBODOC System and to
significantly increase its technical staff. The Company also plans to increase
spending on sales and marketing. See "Use of Proceeds." The Company expects
operating losses to continue until sales of its products increase significantly.
See "Risk Factors -- History of Losses; Accumulated Deficit; Anticipated Future
Losses."
 
RESULTS OF OPERATIONS

  Six Months Ended June 30, 1997 Compared to Six Months Ended June 30, 1996

   
     Net Sales.  Net sales for the six months ended June 30, 1997 (the "1997
Interim Period") were approximately $1,380,000, largely attributable to the sale
of two ROBODOC Systems, compared to the six months ended June 30, 1996 (the
"1996 Interim Period") of approximately $1,064,000 which included the sale of
three ROBODOC Systems. The increase in net sales for the 1997 Interim Period is
due to a higher average selling price of the ROBODOC System to customers, as
compared to the initial commercial units sold in 1996. The selling price of the
ROBODOC System is negotiated with each customer and varies based upon the terms
of payment, terms of the service contract and arrangements for supplying
consumables.

   
     Cost of Sales.  Cost of sales for the 1997 Interim Period was approximately
$532,000 (39% of net sales) as compared to the 1996 Interim Period of
approximately $458,000 (43% of net sales). The improved cost as a percent of
sales in the 1997 Interim Period is a result of higher selling prices for the
ROBODOC System. Manufacturing overhead costs in the 1997 Interim Period
increased $74,000 as the Company moved from it's pilot manufacturing operation
in the 1996 Interim Period towards creating the infrastructure necessary to
support on-going manufacturing.

   
     Selling, General and Administrative.  Selling, general and administrative
expenses for the 1997 Interim Period (approximately $1,384,000) increased by
approximately $497,000, or 56%, as compared to the 1996 Interim Period
(approximately $887,000). Marketing costs increased approximately $264,000 with
the addition of a European Sales Manager, increased participation in medical
conferences and travel to potential customer sites. General and administrative
costs increased approximately $233,000 to support increased growth and as well
as investor relations.

                                       23
   26

     Research and Development.  Research and development expenses for the 1997
Interim Period (approximately $1,184,000) increased by approximately $206,000,
or approximately 21%, as compared to the 1996 Interim Period (approximately
$978,000), due to additional engineering staff required to support new
applications of existing products and new product development projects.

   
     Stock Compensation.  Stock compensation expense during the 1997 Interim
Period was $90,000, $156,000 lower than the 1996 Interim Period ($246,000). This
decrease is due to the immediate vesting of certain stock options in the 1996
Interim Period. The Company charged to operations in 1996 deferred stock
compensation relating to stock options granted during 1996 with exercise prices
less than the estimated fair value of the Company's Common Stock, as determined
by an independent valuation analysis, on the date of grant. Deferred
compensation for the non-vested portion is being amortized into expense over the
vesting period of the stock options, which generally range from three to five
years. Stock compensation expense in the 1997 Interim Period represents the
additional vesting which occurred in the first six months of 1997.

   
     Interest Income.  Interest income for the 1997 Interim Period
(approximately $125,000) increased by approximately $86,000, or 221%, as
compared to the 1996 Interim Period (approximately $39,000), primarily due to
higher average cash balances during the 1997 Interim Period as a result of the
Company's initial public offering in November 1996.

   
     Other Income and Expense.  Other income for the 1997 Interim Period was
approximately $14,000 compared to an expense of approximately $21,000 in the
1996 Interim Period. The primary reason for the difference is the weakening of
the Dutch Guilder against the U.S. Dollar during 1996, as compared to a
strengthening Dutch Guilder against the dollar in the first six months of 1997.
This resulted in currency transaction gains and losses on the U.S. currency
obligations of the Company's wholly owned subsidiary in The Netherlands,
Integrated Surgical Systems BV.

   
     Net Loss.  The net loss for the 1997 Interim Period (approximately
$1,688,000) increased by approximately $197,000, or approximately 13%, as
compared to the net loss for the 1996 Interim Period (approximately $1,491,000),
primarily due to the higher operating expenses partially offset by improved
gross margins. The improved gross margin is primarily attributable to a higher
selling price for the ROBODOC System.

   
  Fiscal Years Ended December 31, 1996 and 1995

     Net Sales.  Net sales for the fiscal year ended December 31, 1996 ("Fiscal
1996") increased by approximately $2,106,000, as compared to the fiscal year
ended December 31, 1995 ("Fiscal 1995"). The increase is a result of commercial
sales of the ROBODOC System to customers in Germany and Austria. No ROBODOC
Systems were sold during Fiscal 1995. Sales of consumables during Fiscal 1996
(approximately $140,000, or 6% of net sales), decreased by approximately
$35,000, or 20%, as compared to Fiscal 1995 when sales of consumables accounted
for all net revenue, primarily due to certain number of consumables being
provided without charge to new customers during 1996.
 
     Cost of Sales.  Cost of sales for Fiscal 1996 (approximately $884,000)
increased by approximately $814,000 as compared to Fiscal 1995 (approximately
$70,000), as a result of the first commercial sales of the ROBODOC System in
Fiscal 1996. Cost of sales as a percentage of net sales was 39% for Fiscal 1996
and 40% for Fiscal 1995.
 
     Selling, General and Administrative.  Selling, general and administrative
expenses for Fiscal 1996 (approximately $2,066,000), increased by approximately
$397,000, or 24%, as compared to Fiscal 1995 (approximately $1,669,000),
primarily due to the Company's participation in tradeshows in Europe during
Fiscal 1996.
 
     Research and Development.  Research and development expenses for Fiscal
1996 (approximately $2,469,000) increased by approximately $108,000, or
approximately 5%, as compared to Fiscal 1995 (approximately $2,361,000),
primarily due to staff increases required for development of additional
applications.
 
     Stock Compensation.  During Fiscal 1996, the Company recorded deferred
stock compensation of approximately $784,000 relating to stock options granted
during the period with exercise prices less than the estimated fair value of the
Company's Common Stock, as determined by an independent valuation analysis, on
the date of grant. The deferred stock compensation is being amortized into
expense over the vesting period of
 
                                       24
   27

the stock options, which generally ranges from 3 to 5 years. Deferred
compensation relating to stock options which vested immediately was expensed on
the date of grant. Compensation expense of approximately $357,000 was recorded
during Fiscal 1996 relating to these stock options, and the remaining $427,000
will be amortized into expense in future periods.

     Interest Income.  Interest income for Fiscal 1996 (approximately $88,000)
decreased by approximately $19,000, or 18%, as compared to Fiscal 1995
(approximately $107,000), due to money market conditions resulting in improved
return on the Company's investments during Fiscal 1995.
 
     Interest Expense.  The Company had no interest expense for Fiscal 1996
compared to Fiscal 1995 (approximately $288,000). Interest expense for Fiscal
year 1995 was primarily associated with a $3,000,000 convertible note, bearing
interest at 9.25% per annum. The principal amount of this note, together with
interest that had accrued from the date of issuance, was converted in December
1995 into a warrant to purchase Common Stock.
 
     Other Income and Expense.  Other expense for Fiscal 1996 was approximately
$31,000, as compared to other income for Fiscal 1995 of approximately $56,000.
The primary reason for the difference is the strengthening of the Dutch Guilder
against the U.S. Dollar during Fiscal 1995, as compared to a weakening of the
Dutch Guilder against the U.S. Dollar in Fiscal 1996. This resulted in currency
transaction gains and losses on the U.S. currency obligations of the Company's
wholly owned subsidiary in The Netherlands, Integrated Surgical Systems BV.
 
     Provision for Income Taxes.  As a result of the issuance of the Company's
Series D Preferred Stock in connection with the recapitalization of the Company
in December 1995, a change of ownership (as defined in Section 382 of the
Internal Revenue Code of 1986, as amended) occurred. As a result of this change,
the Company's federal and state net operating loss carryforwards generated
through December 31, 1995 (approximately $13,500,000 and $4,500,000,
respectively) will be subject to a total annual limitation in the amount of
approximately $400,000. Except for the amounts described below, the Company
expects that the carryforward amounts will not be available prior to the
expiration of the carryforward periods. As a consequence of the limitation, the
Company had at December 31, 1996 a net operating loss carryover of approximately
$8,700,000 for federal income tax purposes which expires between 2005 and 2011,
and a net operating loss carryforward of approximately $2,100,000 for state
income tax purposes which expires between 1997 and 2001. See Note 7 of notes to
consolidated financial statements.
 
     Net Loss.  The net loss for Fiscal 1996 (approximately $3,449,000)
decreased by approximately $605,000, or 15%, as compared to the net loss for
Fiscal 1995 (approximately $4,054,000), primarily due to improved gross margin
partially offset by an increase in operating expenses, principally due to stock
compensation expense, increased participation in tradeshows in Germany and
increased research and development staffing.
 
     Preferred Stock Dividends.  The Company accumulated preferred stock
dividends on the Series B and Series C Preferred Stock at 8% per annum until
December 1995, when these cumulative dividends, together with the Series B and
Series C Preferred Stock, were converted into Common Stock. The Series D
Preferred Stock, which was outstanding until it was automatically converted upon
the close of the Company's Initial Public Offering, did not provide for
cumulative dividends.
 
LIQUIDITY AND CAPITAL RESOURCES
 
     Since inception, the Company's expenses have exceeded net sales. Operations
have been funded primarily from the issuance of debt and the sale of equity
securities aggregating approximately $23.8 million. In addition, the Company was
the beneficiary of proceeds from a $3 million key-man life insurance policy in
1993 upon the death of one of its executives.

     The Company used cash from operating activities of approximately
$3,508,000, $3,432,000, $1,781,000 and $2,182,000 in Fiscal 1995, Fiscal 1996,
and the 1996 and 1997 Interim Periods, respectively. Net cash used for
operations in each of these periods resulted primarily from the net loss. Cash
used for operations in Fiscal 1995 reflected a decrease in inventory of
approximately $138,000 due to the disbursement of items in inventory to conduct
clinical trials, an increase in other liabilities due to an accrual to recognize
costs related to the completion of the Robodoc clinical trials and payments made
under a severance agreement with a

                                       25
   28

former executive officer in the approximate amount of $163,000. Cash used for
operations in Fiscal 1996 reflected a payment made on a note payable held by a
supplier, a decrease in a customer deposit relating to the delivery of a
commercial system and increases in accounts receivable and inventory. Cash used
for operations in the 1996 Interim Period reflected a payment made on a note
payable held by a supplier and a decrease in a customer deposit relating to the
delivery of a commercial system. Cash used for operations in the 1997 Interim
Period reflected an increase in inventories, an increase in customer deposits, a
decrease in receivables and a decrease in payables to a subcontractor. The
Company is eligible to receive reimbursement for 49% of its qualified
expenditures under the terms of a grant from the National Institute for
Standards & Technology ("NIST"). The Company received reimbursements from this
program of approximately $19,000 and $116,000 for Fiscal 1995 and Fiscal 1996,
respectively.

   
     The Company's investing activities have consisted primarily of expenditures
for property and equipment which totaled approximately $121,000, $41,000,
$10,000 and $102,000 in Fiscal 1995, Fiscal 1996, and the 1996 and 1997 Interim
Periods, respectively. Included in Fiscal 1995 is a ROBODOC System owned by the
Company and placed in a clinic in Germany for clinical evaluation. This system
was sold to the clinic during Fiscal 1996.

   
     Cash provided by financing activities from inception through June 30, 1997
comprised the net cash proceeds from the sale of a convertible note in the
principal amount of $3,000,000, the sale of convertible preferred stock and
warrants for $14,676,000, and the sale of Common Stock and warrants for
approximately $6,090,000, resulting from the Company's initial public offering
in November 1996, and approximately $16,300 from the exercise of stock options
during the first six months of 1997. As part of the recapitalization of the
Company in December 1995, the entire $3,000,000 principal amount of the
convertible note, together with accrued interest thereon of approximately
$1,224,000, was converted into a warrant to purchase Common Stock. A total of
$11,734,000 and $2,942,000 of preferred stock and warrants to purchase preferred
stock was converted into Common Stock and warrants to purchase common stock in
December 1995 and November 1996, respectively.

   
     The Company expects to incur additional operating losses at least through
1997. These losses will be as a result of expenditures related to product
development projects and the establishment of marketing, sales, service and
training organizations. The timing and amounts of these expenditures will depend
on many factors, some of which are beyond the Company's control, such as the
requirements for and time required to obtain FDA authorization to market the
ROBODOC System, the progress of the Company's product development projects and
market acceptance of the Company's products. The Company expects its current
funding (including the anticipated proceeds of this Offering) and cash flow from
operations will be sufficient to finance its operations through 1999.

   
INVESTMENTS IN PLANT, PROPERTY AND EQUIPMENT

   

                                                                 YEARS ENDED
                                                                 DECEMBER 31,          SIX MONTHS
                                                            ----------------------   ENDED JUNE 30,
                                                            1994     1995     1996        1997
                                                            ----     ----     ----   --------------
                                                                    (DOLLARS IN THOUSANDS)
                                                                         
Integrated Surgical Systems, Inc........................    $476     $121     $41         $102
IMMI....................................................      --     $194     $39         $194
                                                            ----     ----     ---         ----
                                                            $476     $315     $80         $296
                                                            ----     ----     ---         ----

 
   
     Investments in 1994 included the capitalization of ROBODOC equipment used
for clinical evaluations.

   
     Investments in 1995 and 1996 were comprised primarily of computers, office
furniture and fixtures and other equipment to support research and engineering
development efforts.

   
     Investments during the six months ended June 30, 1997 were for computers,
office furniture and fixtures and other equipment necessary to support expanding
operations. In addition, IMMI spent $121,000 on the capitalization of NeuroMate
equipment.

                                       26
   29
 
                                    GLOSSARY
 
     The following glossary is intended to provide the reader with an
explanation of certain terms used in this Prospectus.
 
510(k).....................  Pre-market notification application required in the
                             United States to market medical devices that are
                             "substantially equivalent" to medical devices
                             previously approved by the FDA or were marketed in
                             the United States prior to May 28, 1976 (the date
                             of the Medical Device Amendment to the FDC Act)
                             pursuant to the FDC Act.
 
ACETABULUM.................  Hip socket.
 
ACTIVE ROBOT...............  A robot that is capable of moving by itself. In the
                             context of robotic surgery, active robot refers to
                             a robot that performs a segment of a surgical
                             procedure under the supervision of a surgeon.
 
CE MARK....................  The European conformity mark.
 
CONSUMABLES................  Disposable items consumed each time a surgery is
                             performed including sterile drapes, bone screws,
                             cutters and control pendants.
 
CT SCAN....................  Computerized tomography scan, which produces
                             multiple x-ray "slices" taken close together, which
                             when reconstructed by a computer provide an
                             accurate three dimensional picture of a patient's
                             anatomy.
 
FDA........................  U.S. Food and Drug Administration.
 
FDC Act....................  Federal Food, Drug and Cosmetic Act, as amended,
                             and the regulations promulgated thereunder.
 
FIXATOR....................  Device which holds the leg bone still and attaches
                             it to the robot base.
 
IDE........................  Investigational device exemption pursuant to the
                             FDC Act.
 
GMP........................  Good manufacturing practices regulations
                             promulgated by the FDA pursuant to the FDC Act.
 
IMPLANT....................  Usually inert metal "hardware" left in the body to
                             repair injuries or replace joints.
 
IMPLANT LIBRARY............  Visual three dimensional renderings of all the
                             sizes and shapes of implants available for use on
                             the system.
 
ISO........................  Manufacturing standards established by the
                             International Standards Organization.
 
MRI........................  Magnetic resonance imaging, a method of collecting
                             images of the body using radio waves, but without
                             radiation.
 
NIST.......................  National Institute of Standards and Technology of
                             the United States Department of Commerce.
 
ORTHOPAEDICS...............  The branch of surgery concerned with the skeletal
                             system.
 
OSTEOTOMY..................  An angular cut in a bone usually removing a wedge.
 
PASSIVE ROBOT..............  A passive robot requires the application of
                             external forces to cause motion. In the context of
                             robotic surgery, a passive robot is used only as an
                             aiming or holding device.
 
PMA........................  Pre-market approved application required in the
                             United States to market new medical devices
                             pursuant to the FDC Act.
 
PROSTHESIS.................  An artificial substitute for a body part, including
                             joints.
 
THR........................  Primary total hip replacement.
 
TKR........................  Total knee replacement.
 
                                       27
   30
 
                                    BUSINESS

     The Company develops, manufactures, markets and services image-directed,
computer-controlled robotic products for orthopaedic and neurosurgical
applications.

   
Orthopaedic Business

   
     The Company's principal orthopaedic product is the ROBODOC(R) Surgical
Assistant System, consisting of a computer-controlled surgical robot and the
Company's ORTHODOC(R) Presurgical Planner. The ROBODOC System has been used for
primary total hip replacement surgery on over 1,500 patients in Europe and the
United States. The Company believes its "active" robotic system is the only
available system that can accurately perform key segments of surgical procedures
with precise tolerances generally not attainable by traditional manual surgical
techniques. The ROBODOC System also allows the surgeon to prepare a preoperative
plan specifically designed for the characteristics of the individual patient's
anatomy. The technology for the ROBODOC System was initially developed at the
University of California, Davis, in collaboration with IBM.

     The ORTHODOC is a computer workstation that utilizes the Company's
proprietary software for preoperative surgical planning. The ORTHODOC is a part
of the ROBODOC System, but the Company also plans to market it separately. The
ORTHODOC converts CT scan data of a patient's femur into three-dimensional
images, and through a graphical user interface, allows the surgeon to examine
the bone more thoroughly and to select the optimal implant for the patient using
a built-in library of available implants. A tape of the planned surgical
procedure, developed by the ORTHODOC, guides the surgical robot arm of the
ROBODOC System to accurately mill a cavity in the bone, thus allowing the
surgeon to properly orient and align the implant. Prior to the primary surgery,
two titanium locator pins are placed in the patient's femur in an outpatient
procedure. These locator pins are used during the primary procedure to orient
the ROBODOC System to the ORTHODOC preoperative plan. Non-clinical scientific
data published by scientists from the Company and IBM demonstrate that as a
result of the precise milling of a cavity, the ROBODOC System achieves over 95%
bone-to-implant contact, as compared to an average of 20% bone-to-implant
contact when surgery is performed manually.

     THR surgery involves the insertion of an implant into a cavity created in
the patient's femur. The Company believes that precise fit and correct alignment
of the implant within the femoral cavity are key factors in the long-term
success of THR surgery. In conventional THR surgery, a bone cavity is cut in the
shape of the implant manually with metal tools, and the surgical plan, including
the selection of the size and shape of the implant, is generally formulated
based upon patient data obtained from two-dimensional x-ray images of the
patient's femur. Based upon clinical experience to date in Europe with the
ROBODOC System, patients generally have become weight-bearing in a shorter
period than generally experienced by patients who have had this surgery
performed manually. In addition, clinical data obtained from trials in Europe
and the United States indicates that intraoperative fractures have been
dramatically reduced in the THR surgeries performed with the ROBODOC System (no
intraoperative fractures have resulted from THR surgeries performed with the
ROBODOC System to date). The Company also believes fewer hip revision surgeries
(implant replacements) may be necessary for patients who have had primary THR
surgery performed with the ROBODOC System, as compared to patients who have this
surgery performed manually.

     In the past, a majority of THR implants have been held in place with
acrylic cement, which fills the spaces between the implant and the bone, thereby
anchoring the implant to the femoral cavity ("cemented implants"). During the
1980s, implants that did not require cement ("cementless implants") were
developed with materials designed to stimulate bone ingrowth. The selection of a
cemented or cementless implant generally is based upon a patient's bone
condition and structure, age and activity level. Typically, cemented implants
are used for older, less active patients. Furthermore, most implants require
replacement within five to 20 years of the first operation. The software package
developed by the Company in collaboration with IBM and Johns Hopkins University
eliminates the distortion of the x-ray images of the patient's femur used in
planning hip revision surgery caused by the metal in the existing implant.
Consequently, the surgeon would
 
                                       28
   31
 
have a clearer view of the remaining bone in planning hip revision surgery and
thereby be better able to remove fragmented cement without removing any of the
remaining thin thigh bone.

Neurosurgical Business

   
     The Company entered the neurosurgical business through the acquisition of
IMMI on September 5, 1997. See "Business Acquisition of IMMI." IMMI's principal
neurosurgical product is the NeuroMate System, consisting of an image-guided,
computer-controlled robotic arm, head stabilizer and monitor. The Company also
offers a workstation with presurgical planning software through arrangements
with original equipment manufacturers ("OEMs").

   
     The NeuroMate System has been used to perform over 1,500 neurosurgical
procedures in France and Japan. The Company believes that the NeuroMate System,
which uses IMMI's proprietary robotic arm design and control systems designed
specifically for use in the operating room, is the only image-guided,
computer-controlled robot currently in use to precisely position and hold
critical tools used in the performance of neurosurgical procedures.

   
     Stereotactic neurosurgery involves the registration of the patient's
cranium and brain to external anatomical references such as standard population
atlases or, as currently implemented, to the patient's presurgical CT and
magnetic resonance images (MRI). By registering certain key anatomical features
common to both the images and the patient, the images are used to guide the
surgeon to specific sites within the brain through small openings (i.e., not
necessitating a craniotomy).
    
                               ------------------

     The following table sets forth by product category and geographic area
sales of orthopedic products by the Company and neurosurgical products by IMMI
for the fiscal years ended December 31, 1994, 1995 and 1996 and the six months
ended June 30, 1997.

   

                                             YEARS ENDED DECEMBER 31,
                     -------------------------------------------------------------------------
                                                                                                    SIX MONTHS ENDED
                              1994                     1995                     1996                  JUNE 30, 1997
                     -----------------------   ---------------------   -----------------------   -----------------------
                        $'S       % OF SALES     $'S      % OF SALES      $'S       % OF SALES      $'S       % OF SALES
                     ----------   ----------   --------   ----------   ----------   ----------   ----------   ----------
                                                                                      
Sales by Product
  Category
  Orthopaedic......  $  289,047       100%     $174,521       100%     $2,280,311        84%     $1,335,668        67%
  Neurosurgical....          --        --            --        --         447,310        16%        617,580        31%
  Other............          --        --            --        --              --        --          44,028         2%
                     ----------       ---      --------       ---        --------       ---      ----------       ---
      Total
         Sales.....  $  289,047       100%     $174,521       100%     $2,727,621       100%     $1,997,276       100%
                     ==========       ===      ========       ===        ========       ===      ==========       ===
Sales by Geographic
  Area
  United States....  $  261,778        91%     $  9,295         5%             --        --              --        --
  Europe...........      27,269         9%      165,226        95%     $2,727,621*      100%     $1,410,575        71%
  Japan............          --        --            --        --              --        --         586,701        29%
                     ----------       ---      --------       ---        --------       ---      ----------       ---
      Total
         Sales.....  $  289,047       100%     $174,521       100%     $2,727,621       100%     $1,997,276       100%
                     ==========       ===      ========       ===        ========       ===      ==========       ===

 
- ---------------

* Includes sales of neurosurgical products by IMMI.

   
THE MARKET

   
     The orthopaedic and neurosurgery markets are well established and are now
evolving toward increased reliance on image guidance and computer assistance in
the planning and execution of surgical procedures. Industry experts estimate
that the worldwide image-guided, computer assisted surgery market will rapidly
grow to $7.6 billion by the year 2000.

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Orthopaedic Market

   
     According to an industry study, in 1995 the worldwide orthopaedic market
(which includes power surgical instruments, prosthetic devices, fixation devices
and bone growth stimulants) was approximately $6.8 billion, including
approximately $3.9 billion in the United States (constituting approximately 57%
of the worldwide market) and approximately $1.6 billion in Europe (constituting
approximately 24% of the worldwide market). In 1995, over 600,000 hip implants
were sold worldwide, of which 280,000 were sold in the United States. Similarly
in 1995, over 400,000 knee implants were sold worldwide, of which 289,000 were
sold in the United States. The growth in hip and knee surgeries is expected to
be in the range of 4% to 7% per annum over the next several years. This
anticipated growth is based upon the growth in the number of people reaching an
age (60 and over) where orthopaedic surgeries are more prevalent, and also on an
increasingly active population. Finally, an earlier generation of implanted
prostheses have reached an age where replacement is increasingly necessary, thus
resulting in an increased demand for hip and knee revision surgeries.

   
     According to the American Academy of Orthopaedic Surgeons, in the United
States there are approximately 15,000 orthopaedic surgeons and over 5,000
hospitals performing orthopaedic surgeries that have, or have access to, CT
scanners. Of these, approximately 1,000 hospitals perform over 150 orthopaedic
surgeries (hip and knee) per year. There are approximately 800 hospitals in
Germany that have a CT scanner and perform the vast majority of the orthopaedic
surgeries. Since the procedure for performing THR surgery using the ROBODOC
System requires a CT scan of the patient prior to surgery, these are the primary
centers that would consider purchasing the ROBODOC System. According to industry
sources, there are an additional 1,000 hospitals in the rest of Europe that
perform a significant number of orthopaedic and trauma surgeries.

   
Neurosurgical Market

   
     Because of the relative inaccessibility of the brain and the need to
provide brain-conserving surgical techniques, neurosurgery is rapidly moving
toward increased utilization and reliance on image guidance and the use of
computers in planning and executing surgical procedures. In fact, modern
computer assisted, image-guided surgery was chiefly pioneered in neurosurgical
applications. The market now consists of traditional frame-based devices;
non-microscope, freehand "navigators"; and stereotactic microscopes. All of
these systems are capable of using, or are controlled through, image guidance.

   
     The Company estimates that stereotactic neurosurgery is performed at 1,200
sites worldwide. Eighty-five percent of those sites are in the United States,
Europe and Japan, where the Company will concentrate its sales and marketing
efforts.

STRATEGY

     The Company is seeking to establish itself as a leading provider of
innovative image-directed, computer-controlled robotic technologies worldwide.
The current focus is on the orthopaedic and neurosurgical markets. The Company
also plans to further exploit its image-directed robotics technology by
incorporating additional imaging modalities for presurgical planning, including
ultrasound (which is less expensive than CT) and magnetic resonance imaging
(which unlike CT does not involve the risk of radiation).

   
Orthopaedic Market

   
     The Company currently markets and sells ROBODOC Systems in Europe. The
Company's business strategy over the next two years is to concentrate its
marketing and sales efforts on selling the ROBODOC System throughout Europe and
then Japan, subject to obtaining the requisite approval from the Japanese
Ministry of Health. When and if approval is received from the FDA, the Company
plans to market and sell the ROBODOC System in the United States. The Company
will thereby attempt to establish an installed customer base in Europe, Japan
and other foreign markets through the sale of its ROBODOC System, and offer its
customers separate software packages for each new orthopaedic application if, as
and when developed by the Company. Consequently, the Company's customers would
be able to use the ROBODOC System as

                                       30
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the platform for performing a variety of orthopaedic surgical procedures without
incurring significant additional hardware costs.

Neurosurgical Market

   
     The NeuroMate is currently marketed in Europe and Japan, and its
introduction in the United States is anticipated in early 1998. The Company's
strategy is to market its NeuroMate as the platform system for major
neurosurgeries, and will require its customers to purchase only the
application-specific software and accessories for each new application.

   
PRODUCTS

     The Company's products are:
 
     - ROBODOC System
 
     The ROBODOC System, whose principal components are a computer-controlled,
five-axis surgical robot and the Company's ORTHODOC Presurgical Planner, is an
active robotic system that can accurately perform key segments of surgical
procedures with precise tolerances generally not attainable by traditional
surgical techniques. The ROBODOC System allows the surgeon to prepare a
preoperative plan customized to the characteristics of the individual patient's
anatomy and generates a tape instructing the computer-controlled robot to
implement the surgical plan. The ROBODOC System includes a display console for
screen prompts and surgical plan simulation, a control cabinet for computers and
other electronic components, and proprietary applications and robot control
software. The surgeon communicates with the robot via a sterile controller.
Attendant supplies include custom surgical drapes, specially designed cutters, a
leg-holding device (fixator) and a bone motion-detecting apparatus.

     The sales price of the ROBODOC System is currently $635,000 and includes
full warranty that includes a service contract for the first year, installation,
training and some consumables. The service contract is renewable annually for
$63,500 and entitles the customer to upgrades and limited consumables.

   
     - ORTHODOC System

     The ORTHODOC is a Pentium(R)-based computer workstation that utilizes the
Company's proprietary software for preoperative surgical planning. The ORTHODOC,
an integral part of the ROBODOC System also may be sold separately as a surgical
planner. The ORTHODOC converts CT scan data of a patient's femur into three
dimensional models of the femur on a high-resolution monitor, and through a
graphical user interface permits the surgeon to examine the bone more
thoroughly, select the optimal implant for the patient using a built-in library
of available implants and select the position of the implant in the femur prior
to surgery. Additional software that will utilize images obtained by digitizing
x-ray film is planned as an option for ORTHODOC customers, in addition to other
features such as providing surgeons the ability to plan hip revision cases.
 
     The Company expects the price of the ORTHODOC to range from $33,000 to
$95,000, depending on the features selected.

     - NeuroMate System

   
     The NeuroMate's principal component is a five-axis robot designed
specifically for surgical applications. This proprietary design includes
automatic self-braking joints, sensor redundancy and embedded controllers. In
addition, NeuroMate's low electro-magnetic emissions, easy cleaning and
ergonomic design are all specific to operating room requirements. The NeuroMate
can utilize data (e.g., CT and MRI images) from the site's existing presurgical
planning workstation. If the site does not have a presurgical planning
workstation, the Company can supply one through OEM arrangements with vendors,
or the site can purchase its own independently. Using the workstation and
NeuroMate's virtual images, the surgeon plans the optimal trajectory and robot
position for the surgery. NeuroMate can be configured to position and hold a
variety of surgical tools used in stereotactic surgery with a degree of accuracy
unattainable from other stereotactic devices. Tool guide and robot positioning
is achieved within 45 seconds.

                                       31
   34

     The sales price of the NeuroMate System is approximately $300,000 and
includes full warranty that includes a service contract for the first year,
installation and training. Installation includes interfacing the customer's
presurgical planning workstation to NeuroMate, when required. The service
contract is renewable annually for $30,000.

   
POTENTIAL ORTHOPAEDIC AND NEUROSURGICAL APPLICATIONS

   
     The Company intends to offer separate software packages for each new
application if, as and when developed by the Company. Consequently, the
Company's customers would be able to use the Systems as platforms to perform a
variety of surgical procedures without incurring significant additional hardware
costs. The Company plans to develop software packages for the following
orthopaedic and neurosurgical surgical procedures.

   
     - Potential Orthopaedic Applications

     Hip Revision.  Hip revision surgery generally is required to replace loose
or otherwise failed implants. Most implants require replacement in five to 20
years after the first operation. Hip revision surgery generally is difficult,
time consuming and complex. The metal in the existing implant distorts x-ray
images used for planning the surgery, obstructing the view of the remaining bone
and, if a cemented implant is to be replaced, the location of the cement mantle.
The removal of the fragmented cement without removing any of the remaining thin
bone structure is a major challenge for the surgeon.

     The Company has developed a software package for hip revision surgery using
the ROBODOC System, in collaboration with IBM and Johns Hopkins University. The
development of the hip revision application has been funded in part by a grant
from the National Institute for Standards and Technology (Advanced Technology
Program) of the United States Department of Commerce. See "Business -- Research
and Development." The first phase of the hip revision project related to the
development and implementation of software to create a clearer image of the
remaining bone and fragmented cement in preparing the surgical plan. The second
phase of the project involved its validation in a clinical setting. The Company
believes that its hip revision software will improve surgical planning and
enable the robot to remove cement more precisely than if the hip revision
procedure were performed manually. The Company has completed clinical trials of
the hip revision application in Europe and plans to commence marketing the
software package for the hip revision application to its customers in Europe in
early 1998.

   
     Total Knee Replacement.  The Company plans to develop a software package
for total knee replacement ("TKR") surgery using the ROBODOC System. The
proposed application module is intended to enable the ROBODOC System to select
the optimal implant for the patient and make accurate cuts in the bone, thus
allowing the surgeon to properly orient and align the implant. The proposed
application module to be developed by the Company for TKR surgery performed with
the ROBODOC System, if and when developed, is intended to result in a precise
and accurate fit for implants that are properly sized and placed, regardless of
bone quality. Furthermore, the Company believes that if and when this
application module is developed, implant longevity and the prognosis for
restored biomechanics will be significantly improved as a result of TKR surgery
performed with the ROBODOC System.

     Acetabulum Replacement and Revision.  The Company plans to complement the
THR femoral replacement application with acetabular cup planning and bone
preparation for hip socket replacement surgery. Currently, surgeons estimate the
size of the cup-shaped cavity in hip socket surgery using x-rays, which are
subject to distortion. Working in a narrow space with a limited view, the
surgeon ultimately selects the final cup size through trial and error. Due to
the limitations of available surgical tools, the surgeon is obliged to use a
hemispheric reamer and cup, although the human acetabulum (hip socket) is an
irregular shape. The Company believes that the application module for this
application, if and when developed, would enable the computer-controlled robot
to prepare an accurate bed for the implant, based on its specifications, and
could prepare an irregularly shaped socket for a custom or anatomically-shaped
acetabular component. The three-dimensional capability of the ORTHODOC would
better enable it to determine and display the irregular shape of the acetabulum
and instruct the robot to prepare the proper socket. This procedure potentially
could solve the problem of leg-length discrepancies which often originate at the
acetabulum.
 
                                       32
   35
 
     Osteotomies.  Osteotomies are precise cuts in bone intended to reshape or
realign abnormal or deformed structures. The Company's engineers have generated
a detailed work plan to adapt the ROBODOC System for use in performing long-bone
osteotomies on femurs and tibias (i.e., shin bones). The proposed application
module for this application, if and when developed, is intended to enable the
surgeon using the views of the bone created by the ORTHODOC from CT scan data,
to make trial cuts, remove bone and manipulate the remaining fragments, and
experiment with the appropriate placement of plates and screws. The surgeon's
final plan would be saved on a tape that would instruct the robot where to make
saw cuts. The computer-controlled robot would then orient itself in space by
using topographical features of the operative bone. A fixator would secure the
bone to the robot. The computer-controlled robot would then pre-place screw
holes to facilitate the final realignment and make the actual cuts.

     - Potential Neurosurgical Applications

   
     Spine surgery.  Surgical interventions in the spine generally involve tumor
biopsy/resection; vascular repair; implants of plates, rods, screws, or other
implantable devices or substances; and bone fusions of various types. The
Company believes that its image-directed, computer-controlled robotic technology
is applicable in most of these interventions and will significantly enhance
precision and accuracy in many of them. Spine surgery is a large segment of both
neurosurgery and orthopaedic surgery, as the nature of the abnormality may
involve the nervous system or the vertebral column, or both. A significant part
of this application involves the insertion of vertebral pedicle screws,
discussed below.

   
     Vertebral Pedicle Screws.  Pedicle screws are used to fuse vertebrae in
need of repair due to trauma or herniated disc disease. The procedure involves
the placement of screws straight down the center of an irregular section of a
fragile bone only twice the diameter of the screw itself. Precise placement of a
screw affects the outcome of the surgery. Misplacement of a screw can result in
failure of the repair, trauma to the adjacent spinal cord, or rupture of nearby
blood sinuses which can hemorrhage severely. The Company believes that if and
when the development of the proposed application module for this surgical
procedure is completed, the NeuroMate System will be capable of performing this
surgical procedure more safely and effectively than surgery performed manually
since the computer-controlled robot is better able to precisely orient its tool
in a manner compatible with what is required for screw placement.

AVAILABLE CLINICAL DATA; RISK VERSUS BENEFIT ISSUES

     The Company has conducted a randomized clinical trial in the United States
at three centers using the ROBODOC System. Of the 120 patients enrolled in the
U.S. clinical study, 71 hips received treatment with the ROBODOC System and 65
hips in a control group received conventional THR surgery. In addition, at least
1,400 patients have received treatment with the ROBODOC System in Europe,
although not as part of the formal U.S. clinical study.

     In initial communications with the Company, the FDA has indicated a strong
"preference" for two-year post-operative data from patients in the U.S. clinical
trial. In a recent meeting, however, the FDA indicated that it may accept a PMA
application for filing with two-year post-operative data only on some patients
and permit the Company to submit the additional post-operative data while the
PMA application is under review. However, there can be no assurance that the FDA
will not require complete two-year post-operative data on all patients
participating in the U.S. clinical trial before accepting a PMA application for
filing. The last patient receiving surgery in the U.S. clinical trial will reach
the two-year post-operative mark in February 1998.

     Although the Company's Investigational Device Exemption ("IDE") application
to the FDA for its U.S. clinical study initially requested authorization for 300
patients (150 ROBODOC System; 150 control group), the Company elected to
conclude the clinical study after enrolling only 120 patients, since management
believed that the clinical data from that study, together with the data obtained
from surgeries performed in Europe, would be sufficient to demonstrate the
clinical effectiveness and safety of the ROBODOC System. There have been at
least 1,500 primary THR surgeries performed with the ROBODOC System in the U.S.
clinical trial and the European study (without a control group). If the FDA
concludes that the existing clinical data is insufficient to establish the
safety and efficacy of the ROBODOC System, the FDA could require the

                                       33
   36
 
Company to obtain additional clinical data, which could significantly delay
completion of the PMA review process.
 
     The Company believes that achieving better implant fit and alignment in the
femoral cavity are significant factors in the success of cementless THR surgery.
Based upon a comparison in the U.S. clinical trial of radiographs for ROBODOC
System surgeries versus conventional THR surgeries, the Company believes that
the clinical data appear to indicate that the ROBODOC System achieves better
implant fit and alignment. There can be no assurance that the FDA will reach the
same conclusion, or that the FDA will agree that implant fit and alignment are
significant surgical endpoints.
 
     The Company also believes that a reduced incidence of intraoperative
fractures with the ROBODOC System compared to conventional THR surgery would
offer an important benefit. The scientific and medical literature reports an
intraoperative fracture rate ranging from approximately 6 to 24 percent with
conventional THR surgery. The clinical data from the U.S. clinical trials
reflect no such fractures for ROBODOC System patients versus three for the
control group patients. The clinical data from the European study reflect no
intraoperative fractures with ROBODOC System patients. There can be no assurance
that the FDA will agree that the ROBODOC System offers a clinically significant
reduction in intraoperative fractures.

     The U.S. clinical data reflect significantly greater surgery time and blood
loss with the ROBODOC System, which could raise an issue with the FDA as to the
risk versus benefit of the device. Based on the clinical data to date, the
Company is not aware of clinically significant adverse effects or increased risk
to the patient attributable to the increased surgery time or blood loss. Also,
the European data suggest that it is possible to reduce surgery time as surgeons
gain experience with the device. The surgeons in Europe who have used the
ROBODOC System have reduced surgery time to levels roughly comparable to those
they have experienced with conventional methods of THR surgery. The more limited
clinical data from the U.S. clinical trial, with fewer patients per center, do
not show a decrease. Nonetheless, the Company believes that the reduction in
surgery time shown in the European data can be replicated in the U.S. as
surgeons receive more training and gain more experience with the ROBODOC System.
However, there can be no assurance that the FDA will consider the European data
adequate to extrapolate that surgery time can be reduced in the U.S.

     In February 1995, a law firm specializing in FDA regulatory matters
examined an interim report of preliminary data and concluded that it was
doubtful that the FDA would find that the device was safe and effective for its
intended use, or provided a therapeutic benefit, sufficient to permit PMA
approval, if the FDA were presented with the then existing preliminary data or
future data qualitatively similar to the preliminary data. One of the Company's
principal investigators and a co-inventor of the ROBODOC System reviewed the law
firm's report contemporaneously and disagreed with its conclusions. The interim
report reflected available data from: (i) the U.S. clinical trial, which at the
time consisted of reported data from 34 ROBODOC System hips and 18 control group
hips (except for the intraoperative fracture rate data, which was reported for
51 ROBODOC System subjects and 42 control group subjects); and (ii) the German
study, which consisted of reported data from 20 ROBODOC System patients. To
date, there is reported data in the U.S. clinical trial from 71 ROBODOC System
hips and 65 control group hips, and in the European study from at least 790
ROBODOC System patients. The Company's Director of Regulatory Affairs and
Quality Assurance resigned in September 1996 and subsequently has asserted that
one of the reasons for his resignation was his concern about the adequacy of the
Company's clinical data.
 
     The Company believes that the preliminary data at the time of the interim
report were not sufficient to allow a meaningful evaluation. For example, the
radiographic interpretations measuring the implant fit and alignment parameters
were not yet completed and, therefore, were not included in the interim report
upon which the law firm's analysis was based. Similarly, the law firm's analysis
of the surgery time and blood loss safety concerns does not reflect additional
clinical data collected subsequent to February 1995, which the Company believes
continue to show a lack of clinically significant adverse effects and, in the
German data, a reduction in surgery time as surgeons gain experience with the
ROBODOC System. Also, the more complete data appear to show that the variety of
other adverse events cited in the law firm's report are roughly comparable to
those experienced by the control group subjects, with the exception of
post-operative knee pain (lasting up to six weeks) resulting from the locator
pins used to orient the ROBODOC System. Finally, the law firm's report cited
reliability problems with the device, which at the time was in the prototype
stage. The
 
                                       34
   37
 
Company believes that subsequent refinements in the device and the development
of a commercial model have improved the ROBODOC System's reliability. The
Company has not engaged an independent third party to review the currently
available data.
 
     No assurance can be given that the FDA would agree that the Company's
currently available clinical data show that the ROBODOC System is safe and
effective for its intended use, provides a therapeutic benefit, or has an
acceptable risk/benefit ratio in light of increased surgery time and
intraoperative blood loss or other adverse events not generally associated with
conventional THR surgery. Further, no assurance can be given that the FDA would
not require the Company to obtain additional clinical data to resolve any
concern about the risk/benefit ratio offered by the ROBODOC System. If the
Company were required to obtain such additional data, the FDA review process
could be prolonged by several years.
 
SALES AND MARKETING

     The ROBODOC System cannot be marketed in the United States until clearance
or approval is obtained from the FDA. The Company has received 510(k) clearance
from the FDA to sell the ORTHODOC in the United States. The NeuroMate System
also has received 510(k) clearance from the FDA for marketing in the United
States and from the Japanese Ministry of Health for marketing in Japan.
Presentations to potential customers focus on the clinical benefits obtained by
patients, and the potential financial and marketing benefits obtained by
hospitals and surgeons.

   
     The Company has commenced marketing the ROBODOC System to orthopaedic and
trauma surgeons and hospitals in Europe through direct sales and arrangements
with implant manufacturers. To date, the Company's direct sales efforts have
been primarily in Germany and Austria. Over 850 THR surgeries have been
performed with the ROBODOC Systems at the Berufsgenossenschaftliche Unfallklinik
("BGU") clinic in Frankfurt, Germany since August 1994. As result of a
significant increase in the number of THR surgeries performed at the clinic with
the ROBODOC System, the BGU clinic purchased a second ROBODOC System in the
second quarter of 1996. The Company intends to commence marketing the ORTHODOC
to hospitals, orthopaedic surgeons and implant manufacturers in the United
States and Europe in early 1998.

   
     The NeuroMate System is being marketed in Europe through a direct sales
force and in Japan through a Japanese distributor. In the United States it will
be marketed through a direct sales force and select distributors beginning in
early 1998.

   
     The Company promotes its products through presentations at trade shows and
advertisements in professional journals and technical and clinical publications,
as well as through direct mail campaigns. A significant portion of the net
proceeds of this Offering will be used for marketing and sales activities with
respect to Company's products, primarily in Europe, and to establish a sales and
marketing staff. See "Use of Proceeds."

   
     To accelerate sales and reduce the lengthy sales cycle, the Company has
entered into informal leasing arrangements with two major multinational leasing
companies. Based upon lease financing proposals offered to customers in Germany
by leasing companies, the monthly lease payment for a five-year lease for the
ROBODOC System would be equivalent to the average price of one THR surgery.

MANUFACTURING

     The Company's manufacturing process consists primarily of final assembly of
purchased components, testing of the products and packaging, and is conducted at
its facilities in Sacramento, California and Lyon, France. The Company purchases
substantially all the components for its Systems from outside vendors, then
assembles these parts and installs its proprietary software.

   
     The ROBODOC System consists of the robot, base and the control cabinet,
which are connected through four interface cables, and the ORTHODOC. The
NeuroMate System consists of a robot arm, electronics control and base. Sankyo
Seiki of Japan supplies the robot for the ROBODOC System customized to the
Company's specifications and Audemars-Piguet supplies the customized robot for
the NeuroMate System. Upon delivery of a robot, the Company performs a series of
tests to verify proper functioning. The

                                       35
   38

customization and supply process for the robots currently requires approximately
four months lead time. While the robots can be obtained from other suppliers
with appropriate modifications and engineering effort, there can be no assurance
that delays resulting from the required modifications or engineering effort to
adopt alternative components would not adversely affect the Company. See "Risk
Factors -- Dependence on Supplier for Robot." Ancillary items required to
perform robotic surgeries, including devices for fixing the hip and attaching it
to the robot, numerous probes, cutter bearing sleeves and tool guides, are
assembled and tested separately.

     Consumables, including sterile drapes, bone screws, cutters and pendants,
are also manufactured by outside vendors according to the Company's
specification and are inspected upon receipt to ensure that these specifications
are consistently met. The Company purchases these items in quantity and
distributes them on a per order basis. The Company also coordinates the
packaging and sterilization of certain items. The Company's policy is to procure
its consumables from vendors that it approves after ensuring that the goods
comply with the Company's sterilization requirements.
 
     The ORTHODOC consists of a pentium-based computer workstation and
associated peripherals, and includes the Company's proprietary software. The
Company purchases and then tests the computer as a complete package. A computer
board is added to interface to CT/x-ray scanner input modules and, if required,
the ROBODOC System's tape output drive. The hard drive is reformatted to accept
the operating system, and appropriate ORTHODOC software is installed. The unit
is built configured for 110 or 220 AC volt operation.
 
     The Company's manufacturing facilities are subject to periodic inspection
by the FDA for compliance with Good Manufacturing Practices ("GMP"). In
addition, the Company's products will be required to satisfy European
manufacturing standards for sale in Europe. The Company believes that it is in
compliance with GMP and expects to obtain ISO-9000 certification, which will be
required for sales of its products in Europe after June 14, 1998, by the end of
1997. See "Business -- Government Regulation."
 
RESEARCH AND DEVELOPMENT
 
     Since its inception, the Company's research and development activities have
focused on the development of innovative image-directed computer-controlled
robotic products for surgical applications and operating software for these
products. The Company incurred research and development expenses of
approximately $2,469,000 and $2,361,000 in connection with the development of
the ROBODOC System and the ORTHODOC for the years ended December 31, 1996 and
December 31, 1995, respectively.

     The Company has developed a software package for hip revision surgery, in
collaboration with IBM and Johns Hopkins University, funded in part by a grant
from the National Institute for Standards and Technology (Advanced Technology
Program) of the United States Department of Commerce ("NIST"). Hip revision
surgery generally is difficult, time consuming and complex. The metal in the
existing implant distorts x-ray images used for planning the surgery,
obstructing the remaining bone and, if a cemented implant is to be replaced, the
location of the cement mantle. The removal of the cement mantle without removing
any of the remaining thin bone structure is a major challenge for the surgeon.
The first phase of the hip revision project related to the development and
implementation of software to create a clearer image of the remaining bone and
fragmented cement in preparing the surgical plan. The second phase of the
project involved its validation in a clinical setting. The Company believes that
its hip revision application module will improve surgical planning for hip
revision surgery and enable the robot to remove cement more precisely than if
the hip revision procedure were performed manually.

   
     Under the terms of the NIST grant, the Company, IBM and Johns Hopkins
University are entitled to reimbursement for 49% of the expenses incurred in
connection with the project for a period of three years. The maximum amount of
expenses subject to reimbursement under the grant is approximately $4,000,000,
so that not more than $1,960,000 in expenses may be reimbursed in the aggregate
to the Company, IBM and Johns Hopkins University under the grant. The Company
has incurred research and development expenses of approximately $787,000 in
connection with the hip revision project through June 30, 1997. As of June 30,
1997, the Company had received $304,000 under the terms of the grant. See "Use
of Proceeds" and

                                       36
   39

"Business -- Potential Orthopaedic and Neurosurgical Applications." The Company
has completed clinical trials for the hip revision application in Europe and
plans to commence marketing the software for the hip revision application to its
customers in Europe in early 1998.

   
     The Company offers five lines of prostheses on its library of hip implants
at clinical sites. It is expanding the library to include multiple implant
lines, revision stems, and custom-made prostheses. The Company has received
orders from Howmedica, a division of Pfizer, and Johnson & Johnson Professional,
Inc. ("J&J") to add their respective hip prostheses to its existing software
library, which included the implant libraries of Biomet and DePuy. When
completed, this will allow orthopaedic surgeons to plan hip replacement
surgeries using Howmedica's and J&J's line of implants. The Company will further
expand the library of implants used at clinical sites to include multiple
implant lines, revision stems, and custom-made prostheses. The Company has also
commenced preliminary work with respect to the application of the base
technology for total knee replacement and with respect to the application of the
base technology for total knee replacement surgery.

   
     IMMI is the recipient of an interest-free loan from ANVAR (a national
agency in France established to aid research and development projects) in the
amount of approximately $153,000. This loan provides funding for the development
of the NeuroMate System for spine surgery. This project is currently in its
first phase of development in connection with a University hospital in Lille,
France. Under certain conditions (e.g., if at the completion of the project it
is not deemed a "success") there will be no requirement to repay the loan.

   
     IMMI also is the recipient of a grant from ANVAR in the amount of
approximately $222,000, of which IMMI has received approximately $174,000
through June 30, 1997. This grant funds 50% of the cost to build and install
NeuroMate Systems at two clinics in France as well as the costs to perform a
clinical study at these sites.

   
     As of September 1, 1997, the Company's engineering staff comprised 34
engineers (including 4 Ph.D.s) in a variety of specialities.

   
ACQUISITION OF IMMI

   
     On September 5, 1997, the Company acquired all of the outstanding capital
stock of IMMI in exchange for 619,355 shares of Common Stock (the "IMMI Shares")
in a transaction to be accounted for as a purchase. In connection with the
acquisition, the Company agreed to file a registration statement for the resale
of the IMMI Shares in the United States on or about November 21, 1997, subject
to certain volume limitations. See "Description of Securities -- Shares Eligible
for Future Sale." In addition, the Company guaranteed the payment of
indebtedness incurred by IMMI under a revolving line of credit with Societe
Generale and Banque Populaire du Dauphine Et Des Alpes Du Sud ("Banque
Populaire"). As of June 30, 1997, the aggregate amount of indebtedness payable
under this credit facility was approximately $290,000. The payment of this
indebtedness is secured by a lien on substantially all of the assets of IMMI.

   
     Based on management's preliminary allocation of the purchase price, the
Company expects to incur a charge of approximately $300,000 for in-process
research and development. In addition, the Company will record approximately
$800,000 in annual amortization charges for the acquired technology in
connection with the acquisition of IMMI.

SCIENTIFIC ADVISORY BOARD
 
     The Company has established relationships with the outside scientific
advisors listed below. These scientific and medical experts provide strategic
advice to the Company regarding its research and development programs, new
technological advances and medical requirements. It is anticipated that meetings
of the Company's scientific advisors will be held quarterly.
 
     RUSSELL TAYLOR, PH.D., has been a professor of Computer Science at Johns
Hopkins University since 1995. From 1976 through 1995, Dr. Taylor was a staff
member or manager of various departments at the Research Division of IBM. Dr.
Taylor is a member of the editorial board of the International Journal of
Robotics Research and the Journal of Image Guided Surgery and Medical Image
Analysis. Dr. Taylor received a Ph.D. in Computer Science from Stanford
University in 1976.
 
                                       37
   40
 
     RONALD KIKINIS, M.D. has been the Director of the Surgical Planning
Laboratory of the Department of Radiology, Brigham & Women's Hospital and
Harvard Medical School since 1990 and has been a Research Assistant Professor of
Biomedical Engineering at Boston University since 1992. From 1986 to 1988, Dr.
Kikinis was a research fellow at the University Hospital in Zurich, Switzerland.
He received his M.D. from the University of Zurich in 1982.
 
     KENNETH ALAN KRACKOW, M.D., an orthopaedic surgeon specializing in total
knee replacement, has been a professor of Orthopaedics at the State University
of New York at Buffalo and head of the Department of Orthopaedic Surgery at
Buffalo General Hospital since 1992. From 1978 through 1992, he was a Professor
of Orthopaedic Surgery at Johns Hopkins University. Dr. Krackow received an M.D.
from Duke University in 1971.
 
     RAINER KOTZ, M.D., an orthopaedic surgeon specializing in total hip
replacement and limb salvage, has been the Head of the Department of
Orthopaedics, University of Vienna, Austria since 1984. He is President-elect of
the German Association for Orthopaedics and Traumatology. Dr. Kotz received an
M.D. from the University of Vienna in 1967.
 
COMPETITION

     The principal competition for the ROBODOC System is manual surgery
performed by orthopaedic surgeons, using surgical power tools and manual
devices. The providers of these instruments are the major orthopaedic companies,
which include Howmedica, Inc. (a subsidiary of Pfizer, Inc.), located in New
York; Zimmer, Inc. (a subsidiary of Bristol-Myers Squibb Company), located in
Indiana; Johnson & Johnson Orthopaedics, Inc. (a subsidiary of Johnson &
Johnson), located in New Jersey; DePuy, Inc., located in Indiana; Biomet, Inc.
located in Indiana; and Osteonics, Inc. (a subsidiary of the Stryker
Corporation), located in New Jersey. MAQUET, a manufacturer of operating tables
located in Germany, has recently announced that it intends to market a device
similar to ROBODOC in mid 1998. The principal competition for NeuroMate is from
manufacturers of frame-based and frameless stereotactic systems, some of which
are commonly called "navigators". Approximately twenty navigator models have
been introduced, including those by Radionics, Sofamor Danek, and Ohio Medical
Surgical Products, all located in the U.S.; Elekta, located in Sweden; and,
Fischer Leibingher and Brain Lab, both located in Germany. In addition, there
are companies in the medical products industry capable of developing and
marketing computer-controlled robotic systems for surgical applications, many of
whom have significantly greater financial, technical, manufacturing, marketing
and distribution resources than those of the Company, and have established
reputations in the medical device industry. However, the Company believes that
it enjoys a significant competitive advantage over such companies in view of the
time required to develop an image-directed, computer controlled robotic system
and to obtain the necessary regulatory approvals, including the sponsorship of
clinical trials. There can be no assurance that future competition will not have
a material adverse effect on the Company's business.

     The Company's ROBODOC System represents a significant technological
advancement with respect to the manner in which THR surgery is performed. The
Company's image-directed, computer-controlled robotic technology is intended to
complement, rather than replace, surgeons in performing THR and other
orthopaedic surgeries. Although there are companies which market technologically
advanced surgical tools used by surgeons in performing orthopaedic surgeries,
including passive robot systems that direct the surgeon in planning and
performing surgical procedures (e.g., aiming and holding devices), the Company
believes that the ROBODOC System is the only active robotic system that performs
a key segment of THR surgery (i.e., milling a bone cavity) under the supervision
of a surgeon.

     The Company believes the NeuroMate System is the only robotic system
presently used for neurosurgery which provides superior accuracy and flexibility
as compared to other techniques.

WARRANTY AND SERVICE

     The Company offers a full warranty, covering parts and labor, for the first
year following the purchase of its products, which warranty coverage can be
extended on an annual basis by purchasing a maintenance agreement at a price of
approximately 8 to 10% of the original purchase price of the product.

                                       38
   41
 
     Generally, minor problems have been diagnosed through modem and fixed
on-site by users. The Company has developed a service program using a high
volume clinical site as a model. The Company plans to provide 24-hour turnaround
time for any site. The Company has contracted with a third party in Europe to
service the Company's customer base.

     The Company trains its customers with its in-house technical staff and with
a third party trainer in Europe.

PATENTS AND PROPRIETARY RIGHTS
 
     The Company relies on a combination of patent, trade secret, copyright and
trademark laws and contractual restrictions to establish and protect proprietary
rights in its products and to maintain its competitive position.

     The Company has filed four patent applications, and is preparing for filing
additional patent applications covering various aspects of its technology. In
addition, IBM has agreed not to assert infringement claims against the Company
with respect to an IBM patent relating to robotic medical technology, to the
extent such technology is used in the Company's products. Furthermore,
significant portions of the ORTHODOC and ROBODOC System software are protected
by copyrights. IBM has granted the Company a royalty-free license for the
underlying software code for the ROBODOC System. In addition, the Company has
registered the marks ROBODOC and ORTHODOC.

     The Company's ability to compete successfully may depend, in part, on its
ability to obtain and protect patents, protect trade secrets and operate without
infringing the proprietary rights of others. However, there can be no assurance
that patents will issue from pending or future patent applications, or that the
Company will continue to develop its own patentable technologies. Further, there
can be no assurance that any patents that may be issued in the future will
effectively protect the Company's technology or provide a competitive advantage
for the Company's products or will not be challenged, invalidated, or
circumvented in the future. In addition, there can be no assurance that
competitors, many of which have substantially more resources than the Company
and have made substantial investments in competing technologies, will not obtain
patents that will prevent, limit or interfere with the Company's ability to
make, use or sell its products either in the United States or internationally.
 
     Patent applications in the United States are maintained in secrecy until
patents issue, and patent applications in foreign countries are maintained in
secrecy for a period after filing. Publication of discoveries in the scientific
or patent literature tends to lag behind actual discoveries and the filing of
related patent applications. Patents issued and patent applications filed
relating to medical devices are numerous, and there can be no assurance that
current and potential competitors and other third parties have not filed or in
the future will not file applications for, or have not received or in the future
will not receive, patents or obtain additional proprietary rights relating to
products or processes used or proposed to be used by the Company.

     The Company's patent counsel has not undertaken any infringement study to
determine whether the Company's products and pending patent applications
infringe on other existing patents due to the Company's belief that an
infringement study would not be cost-effective, nor offer significant protection
against potential infringement claims, if and when made. The medical device
industry has been characterized by substantial competition and litigation
regarding patent and other proprietary rights. The Company intends to vigorously
protect and defend its patents and other proprietary rights relating to its
proprietary technology. Litigation alleging infringement claims against the
Company (with or without merit), or instituted by the Company to enforce patents
issued to the Company or to protect trade secrets or know-how owned by the
Company or to determine the enforceability, scope and validity of the
proprietary rights of others, is costly and time consuming. If any relevant
claims of third-party patents are upheld as valid and enforceable in any
litigation or administrative proceedings, the Company could be prevented from
practicing the subject matter claimed in such patents, or could be required to
obtain licenses from the patent owners of each patent, or to redesign its
products or processes to avoid infringement. There can be no assurance that such
licenses would be available or, if available, would be available on terms
acceptable to the Company or that the Company would be successful in any attempt
to redesign its products or processes to avoid infringement. Accordingly, an
adverse determination in a judicial or administrative proceeding or failure to
obtain necessary licenses could prevent

                                       39
   42
 
the Company from manufacturing and selling its products, which would have a
material adverse effect on the Company's business, financial condition and
results of operations.
 
     The Company requires each of its employees, consultants, and advisors to
execute confidentiality and assignment of inventions and proprietary information
agreements in connection with their employment, consulting or advisory
relationships with the Company. These agreements generally provide that all
inventions, ideas and improvements made or conceived by the individual arising
out of his relationship with the Company will be the exclusive property of the
Company. This information is required to be kept confidential and not disclosed
to third parties, except with the consent of the Company or under certain
circumstances. However, there can be no assurance that these agreements will
provide effective protection for the Company's proprietary information in the
event of unauthorized use or disclosure of such information, or that the Company
will have adequate remedies in the event of such breach. Furthermore, no
assurance can be given that competitors will not independently develop
substantially equivalent proprietary information and techniques or otherwise
gain access to the Company's proprietary technology, or that the Company can
meaningfully protect its rights in unpatented proprietary technology.
 
GOVERNMENT REGULATION
 
     The medical devices to be marketed and manufactured by the Company are
subject to extensive regulation by the FDA and, in some instances, by foreign
and state governments. Pursuant to the Federal Food, Drug, and Cosmetic Act of
1976, as amended, and the regulations promulgated thereunder (the "FDC Act"),
the FDA regulates the clinical testing, manufacture, labeling, distribution, and
promotion of medical devices. Noncompliance with applicable requirements can
result in, among other things, fines, injunctions, civil penalties, recall or
seizure of products, total or partial suspension of production, failure of the
government to grant pre-market clearance or pre-market approval for devices,
withdrawal of marketing clearances or approvals, and criminal prosecution. The
FDA also has the authority to request repair, replacement or refund of the cost
of any device manufactured or distributed by the Company.
 
     In the United States, medical devices are classified into one of three
classes (Class I, II or III), on the basis of the controls deemed necessary by
the FDA to reasonably assure their safety and effectiveness. Under FDA
regulations, Class I devices are subject to general controls (e.g., labeling,
pre-market notification and adherence to good manufacturing practices ("GMP"))
and Class II devices are subject to general and special controls (e.g.,
performance standards, postmarket surveillance, patient registries, and FDA
guidelines). Generally, Class III devices are those which must receive
pre-market approval by the FDA to ensure their safety and effectiveness (e.g.,
life-sustaining, life-supporting and implantable devices, or new devices which
are not substantially equivalent to legally marketed devices).
 
     Before a new device can be introduced into the market, the manufacturer
must generally obtain FDA permission to market through either a 510(k)
notification or a pre-market approval ("PMA") application. A 510(k) clearance
will be granted if the submitted information establishes that the proposed
device is "substantially equivalent" to a legally marketed Class I or II medical
device, or to a pre-amendment Class III medical device for which the FDA has not
called for PMAs. The FDA has recently been requiring a more vigorous
demonstration of substantial equivalence than in the past, including in some
cases requiring clinical data. It generally takes from four to 12 months from
the date of submission to obtain a 510(k) clearance, but it may take longer. The
FDA may determine that a proposed device is not substantially equivalent to a
legally marketed device, or that additional information is needed before a
substantial equivalence determination can be made. A "not substantially
equivalent" determination, or a request for additional information, could delay
the market introduction of a new product that falls into this category and could
have a material adverse effect on the Company's business, financial condition
and results of operations. For any of the Company's products that are cleared
through the 510(k) process, modifications or enhancements that could
significantly affect the safety or efficacy of the device or that constitute a
major change to the intended use of the device will require new 510(k)
submissions.
 
     A PMA application must be filed if a proposed device is not substantially
equivalent to a legally marketed Class I or Class II device, or if it is a
pre-amendment Class III device for which FDA has called for PMAs. A
 
                                       40
   43
 
PMA application must be supported by valid scientific evidence, which typically
includes extensive data, including human clinical trial data to demonstrate the
safety and effectiveness of the device. The PMA application must also contain
the results of all relevant bench tests, laboratory and animal studies, a
complete description of the device and its components, and a detailed
description of the methods, facilities and controls used to manufacture the
device. In addition, the submission must include the proposed labeling,
advertising literature and any required training materials.
 
     Upon receipt of a PMA application, the FDA makes a threshold determination
as to whether the application is sufficiently complete to permit a substantive
review. If the FDA determines that the PMA application is sufficiently complete
to permit a substantive review, the FDA will accept the application for filing.
Once the submission is accepted for filing, the FDA begins an in-depth review of
the PMA. An FDA review of a PMA application generally takes one to two years
from the date the PMA application is accepted for filing, but may take
significantly longer. The review time is often significantly extended by the FDA
asking for more information or clarification of information already provided in
the submission. During the review period, an advisory committee, typically a
panel of clinicians, will likely be convened to review and evaluate the
application and provide recommendations as to whether the device should be
approved. The FDA is not bound by the recommendations of the advisory panel.
Toward the end of the PMA review process, the FDA generally will conduct an
inspection of the manufacturer's facilities to ensure that the facilities are in
compliance with applicable GMP requirements.
 
     If the FDA's evaluations of both the PMA application and the manufacturing
facilities are favorable, the FDA will either issue an approval letter or an
approvable letter, which usually contains a number of conditions which must be
met in order to secure final approval of the PMA. When and if those conditions
have been fulfilled to the satisfaction of FDA, the agency will issue a PMA
approval letter, authorizing commercial marketing of the device for certain
indications. If the FDA's evaluation of the PMA application or manufacturing
facilities are not favorable, the FDA will deny approval of the PMA application
or issue a "non-approvable letter." The FDA may also determine that additional
clinical trials are necessary, in which case PMA approval may be delayed for
years while additional clinical trials are conducted and submitted in an
amendment to the PMA. The PMA process can be expensive, uncertain and lengthy
and a number of devices for which FDA approval has been sought by other
companies have never been approved for marketing.
 
     Modifications to a device that is the subject of an approved PMA, its
labeling, or manufacturing process may require approval by the FDA of PMA
supplements or new PMAs. Supplements to a PMA often require the submission of
the same type of information required for an initial PMA, except that the
supplement is generally limited to that information needed to support the
proposed change from the product covered by the original PMA.

     There can be no assurance that the Company will be able to obtain necessary
regulatory approvals for the ROBODOC System or products under development on a
timely basis, or at all, or that the Company will have the necessary resources
to obtain such approval. Delays in receipt of or failure to receive such
approvals, the loss of previously received approvals, or failure to comply with
existing or future regulatory requirements would have a material adverse effect
on the Company's business, financial condition and results of operation.

     If human clinical trials of a device are required in connection with either
a 510(k) notification or a PMA application, and the device presents a
"significant risk," the sponsor of the trial (usually the manufacturer or the
distributor of the device) is required to file an investigational device
exemption ("IDE") application prior to commencing human clinical trials. The IDE
application must be supported by data, typically including the results of animal
and laboratory testing. If the IDE application is reviewed and approved by the
FDA and one or more appropriate Institutional Review Boards ("IRBs"), human
clinical trials may begin at a specific number of investigational sites with a
specific number of patients, as approved by the FDA. If the device presents a
"nonsignificant risk" to the patient, a sponsor may begin the clinical trial
after obtaining approval for the study by one or more appropriate IRBs, without
the need for FDA approval. Sponsors of clinical trials are permitted to sell
those devices distributed in the course of the study provided such compensation
does not exceed recovery of the costs of manufacture, research, development and
handling. An IDE supplement must
 
                                       41
   44
 
be submitted to and approved by the FDA before a sponsor or an investigator may
make a change to the investigational plan that may affect its scientific
soundness or the rights, safety or welfare of human subjects.
 
     Any products manufactured or distributed by the Company pursuant to the FDA
clearances or approvals are subject to pervasive and continuing regulation by
the FDA, including recordkeeping requirements and reporting of adverse
experiences with the use of the device. Device manufacturers are required to
register their establishments and list their devices with the FDA and with
certain state agencies and are subject to periodic inspections by the FDA and
certain state agencies. The FDC Act requires devices to be manufactured in
accordance with the QSR regulation, which imposes certain procedural and
documentation requirements upon the Company with respect to manufacturing and
quality assurance activities. The QSR revises the previous GMP regulation and
imposes certain enhanced requirements that are likely to increase the cost of
compliance, including design controls.

     The Company intends to submit a PMA to the FDA in late 1997 for approval to
market the ROBODOC System in the United States. The Company intends to make an
informal pre-PMA submission of the clinical data to the FDA. Depending upon the
FDA's review of this submission, the target date for submitting a PMA
application could be extended. There can be no assurance that the PMA
application, once submitted, will be accepted for filing, found approvable, or,
if found approvable, will not take longer than expected to obtain approval, or
will not include unfavorable post-approval restrictions (for example,
limitations on the indicated patient population). See "Risk Factors -- Available
Clinical Data; Risk Versus Benefit Issues."

     After receipt of PMA approval, if any, the Company expects that the FDA
would consider new surgical applications for the ROBODOC System to be new
indications for use, which generally would require FDA approval of a PMA
supplement or, possibly, a new PMA. The FDA is also likely to require additional
approvals before the agency will permit the Company to incorporate new imaging
modalities (such as ultrasound and MRI) or other new technologies in the ROBODOC
System. The FDA likely will require that such additional approvals be supported
by new clinical data.
 
     In February 1996, the Company filed a 510(k) submission for the ORTHODOC as
a stand-alone device. Such 510(k) submission is the first product clearance or
approval filing made by the Company with the FDA. In January 1997, the ORTHODOC
received clearance from the FDA for marketing in the United States.

     The NeuroMate System received 510(k) clearance from the FDA for marketing
in the United States in May 1997.

     Labeling and promotion activities are subject to scrutiny by the FDA and,
in certain instances, by the Federal Trade Commission. Current FDA enforcement
policy prohibits marketing approved medical devices for unapproved uses. The
Company and its products are also subject to a variety of state laws and
regulations in those states or localities where its products are or will be
marketed. Any applicable state or local regulations may hinder the Company's
ability to market its products in those states or localities. Manufacturers are
also subject to numerous federal, state and local laws relating to such matters
as safe working conditions, manufacturing practices, environmental protection,
fire hazard control and disposal of hazardous or potentially hazardous
substances. There can be no assurance that the Company will not be required to
incur significant costs to comply with such laws and regulations now or in the
future or that such laws or regulations will not have a material adverse effect
upon the Company's business, financial condition or results of operations.
 
     Exports of products subject to the 510(k) notification requirements, but
not yet cleared to market, are permitted without FDA export approval provided
certain requirements are met. Unapproved products subject to the PMA
requirements must receive prior FDA export approval unless they are approved for
use by any member country of the European Union and certain other countries,
including Australia, Canada, Israel, Japan, New Zealand, Switzerland and South
Africa, in which case they can be exported to any country without prior FDA
approval. To obtain FDA export approval, when it is required, certain
requirements must be met and information must be provided to the FDA, including
documentation demonstrating that the product is approved for import into the
country to which it is to be exported and, in some instances, safety data from
animal or human studies. There can be no assurance that the Company will receive
FDA export approval when such approval is necessary, or that countries to which
the devices are to be exported will approve the
 
                                       42
   45
 
devices for import. Failure of the Company to obtain CPEs, meet FDA's export
requirements, or obtain FDA export approval when required to do so, could have a
material adverse effect on the Company's business, financial condition and
results of operations.

     The introduction of the Company's products in foreign markets has subjected
will continue to subject the Company to foreign regulatory clearances which may
impose additional substantive costs and burdens. International sales of medical
devices are subject to the regulatory requirements of each country. The
regulatory review process varies from country to country. Many countries also
impose product standards, packaging requirements, labeling requirements and
import restrictions on devices. In addition, each country has its own tariff
regulations, duties and tax requirements. Approval by the FDA and foreign
government authorities is unpredictable and uncertain, and no assurance can be
given that the necessary approvals or clearances for the Company's products will
be granted on a timely basis or at all. Delays in receipt of, or a failure to
receive, such approvals or clearances, or the loss of any previously received
approvals or clearances, could have a material adverse effect on the Company's
business, financial condition and results of operations.

   
     The ROBODOC System satisfies international electromedical standard IEC
601-1 and the protection requirements of the Electromagnetic Compatibility
Directive (89/336/EEC), thus allowing the Company to apply the CE Mark. This
conformity is evidenced by the grant of a GS-Mark by Technische Ubermachtungs
Verein Rheinland ("TUV"), a testing body in Germany, under current German
regulations. The ROBODOC System also satisfies the relevant provisions of the
Medical Device Directive for a Class II b Medical Device.

   
     The NeuroMate System satisfies the relevant provisions of the Medical
Device Directive for a Class IIb Medical Device, thus allowing the Company to
apply the CE Mark. In June 1997, the NeuroMate System received clearance from
the Japanese Ministry of Health for marketing in Japan.

     The Company's products are subject to continued and pervasive regulation by
the FDA and foreign and state regulatory authorities. Changes in existing
requirements or adoption of new requirements or policies could adversely affect
the ability of the Company to comply with regulatory requirements. Failure to
comply with regulatory requirements could have a material adverse effect on the
Company's business, financial condition and results of operations. There can be
no assurance that the Company will not be required to incur significant costs to
comply with laws and regulations in the future or that the failure to comply
with such laws or regulations will not have a material adverse effect upon the
Company's business, financial condition or results of operations.
 
PRODUCT LIABILITY

     The manufacture and sale of medical products exposes the Company to the
risk of significant damages from product liability claims. The Company maintains
product liability insurance against product liability claims in the amount of $5
million per occurrence and $5 million in the aggregate. In addition, in
connection with the sale of its ROBODOC System, the Company enters into
indemnification agreements with its customers pursuant to which the customers
indemnify the Company against any claims against it arising from improper use of
the ROBODOC System. There can be no assurance, however, that the coverage limits
of the Company's insurance policies will be adequate, that the Company will
continue to be able to procure and maintain such insurance coverage, that such
insurance can be maintained at acceptable costs, or that customers will be able
to satisfy indemnification claims. Although the Company has not experienced any
product liability claims to date, a successful claim brought against the Company
in excess of its insurance coverage could have a materially adverse effect on
the Company's business, financial condition, and results of operations.

FACILITIES

     The Company's executive offices and production facilities, comprising a
total of approximately 17,000 square feet of space, are located in Sacramento,
California and Lyon, France. The Company occupies the facilities in Sacramento
pursuant to two leases that expire on June 30, 1998. The total rent expense for
these premises is approximately $12,600 per month. The lease for the Company's
manufacturing facility in Sacramento provides for escalation of rent at the rate
of 5% per annum. The facility in Lyon is located within a

                                       43
   46

university and is provided free of charge to the Company at this time. See Note
8 of notes to IMMI's consolidated financial statements. The Company is
considering alternative lease arrangements, and believes that alternative space
is available on reasonable terms. While the Company believes that its existing
facilities are adequate for its present operations, it anticipates that after
its leases expire, it will be required to relocate to larger facilities in
Sacramento and Lyon to accommodate future growth in manufacturing and research
and development.

EMPLOYEES

     As of August 31, 1997, the Company had 50 full time employees, of which 8
employees are employed by other entities but work full time for the Company,
including 26 in research and development, 9 in manufacturing, 2 in regulatory
affairs, 6 in sales and marketing and 7 in administration. The Company also has
3 part-time employees. None of the Company's employees is covered by a
collective bargaining agreement. The Company believes its relationship with its
employees is satisfactory.

LITIGATION
 
     The Company is not a party to any legal proceedings.
 
                                       44
   47
 
                                   MANAGEMENT
 
DIRECTORS, EXECUTIVE OFFICERS AND KEY EMPLOYEES
 
     The directors, executive officers and key employees of the Company are as
follows:

                  NAME                AGE                          POSITION
    --------------------------------  ----  ------------------------------------------------------
                                      
    Ramesh C. Trivedi...............    57  President, Chief Executive Officer and a Director
    James C. McGroddy...............    60  Chairman of the Board
    Mark Winn.......................    47  Chief Financial Officer and Secretary
    Leland Witherspoon..............    45  Vice President, Engineering
    Peter Kazanzides................    35  Director of Robotics and Software
    Brent D. Mittelstadt............    38  Director of Biomedical Applications
    Mary Edwards....................    42  Director of Regulatory Affairs
    Hans Weynschenk.................    47  Director of Marketing, Orthopaedics
    Jerome Lebon....................    42  Director of Marketing, Neurosurgery
    Stu Heald.......................    60  Manager of Manufacturing
    Jeffrey A. Johnson..............    46  Director of Marketing, U.S.A.
    John N. Kapoor..................    53  Director
    Paul A.H. Pankow................    67  Director
    Gerald D. Knudson...............    53  Director
    Patrick G. Hays.................    54  Director

 
     The Board of Directors has two standing committees, an Audit Committee and
a Compensation Committee.
 
     The Audit Committee is composed of Dr. McGroddy, Dr. Kapoor and Mr. Pankow.
The duties of the Audit Committee include recommending the engagement of
independent auditors, reviewing and considering reports of the auditors and
others relating to management and internal controls. The Audit Committee was
appointed in December 1996 and therefore held no meetings in 1996.
 
     The Company's Compensation Committee is composed of Dr. McGroddy, Dr.
Kapoor and Mr. Pankow. The duties of the Compensation Committee are to recommend
to the Board remuneration for officers of the Company to determine the number
and issuance of options pursuant to the Company's stock option plans and to
recommend the establishment of and to monitor a compensation and incentive
program for all executives of the Company. The Compensation Committee held four
meetings in 1996.
 
     RAMESH C. TRIVEDI, PH.D., has been President, Chief Executive Officer and a
Director of the Company since November 1995, and served as a consultant to the
Company from February 1995 until November 1995. Dr. Trivedi has over 25 years
experience in the healthcare field. Dr. Trivedi founded California Biomedical
Consultants in 1987, an international consulting firm. From 1985 to 1986, Dr.
Trivedi was the President and Chief Executive Officer of DigiRad Corporation, a
medical imaging company. From 1978 to 1984, he was the director of business
development of Syva Company and the General Manager of Synaco, Inc., divisions
of Syntex Corporation, a pharmaceutical company. From 1972 to 1978, Dr. Trivedi
was the head of the product management group at the Worthington division of
Millipore Corporation, a membrane filtration company, and the head of the
chemistry group of the Diagnostic Division of Pfizer, Inc. from 1971 to 1972.
Dr. Trivedi received a Ph.D. in Chemical Engineering from Lehigh University in
1970 and an MBA from Pepperdine University in 1981.
 
     JAMES C. MCGRODDY, PH.D., has been Chairman of the Board of Directors of
the Company since November 1995. From 1965 through December 1996, Dr. McGroddy
was employed by IBM. From January 1996 through December 1996, Dr. McGroddy
served as Senior Vice President and Special Advisor to the
 
                                       45
   48
 
Chairman of IBM. From May 1989 to December 1995, Dr. McGroddy was Senior Vice
President of Research of IBM with responsibility for approximately 2,500
technical professionals in IBM's seven research laboratories around the world.
He was a member of IBM's Worldwide Management Council. Dr. McGroddy has been
involved in the development of the Company since its inception in October 1990,
initially as an advisor and since November 1995 as a Director. Dr. McGroddy
received a Ph.D. in physics from the University of Maryland in 1965. See
"Certain Transactions -- Initial Transactions with IBM."

     MARK W. WINN has been Chief Financial Officer of the Company since
September 1997. From November 1991 to August 1997 Mr. Winn served as the Senior
Vice President and Chief Financial Officer of Research Medical, Inc., a
manufacturer and developer of specialty cardiovascular and pharmaceutical
products. From 1984 to 1991 Mr. Winn was the Vice President and Chief Financial
Officer of Gory Associated Industries, a South Florida building products
manufacturer. He received his MBA and BA from Brigham Young University in 1975
and 1974 respectively.

     LELAND WITHERSPOON, has been Vice President, Engineering since April 1997.
From February 1992 to April 1997, Mr. Witherspoon was Director Product Research
and Development for Sorin Biomedicals, Inc., a developer and manufacturer of
cardiopulmonary and cardiovascular products. From November 1990 to January 1992,
he was Manager of Research and Development for Pfizer/Shiley, a developer and
manufacturer of cardiopulmonary and cardiovascular equipment and disposables.
From March 1979 to October 1990, Mr. Witherspoon held various technical and
management positions with Xerox Medical Systems, a manufacturer and developer of
diagnostic medical electronic and mechanical systems. Mr. Witherspoon received a
BSEE from Rensselaer Polytechnic Institute in 1974.
 
     PETER KAZANZIDES, PH.D., a co-founder of the Company, has been an employee
of the Company since November 1990 and Director of Robotics and Software of the
Company since December 1995. He received Sc.B., Sc.M., and Ph.D. degrees in
electrical engineering from Brown University in 1983, 1985, and 1988,
respectively. His dissertation focused on force control and multiprocessor
systems for robotics. He performed post-doctoral research in surgical robotics
from March 1989 to March 1990 at the IBM T.J. Watson Research Center.
 
     BRENT D. MITTELSTADT, a co-founder of the Company, has been an employee of
the Company since November 1990 and Director of Surgical Applications of the
Company since December 1995. He began research in surgical robotics in 1986 as a
visiting research scientist at the IBM T.J. Watson Research Center and is
responsible for much of the early development of CT guided robotic systems for
total hip replacement surgery. Mr. Mittelstadt received a B.S. in Biology from
the University of Arizona in 1984.

     MARY J. EDWARDS has been Director of Regulatory Affairs of the Company
since July, 1997. Ms. Edwards served as a Senior Consultant for C.L. McIntosh,
Inc., a Washington, D.C. based regulatory consulting group directing its west
coast operations. Ms. Edwards also worked as the Director of Regulatory Affairs
for Nobel Biocare, an international medical device company located in
Gothenburg, Sweden, and for W.L. Gore & Associates, Inc., a Class III medical
device manufacturer. Ms. Edwards also served as the Industry Representative to
FDA's Scientific Advisory Panel for Dental Products.

   
     HANS WEYENSCHENK has been Director of Marketing, Orthopaedics, of the
Company since February 1997. Prior thereto, he was employed by Vitatron Medical,
Inc., a wholly-owned subsidiary of Medtronics (a manufacturer of cardiac
products), as Director of Marketing, Communications and Services from 1996 to
February 1997 and Director of International Sales from 1987 to 1995.

   
     JEROME LEBON has been Director of Marketing, Neurosurgery, of the Company
since September 5, 1997. From 1996 until September 1997, he was Executive Vice
President of International Sales of IMMI. From 1987 to 1995, he was
International Vice President of Technomed International, a lithrotripsy company
in France. From 1984 to 1986, Mr. Lebon was Business Development Manager of Sopa
Development Company, an engineering hospital turn-key company in France. From
1980 to 1985, he was employed by Thomson CGR, initially as Area Manager for
Latin America and then as Vice President, Sales and Marketing of its Brazilian
and Argentinian subsidiaries.

                                       46
   49
 
     STU HEALD has been Manager of Manufacturing of the Company since June 1996.
Mr. Heald has over 30 years experience in manufacturing products. From September
1993 to June 1996, Mr. Heald served as Operations Manager at Advanced Power
Solutions, a division of M&L Enterprises, Inc., a manufacturer of power
supplies. From October 1986 to August 1993, Mr. Heald served as Shop Operation
Manager at Resonex Inc., a manufacturer of magnetic resonance imaging systems.
Mr. Heald received a B.S. in Industrial Management from California State
University San Francisco in 1962.

     JEFFREY A. JOHNSON has been Director of Marketing, U.S.A. of the Company
since June 1997. From 1992 to June 1997 Mr. Johnson was Marketing Manager for
Sorin Biomedical, Inc., a developer and manufacturer of cardiopulmonary and
cardiovascular equipment. From 1984 to 1991 Mr. Johnson was a Product Manager
for the Ultrasound division of Philips Medical Systems, Inc. He received an MBA
from the University of California, Irvine in 1991 and an MS from University of
California, Los Angeles in 1976.

     JOHN N. KAPOOR, PH.D., has been a Director of the Company since December
1995. Dr. Kapoor founded EJ Financial Enterprises, Inc., a healthcare consulting
and investment company, in March 1990, of which he is currently President. Since
October 1990, Dr. Kapoor has been Chairman of Option Care, Inc., a franchiser of
home infusion therapy businesses. Dr. Kapoor has been the Chairman of Unimed
Pharmaceuticals, Inc., a specialty pharmaceutical company since 1990. Since May
1996, Dr. Kapoor has been Chief Executive Officer of Akorn, Inc., a manufacturer
and distributor of ophthalmic products, of which Dr. Kapoor has also served as
Chairman since May 1996. In addition, Dr. Kapoor has served as chairman of
NeoPharm, Inc., a cancer drug research and development company. Dr. Kapoor also
served as Chairman of Lyphomed, Inc., a pharmaceutical company, from 1983 to
1990, and was a Director of Lunar Corp., a manufacturer and marketer of x-ray
and ultrasound systems, from May 1990 to April 1996. Dr. Kapoor received a Ph.D.
in medicinal chemistry from State University of New York in 1970.
 
     PAUL A.H. PANKOW has been a Director of the Company since May 1995. Since
March 1995, Mr. Pankow has been President of PAP Consulting, a business and
technical consulting firm. From September 1959 to February 1995, Mr. Pankow held
various positions with 3M Corporation, most recently as a Vice President, and as
Chief Executive Officer of its Imaging Systems Division. He has served as
chairman of the Optoelectronic Industry Development Association and is a member
of several other industry boards. Mr. Pankow received a B.S. in mechanical
engineering and business administration from the University of Minnesota in
1956.
 
     GERALD D. KNUDSON has been a Director of the Company since May 1997. Since
January 1997, Mr. Knudson has been Executive Vice President of Sterling
Diagnostic Imaging, Inc., a manufacturer and distributor of medical diagnostic
imaging products. From 1994 to 1996, Mr. Knudson was President, Medical Systems
Division of Polaroid which manufactured medical diagnostic imaging printers and
film. From 1988 to 1994, Mr. Knudson was Chief Executive Officer of Resonex,
Inc., a manufacturer of MRI systems. Previously, Mr. Knudson held various
executive and marketing positions in the life science industry since 1966. Mr.
Knudson received a B.A. in Biology from Augustana College in 1965.
 
     PATRICK G. HAYS has been a Director of the Company since May 1997. Since
February 1995, Mr. Hays has been President and Chief Executive Officer of Blue
Cross and Blue Shield Association, the national coordinating body for the United
States' sixty-two community-based and independent Blue Cross and Blue Shield
Plans, collectively, the United States' largest insurer. From 1980 to 1995, Mr.
Hays was President and Chief Executive Officer of Sutter Health, a vertically
integrated provider of health services in northern California. Previously, Mr.
Hays held various administrative and executive positions with healthcare
providers since 1971. Mr. Hays received a Master's degree in Healthcare
Administration from the University of Minnesota in 1971.

     On August 16, 1992, a lawsuit was filed against Dr. Kapoor in the United
States District Court for the Northern District of Illinois by Fujisawa
Pharmaceutical Co., Ltd. and Fujisawa USA, Inc. ("Fujisawa"). The complaint
alleged that Dr. Kapoor, while President and Chief Executive Officer of
Lyphomed, Inc., a company acquired by Fujisawa, violated provisions of the
Federal securities laws and the Racketeer Influenced and Corrupt Organizations
Act (RICO), and also asserted certain state law claims. The factual basis of the
complaints alleges that Dr. Kapoor filed false applications for generic drug
approvals with the FDA on behalf

                                       47
   50

of Lyphomed, Inc. On July 25, 1996, the complaint was dismissed in part, and Dr.
Kapoor was granted summary judgment on the remaining claims. On June 16, 1997,
the Court of Appeals for the 7th Circuit reversed the District Court's order
granting summary judgment and remanded the case to the District Court. Dr.
Kapoor vigorously denies the allegations and filed a complaint against Fujisawa
in Illinois state court on August 27, 1996 claiming breach of contract,
defamation of character and other state law claims.

     All directors hold office until the annual meeting of stockholders of the
Company following their election or until their successors are duly elected and
qualified. Officers are appointed by the Board of Directors and serve at its
discretion.

     The Company has adopted a policy of compensating independent directors in
the amount of $7,500 annually and $500 additional for each Board of Directors
meeting attended and $250 for each telephonic Board of Directors meeting
attended. Members who serve on either the Audit or Compensation Committees are
to be paid $300 for each meeting attended and $150 for each telephonic meeting
attended. Committee chairmen are also to be paid a fee of $500 per annum.

     The Company will also grant independent members of the Board of Directors
ten year non-qualified stock options to purchase 3,500 shares of the Company's
Common Stock at an exercise price equal to the greater of the fair market value
on the date of issue or $5.00 per share.
 
     No member of the Compensation Committee was an officer or employee of the
Company or of any of its subsidiaries during the prior year or was formerly an
officer of the Company or of any of its subsidiaries. None of the Executive
Officers of the Company has served on the Board of Directors or Compensation
Committee during the last fiscal year of any other entity, any of whose officers
served either on the Board of Directors of the Company or on the Compensation
Committee of the Company.
 
     On July 26, 1996, Mr. Pankow was granted an option to purchase 2,704 shares
of Common Stock at an exercise price of $2.07 per share. On January 24, 1997,
Dr. McGroddy was granted an option to purchase 25,000 shares of Common Stock at
an exercise price of $5.00 per share.
 
SUMMARY COMPENSATION TABLE
     The following table sets forth the compensation awarded to, earned by or
paid to the Company's Chief Executive Officer and each other executive officer
of the Company whose salary and bonus for the year ended December 31, 1996
exceeded $100,000 (collectively, the "Named Executive Officers").

                                            ANNUAL
                                         COMPENSATION                           LONG-TERM COMPENSATION
                                      ------------------     OTHER ANNUAL       SECURITIES UNDERLYING
    NAME AND PRINCIPAL POSITION       YEAR      SALARY      COMPENSATION(3)            OPTIONS
- ------------------------------------  -----    ---------    ---------------     ----------------------
                                                                    
Ramesh C. Trivedi...................   1996     $264,000        $50,000                 316,907
  Chief Executive Officer and
     President
Wendy Shelton-Paul(1)...............   1996     $120,000        $30,000                  30,415
  Vice President of Medical Affairs
Michael J. Tomczak(2)...............   1996     $112,000        $30,000                  30,415
  Vice President and Chief Financial
     Officer

- ---------------
(1) Dr. Shelton-Paul resigned from her position as Vice President of Medical
    Affairs effective December 31, 1996.

(2) Mr. Tomczak has resigned from his positions with the Company and will cease
    to be an employee of the Company effective September 30, 1997.

   
(3) Represents cash incentive bonus.

EMPLOYMENT AGREEMENTS
 
     On December 8, 1995, the Company entered into an employment agreement with
Dr. Ramesh C. Trivedi, the Company's Chief Executive Officer and President. The
agreement is for no specified term and provides for the at-will employment of
Dr. Trivedi. Pursuant to the employment agreement, Dr. Trivedi is to receive an
annual salary of $264,000 ($22,000 per month), plus out-of-pocket expenses. Dr.
Trivedi's employment agreement provides for the grant of options to purchase
316,907 shares of the Company's
 
                                       48
   51
 
Common Stock, at an exercise price of $0.07 per share, which were granted in
February 1996. Upon termination by the Company, other than for cause (as defined
in the employment agreement), Dr. Trivedi is entitled to receive his monthly
salary for a period of nine months following the date of termination and
consulting fees (at his then prevailing consulting rate) for three months of
consulting services to be rendered during the 12 months following such
termination.
 
     None of the other Named Executive Officers has an employment agreement with
the Company.
 
STOCK OPTIONS
 
     The following table contains information concerning the grant of stock
options under the Company's 1995 Stock Option Plan to Dr. Trivedi, Dr.
Shelton-Paul and Mr. Tomczak during the fiscal year ended December 31, 1996. See
"Management -- Stock Option Plan" and Note 6 to notes to consolidated financial
statements appearing elsewhere in this Prospectus.

                                                 NUMBER OF       PERCENT OF
                                                  SHARES       TOTAL OPTIONS    EXERCISE
                                                UNDERLYING       GRANTED TO      PRICE
                                                  OPTIONS       EMPLOYEES IN      PER      EXPIRATION
                      NAME                     GRANTED(1)(3)   FISCAL YEAR(3)   SHARE(2)      DATE
    -----------------------------------------  -------------   --------------   --------   ----------
                                                                               
    Ramesh C. Trivedi........................     316,907           41.7%        $ 0.07      02/16/06
    Wendy Shelton-Paul.......................      30,415            4.3%        $ 0.07      02/16/06
    Michael J. Tomczak.......................      30,415            4.3%        $ 0.07      02/16/06

- ---------------
(1) Stock options are granted at the discretion of the Compensation Committee of
    the Company's Board of Directors. Stock options have a 10-year term and vest
    periodically over a period not to exceed five years.
 
(2) The Compensation Committee of the Company's Board of Directors may elect to
    reduce the exercise price of any option to the current fair market value of
    the Common Stock if the value of the Common Stock has declined from the date
    of grant.
 
(3) Does not include the options previously outstanding under the Company's 1991
    Stock Option Plan which were repriced on February 16, 1996. See the table
    captioned "Repricing of Options" below.

     The following table summarizes for each of the Named Executive Officers the
total number of unexercised options, if any, held at December 31, 1996, and the
aggregate dollar value of in-the-money, unexercised options, held at December
31, 1996, in each case after giving effect to the replacement in February 1996
of previously held options. The value of the unexercised, in-the-money options
at December 31, 1996, is the difference between the value of the underlying
Common Stock on December 31, 1996 ($5.00 per share) and their exercise or base
price ($0.07 per share).

AGGREGATED OPTION EXERCISES -- JANUARY 1, 1996 -- DECEMBER 31, 1996 AND DECEMBER
                             31, 1996 OPTION VALUES

                       SHARES ACQUIRED UPON
                       EXERCISE OF OPTIONS
                          DURING FISCAL            NUMBER OF SECURITIES              VALUE OF UNEXERCISED
                             1996(1)              UNDERLYING UNEXERCISED            IN-THE-MONEY OPTIONS AT
                       --------------------    OPTIONS AT DECEMBER 31, 1996            DECEMBER 31, 1996
                                    VALUE      -----------------------------     -----------------------------
        NAME           NUMBER     REALIZED     EXERCISABLE     UNEXERCISABLE     EXERCISABLE     UNEXERCISABLE
- ---------------------  -------    ---------    -----------     -------------     -----------     -------------
                                                                               
Ramesh C. Trivedi....       --           --      163,559          153,348         $ 806,346        $ 756,006
Wendy Shelton-Paul...       --           --       40,553           57,449         $ 199,926        $ 283,224
Michael J. Tomczak...       --           --       64,620           33,850         $ 318,577        $ 166,881

                                       49
   52
 
                              REPRICING OF OPTIONS

                                                                                                   LENGTH OF
                                        NUMBER OF                        EXERCISE                   ORIGINAL
                                        SECURITIES                       PRICE OF                    OPTION
                                        UNDERLYING   MARKET PRICE OF     STOCK AT                TERM REMAINING
                             REPRICE/    OPTIONS      STOCK AT TIME      TIME OF        NEW        AT DATE OF
                             REGRANT     REPRICED     OF REPRICING     REPRICING OR   EXERCISE    REPRICING OR
           NAME                DATE     OR AMENDED    OR AMENDMENT      AMENDMENT      PRICE       AMENDMENT
- ---------------------------  --------   ----------   ---------------   ------------   --------   --------------
                                                                               
Wendy Shelton-Paul.........   2/16/96     67,587          $.888           $ 4.88        $.07       9.25 years
Michael J. Tomczak.........   2/16/96     43,932          $.888           $ 4.88        $.07       9.25 years
Michael J. Tomczak.........   2/16/96      6,759          $.888           $ 7.84        $.07          8 years
Michael J. Tomczak.........   2/16/96     13,308          $.888           $ 7.84        $.07        6.5 years
Michael J. Tomczak.........   2/16/96      4,056          $.888           $ 3.33        $.07          6 years

     The Compensation Committee of the Board of Directors approved the
replacement of these options to Dr. Shelton-Paul and Mr. Tomczak, and options to
other employees of the Company, at an exercise price of $.07 per share, having
concluded that the principal purpose of the Company's stock option program
(i.e., to provide an equity incentive to employees to remain in the employment
of the Company and to work diligently in its best interests) would not be
achieved for those employees holding options exercisable above the market price
of the Common Stock. In connection with the granting of these replacement
options, participating option holders agreed not to exercise any option for a
period of six months from the date of such regrant.
 
STOCK OPTION PLAN

     On December 13, 1995, the Board of Directors adopted, and stockholders
approved, the 1995 Stock Option Plan (the "Plan"). The Plan is to be
administered by the Board of Directors or a committee thereof. The Plan is
currently administered by the Compensation Committee of the Board of Directors.
The Plan, as initially adopted, authorized the Company to grant stock purchase
rights and/or options to acquire an aggregate of 1,108,949 shares of Common
Stock to directors, employees (including officers) and consultants of the
Company ("Plan participants"). On September 16, 1996, the Board of Directors of
the Company adopted an amendment to the Plan, increasing the number of shares of
Common Stock covered by the Plan to 1,249,070 shares, and approved by the
stockholders in November 1996.

   
     The Company has outstanding options to purchase an aggregate of 1,162,905
shares granted pursuant to the Plan and options to purchase an aggregate of
5,408 shares granted pursuant to the Company's 1991 Stock Option Plan, which was
terminated in December 1995. Options to purchase an aggregate of 65,442 shares
of Common Stock remain available for grant under the Plan. No stock purchase
rights have been granted pursuant to the Plan.

   
     The Plan authorizes the issuance of incentive stock options ("ISOs"), as
defined in Section 422A of the Internal Revenue Code of 1986, non-qualified
stock options ("NQSOs", and together with ISOs, "Options") and stock purchase
rights ("SPRs"). Consultants and directors who are not also employees of the
Company are eligible for grants of only NQSOs and/or SPRs. The exercise price of
each ISO may not be less than 100% of the fair market value of the Common Stock
at the time of grant, except that in the case of a grant to an employee who owns
10% or more of the outstanding stock of the Company or a subsidiary or parent of
the Company (a "10% Stockholder"), the exercise price may not be less than 110%
of the fair market value on the date of grant. The aggregate fair market value
of the shares covered by ISOs granted under the Plan that become exercisable by
a Plan participant for the first time in any calendar year is subject to a
$100,000 limitation. The exercise price of each NQSO is determined by the Board,
or committee thereof, in its discretion, provided that the exercise price of a
NQSO is not less than 85% of the fair market value of the Common Stock on the
date of grant. The Board, or committee thereof, determines the term of the
Options and SPRs, except that in no event may an Option have a term of more than
ten (10) years (five (5) years with respect to ISOs granted to a 10%
Stockholder), and the terms of vesting, except that in no event may an Option
vest at a rate less than 20% per year. A recipient of an SPR must exercise such
right within the period, not to exceed thirty (30) days from the date of grant,
determined by the Board, or committee thereof. The Board, or committee thereof,
may reserve to the Company upon the grant of an SPR, an option to repurchase
upon a Plan participant's termination of employment, any stock acquired upon his
exercise of the SPR at the

                                       50
   53

SPR exercise price. Any such repurchase option will lapse at a rate of not less
than 20% per year commencing on the date of the Plan participant's purchase.
Options and SPRs granted under the Plan are not transferable, other than by will
or by the laws of descent and distribution. No stock options or SPRs may be
granted under the Plan after December 12, 2005.

     Subject to the provisions of the Plan, the Board, or a committee thereof,
has the authority to determine the individuals to whom the stock options or SPRs
are to be granted, the number of shares to be covered by each option or SPR, the
exercise price, the type of option, the exercise period, the restrictions, if
any, on the exercise of the option or SPR, the terms for the payment of the
exercise price and other terms and conditions. Payments by holders of options or
SPRs upon exercise of an option may be made (as determined by the Board or a
committee thereof) in cash or such other form of payment as may be permitted
under the Plan, including without limitation, by promissory note or by delivery
of shares of Common Stock.
 
     In February 1996, the Compensation Committee of the Board of Directors
authorized the grant of options to purchase an aggregate of 242,746 shares of
Common Stock, at an exercise price of $0.07 per share, to certain officers,
directors and employees of the Company pursuant to the Company's 1995 Stock
Option Plan, including options to purchase 67,587 shares granted to Dr. Wendy
Shelton-Paul, Vice President of Medical Affairs of the Company, and options to
purchase 68,055 shares granted to Michael J. Tomczak, Vice President and Chief
Financial Officer of the Company. These options were issued in replacement of
options previously granted pursuant to the Company's 1991 Stock Option Plan,
with exercise prices ranging from $3.33 to $7.84 per share, surrendered for
cancellation.
 
INDEMNIFICATION OF OFFICERS AND DIRECTORS AND LIMITATION ON DIRECTOR LIABILITY
 
     Article VI of the Company's by-laws provides that a director or officer
shall be indemnified against expenses (including attorneys' fees), judgments,
fines and amounts paid in settlement (provided such settlement is approved in
advance by the Company) in connection with certain actions, suits or
proceedings, whether civil, criminal, administrative or investigative (other
than an action by or in the right of the corporation -- a "derivative action")
if he acted in good faith and in a manner he reasonably believed to be in or not
opposed to the best interests of the Company, and, with respect to any criminal
action or proceeding, had no reasonable cause to believe his conduct was
unlawful. A similar standard of care is applicable in the case of derivative
actions, except that indemnification only extends to expenses (including
attorneys' fees) incurred in connection with the defense or settlement of such
an action, except that no person who has been adjudged to be liable to the
Company shall be entitled to indemnification unless a court determines that
despite such adjudication of liability, but in view of all of the circumstances
of the case, the person seeking indemnification is fairly and reasonably
entitled to be indemnified for such expenses as the court deems proper.
 
     Insofar as indemnification for liabilities arising under the Securities Act
may be permitted to directors, officers and controlling persons of the Company
pursuant to the foregoing provisions or otherwise, the Company has been advised
that in the opinion of the Securities and Exchange Commission such
indemnification is against public policy as expressed in the Securities Act and
is therefore unenforceable.
 
     Article 11 of the Company's certificate of incorporation eliminates the
personal liability of the Company's directors to the Company or its stockholders
for monetary damages for breach of their fiduciary duties as a director to the
fullest extent provided by Delaware law. Section 102(b)(7) of the Delaware
General Corporation Law ("DGCL") provides for the elimination of such personal
liability, except for liability (i) for any breach of the director's duty of
loyalty to the Company or its stockholders, (ii) for acts or omissions not in
good faith or which involve intentional misconduct or a knowing violation of
law, (iii) under Section 174 of the DGCL or (iv) for any transaction from which
the director derived any improper personal benefit.
 
                                       51
   54
 
                              CERTAIN TRANSACTIONS
TRANSACTIONS WITH FOUNDERS
 
     In connection with the formation of the Company, the Company sold 38,880
shares, 20,935 shares, 5,441 shares and 2,332 shares of Common Stock to Howard
A. Paul, William Bargar, Brent Mittelstadt and Peter Kazanzides (collectively
the "Founders"), respectively, for a purchase price of $0.07 per share. Dr. Paul
served as the Chief Executive Officer and President of the Company from
inception until his death in February 1993. Dr. Kazanzides and Mr. Mittelstadt
are key employees of the Company, and Dr. Bargar serves as a consultant to the
Company. See "Management."
 
INITIAL TRANSACTIONS WITH IBM
 
     In connection with the formation of the Company and pursuant to a Loan and
Warrant Purchase Agreement dated as of February 6, 1991 (the "IBM Loan
Agreement"), the Company granted IBM a warrant to purchase 67,587 shares of
Common Stock, at an exercise price of $0.07 per share, originally exercisable
until February 6, 1998. The expiration date of the warrant was extended until
December 31, 2000 in connection with the recapitalization of the Company in
December 1995, described below. In addition, pursuant to the IBM Loan Agreement,
during 1991 the Company borrowed an aggregate of $3,000,000 from IBM in
consideration for the Company's 9.25% Convertible Subordinated Loan Note in the
principal amount of $3,000,000 (the "IBM Note"). The IBM Note was convertible
into shares of Series A Preferred Stock at a conversion price of $33.29 per
share.
 
     In connection with the IBM loan transaction, the Company entered into a
Stockholders' Agreement with the Founders and IBM dated February 6, 1991 (the
"Stockholders' Agreement"). Pursuant to the Stockholders' Agreement, IBM has the
right to nominate a member of the Board of Directors of the Company (and the
stockholders agreed to vote their shares for such nominee) and to have a
non-voting observer attend meetings of the Board of Directors. In addition, the
Stockholders' Agreement grants IBM a right of first refusal with respect to
proposed transfers of Founder's shares to a "Competitor" (as defined). The
Stockholders' Agreement also restricts transfers of Founder's shares other than
to the Company, IBM or to a third party approved by IBM in writing. The
foregoing restriction will terminate on February 6, 1998, or earlier upon
consummation of (i) an initial underwritten firm commitment public offering of
the Common Stock resulting in gross proceeds of at least $15 million, or (ii)
the acquisition of the Company, whether by merger, acquisition of all or
substantially all of its assets, or acquisition of substantially all of its
voting securities.
 
     Pursuant to a License Agreement, dated February 6, 1991, IBM granted the
Company a non-exclusive, worldwide royalty-free license to the underlying
software code for the ROBODOC System.
 
SERIES B PREFERRED STOCK FINANCING
 
     Pursuant to a Stock Purchase Agreement dated as of April 10, 1992, Sutter
Health and The John N. Kapoor Trust (the "Kapoor Trust") each purchased 30,482
shares of the Company's Series B Preferred Stock, or a total of 60,964 shares,
for a purchase price of $4,000,370 ($65.62 per share). The Series B Preferred
Stock was convertible into shares of Common Stock at a conversion price of
$65.62 per share.
 
SERIES C PREFERRED STOCK FINANCING
 
     Pursuant to a Stock Purchase Agreement dated as of November 13, 1992,
Sutter Health and Keystone Financial Corporation ("Keystone") purchased 89,604
and 12,801 shares, respectively, for a total of 102,405 shares, of the Company's
Series C Preferred Stock, for a purchase price of $7,000,002 and $1,000,000,
respectively ($78.12 per share). The Series C Preferred Stock was convertible
into shares of Common Stock at a conversion price of $78.12 per share.
 
DECEMBER 1995 RECAPITALIZATION
 
     Pursuant to a Series D Preferred Stock and Warrant Purchase Agreement (the
"1995 Stock Purchase Agreement") dated as of December 21, 1995, the Company
effected the recapitalization described below.
 
     The Company effected a one-for-five reverse stock split of its capital
stock, and all outstanding shares of Series B and Series C Preferred Stock were
converted into shares of Common Stock. Upon conversion of the Series B Preferred
Stock, the Company issued 30,482 shares of Common Stock to each of Sutter Health
and
 
                                       52
   55
 
the Kapoor Trust, or a total of 60,964 shares. In addition, the Company issued
8,955 shares of Common Stock to each of Sutter Health and the Kapoor Trust, or a
total of 17,910 shares, in exchange for the cancellation of all accumulated
dividends on the Series B Preferred Stock. Upon conversion of the Series C
Preferred Stock, the Company issued 89,604 shares of Common Stock to Sutter
Health and 12,801 shares of Common Stock to Keystone, or a total of 102,405
shares. In addition, the Company issued 19,512 shares of Common Stock to Sutter
Health and 3,169 shares of Common Stock to Keystone, or a total of 22,681
shares, in exchange for the cancellation of all accumulated dividends on the
Series C Preferred Stock.
 
     As part of the recapitalization, IBM received a warrant to purchase 126,895
shares of Common Stock, at an exercise price of $0.01 per share, which expires
on December 31, 2005, in exchange for the cancellation of the IBM Note in the
principal amount of $3,000,000 and accrued interest thereon of $1,224,373. In
addition, the expiration date of the warrant issued to IBM in connection with
the formation of the Company was extended until December 31, 2000.
 
     Pursuant to the 1995 Stock Purchase Agreement, EJ Financial Investments V,
L.P. ("EJ Financial") purchased 693,194 shares of Series D Preferred Stock for
an aggregate purchase price of $666,667 ($0.96 per share), and IBM purchased a
warrant to purchase 1,386,390 shares of Series D Preferred Stock, exercisable at
any time prior to December 31, 2005, at an exercise price of $0.01 per share,
for an aggregate purchase price of $1,333,333 ($0.96 per warrant). In addition,
EJ Financial received an option to purchase an additional 346,597 shares of
Series D Preferred Stock, on the same terms as it purchased the Series D
Preferred Stock and IBM received an option to purchase warrants to purchase an
additional 693,194 shares of Series D Preferred Stock, on the same terms it
purchased the Series D Warrants (the options granted to EJ Financial and IBM
being hereinafter referred to collectively as the "Standby Options"). On
February 19, 1996, each of EJ Financial and IBM exercised its Standby Option, as
required by the terms thereof, since the Company was unable to obtain
alternative financing on substantially the same terms as the Standby Options
prior to the expiration thereof.
 
     As part of the recapitalization of the Company, Sutter Health, Sutter
Health Venture Partners and Keystone received warrants to purchase 390,888
shares, 11,899 shares and 43,300 shares, of Common Stock, respectively, at an
exercise price of $0.74 per share, in consideration for their consent to the
terms of the recapitalization, including the sale of the Series D Preferred
Stock. Sutter Health, Sutter Health Venture Partners and Keystone received
additional warrants to purchase 121,686 shares, 3,705 shares and 13,481 shares,
respectively, of Common Stock, at an exercise price of $0.74 per share, in
connection with the exercise by EJ Financial and IBM of the Standby Options.
Subsequently, Sutter Health, Sutter Health Venture Partners and Keystone agreed
to amend these warrants to permit payment of the exercise price by surrender of
a portion of the warrants in lieu of payment of the cash exercise price.
Accordingly, on August 25, 1996, Sutter Health and Sutter Health Venture
Partners received 449,374 shares and 13,680 shares of Common Stock, respectively
(or 63,200 fewer shares and 1,924 fewer shares, respectively, than they would
have received if the exercise price had been paid in cash) and on October 29,
1996, Keystone received 49,777 shares of Common Stock (or 7,002 fewer shares
than it would have received if the exercise price had been paid in cash.)
 
     In connection with the recapitalization of the Company, the Company granted
stockholders who did not purchase Series D Preferred Stock or warrants to
purchase Series D Preferred Stock rights to purchase Series D Preferred Stock on
the same terms and conditions as those shares purchased under the 1995 Stock
Purchase Agreement, which rights expired unexercised on March 5, 1996.
 
REGRANT OF LOWER-EXERCISE PRICE OPTIONS TO REPLACE PRIOR GRANTS
 
     In February 1996, the Compensation Committee of the Board of Directors
authorized the grant of options to purchase an aggregate of 242,736 shares of
Common Stock, at an exercise price of $0.07 per share, to certain officers,
directors, and employees of the Company pursuant to the Company's 1995 Stock
Option Plan, including options to purchase 67,587 shares granted to Dr. Wendy
Shelton-Paul, Vice President of Medical Affairs of the Company, and options to
purchase 68,055 shares granted to Michael J. Tomczak, Vice President and Chief
Financial Officer of the Company. These options were issued in replacement of
options previously granted pursuant to the Company's 1991 Stock Option Plan,
with exercise prices ranging from $3.33 to $7.84 per share, surrendered for
cancellation. See the table captioned "Repricing of Options" under
"Management -- Stock Options."
 
                                       53
   56
 
                         SECURITY OWNERSHIP OF CERTAIN
                        BENEFICIAL OWNERS AND MANAGEMENT
 
     The following table sets forth certain information concerning the
beneficial ownership of the Company's Common Stock immediately prior to and
after the Offering by (i) each stockholder known by the Company to be a
beneficial owner of more than five percent of the outstanding Common Stock, (ii)
each director of the Company and each executive officer listed in the
Compensation Table under the caption "Management -- Summary Compensation Table"
and (iii) all directors and officers as a group.

                                                                              PERCENTAGE OF COMMON STOCK
                                                  AMOUNT AND NATURE OF           BENEFICIALLY OWNED(1)
                                                 BENEFICIAL OWNERSHIP(1)     -----------------------------
                                                 -----------------------       BEFORE             AFTER
NAME                                                  OWNERSHIP(1)           OFFERING(2)       OFFERING(3)
- -----------------------------------------------  -----------------------     -----------       -----------
                                                                                      
International Business Machines Corporation....         2,274,066(5)            36.32%(6)         24.11%(7)
  Old Orchard Road
  Armonk, NY 10504
EJ Financial Investments V, L.P................         1,039,792               26.08%            14.53%
  225 East Deer Path Road
  Suite 250
  Lake Forest, IL 60045
Sutter Health and Sutter Health Venture........           611,607(8)            15.34%             8.54%
  Partners, L.P
  One Capitol Mall
  Sacramento, CA 95814
Ramesh C. Trivedi(4)...........................           210,743(9)             5.02%(10)         2.86%(11)
John N. Kapoor(4)..............................         1,039,792(12)           26.08%            14.53%
James C. McGroddy(4)...........................            21,000(13)           *                 *
Paul A.H. Pankow(4)............................             1,465(14)           *                 *
Patrick G. Hays(4).............................                --                  --                --
Gerald D. Knudson(4)...........................                --                  --                --
Michael J. Tomczak.............................            77,103(9)             1.90%(15)         1.07%(16)
Wendy Shelton Paul.............................            99,850(17)            2.47%(18)        13.83%(19)
All directors and officers as a group (8
  persons).....................................         1,449,953(20)           33.44%(21)        19.36%(22)

 
- ---------------
   
  *  Less than one percent.

   
 (1) Unless otherwise indicated, each person has sole investment and voting
     power with respect to the shares indicated, subject to community property
     laws, where applicable. For purposes of computing the percentage of
     outstanding shares held by each person or group of persons named above on
     September 1, 1997, any security which such person or group of persons has
     the right to acquire within 60 days after such date is deemed to be
     outstanding for the purpose of computing the percentage ownership for such
     person or persons, but is not deemed to be outstanding for the purpose of
     computing the percentage ownership of any other person.

   
 (2) Except as otherwise stated, calculated based upon 3,986,311 shares of
     Common Stock issued and outstanding.

   
 (3) Gives effect to the issuance of 3,171,771 shares of Common Stock in the
     Offering.

 (4) Address is c/o the Company, 829 West Stadium Lane, Sacramento, California
     95834.
 
 (5) Includes warrants to purchase 2,079,584 shares of Common Stock at an
     exercise price of $0.01 per share exercisable until December 31, 2005,
     warrants to purchase 67,587 shares of Common Stock at an exercise price of
     $0.07 per share exercisable until December 31, 2000, and warrants to
     purchase 126,895 shares of Common Stock at an exercise price of $0.01 per
     share exercisable until December 31, 2005, all of which warrants are
     presently exercisable.

 (6) Calculated based upon 6,260,377 shares of Common Stock issued and
     outstanding.

                                       54
   57

 (7) Calculated based upon 9,432,148 shares of Common Stock issued and
     outstanding.

   
 (8) Includes 593,538 shares of Common Stock owned by Sutter Health and 18,069
     shares of Common Stock beneficially owned by Sutter Health Venture Partners
     I, L.P. ("Sutter Partners"), an affiliate of Sutter Health.

   
 (9) Represents shares issuable upon the exercise of stock options exercisable
     within 60 days, at an exercise price of $0.07 per share.

   
(10) Calculated based upon 4,197,054 shares of Common Stock issued and
     outstanding.

   
(11) Calculated based upon 7,368,825 shares of Common Stock issued and
     outstanding.

   
(12) Represents shares of Common Stock owned by EJ Financial Investments V,
     L.P., a limited partnership of which Mr. Kapoor is the managing general
     partner. Mr. Kapoor disclaims beneficial ownership of such shares.

   
(13) Includes 20,000 shares of Common Stock owned by Dr. McGroddy and 1,000
     shares of Common Stock beneficially owned by his daughter.

   
(14) Represents shares issuable upon exercise of stock options exercisable
     within 60 days, at an exercise price of $2.07.

   
(15) Calculated based upon 4,063,414 shares of Common Stock issued and
     outstanding.

   
(16) Calculated based upon 7,235,185 shares of Common Stock issued and
     outstanding.

   
(17) Includes 60,970 shares issuable upon exercise of stock options exercisable
     within 60 days at an exercise price of $0.07 per share.

   
(18) Calculated based upon 4,047,281 shares of Common Stock issued and
     outstanding.

   
(19) Calculated based upon 7,219,052 shares of Common Stock issued and
     outstanding.

   
(20) Includes 331,734 shares of Common Stock issuable upon exercise of options
     exercisable within 60 days, at exercise prices ranging from $0.07 to $2.07
     per share.

   
(21) Calculated based upon 4,336,592 shares of Common Stock issued and
     outstanding.

   
(22) Calculated based upon 7,489,816 shares of Common Stock issued and
     outstanding.

                                       55
   58
 
                           DESCRIPTION OF SECURITIES

     The authorized capital stock of the Company consists of 15,000,000 shares
of Common Stock, $0.01 par value per share and 1,000,000 shares of "blank check"
preferred stock, par value $0.01 per share. As of the date of this Prospectus,
3,986,311 shares of Common Stock are issued and outstanding and no shares of
preferred stock are outstanding.

     The following are brief descriptions of the securities offered hereby and
other securities of the Company. The rights of the holders of shares of the
Company's capital stock are established by the Company's certificate of
incorporation, as amended, the Company's by-laws and Delaware law. The following
statements do not purport to be complete or give full effect to statutory or
common law, and are subject in all respects to the applicable provisions of the
certificate of incorporation, by-laws and state law.
 
COMMON STOCK
 
     Holders of the Common Stock are entitled to one vote per share, and subject
to the rights of holders of preferred stock, to receive dividends when, as and
if declared by the Board of Directors and to share ratably in the assets of the
Company legally available for distribution to holders of Common Stock in the
event of the liquidation, dissolution or winding up of the Company. Holders of
the Common Stock do not have subscription, redemption, conversion or preemptive
rights.
 
     Each share of Common Stock is entitled to one vote on any matter submitted
to the holders, except that holders are entitled to cumulate their votes in the
election of Directors. In other words, a stockholder may give one nominee a
number of votes equal to the number of Directors to be elected, multiplied by
the number of votes to which the stockholder's shares are normally entitled, or
he may distribute his votes among as many candidates as he sees fit. The
candidates receiving the highest number of votes shall be elected. If a
stockholder gives notice at the meeting prior to the voting, of such
stockholder's intention to cumulate his votes, all stockholders may cumulate
their votes for candidates in nomination. On all other matters which may
properly come before the meeting, each share has one vote. The Board is
empowered to fill any vacancies on the Board created by the resignation of
Directors. Except as otherwise required by the DGCL, all stockholder action
(other than the election of the Directors, who are elected by a plurality vote)
is subject to approval by a majority of the shares of Common Stock present at a
stockholders' meeting at which a quorum (a majority of the issued and
outstanding shares of the Common Stock) is present in person or by proxy, or by
written consent pursuant to Delaware law.
 
     All shares of Common Stock outstanding are fully paid and non-assessable,
and the shares of Common Stock offered hereby, when issued upon payment of the
purchase price set forth on the cover page of this Prospectus, will be fully
paid and non-assessable.

     The Board of Directors is authorized to issue additional shares of Common
Stock within the limits authorized by the Company's certificate of
incorporation, as amended, without further stockholder action. The Company has
agreed that it will not issue any securities, except as disclosed in this
Prospectus, through November 21, 1998, without the consent of Rickel &
Associates, Inc. The Company has agreed with Investmentbank Austria that for a
period of six months following the closing of this Offering, it will not issue
or sell, offer or contract to issue or sell, grant any option for issuance or
sale of, or otherwise dispose of, directly or indirectly, any Common Stock or
any securities convertible into, exchangeable for, or representing the right to
receive Common Stock without, in each case, the prior written consent of
Investmentbank Austria, which consent will not be unreasonably withheld.

OPTIONS AND WARRANTS

     Options.  The Company has outstanding options to purchase an aggregate of
1,168,313 shares of Common Stock, at exercise prices ranging from $0.07 to
$8.25, which expire at various dates from February 4, 2002 to September 2, 2007.
See "Management -- Stock Option Plan."

   
     Warrants.  The Company has outstanding warrants to purchase an aggregate of
4,332,816 shares of Common Stock, at exercise prices ranging from $0.01 to
$8.25, which expire at various dates through

                                       56
   59

December 31, 2005. Warrants to purchase 1,753,750 shares of Common Stock were
issued in the Company's initial public offering in November 1996 (the "Public
Warrants"). Each Public Warrant entitles the registered holder thereof to
purchase one share of Common Stock at $6.00 per share for a period of four years
commencing November 20, 1997 and ending November 19, 2001 (the "Exercise
Period"). The exercise price and the number of shares of Common Stock issuable
upon the exercise of each Public Warrant are subject to adjustment in the event
of a stock split, stock dividend, recapitalization, merger, consolidation or
certain other events. The Public Warrants may be redeemed by the Company, at a
price of $.10 per Public Warrant, upon not less than 30 days prior written
notice at any time during the Exercise Period, provided the average of the
closing bid quotations of the Common Stock, during the period of twenty (20)
consecutive trading days ending on the third day prior to the date upon which
the notice of redemption is given, as reported on The Nasdaq SmallCap Market (or
if the Common Stock is not quoted thereon, the closing sale price of the Common
Stock on the Nasdaq National Market or other principal securities exchange upon
which the Common Stock is then quoted or listed, or such other reporting system
that provides closing sale prices for the Common Stock), has been at least 150%
of the then exercise price of the Public Warrants. The Company has agreed to pay
Rickel & Associates, Inc. under circumstances in accordance with applicable NASD
rules a fee of 5% of the exercise price of each Public Warrant exercised for
soliciting the exercise of outstanding Public Warrants.

PREFERRED STOCK

     The Company is authorized to issue up to 1,000,000 shares of preferred
stock with such designations, rights and preferences as may be determined from
time to time by the Board of Directors. Accordingly, the Board of Directors is
empowered, without further stockholder approval, to issue preferred stock with
dividend, liquidation, conversion, voting or other rights that could decrease
the amount of earnings and assets available for distribution to holders of
Common Stock or adversely affect the voting power or other rights of the holders
of the Company's Common Stock. In the event of issuance, the preferred stock
could be utilized, under certain circumstances, as a method of discouraging,
delaying or preventing a change in control of the Company. The Company has no
present intention to issue any shares of preferred stock, and following the
Closing, no shares of preferred stock will be outstanding. Until November 21,
1998, the Company is required to obtain the consent of Rickel & Associates,
Inc., to the issuance of any securities other than as specified in this
Prospectus.

STATUTORY PROVISIONS AFFECTING STOCKHOLDERS

     The Company is subject to Section 203 of the Delaware General Corporation
Law, the State of Delaware's "business combination" statute. In general, such
statute prohibits a publicly held Delaware corporation from engaging in various
"business combination" transactions with any "interested stockholder" for a
period of three years after the date of the transaction in which the person
became an "interested stockholder," unless (i) the transaction in which the
interested stockholder obtained such status or the "business combination" is
approved by the Board of Directors prior to the date the interested stockholder
obtained such status; (ii) upon consummation of the transaction which resulted
in the stockholder becoming an "interested stockholder," the "interested
stockholder" owned at least 85% of the voting stock of the corporation
outstanding at the time the transaction commenced, excluding for purposes of
determining the number of shares outstanding those shares owned by (a) persons
who are directors and officers and (b) employee stock plans in which employee
participants do not have the right to determine confidentially whether shares
held subject to the plan will be tendered in a tender or exchange offer; or
(iii) on or subsequent to such date the "business combination" is approved by
the Board of Directors and authorized at an annual or special meeting of
stockholders by the affirmative vote of at least 66 2/3% of the outstanding
voting stock which is not owned by the "interested stockholder." A "business
combination" includes mergers, asset sales and other transactions resulting in
financial benefit to a stockholder. An "interested stockholder" is a person who,
together with affiliates and associates, owns (or within three years, did own)
15% or more of a corporation's voting stock. The statute could prohibit or delay
mergers or other takeover or change in control attempts with respect to the
Company and, accordingly, may discourage attempts to acquire the Company.

                                       57
   60
 
REGISTRATION RIGHTS
 
     Pursuant to a Registration Rights Agreement dated as of December 21, 1995
entered into in connection with the 1995 Stock Purchase Agreement and the
recapitalization of the Company effected thereby, the Company granted certain
registration rights to IBM, the Kapoor Trust, EJ Financial, Sutter Health
Venture Partners I, L.P., and Keystone (collectively, the "Rights Holders"),
with respect to shares of Common Stock issued or issuable to the Rights Holders
in certain financing transactions, including shares issuable upon exercise of
warrants or issued on the conversion of the Series D Preferred Stock
(collectively, "Registrable Shares").

     If the Company proposes to register any of its securities under the
Securities Act (other than in connection with an employee benefit plan or
pursuant to a merger, exchange offer or other acquisition transaction requiring
registration under the Securities Act), whether for its own account or for the
account of another holder of Company securities, the Rights Holders are entitled
to include Registrable Shares owned by them in any such registration ("piggyback
registration rights"). If any such registration is an underwritten registration,
the Company is required to include that portion of the Registrable Shares that
each Rights Holder proposes to sell representing an aggregate of 25% of the
offering (or in the case of an initial public offering, an aggregate of 15% of
such offering) before inclusion of other shares. If, after taking into account
shares offered by the Company and other holders of registration rights, the
managing underwriter for that offering determines that additional Registrable
Shares can be sold, the balance of the Registrable Shares will be included pro
rata in the registration.

   
     Rights Holders holding at least 35% of the aggregate Registrable Shares and
securities convertible into Registrable Shares also have the right to require
the Company to prepare and file on two occasions a registration statement with
respect to the Registrable Shares. However, the Company is not required to
effect a registration (x) with respect to less than 35% of the aggregate
Registrable Shares and shares convertible into Registrable Shares, unless the
aggregate offering price (net of underwriting discounts and commissions), would
exceed $7,500,000 or (y) if the Company delivers an opinion reasonably
acceptable to counsel for the Rights Holders that the Registrable Shares may be
sold without registration under Rule 144 under the Securities Act without any
limitation with respect to offerees or the size of the transaction. The
Registered Holders have agreed not to exercise their registration rights until
May 21, 1998.

   
     Pursuant to a Registration Rights Agreement dated as of September 5, 1997
entered into in connection with the acquisition of IMMI, the Company granted
piggyback registration rights to the former shareholders of IMMI with respect to
the shares of Common Stock issued to them in connection with the acquisition. If
the Company proposes to register any of its securities under the Securities Act
(other than the Offering or in connection with an employee benefit plan or
pursuant to a merger, exchange offer or other acquisition transaction requiring
registration under the Securities Act), whether for its own account or for the
account of another holder of Company securities, the former shareholders of IMMI
are entitled to include the IMMI shares owned by them in any such registration.
These registration rights expire on the earlier of September 5, 1999 and the
resale of all the IMMI Shares.

   
     The Company granted Rickel & Associates, Inc., managing underwriter of its
initial public offering in November 1996, certain registration rights with
respect to the shares of Common Stock and warrants issuable upon the exercise of
the underwriter's warrants issued in connection with that offering. Rickel &
Associates, Inc. has agreed not to exercise such registration rights until May
21, 1998, or until such earlier date as the Company gives holders of the
warrants issued in that offering written notice of the redemption of such
warrants. The Company also has granted the holders of the Advisors' Warrants
certain registration rights with respect to the shares of Common Stock issuable
upon the exercise thereof. See "Underwriting."

SHARES ELIGIBLE FOR FUTURE SALE

     Upon completion of this Offering, the Company will have 7,158,082 shares of
Common Stock outstanding, of which only 4,712,989 shares of Common Stock will be
transferable without restriction under the Securities Act. The remaining
2,445,093 shares, issued in private transactions, will be "restricted
securities" (as that term is defined in Rule 144 promulgated under the
Securities Act) which may be publicly

                                       58
   61

sold only if registered under the Securities Act or if sold in accordance with
an applicable exemption from registration, such as Rule 144. In general, under
Rule 144 as currently in effect, subject to the satisfaction of certain other
conditions, a person, including an affiliate of the Company, who has
beneficially owned restricted securities for at least two years, is entitled to
sell (together with any person with whom such individual is required to
aggregate sales), within any three-month period, a number of shares that does
not exceed the greater of 1% of the total number of outstanding shares of the
same class, or, if the Common Stock is quoted on Nasdaq or a national securities
exchange, the average weekly trading volume during the four calendar weeks
preceding the sale. A person who has not been an affiliate of the Company for at
least three months, and who has beneficially owned restricted securities for at
least three years is entitled to sell such restricted securities under Rule 144
without regard to any of the limitations described above. Officers, directors
and the other existing securityholders of the Company owning or having rights to
acquire in the aggregate 5,129,759 shares of Common Stock constituting
restricted securities, have agreed not to sell or otherwise dispose of any
shares of Common Stock (other than shares purchased in open market
transactions), until May 21, 1998 without the prior written consent of Rickel &
Associates, Inc.. Following expiration of the term of the Lock-Up Agreements,
1,806,850 shares of Common Stock will become eligible for resale pursuant to
Rule 144 commencing in the second quarter of 1998, subject to the volume
limitations and compliance with the other provisions of Rule 144. An additional
2,465 shares, 1,722 shares and 15,604 shares constituting restricted securities
not subject to Lock-Up Agreements will become eligible for resale pursuant to
Rule 144 following the completion of this Offering, in the second quarter of
1997 and in the fourth quarter of 1997, respectively, subject to the volume
limitations and compliance with the other provisions of Rule 144. In addition,
securityholders of the Company owning or having rights to acquire in the
aggregate 4,030,649 shares of Common Stock granted certain registration rights
with respect to those shares have agreed that they will not exercise such
registration rights until May 21, 1998. The Company has agreed to file a
registration statement for the resale in the United States of the 619,355 shares
of Common Stock (the "IMMI Shares") issued in connection with the acquisition of
IMMI, on or about November 21, 1997. The shareholders of IMMI have agreed not to
sell their IMMI Shares prior to March 5, 1999, except as follows: (i) prior to
December 5, 1997, an aggregate of 50,000 shares; (ii) from December 6, 1997
through March 5, 1998, an aggregate of 50,000 shares plus 1% of the total number
of shares of Common Stock traded on Nasdaq during the preceding three month
period; (iii) from March 6, 1998 through June 5, 1998, an aggregate of 75,000
shares plus 1% of the total number of shares of Common Stock traded on Nasdaq
during the preceding three month period; (iv) from June 6, 1998 through
September 5, 1998, an aggregate of 100,000 shares plus 1% of the total number of
shares of Common Stock traded on Nasdaq during the preceding three month period;
(v) from September 6, 1998 through December 5, 1998, an aggregate of 100,000
shares plus 1% of the total number of shares of Common Stock traded on Nasdaq
during the preceding three month period; and (vi) from December 6, 1998 through
March 5, 1999, an aggregate of 100,000 shares plus 1% of the total number of
shares of Common Stock traded on Nasdaq during the preceding three month period.
Thereafter, resales of the IMMI Shares must be in compliance with the volume
limitation and other conditions of Rule 144. The Company also has granted the
former shareholders of IMMI piggyback registration rights (other than in
connection with the Offering and certain other types of offerings) for resales
of the IMMI Shares. The Company granted Rickel & Associates, Inc. certain
registration rights with respect to the shares of Common Stock and warrants
issuable upon exercise of the underwriter's warrants issued in connection with
that offering. Furthermore, the holders of the Advisors' Warrants have demand
and piggyback registration rights with respect to the shares of Common Stock
issuable upon exercise thereof. See "Description of Securities -- Registration
Rights" and "Certain Transactions."

   
DIVIDEND POLICY

     Since its inception, the Company has not paid any dividends on its Common
Stock and it does not anticipate paying such dividends in the foreseeable
future. The Company intends to retain earnings, if any, to finance its
operations.
 
                                       59
   62
 
REPORTS TO STOCKHOLDERS

     The Company distributes to its stockholders annual reports containing
financial statements audited and reported upon by its independent certified
public accountants after the end of each fiscal year, and makes available such
other periodic reports as the Company may deem to be appropriate or as may be
required by law or by the rules or regulations of any stock exchange on which
the Company's Common Stock is listed. The Company's fiscal year end is December
31.

TRANSFER AGENT AND WARRANT AGENT
 
     The Company has engaged American Stock Transfer and Trust Company to act as
Transfer Agent for the Company's Common Stock and Warrant Agent for the
Warrants.
 
                                       60
   63

                                  UNDERWRITING

     Subject to the terms and conditions of the purchase agreement between the
Company and the Managers (the "Purchase Agreement"), the Company has agreed to
sell to the Managers named below, and the Managers have severally, and not
jointly, agreed to purchase, the number of securities set forth opposite their
respective names below.

   

                                     MANAGERS                                 SHARES
        ------------------------------------------------------------------  ----------
                                                                         
        Investmentbank Austria............................................      --
 
                                                                            ----------
                                                                            3,171,771
                                                                             ========

 
   
     The Purchase Agreement provides that the obligations of the Managers are
subject to certain conditions precedent. The Managers are committed to purchase
all of the above securities if any are purchased.

   
     Investmentbank Austria has advised the Company that the managers propose
initially to offer the shares of Common Stock offered hereby at the public
offering price set forth on the cover page of this Prospectus.

   
     The Company has entered into a Restated Placement Agreement with
Investmentbank Austria and VMR (the "Placement Agreement") pursuant to which VMR
will act as Placement Coordinator for the Offering and receive a fee of 3.5% of
the gross proceeds of the Offering.

   
     The Purchase Agreement and the Placement Agreement provide that
Investmentbank Austria and VMR will receive a non-accountable expense allowance
equal to 2% and 0.75%, respectively, of the gross proceeds of the Offering, of
which $25,000 has been paid to VMR by the Company to date. The Company also has
agreed to pay all expenses in connection with qualifying the Shares of Common
Stock offered hereby for sale under the laws of such states and other
jurisdictions as the Managers may designate, including expenses of counsel
retained for such purpose by the Managers.

   
     Pursuant to the Over-Allotment Option, which is exercisable for a period of
30 days after the closing of the Offering, Investmentbank Austria may purchase
up to 15% of the total number of shares of Common Stock offered hereby, solely
to cover over-allotments.

   
     The Company has agreed to sell to each of Investmentbank Austria and VMR,
for nominal consideration, the Advisors' Warrants to purchase that number of
shares of Common Stock equal to 5% of the shares of Common Stock sold in the
Offering (exclusive of the Over-Allotment Option). The Advisors' Warrants will
not be exercisable for a period of one year after the date of this Prospectus.
Thereafter, for a period of four years, the Advisors' Warrants will be
exercisable at an amount equal to 120% above the offering price of the Common
Stock sold in this Offering. The Advisors' Warrants are not transferable for a
period of one year after the date of this Prospectus, except to the other
Managers, officers of the Managers or VMR, members of the selling group and
their officers and partners. The Company also has granted certain demand and
"piggyback" registration rights to the holders of the Advisors' Warrants.

   
     For the life of the Advisors' Warrants, the holders thereof are given, at
nominal cost, the opportunity to profit from a rise in the market price of the
Common Stock with a resulting dilution in the interest of other stockholders.
Further, such holders may be expected to exercise the Advisors' Warrants at a
time when the Company would in all likelihood be able to obtain equity capital
on terms more favorable than those provided in the Advisors' Warrants.

   
     The Purchase Agreement requires the Company to indemnify the Managers
against certain liabilities in connection with the Offering, including
liabilities under the Securities Act. The Placement Agreement also requires the
Company to indemnify Investmentbank Austria and VMR against such liabilities.

                                       61
   64

     The Company has agreed to retain VMR as a consultant for a 12 month period
following the Offering for a fee of $2,000 per month, or a total of $24,000. VMR
will provide the Company with general financial advisory services on an
as-needed basis with respect to possible financing or acquisitions by the
Company and related matters. VMR will not be obligated to provide any minimum
number of hours of consulting services to the Company.

   
                                 LEGAL MATTERS

   
     The validity of the securities registered in the Registration Statement of
which this Prospectus forms a part will be passed upon for the Company by Snow
Becker Krauss P.C., 605 Third Avenue, New York, New York 10158-0125. Certain
legal matters will be passed upon for the Managers as to English law by Skadden,
Arps, Slate, Meagher & Flom LLP, London, United Kingdom, English counsel to the
Managers.

                                    EXPERTS

     The consolidated financial statements of Integrated Surgical Systems, Inc.
at December 31, 1996 and for each of the two years in the period ended December
31, 1996, appearing in this Prospectus and Registration Statement, have been
audited by Ernst & Young LLP, independent auditors, as set forth in their report
thereon appearing elsewhere herein, and are included in reliance upon such
report given upon the authority of such firm as experts in accounting and
auditing.

   
     The consolidated financial statements of Innovative Medical Machines
International, S.A. at December 31, 1996 and for each of the two years in the
period ended December 31, 1996, appearing in this Prospectus and Registration
Statement, have been audited by Ernst & Young Entrepreneurs Department D'Ernst &
Young Audit, independent auditors, as set forth in their report thereon
appearing elsewhere herein, and are included in reliance upon such report given
upon the authority of such firm as experts in accounting and auditing.

                             ADDITIONAL INFORMATION
 
     The Company has filed with the Securities and Exchange Commission a
Registration Statement on Form SB-2 under the Securities Act with respect to the
securities offered hereby. This Prospectus does not contain all the information
set forth in the Registration Statement and the exhibits thereto as permitted by
the Rules and Regulations of the Commission. For further information with
respect to the Company and such securities, reference is made to the
Registration Statement and to the exhibits filed therewith. Statements contained
in this Prospectus as to the contents of any contracts or other documents
referred to herein are not necessarily complete and where such contract or other
document is an exhibit to the Registration Statement, each such statement is
qualified in all respects by the provisions of such exhibit to which reference
is made for a full statement of the provisions thereof. The Registration
Statement, including exhibits filed therewith, may be inspected, without charge,
at the principal office of the Commission located at 450 Fifth Street, N.W.,
Room 1024, Washington, D.C. 20549 and at the Commission's regional offices
located at Seven World Trade Center, Suite 1300, New York, New York 10048, and
at 500 West Madison Street, Suite 1400 Chicago, Illinois 60661-2511. Copies of
all or any part of the Registration Statement (including the exhibits thereto)
also may be obtained from the Public Reference Section of the Commission at the
Commission's principal office in Washington, D.C., at the Commission's
prescribed rates. Electronic registration statements made through the Electronic
Data Gathering Analysis and Retrieval system are publicly available through the
Commission's web site at http://www.sec.gov.
 
                                       62
   65

                   INDEX TO CONSOLIDATED FINANCIAL STATEMENTS

   
                       INTEGRATED SURGICAL SYSTEMS, INC.

   

Report of Ernst & Young LLP, Independent Auditors.....................................    F-2
 
Consolidated Balance Sheets at December 31, 1996 (audited) and June 30, 1997
  (unaudited).........................................................................    F-3
 
Consolidated Statements of Operations for the years ended December 31, 1995 and 1996
  (audited) and the six months ended June 30, 1996 and 1997 (unaudited)...............    F-4
 
Consolidated Statements of Stockholders' Equity for the years ended December 31, 1995
  and 1996 (audited) and the six months ended June 30, 1997 (unaudited)...............    F-5
 
Consolidated Statements of Cash Flows for the years ended December 31, 1995 and 1996
  (audited) and the six months ended June 30, 1996 and 1997 (unaudited)...............    F-6
 
Notes to Consolidated Financial Statements............................................    F-7
 
INNOVATIVE MEDICAL MACHINES INTERNATIONAL, SA.
 
Report of Ernst & Young Entrepeneurs Department D'Ernst & Young Audit, Independent
  Auditors............................................................................   F-16
Consolidated Balance Sheets at December 31, 1996 (audited) and June 30, 1997
  (unaudited).........................................................................   F-17
Consolidated Statements of Operations for the years ended December 31, 1995 and 1996
  (audited) and the six months ended June 30, 1996 and 1997 (unaudited)...............   F-18
Consolidated Statements of Stockholders' Equity (Deficit) for the years ended December
  31, 1995 and 1996 (audited) and the six months ended June 30, 1997 (unaudited)......   F-19
Consolidated Statements of Cash Flows for the years ended December 31, 1995 and 1996
  (audited) and the six months ended June 30, 1996 and 1997 (unaudited)...............   F-20
Notes to Consolidated Financial Statements............................................   F-21
 
INDEX TO UNAUDITED PRO FORMA
  COMBINED CONDENSED FINANCIAL STATEMENTS
 
Unaudited Pro Forma Combined Condensed Financial Statements...........................   F-28
Unaudited Pro Forma Combined Condensed Balance Sheet at June 30, 1997.................   F-29
Unaudited Pro Forma Combined Condensed Statement of Operations for the year ended
  December 31, 1996...................................................................   F-30
Unaudited Pro Forma Combined Condensed Statement of Operations for the six months
  ended June 30, 1997.................................................................   F-31
Notes to Unaudited Pro Forma Combined Condensed Financial Statements..................   F-32

 
                                       F-1
   66
 
               REPORT OF ERNST & YOUNG LLP, INDEPENDENT AUDITORS
 
The Board of Directors and Stockholders
Integrated Surgical Systems, Inc.
 
     We have audited the accompanying consolidated balance sheet of Integrated
Surgical Systems, Inc. as of December 31, 1996, and the related consolidated
statements of operations, stockholders' equity, and cash flows for the years
ended December 31, 1995 and 1996. These financial statements are the
responsibility of the Company's management. Our responsibility is to express an
opinion on these financial statements based on our audits.
 
     We conducted our audits in accordance with generally accepted auditing
standards. Those standards require that we plan and perform the audit to obtain
reasonable assurance about whether the financial statements are free of material
misstatement. An audit includes examining, on a test basis, evidence supporting
the amounts and disclosures in the financial statements. An audit also includes
assessing the accounting principles used and significant estimates made by
management, as well as evaluating the overall financial statement presentation.
We believe that our audits provide a reasonable basis for our opinion.
 
     In our opinion, the financial statements referred to above present fairly,
in all material respects, the consolidated financial position of Integrated
Surgical Systems, Inc. at December 31, 1996, and the consolidated results of its
operations and its cash flows for the years ended December 31, 1995 and 1996 in
conformity with generally accepted accounting principles.
 
                                                               ERNST & YOUNG LLP
 
Sacramento, California
   
January 31, 1997, except for

Note 10, as to which the date

is September 5, 1997

                                       F-2
   67
 
                       INTEGRATED SURGICAL SYSTEMS, INC.
 
                          CONSOLIDATED BALANCE SHEETS

                                                                                     JUNE 30,
                                                                                       1997
                                                                  DECEMBER 31,     ------------
                                                                      1996
                                                                  ------------     (UNAUDITED)
                                                                             
ASSETS
Current assets:
  Cash and cash equivalents.....................................  $  6,001,079     $  3,685,731
  Accounts receivable...........................................       600,568          655,023
  Inventory.....................................................     1,030,262        1,790,371
  Other current assets..........................................       128,648          245,405
                                                                  ------------     ------------
Total current assets............................................     7,760,557        6,376,530
Net property and equipment......................................       251,037          269,658
Other assets....................................................        17,837           17,169
                                                                  ------------     ------------
                                                                  $  8,029,431     $  6,663,357
                                                                  ============     ============
LIABILITIES AND STOCKHOLDERS' EQUITY
Current liabilities:
  Accounts payable..............................................  $    676,201     $  1,046,771
  Value added taxes payable.....................................       272,596          270,289
  Accrued payroll and related expenses..........................       195,742          103,673
  Customer deposits.............................................       125,000          257,172
  Accrued product retrofit costs................................       135,348          135,348
  Payable to subcontractor......................................       110,176               --
  Other current liabilities.....................................       192,064          195,592
                                                                  ------------     ------------
Total current liabilities.......................................     1,707,127        2,008,845
Commitments
Stockholders' equity:
  Preferred stock, $0.01 par value, 1,000,000 shares authorized;
     no shares issued and outstanding...........................            --               --
  Common stock, $0.01 par value, 15,000,000 shares authorized;
     3,361,161 shares issued and outstanding at December 31,
     1996 and 3,366,956 shares issued and outstanding at June
     30, 1997...................................................        33,611           33,669
  Additional paid-in capital....................................    25,807,264       25,775,656
  Deferred stock compensation...................................      (426,417)        (336,417)
  Accumulated translation adjustment............................         8,657          (29,994)
  Accumulated deficit...........................................   (19,100,811)     (20,788,402)
                                                                  ------------     ------------
Total stockholders' equity......................................     6,322,304        4,654,512
                                                                  ------------     ------------
                                                                  $  8,029,431     $  6,663,357
                                                                  ============     ============

 
                            See accompanying notes.
 
                                       F-3
   68
 
                       INTEGRATED SURGICAL SYSTEMS, INC.
 
                     CONSOLIDATED STATEMENTS OF OPERATIONS

                                                                             SIX MONTHS ENDED
                                         YEARS ENDED DECEMBER 31,                JUNE 30,
                                        ---------------------------     ---------------------------
                                           1995            1996            1996            1997
                                        -----------     -----------     -----------     -----------
                                                                                (UNAUDITED)
                                                                            
Net sales.............................  $   174,521     $ 2,280,311     $ 1,064,206     $ 1,379,696
Cost of sales.........................       70,179         884,152         458,483         531,693
                                        -----------     -----------      ----------      ----------
                                            104,342       1,396,159         605,723         848,003
Operating expenses:
  Selling, general and
     administrative...................    1,668,947       2,066,236         887,283       1,383,596
  Research and development............    2,361,125       2,468,535         977,616       1,183,519
  Stock compensation..................           --         357,249         246,000          90,000
                                        -----------     -----------      ----------      ----------
                                          4,030,072       4,892,020       2,110,899       2,657,115
Other income (expense):
  Interest income.....................      107,306          87,933          38,723         125,147
  Interest expense....................     (287,792)             --              --              --
  Other...............................       55,801         (30,635)        (20,958)         14,374
                                        -----------     -----------      ----------      ----------
Loss before provision for income
  taxes...............................   (4,050,415)     (3,438,563)     (1,487,411)     (1,669,591)
Provision for income taxes............        3,113          10,266           3,183          18,000
                                        -----------     -----------      ----------      ----------
Net loss..............................   (4,053,528)     (3,448,829)     (1,490,594)     (1,687,591)
Preferred stock dividends.............     (936,325)             --              --              --
                                        -----------     -----------      ----------      ----------
Net loss applicable to common
  stockholders........................  $(4,989,853)    $(3,448,829)    $(1,490,594)    $(1,687,591)
                                        ===========     ===========      ==========      ==========
Net loss per common and common share
  equivalent..........................       $(1.19)         $(0.79)         $(0.34)         $(0.50)
                                        ===========     ===========      ==========      ==========
Shares used in per share
  calculations........................    4,178,877       4,373,947       4,377,643       3,364,567
                                        ===========     ===========      ==========      ==========

 
                            See accompanying notes.
 
                                       F-4
   69
 
                       INTEGRATED SURGICAL SYSTEMS, INC.
                CONSOLIDATED STATEMENTS OF STOCKHOLDERS' EQUITY

                                                CONVERTIBLE
                                              PREFERRED STOCK         COMMON STOCK       ADDITIONAL      DEFERRED     ACCUMULATED
                                           ---------------------   -------------------     PAID-IN        STOCK       TRANSLATION
                                             SHARES      AMOUNT     SHARES     AMOUNT      CAPITAL     COMPENSATION   ADJUSTMENT
                                           ----------   --------   ---------   -------   -----------   ------------   -----------
                                                                                                 
Balance at December 31, 1994.............     163,369   $  1,634      69,205   $   691   $11,748,261    $       --     $   1,754
  Sale of common stock...................          --         --         781         8         2,585            --            --
  Conversion of note payable into a
    warrant to purchase common stock.....          --         --          --        --     4,224,373            --            --
  Conversion of Series B and Series C
    preferred stock into common stock....    (163,369)    (1,634)    163,369     1,634            --            --            --
  Conversion of accumulated dividends
    preferred stock into common stock....          --         --      40,591       406          (406)           --            --
  Sale of Series D convertible preferred
    stock and a warrant to purchase
    Series D preferred stock.............     693,195      6,932          --        --     1,934,719            --            --
  Net loss...............................          --         --          --        --            --            --            --
  Translation adjustment.................          --         --          --        --            --            --         3,543
                                           ----------   ---------  ---------   -------   -----------     ---------       -------
Balance at December 31, 1995.............     693,195      6,932     273,946     2,739    17,909,532            --         5,297
  Exercise of stock options..............          --         --       9,592        96           587            --            --
  Sale of Series D convertible preferred
    stock and a warrant to purchase
    Series D preferred stock.............     346,597      3,466          --        --       996,534            --            --
  Sale of common stock and warrants, net
    of expense...........................          --         --   1,525,000    15,250     6,122,073            --            --
  Exercise of warrants...................          --         --     512,831     5,128        (5,128)           --            --
  Conversion of Series D convertible
    preferred stock to common stock......  (1,039,792)   (10,398)  1,039,792    10,398            --            --            --
  Deferred stock compensation............          --         --          --        --       783,666      (783,666)           --
  Stock compensation expense.............          --         --          --        --            --       357,249            --
  Net loss...............................          --         --          --        --            --            --            --
  Translation adjustment.................          --         --          --        --            --            --         3,360
                                           ----------   ---------  ---------   -------   -----------     ---------       -------
Balance at December 31, 1996.............          --         --   3,361,161    33,611    25,807,264      (426,417)        8,657
  Exercise of stock options
    (unaudited)..........................          --         --       5,795        58        16,214            --            --
  Stock compensation expense
    (unaudited)..........................          --         --          --        --            --        90,000            --
  Additional offering expenses
    (unaudited)..........................          --         --          --        --       (47,822)           --            --
  Translation adjustment (unaudited).....          --         --          --        --            --            --       (38,651)
  Net loss (unaudited)...................          --         --          --        --            --            --            --
                                           ----------   ---------  ---------   -------   -----------     ---------       -------
Balance at June 30, 1997 (unaudited).....          --   $     --   3,366,956   $33,669   $25,775,656    $ (336,417)    $ (29,994)
                                           ==========   =========  =========   =======   ===========     =========       =======

 
                                                             TOTAL
                                           ACCUMULATED    STOCKHOLDERS'
                                             DEFICIT        EQUITY
                                           ------------   -----------
                                                    
Balance at December 31, 1994.............  $(11,598,454)  $   153,886
  Sale of common stock...................            --         2,593
  Conversion of note payable into a
    warrant to purchase common stock.....            --     4,224,373
  Conversion of Series B and Series C
    preferred stock into common stock....            --            --
  Conversion of accumulated dividends
    preferred stock into common stock....            --            --
  Sale of Series D convertible preferred
    stock and a warrant to purchase
    Series D preferred stock.............            --     1,941,651
  Net loss...............................    (4,053,528)   (4,053,528)
  Translation adjustment.................            --         3,543
                                           ------------   -----------
Balance at December 31, 1995.............   (15,651,982)    2,272,518
  Exercise of stock options..............            --           683
  Sale of Series D convertible preferred
    stock and a warrant to purchase
    Series D preferred stock.............            --     1,000,000
  Sale of common stock and warrants, net
    of expense...........................            --     6,137,323
  Exercise of warrants...................            --            --
  Conversion of Series D convertible
    preferred stock to common stock......            --            --
  Deferred stock compensation............            --            --
  Stock compensation expense.............            --       357,249
  Net loss...............................    (3,448,829)   (3,448,829)
  Translation adjustment.................            --         3,360
                                           ------------   -----------
Balance at December 31, 1996.............   (19,100,811)    6,322,304
  Exercise of stock options
    (unaudited)..........................            --        16,272
  Stock compensation expense
    (unaudited)..........................            --        90,000
  Additional offering expenses
    (unaudited)..........................            --       (47,822)
  Translation adjustment (unaudited).....            --       (38,651)
  Net loss (unaudited)...................    (1,687,591)   (1,687,591)
                                           ------------   -----------
Balance at June 30, 1997 (unaudited).....  $(20,788,402)  $ 4,654,512
                                           ============   ===========

 
                            See accompanying notes.
 
                                       F-5
   70
 
                       INTEGRATED SURGICAL SYSTEMS, INC.
 
                     CONSOLIDATED STATEMENTS OF CASH FLOWS
 
                INCREASE (DECREASE) IN CASH AND CASH EQUIVALENTS

                                                                                  SIX MONTHS ENDED
                                                  YEARS ENDED DECEMBER 31,            JUNE 30,
                                                  -------------------------   -------------------------
                                                     1995          1996          1996          1997
                                                  -----------   -----------   -----------   -----------
                                                                                     (UNAUDITED)
                                                                                
Cash flows from operating activities:
Net loss........................................  $(4,053,528)  $(3,448,829)  $(1,490,594)  $(1,687,591)
Adjustments to reconcile net loss to net cash
  used in operating activities:
  Depreciation..................................      288,344       221,162       103,692        83,678
  Stock compensation............................           --       357,249       246,000        90,000
  Changes in operating assets and liabilities:
     Accounts receivable........................      (30,326)     (549,761)     (102,983)      (54,455)
     Inventory..................................      137,625      (283,290)       96,985      (760,108)
     Other current assets.......................          850        15,769           785      (116,756)
     Note payable...............................       20,701      (274,498)     (207,461)           --
     Accounts payable...........................      (42,058)      466,796       (43,089)      370,570
     Value added taxes payable..................        9,321       258,395      (469,991)       (2,307)
     Accrued payroll and related expenses.......     (222,896)      156,142        19,652       (92,069)
     Customer deposits..........................       (1,883)     (344,991)       (9,652)      132,172
     Accrued product retrofit costs.............     (114,680)      (24,652)           --            --
     Accrued interest...........................      286,645            --            --            --
     Payable to subcontractor...................           --       110,176            --      (110,176)
     Other current liabilities..................      210,023       (94,852)       80,980         3,527
     Translation adjustment.....................        3,543         3,360        (5,038)      (38,651)
                                                   ----------    ----------     ---------     ---------
Net cash used in operating activities...........   (3,508,319)   (3,431,824)   (1,780,714)   (2,182,166)
Cash flows from investing activities:
Purchase of property and equipment..............     (121,008)      (41,348)      (10,034)     (102,300)
Decrease (increase) in other assets ............        1,035        (3,578)          217           668
                                                   ----------    ----------     ---------     ---------
Net cash used in investing activities...........     (119,973)      (44,926)       (9,817)     (101,632)
Cash flows from financing activities:
Proceeds from convertible preferred stock.......    1,941,651     1,000,000     1,000,000            --
Net proceeds from sale of common stock and
  warrants......................................           --     6,137,323            17       (47,822)
Proceeds from exercise of stock options.........        2,593           683            --        16,272
                                                   ----------    ----------     ---------     ---------
Net cash provided by (used in) financing
  activities....................................    1,944,244     7,138,006     1,000,017       (31,550)
                                                   ----------    ----------     ---------     ---------
Net increase (decrease) in cash and cash
  equivalents...................................   (1,684,048)    3,661,256      (790,514)   (2,315,348)
Cash and cash equivalents at beginning of
  period........................................    4,023,871     2,339,823     2,339,823     6,001,079
                                                   ----------    ----------     ---------     ---------
Cash and cash equivalents at end of period......  $ 2,339,823   $ 6,001,079   $ 1,549,309   $ 3,685,731
                                                   ==========    ==========     =========     =========

 
                            See accompanying notes.
 
                                       F-6
   71
 
                       INTEGRATED SURGICAL SYSTEMS, INC.
 
                   NOTES TO CONSOLIDATED FINANCIAL STATEMENTS
                               DECEMBER 31, 1996
   
                 (INFORMATION WITH RESPECT TO JUNE 30, 1997 AND

           THE SIX MONTHS ENDED JUNE 30, 1996 AND 1997 IS UNAUDITED)

1.  DESCRIPTION OF BUSINESS
 
     Integrated Surgical Systems, Inc. (the "Company") was incorporated on
October 1, 1990 in Delaware. The Company develops, manufactures, markets and
services image-directed, robotic products for surgical applications. The
Company's principal product is the ROBODOC(R) Surgical Assistant System
("ROBODOC System"), a computer-controlled surgical robot, and the Company's
ORTHODOC(R) Presurgical Planner, consisting of a computer workstation that
utilizes the Company's proprietary software for pre-operative surgical planning.
The first application for the ROBODOC System has been directed at cementless
primary total hip replacement surgery and is currently marketed to customers in
Europe.
 
     On June 1, 1994, the Company acquired all shares of Gasfabriek Thijssen
Holding BV (later renamed Integrated Surgical Systems BV), a non-operating
Netherlands corporation, for approximately $4,000. The acquisition was accounted
for as a purchase. Integrated Surgical Systems BV purchases and licenses
products and technology from Integrated Surgical Systems, Inc. for distribution
in Europe and other markets.
 
2.  SIGNIFICANT ACCOUNTING POLICIES
 
CONSOLIDATION
 
     The consolidated financial statements include the accounts of the Company
and its wholly-owned subsidiary. All significant intercompany balances and
transactions have been eliminated in consolidation.
 
FOREIGN CURRENCY TRANSLATION

     The financial position and results of operations of Integrated Surgical
Systems BV are measured using the subsidiary's local currency (Guilders). The
subsidiary's balance sheet accounts are translated at the current year-end
exchange rate and statement of operations amounts are translated at the average
exchange rate for the period. Translation adjustments are recorded as a separate
component of stockholders' equity. Foreign currency transaction gains and losses
were not material during the years ended December 31, 1995 and 1996 and the six
months ended June 30, 1996 and 1997.

REVENUE RECOGNITION
 
     Revenues from sales without significant Company obligations beyond delivery
are recognized upon delivery of the products. Revenues pursuant to agreements
which include significant Company obligations beyond delivery are deferred until
the Company's remaining obligations are insignificant. Revenues are recognized
net of any deferrals for estimated future liabilities under contractual product
warranty provisions. Estimated future product retrofit costs for ROBODOC Systems
sold for clinical trials have been accrued in the accompanying financial
statements. Future retrofit costs are those expected to be required to update
ROBODOC Systems to the equivalent level of performance expected to be approved
by the Food and Drug Administration ("FDA").
 
RESEARCH AND DEVELOPMENT
 
     Software development costs incurred subsequent to the determination of the
product's technological feasibility and prior to the product's general release
to customers are not material to the Company's financial position or results of
operations, and have been charged to research and development expense in the
accompanying consolidated statements of operations. Grants received from third
parties for research and development activities are recorded as revenue over the
term of the agreement as the related activities are conducted. Research and
development costs are expensed as incurred.
 
                                       F-7
   72
 
                       INTEGRATED SURGICAL SYSTEMS, INC.
 
           NOTES TO CONSOLIDATED FINANCIAL STATEMENTS -- (CONTINUED)
 
CONCENTRATION OF CREDIT RISK
 
     The Company sells its products to companies in the healthcare industry and
performs periodic credit evaluations of its customers and generally does not
require collateral. The Company believes that adequate provision for
uncollectible accounts receivable has been made in the accompanying financial
statements. The Company maintains substantially all of its cash at three
financial institutions.
 
FINANCIAL STATEMENT ESTIMATES
 
     The preparation of financial statements in conformity with generally
accepted accounting principles requires management to make estimates and
assumptions that affect the reported amounts of assets and liabilities and
disclosures of contingent assets and liabilities at the date of the financial
statements and the reported amounts of revenues and expenses during the
reporting period. Actual results could differ from those estimates.
 
CASH EQUIVALENTS

     The Company invests its excess cash in high-quality debt instruments. The
Company considers highly liquid investments with maturities of three months or
less from the acquisition date of the instrument to be cash equivalents. The
carrying amounts reported in the balance sheet for cash and cash equivalents
approximate those assets' fair values. Cash equivalents consist primarily of
commercial paper. At December 31, 1996, and June 30, 1997, the fair value of
available-for-sale securities of $4,969,266 and $2,984,636, respectively,
included in cash and cash equivalents approximates their historical cost.

PROPERTY AND EQUIPMENT
 
     Property and equipment are stated at cost. Depreciation is calculated using
the straight-line method over estimated useful lives of 3 to 5 years, or the
lease term, whichever is shorter.
 
INVENTORY
 
     Inventory is recorded at the lower of cost (first-in, first-out method) or
market and consists of materials and supplies used in the manufacture of the
ROBODOC System.
 
INVENTORY CONSISTS OF THE FOLLOWING:

                                                                               JUNE 30,
                                                                                 1997
                                                             DECEMBER 31,     -----------
                                                                 1996
                                                             ------------     (UNAUDITED)
                                                                        
        Raw materials......................................   $  321,313      $   706,114
        Work-in process....................................      459,524          363,803
        Finished goods.....................................      249,425          720,454
                                                               ---------        ---------
                                                              $1,030,262      $ 1,790,371
                                                               =========        =========

 
STOCK-BASED COMPENSATION
 
     As permitted under the provisions of Statement of Financial Accounting
Standards No. 123 "Accounting for Stock-Based Compensation" ("SFAS No. 123"),
the Company has elected to account for stock-based compensation using the
intrinsic value method prescribed by Accounting Principles Board Opinion No. 25,
"Accounting for Stock Issued to Employees" ("APB No. 25"). Under the intrinsic
value method, compensation cost is the excess, if any, of the quoted market
price or fair value of the stock at the grant date or other measurement date
over the amount an employee must pay to acquire the stock.
 
                                       F-8
   73
 
                       INTEGRATED SURGICAL SYSTEMS, INC.
 
           NOTES TO CONSOLIDATED FINANCIAL STATEMENTS -- (CONTINUED)
 
INCOME TAXES
 
     The liability method is used to account for income taxes. Under this
method, deferred income tax assets and liabilities are determined based on
differences between the financial reporting and tax bases of assets and
liabilities and are measured using the enacted tax rates and laws that are
scheduled to be in effect when the differences are expected to reverse.
 
NET LOSS PER SHARE
 
     Except as noted below, net loss per share is based on the weighted average
number of shares of common stock outstanding during the period. Common stock
issuable upon the exercise of common stock warrants and stock options have been
excluded from the computation because their inclusion would be anti-dilutive.
Pursuant to the Securities and Exchange Commission Staff Accounting Bulletins,
common and common equivalent shares issued by the Company at prices below the
initial public offering price during the 12 month period prior to the offering
date of November 21, 1996 have been included in the calculation as if they were
outstanding for all periods presented prior to the initial public offering
(using the treasury stock method at the initial public offering price of $5.00
per share). As described in Note 6, common stock was issued on December 20, 1995
in connection with the conversion of preferred stock and accumulated dividends.
Net loss per share for the year ended December 31, 1995 would have been ($0.93)
per share had the conversion occurred on January 1, 1995.
 
     In February 1997, the Financial Accounting Standards Board issued Statement
No. 128, Earnings Per Share, which is required to be adopted on December 31,
1997. At that time, the Company will be required to change the method currently
used to compute earnings per share and to restate all prior periods. Under the
new requirements for calculating primary earnings per share, the dilutive effect
of stock options will be excluded. The impact of Statement 128 on the Company's
calculation of earnings per share is not expected to be material.
 
SIGNIFICANT CUSTOMERS AND FOREIGN SALES

     The Company recognized approximately 95% of its revenue from one customer
during the year ended December 31, 1995, and approximately 100% of its revenues
from four customers during the year ended December 31, 1996. Foreign sales were
approximately $165,000 and $2,280,000 for the years ended December 31, 1995 and
December 31, 1996, respectively. During each of the six months ended June 30,
1996 and 1997, the Company recognized 100% and 92%, respectively, of its
revenues from two different customers in each period. Foreign sales for the six
months ended June 30, 1996 and 1997 were $1,064,206 and $1,379,696,
respectively.

RECLASSIFICATIONS
 
     Certain amounts reported in prior years financial statements have been
reclassified to conform with the 1996 presentation.
 
                                       F-9
   74
 
                       INTEGRATED SURGICAL SYSTEMS, INC.
 
           NOTES TO CONSOLIDATED FINANCIAL STATEMENTS -- (CONTINUED)
 
3.  PROPERTY AND EQUIPMENT
 
     Property and equipment consists of the following:

                                                         DECEMBER 31, 1996     JUNE 30, 1997
                                                         -----------------     -------------
                                                                                (UNAUDITED)
                                                                         
        ROBODOC System equipment.......................     $   327,793         $   327,793
        Other equipment................................         800,374             881,629
        Furniture and fixtures.........................          41,258              56,219
        Leasehold improvements.........................          86,816              92,899
                                                             ----------          ----------
                                                              1,256,241           1,358,540
        Less accumulated depreciation..................       1,005,204           1,088,882
                                                             ----------          ----------
                                                            $   251,037         $   269,658
                                                             ==========          ==========

 
4.  REVERSE STOCK SPLIT
 
     On December 20, 1995, the Company effected a one-for-five reverse split of
the Company's common stock. In November 1996, the Company effected a
one-for-1.479586 reverse split of the Company's common stock. All references in
the accompanying financial statements to the number of capital shares and
per-share amounts have been retroactively restated to reflect the reverse
splits.
 
5.  NOTES PAYABLE
 
     A long-term note payable was entered into between the Company and a large
corporation, a representative of which was a member of the Company's Board of
Directors. The corporation is also a warrant holder of the Company. Simple
interest on the note payable accrued at 9.25% per annum. On December 20, 1995,
the long-term note payable and accrued interest totaling $4,224,373 was
converted into a warrant to purchase 126,895 shares of the Company's common
stock at $0.01 per share which is currently exercisable and expires on December
31, 2005.

     In conjunction with the note agreement, the Company also entered into a
License Agreement with this corporation whereby the corporation granted the
Company the rights to the technology underlying the ROBODOC System at the time
of the Company's incorporation. In consideration for this License Agreement, the
Company issued to the corporation a warrant to purchase 67,587 shares of the
Company's common stock at a price of $0.07 per share. This warrant expires on
December 31, 2000 and has not been exercised as of June 30, 1997.

6.  STOCKHOLDERS' EQUITY
 
COMMON STOCK
 
     As of December 31, 1996 the Company has reserved a total of 5,572,366
shares of common stock pursuant to warrants and options outstanding and reserved
for future issuance.
 
INITIAL PUBLIC OFFERING

     In November 1996, the Company sold in its initial public offering, a total
of 1,525,000 shares of common stock at $5.00 per share and 1,753,750 warrants at
$0.10 per warrant. In addition, the Company sold to its underwriter warrants to
purchase an additional 305,000 shares for total consideration of $10.00. The net
proceeds after underwriters' commissions and fees and other costs associated
with the offering were approximately $6,090,000.

                                      F-10
   75
 
                       INTEGRATED SURGICAL SYSTEMS, INC.
 
           NOTES TO CONSOLIDATED FINANCIAL STATEMENTS -- (CONTINUED)
 
     Each warrant entitles the holder to purchase one share of common stock at
an exercise price of $6.00 per share, subject to adjustment in certain events,
at any time during the period commencing November 20, 1997, and thereafter for a
period of four years. The warrants are subject to redemption by the Company at
$0.10 per warrant at any time during the exercise period on not less than 30
days prior written notice to the holders of the warrants provided certain
criteria regarding the price performance of the Company's common stock are met.
 
CONVERTIBLE PREFERRED STOCK
 
     On December 20, 1995, all outstanding shares of Series B and Series C
preferred stock were converted into 60,964 and 102,405 shares of common stock,
respectively. Also on that date, all accumulated and unpaid dividends on Series
B and Series C were converted into 17,910 and 22,681 shares of the Company's
common stock, respectively.

     The Company entered into a Series D preferred stock and warrant agreement
during 1995. Under the terms of this agreement, the Company received $2 million
in proceeds at the first closing which occurred on December 21, 1995, and
granted an option to purchase additional Series D stock and a warrant to
purchase Series D Stock as described below. At the first closing, the Company
sold 693,195 shares of Series D preferred stock for $0.96 per share. It also
sold for $1,333,333 a warrant to purchase 1,386,390 shares of Series D at $0.01
per share. The warrant expires on December 31, 2005 and has not been exercised
as of June 30, 1997. The purchasers received an option to purchase an additional
346,597 shares of Series D preferred stock and a warrant to purchase an
additional 693,194 shares of Series D preferred stock, all with the same terms
as in the first closing. On February 19, 1996, the option holder exercised the
option and the Company sold 346,597 shares of Series D preferred stock for $0.96
per share. The Company also sold a warrant for $666,667 to purchase 693,194
shares of Series D at $0.01 per share.

     Series B and Series C preferred stockholders who did not purchase Series D
stock were issued warrants to purchase an aggregate of 584,959 shares of the
Company's common stock at a price of $0.74 per share in consideration for their
consent to the terms of the recapitalization and Series D stock sale.
 
     On August 25, 1996 and October 29, 1996, certain holders of these warrants
entered into amended warrant agreements with the Company which included a
provision allowing for a cashless exercise. Under the terms of the cashless
exercise, these warrant holders accepted a 72,126 fewer shares as consideration
for not being required to make the cash exercise payment of $0.74 per share.
This resulted in these warrant holders receiving 512,831 shares of Common Stock
upon their exercise on August 25, 1996 and October 29, 1996.
 
     As per the terms of the convertible preferred stock agreement, upon the
closing of the Company's initial public offering in November 1996, each of the
1,039,792 shares of outstanding Series D preferred stock were automatically
converted into the same number of shares of common stock. On the same date, the
warrants outstanding to purchase a total of 2,079,584 shares of Series D
preferred stock were converted into warrants to purchase the same number of
shares of common stock.
 
     In November 1996, the Board of Directors amended, and the stockholders
subsequently approved, the Company's Articles of Incorporation to authorize
1,000,000 shares of undesignated preferred stock. Preferred stock may be issued
from time to time in one or more series. The Board of Directors is authorized to
determine the rights, preferences, privileges and restrictions granted to and
imposed upon any wholly unissued series of preferred stock and designation of
any such series without any vote or action by the Company's stockholders.
 
                                      F-11
   76
 
                       INTEGRATED SURGICAL SYSTEMS, INC.
 
           NOTES TO CONSOLIDATED FINANCIAL STATEMENTS -- (CONTINUED)
 
STOCK OPTION PLANS
 
     The Company has elected to follow Accounting Principles Board Opinion No.
25 "Accounting for Stock Issued to Employees" and related Interpretations in
accounting for its employees stock options because, as discussed below, the
alternative fair value accounting provided for under FASB Statement No. 123,
"Accounting for Stock-Based Compensation," requires use of option valuation
models that were not developed for use in valuing employee stock options.
 
     The Company established a stock option plan in 1991 (the "1991 Plan") and
on December 13, 1995, it established a new stock option plan (the "1995 Plan").
Certain employees of the Company surrendered their options under the 1991 Plan
in return for new and additional options granted under the 1995 Plan. Officers,
employees, directors and consultants to the Company may participate in the
Plans. Options granted under the Plans may be incentive stock options or
non-statutory stock options. 1,249,070 shares of the Company's common stock have
been reserved for issuance under the Plans. Options granted generally have a
term of ten years from the date of the grant. The exercise price of incentive
stock options granted under the Plans may not be less than 100% of the fair
market value of the Company's common stock on the date of the grant. The
exercise price of non-statutory stock options granted under the Plans may not be
less than 85% of the fair market value of the Company's common stock on the date
of the grant. For a person who, at the time of the grant, owns stock
representing 10% of the voting power of all classes of Company stock, the
exercise price of the incentive stock options or the non-statutory stock options
granted under the Plans may not be less than 110% of the fair market value of
the common stock on the date of the grant.
 
     Pro forma information regarding net income (loss) and earnings (loss) per
share is required by SFAS No. 123, which also requires that the information be
determined as if the Company has accounted for its employee stock options
granted subsequent to December 31, 1994 under the fair value method of that
Statement. The fair value for these options was estimated at the date of grant
using the Black-Scholes option pricing model with the following weighted-average
assumptions for 1995 and 1996, respectively: risk-free interest rates of 6.25%
and 5.43%; a dividend yield of 0%; volatility factors of the expected market
price of the Company's common stock of 0.50; and an expected life of the option
of 5 and 3.2 years.
 
     The Black-Scholes option valuation model was developed for use in
estimating the fair value of traded options which have no vesting restrictions
and are fully transferable. In addition, option valuation models require the
input of highly subjective assumptions including the expected stock price
volatility. Because the Company's employee stock options have characteristics
significantly different from those of traded options, and because changes in the
subjective input assumptions can materially affect the fair value estimate, in
management's opinion, the existing models do not necessarily provide a reliable
single measure of the fair value of its employee stock options. For purposes of
pro forma disclosures, the estimated fair value of the options is amortized to
expense over the vesting period. The Company's pro forma information follows:

                                                               1995            1996
                                                            -----------     -----------
                                                                      
        Pro forma net loss................................  $(4,064,392)    $(3,464,434)
        Pro forma net loss per share......................  $     (1.20)    $     (0.79)

     Because SFAS No. 123 is applicable only to options granted subsequent to
December 31, 1994, its pro forma effect will not be fully reflected until 1999.
 
                                      F-12
   77
 
                       INTEGRATED SURGICAL SYSTEMS, INC.
 
           NOTES TO CONSOLIDATED FINANCIAL STATEMENTS -- (CONTINUED)

     The following summarizes activity under the Plans for the years ended
December 31, 1995 and 1996 and the six months ended June 30, 1997:

   

                                                                               WEIGHTED
                                                                               AVERAGE
                                                                 NUMBER OF     EXERCISE
                                                                  SHARES        PRICE
                                                                 ---------     --------
                                                                         
        Outstanding at December 31, 1994.......................     53,032
          Granted (at $4.88 per share).........................     32,713
          Canceled (at $3.33 to $7.84 per share)...............     (9,439)
          Exercised (at $3.33 per share).......................       (781)
                                                                 ---------
        Outstanding at December 31, 1995 (at $3.33 to $7.84 per
          share)...............................................     75,525      $ 4.63
          Granted (at $0.07 to $5.00 per share)................    951,545        0.27
          Canceled (at $.07 to $7.84 per share)................    (70,294)       4.08
          Exercised (at $.07 to $.25 per share)................     (9,592)       0.07
                                                                 ---------
        Outstanding at December 31, 1996 (at $0.07 to $7.84 per
          share)...............................................    947,184        0.42
          Granted (at $5.00 to $7.625 per share) (unaudited)...    211,332
          Canceled (at $.07 to $6.13 per share) (unaudited)....    (37,806)
          Exercised (at $.07 to $3.33 per share) (unaudited)...     (5,795)
                                                                 ---------
        Outstanding at June 30, 1997 (at $0.07 to $7.84 per
          share)(unaudited)....................................  1,114,915
                                                                 =========

 
     The weighted average exercise price of options granted in 1996 with option
prices less than the fair market value of the Company's stock on the grant date
was $0.48 and the weighted average grant date fair value of these options was
$0.89. The weighted average exercise price of options granted in 1996 with
option prices equal to the fair market value of the Company's stock on the grant
date was $5.00 and the weighted average grant date fair value of these options
was $2.31.
 
     The following summarizes information related to options outstanding and
options exercisable at December 31, 1996:

                               WEIGHTED AVERAGE
EXERCISE       OPTIONS       REMAINING CONTRACTUAL       OPTIONS
 PRICE       OUTSTANDING        LIFE (IN YEARS)        EXERCISABLE
- --------     -----------     ---------------------     -----------
                                              
 $ 0.07        873,949                9.2                344,352
 $ 2.07         21,631                9.6                  1,014
 $ 3.33          4,867                5.1                  4,867
 $ 4.88          2,704                8.4                    902
 $ 5.00         30,277                9.8                     --
 $ 7.84         13,756                6.0                 10,777
             -----------                               -------- ---
               947,184                                   361,912
             ===========                               ===========

     Of the options outstanding at December 31, 1996, options to purchase
361,912 shares of common stock were immediately exercisable at a
weighted-average exercise price of $0.36 per share. A total of 292,366 shares
were still available for grant under the 1995 Plan at December 31, 1996.
 
     During the year ended December 31, 1996, the Company recorded deferred
stock compensation of $783,666 relating to stock options granted during the
period with exercise prices less than the estimated fair value of the Company's
common stock, as determined by an independent valuation analysis, on the date of
grant. The deferred stock compensation is being amortized into expense over the
vesting period of the stock options which generally range from 3 to 5 years.
Deferred compensation relating to stock options which vested
 
                                      F-13
   78
 
                       INTEGRATED SURGICAL SYSTEMS, INC.
 
           NOTES TO CONSOLIDATED FINANCIAL STATEMENTS -- (CONTINUED)
 
immediately was expensed on the date of grant. Compensation expense of $357,249
was recorded during the year ended December 31, 1996 relating to these options,
and the remaining $426,417 will be amortized into expense in future periods.
 
7.  INCOME TAXES

     The income tax provisions for the years ended December 31, 1995 and 1996
and the six months ended June 30, 1996 and 1997 are comprised of currently
payable state franchise taxes and currently payable foreign income taxes.

     Deferred taxes result from temporary differences in the recognition of
certain revenue and expense items for income tax and financial reporting
purposes. The significant components of the Company's deferred taxes as of
December 31, 1995 and 1996 are as follows:

                                                               1995            1996
                                                            -----------     -----------
                                                                      
        Deferred tax assets:
          Net operating loss carryover....................  $ 2,200,000     $ 3,000,000
          Capitalized research and development............       16,000         245,000
          Accrued product retrofit costs..................       95,000          56,000
          Inventory.......................................       97,000          85,000
          Depreciation....................................       65,000         102,000
          Stock compensation..............................           --         154,000
          Other...........................................       39,000         158,000
                                                             ----------      ----------
                                                              2,512,000       3,800,000
          Less: Valuation allowance.......................   (2,512,000)     (3,800,000)
                                                             ----------      ----------
        Net deferred taxes................................  $        --     $        --
                                                             ==========      ==========

 
     The principal reasons for the difference between the effective income tax
rate and the federal statutory income tax rate are as follows:

                                                             YEARS ENDED DECEMBER 31,
                                                            ---------------------------
                                                               1995            1996
                                                            -----------     -----------
                                                                      
        Federal benefit expected at statutory rates.......  $(1,377,000)    $(1,172,000)
        Net operating loss with no current benefit........    1,377,000       1,172,000
        State franchise taxes.............................        3,046          10,000
        Foreign income taxes..............................           67             266
                                                            -----------     -----------
                                                            $     3,113     $    10,266
                                                            ===========     ===========

     In connection with the Company's Series D preferred stock sale (Note 6) a
change of ownership (as defined in Section 382 of the Internal Revenue Code of
1986, as amended) occurred. As a result of this change, the Company's federal
and state net operating loss carryforwards generated through December 21, 1995
(approximately $13,500,000 and $4,500,000, respectively) will be subject to a
total annual limitation in the amount of approximately $400,000. Except for the
amounts described below, the Company expects that the carryforward amounts will
not be available prior to the expiration of the carryforward periods.
 
     As a consequence of the limitation, the Company has at December 31, 1996 a
net operating loss carryover of approximately $8,700,000 for federal income tax
purposes which expires between 2005 and 2011, and a net operating loss
carryforward of approximately $2,100,000 for state income tax purposes which
expires between 1997 and 2001.
 
                                      F-14
   79
 
                       INTEGRATED SURGICAL SYSTEMS, INC.
 
           NOTES TO CONSOLIDATED FINANCIAL STATEMENTS -- (CONTINUED)
 
     The Company paid $5,280 and $1,600 for income and franchise taxes during
the years ended December 31, 1995 and 1996, respectively.
 
8.  COMMITMENTS

     The Company leases its facilities under two non-cancelable operating
leases. One of the leases has an escalation clause of 5% per annum and has a
term of approximately five years. The Company's other facility does not have an
escalation clause and has a term of approximately 3 years. Future payments under
non-cancelable facility operating leases are approximately as follows:

                                                                  
                1997...............................................  $86,000
                1998...............................................  $44,000

   
     Aggregate rental expense under these leases amounted to $135,980, $141,456
and $76,128 during the years ended December 31, 1995 and 1996, and the six
months ended June 30, 1997, respectively.

   
     Future minimum payments under non-cancelable equipment operating leases are
approximately $13,000 per year through the year ended December 31, 2000. Rental
expense for these non-cancelable leases during the years ended December 31, 1995
and 1996 and the six months ended June 30, 1997 was approximately $14,000,
$13,000 and $7,000, respectively.

9.  NIST GRANT
 
     During 1994, the Company received notification it was awarded a $1,960,000
National Institute of Science and Technology ("NIST") grant from the U.S.
Department of Commerce ("USDC"). The grant is shared by the Company and two
strategic partners to fund approximately 49% of a $4 million joint development
project to adapt the ROBODOC System for use in hip revision surgery. The
development project and related NIST Grant began in 1995. The Company received
$19,409 and $116,049 in proceeds under this grant during the years ended
December 31, 1995 and December 31, 1996, respectively. As of December 31, 1996,
the Company had received $110,176 from the USDC which is payable to a
subcontractor for work performed by it under the development agreement.

10.  SUBSEQUENT EVENT

   
     Effective September 5, 1997, the Company acquired all of Innovative Medical
Machines International, S.A.'s ("IMMI") issued and outstanding capital stock,
stock warrants and convertible debt in a transaction accounted for as a
purchase. The purchase price consisted of 619,355 shares of the Company's common
stock with a fair market value of approximately $3.9 million and the assumption
of approximately $1 million of IMMI's liabilities. The purchase agreement places
certain restrictions for a period of eighteen months on the future sale of the
Company's stock issued in connection with the purchase.

                                      F-15
   80

                REPORT OF ERNST & YOUNG ENTREPRENEURS DEPARTMENT
                  D'ERNST & YOUNG AUDIT, INDEPENDENT AUDITORS

The Board of Directors and Stockholders
Innovative Medical Machines International, S.A.
 
     We have audited the accompanying consolidated balance sheet of Innovative
Medical Machines International, S.A. as of December 31, 1996, and the related
consolidated statements of operations, stockholders' equity (deficit), and cash
flows for the years ended December 31, 1995 and 1996. These financial statements
are the responsibility of the Company's management. Our responsibility is to
express an opinion on these financial statements based on our audits.
 
     We conducted our audits in accordance with generally accepted auditing
standards. Those standards require that we plan and perform the audit to obtain
reasonable assurance about whether the financial statements are free of material
misstatement. An audit includes examining, on a test basis, evidence supporting
the amounts and disclosures in the financial statements. An audit also includes
assessing the accounting principles used and significant estimates made by
management, as well as evaluating the overall financial statement presentation.
We believe that our audits provide a reasonable basis for our opinion.
 
     In our opinion, the financial statements referred to above present fairly,
in all material respects, the consolidated financial position of Innovative
Medical Machines International, S.A. at December 31, 1996, and the consolidated
results of its operations and its cash flows for the years ended December 31,
1995 and 1996 in accordance with generally accepted accounting principles.
 
     The accompanying financial statements have been prepared assuming that
Innovative Medical Machines International, S.A. will continue as a going
concern. As more fully described in Note 1, the Company has incurred recurring
operating losses. This condition raises substantial doubt about the Company's
ability to continue as a going concern. Management's plans in regard to this
matter are also described in Note 1. The financial statements do not include any
adjustments to reflect the possible future effects on the recoverability and
classification of assets or the amounts and classification of liabilities that
may result from the outcome of this uncertainty.

                                          ERNST & YOUNG ENTREPRENEURS DEPARTMENT

                                    D'ERNST & YOUNG AUDIT

                                    Marc Bonhomme

                                    Partner

   
Villeurbanne, France
    
September 10, 1997
 
                                      F-16
   81
 
                INNOVATIVE MEDICAL MACHINES INTERNATIONAL, S.A.
 
                          CONSOLIDATED BALANCE SHEETS

                                                                                      JUNE 30,
                                                                                        1997
                                                                    DECEMBER 31,     -----------
                                                                        1996
                                                                    ------------     (UNAUDITED)
                                                                               
                                             ASSETS
Current assets
  Cash............................................................  $     93,658     $    91,285
  Accounts receivable.............................................            --         198,401
  Value added tax receivable......................................        39,353          27,599
  Tax credit receivable...........................................       110,264          98,373
  Inventory.......................................................       274,158         134,572
  Other current assets............................................        80,538          14,344
                                                                     -----------     -----------
Total current assets..............................................       597,971         564,574
Property and equipment, net.......................................       125,111         258,368
                                                                     -----------     -----------
                                                                    $    723,082     $   822,942
                                                                     ===========     ===========
 
                         LIABILITIES AND STOCKHOLDERS' EQUITY (DEFICIT)
Current liabilities
  Accounts payable to affiliates..................................  $     53,315     $   105,238
  Accounts payable................................................       137,009         242,797
  Accrued payroll and related expenses............................       114,248          84,078
  Current portion of long term bank loans.........................       107,966         313,620
  Customer deposits...............................................       317,265              --
  Deferred grant income...........................................            --          94,110
  Other current liabilities.......................................        69,334          61,611
                                                                     -----------     -----------
Total current liabilities.........................................       799,137         901,454
  Long term bank loans............................................            --          37,648
  Convertible debt................................................       143,221         127,777
  Note payable....................................................       164,856         147,079
Commitments and contingencies (Notes 1 and 8)
Stockholders' equity (deficit)
  Common stock, $28.41 par value, 25,225 shares authorized, issued
     and outstanding..............................................       716,578         716,578
  Additional paid in capital......................................       466,932         466,932
  Accumulated translation adjustment..............................         9,654          30,165
  Accumulated deficit.............................................    (1,577,296)     (1,604,691)
                                                                     -----------     -----------
Total stockholders' equity (deficit)..............................      (384,132)       (391,016)
                                                                     -----------     -----------
                                                                    $    723,082     $   822,942
                                                                     ===========     ===========

                            See accompanying notes.
 
                                      F-17
   82
 
                INNOVATIVE MEDICAL MACHINES INTERNATIONAL, S.A.
 
                     CONSOLIDATED STATEMENTS OF OPERATIONS

                                                YEARS ENDED DECEMBER       SIX MONTHS ENDED JUNE
                                                         31,                        30,
                                               -----------------------     ----------------------
                                                 1995          1996          1996          1997
                                               ---------     ---------     ---------     --------
                                                                                (UNAUDITED)
                                                                             
  Net Sales................................    $      --     $ 447,310     $ 147,158     $617,580
  Cost of sales............................           --       200,882        90,525      285,120
                                               ---------     ---------     ---------     --------
  Gross profit.............................           --       246,428        56,633      332,460
 
  Operating expenses:
    Selling, general and administrative....      266,144       600,466       231,592      295,865
    Research and development...............      458,728       545,823       244,373      107,739
                                               ---------     ---------     ---------     --------
  Total operating expenses.................      724,872     1,146,289       475,965      403,604
                                               ---------     ---------     ---------     --------
  Loss from operations.....................     (724,872)     (899,861)     (419,332)     (71,144)
 
  Other income (expense):
    Interest income........................       28,756           567           569           --
    Interest expense.......................       (7,350)      (10,625)       (4,155)     (16,038)
    Grant income...........................           --            --            --       59,787
                                               ---------     ---------     ---------     --------
  Loss before benefit for income taxes.....     (703,466)     (909,919)     (422,918)     (27,395)
    Benefit for income taxes...............      (73,940)           --            --           --
                                               ---------     ---------     ---------     --------
  Net loss.................................    $(629,526)    $(909,919)    $(422,918)    $(27,395)
                                               =========     =========     =========     ========
  Net loss per share.......................    $  (39.01)    $  (39.77)    $  (20.60)    $  (1.09)
                                               =========     =========     =========     ========
  Shares used in per share calculations....       16,137        22,879        20,531       25,225
                                               =========     =========     =========     ========

 
                            See accompanying notes.
 
                                      F-18
   83
 
                INNOVATIVE MEDICAL MACHINES INTERNATIONAL, S.A.
 
           CONSOLIDATED STATEMENTS OF STOCKHOLDERS' EQUITY (DEFICIT)

                                                                                               TOTAL
                                  COMMON STOCK      ADDITIONAL  ACCUMULATED                  STOCKHOLDERS'
                               ------------------    PAID-IN    TRANSLATION   ACCUMULATED     EQUITY
                               SHARES    AMOUNT      CAPITAL    ADJUSTMENT      DEFICIT      (DEFICIT)
                               ------   ---------   ---------   -----------   -----------    ---------
                                                                           
Balance at December 31,
  1994.......................  10,000   $ 187,056   $      --     $    --     $   (37,851)   $ 149,205
  Net loss...................      --          --          --          --        (629,526)    (629,526)
  Cumulative translation
     adjustment..............      --          --          --      15,514              --       15,514
  Issuance of common stock...   8,182     164,188     638,693          --              --      802,881
  Legal change in par
     value...................      --     638,503    (638,503)         --              --           --
                               ------    --------    --------     -------     -----------    ---------
Balance at December 31,
  1995.......................  18,182     989,747         190      15,514        (667,377)     338,074
  Net loss...................      --          --          --          --        (909,919)    (909,919)
  Cumulative translation
     adjustment..............      --          --          --      (5,860)             --       (5,860)
  Issuance of common stock...   7,043     192,650          --          --              --      192,650
  Issuance of common stock
     warrants................      --          --         923          --              --          923
  Legal change in par
     value...................      --    (465,819)    465,819          --              --           --
                               ------    --------    --------     -------     -----------    ---------
Balance at December 31,
  1996.......................  25,225     716,578     466,932       9,654      (1,577,296)    (384,132)
  Net loss (unaudited).......      --          --          --          --         (27,395)     (27,395)
  Cumulative translation
     adjustment
     (unaudited).............      --          --          --      20,511              --       20,511
                               ------    --------    --------     -------     -----------    ---------
Balance at June 30, 1997
  (unaudited)................  25,225   $ 716,578   $ 466,932     $30,165     $(1,604,691)   $(391,016)
                               ======    ========    ========     =======     ===========    =========

 
                            See accompanying notes.
 
                                      F-19
   84
 
                INNOVATIVE MEDICAL MACHINES INTERNATIONAL, S.A.
 
                     CONSOLIDATED STATEMENTS OF CASH FLOWS
                          INCREASE (DECREASE) IN CASH

                                                                             SIX MONTHS ENDED
                                             YEARS ENDED DECEMBER 31,            JUNE 30,
                                             ------------------------     -----------------------
                                                1995          1996          1996          1997
                                             ----------     ---------     ---------     ---------
                                                                                (UNAUDITED)
                                                                            
Cash flows from operating activities:
Net loss...................................  $ (629,526)    $(909,919)    $(422,918)    $ (27,395)
Adjustments to reconcile net loss to net
  cash used in operating activities:
  Depreciation.............................      31,983       101,776        28,298        43,019
  Changes in operating assets and
     liabilities:
     Accounts receivable...................     (10,287)       37,313        37,447      (204,789)
     Value added tax receivable............     (49,354)       17,079        36,255         7,752
     Tax credit receivable.................     (73,940)           --            --            --
     Inventory.............................    (148,790)       28,737         5,695       113,563
     Other current assets..................       7,996       (70,511)      (17,396)       59,362
     Accounts payable to affiliates........      84,552      (138,150)     (153,084)       38,806
     Accounts payable......................     (48,213)       78,452        24,963       121,706
     Accrued payroll and related
       expenses............................      47,695        59,542        40,213       (18,424)
     Customer deposits.....................     156,625       171,989       140,914      (292,166)
     Deferred grant income.................          --            --            --        97,140
     Other current liabilities.............       7,621        62,756        11,253           246
                                             ----------     ---------     ---------     ---------
Net cash used in operating activities......    (623,638)     (560,936)     (268,360)      (61,180)
 
Cash flows from investing activities:
Purchases of property and equipment........    (194,078)      (38,808)       (4,764)     (194,329)
                                             ----------     ---------     ---------     ---------
Net cash used in investing activities......    (194,078)      (38,808)       (4,764)     (194,329)
 
Cash flows from financing activities:
Proceeds from bank loans...................     355,167        95,475            --       264,054
Payments on bank loans.....................      (4,560)     (327,099)     (323,257)         (901)
Increase in notes payable..................          --       168,795        12,430            --
Net proceeds from sale of common stock and
  warrants.................................     802,881       193,573       193,573            --
Net proceeds from issuance of convertible
  debt.....................................          --       148,258       148,258            --
                                             ----------     ---------     ---------     ---------
Net cash provided by financing
  activities...............................   1,153,488       279,002        31,004       263,153
                                             ----------     ---------     ---------     ---------
Effect of exchange rate changes on cash....      12,629       (18,295)      (15,352)      (10,017)
                                             ----------     ---------     ---------     ---------
Increase (decrease) in cash................     348,401      (339,037)     (257,472)       (2,373)
Cash beginning of period...................      84,294       432,695       432,695        93,658
                                             ----------     ---------     ---------     ---------
Cash end of period.........................  $  432,695     $  93,658     $ 175,223     $  91,285
                                             ==========     =========     =========     =========

                            See accompanying notes.
 
                                      F-20
   85
 
                INNOVATIVE MEDICAL MACHINES INTERNATIONAL, S.A.
 
                   NOTES TO CONSOLIDATED FINANCIAL STATEMENTS
                               DECEMBER 31, 1996
                 (INFORMATION WITH RESPECT TO JUNE 30, 1997 AND
           THE SIX MONTHS ENDED JUNE 30, 1996 AND 1997 IS UNAUDITED)
 
1.  DESCRIPTION OF BUSINESS AND FINANCING REQUIREMENTS
 
     Innovative Medical Machines International (the "Company") was incorporated
on July 28, 1993 in Grenoble, France. The Company develops, manufactures and
markets image guided robotic devices for surgical applications. The Company's
principal product is the NeuroMate(R), a computer controlled surgical robot
dedicated to stereotactic neurosurgery.
 
     On August 14, 1995 the Company established a wholly owned subsidiary,
Innovative Medical Machines International Inc., as a Delaware corporation for
the purpose of developing its business in the United States.
 
     The Company has incurred substantial losses since inception and has not yet
generated significant revenue. The Company incurred a net loss of $909,919 for
the year ended December 31, 1996 and has an accumulated deficit of $1,577,296 as
of December 31, 1996. To date, the Company has funded its operations primarily
through the sale of debt and equity. Accordingly, the Company's ability to
accomplish its business strategy and to ultimately achieve profitable operations
is dependent upon its ability to raise additional financing. The Company's
management is exploring several funding options and expects to raise additional
capital during 1997. Ultimately, however, the Company will need to achieve
profitable operations in order to continue as a going concern.
 
     These conditions raise substantial doubt about the Company's ability to
continue as a going concern. The financial statements do not include any
adjustments to reflect the uncertainties related to the recoverability and
classification of assets or the amounts and classification of liabilities that
may result from the outcome of this uncertainty.
 
2.  SIGNIFICANT ACCOUNTING POLICIES
 
CONSOLIDATION
 
     The consolidated financial statements include the accounts of the Company
and its wholly-owned subsidiary. All significant intercompany balances and
transactions have been eliminated in consolidation.
 
CURRENCY TRANSLATION

     The financial position and results of operations of Innovative Medical
Machines International, S.A. are measured using the Company's functional
currency (French Francs). The Company's balance sheet accounts are translated at
the current year-end exchange rate and statement of operations are translated at
the average exchange rate for the period. Translation adjustments are recorded
as a separate component of stockholders' equity. Foreign currency transaction
gains and losses were not material during the years ended December 31, 1995 and
1996 and the six months ended June 30, 1996 and 1997.

REVENUE RECOGNITION
 
     Revenues from sales without significant Company obligations beyond delivery
are recognized upon delivery of the products. Revenues pursuant to agreements
which include significant Company obligations beyond delivery are deferred until
the Company's remaining obligations are insignificant.
 
RESEARCH AND DEVELOPMENT
 
     Software development costs incurred subsequent to the determination of the
product's technological feasibility and prior to the product's general release
to customers are not material to the Company's financial
 
                                      F-21
   86
 
                INNOVATIVE MEDICAL MACHINES INTERNATIONAL, S.A.
 
           NOTES TO CONSOLIDATED FINANCIAL STATEMENTS -- (CONTINUED)

position or results of operations, and have been charged to research and
development expense in the Company's consolidated statements of operations.
Research and development costs are expensed as incurred.

GRANT INCOME
 
     Grant income for clinical tests is recognized as the related clinical tests
are performed. Grants received in advance of work to be performed are recorded
as deferred grant income.
 
CONCENTRATION OF CREDIT RISK
 
     The Company sells its products to companies in the healthcare industry and
performs periodic credit evaluations of its customers and generally does not
request collateral. The Company believes that adequate provision for doubtful
accounts receivable has been made in the accompanying financial statements. The
Company maintains substantially all of its cash at two banking institutions.
 
FINANCIAL STATEMENT ESTIMATES
 
     The preparation of financial statements in conformity with United States
generally accepted accounting principles requires management to make estimates
and assumptions that affect the amounts reported in the financial statements and
accompanying notes. Actual results could differ from those estimates.
 
PROPERTY AND EQUIPMENT

     NeuroMate system equipment used for grant related clinical testing is
included in property and equipment. Property and equipment are stated at cost.
Depreciation is calculated using the straight-line method over estimated useful
lives of 3 to 8 years.

INVENTORY
 
     Inventory is recorded at the lower of cost (first-in, first-out method) or
market and consists of materials and supplies used in the manufacture of the
NeuroMate System.
 
     Inventory consists of the following:

                                                         DECEMBER 31, 1996     JUNE 30, 1997
                                                         -----------------     -------------
                                                                                (UNAUDITED)
                                                                         
        Raw materials..................................      $      --           $  50,081
        Finished Goods.................................        274,158              84,491
                                                              --------            --------
                                                             $ 274,158           $ 134,572
                                                              ========            ========

STOCK-BASED COMPENSATION
 
     As permitted under the provisions of Statement of Financial Accounting
Standards No. 123 "Accounting for Stock-Based Compensation" ("SFAS No. 123"),
the Company has elected to account for stock-based compensation using the
intrinsic value method prescribed by Accounting Principles Board Opinion No. 25,
"Accounting for Stock Issued to Employees" ("APB No. 25"). Under the intrinsic
value method, compensation cost is the excess, if any, of the quoted market
price or fair value of the stock at the grant date or other measurement date
over the amount an employee must pay to acquire the stock.
 
                                      F-22
   87
 
                INNOVATIVE MEDICAL MACHINES INTERNATIONAL, S.A.
 
           NOTES TO CONSOLIDATED FINANCIAL STATEMENTS -- (CONTINUED)
 
INCOME TAXES
 
     The liability method is used to account for income taxes. Under this
method, deferred income tax assets and liabilities are determined based on
differences between the financial reporting and tax bases of assets and are
measured using the enacted tax rates and laws that are scheduled to be in effect
when the differences are expected to reverse.
 
NET LOSS PER SHARE
 
     Net loss per share is based on the weighted average number of shares of
common stock outstanding during the period. Common stock issuable upon the
exercise of common stock warrants and convertible debt have been excluded from
the computation because their inclusion would be anti-dilutive.

     In February 1997, the Financial Accounting Standards Board issued Statement
No. 128, Earnings Per Share, which is required to be adopted on December 31,
1997. At that time, the Company will be required to change the method currently
used to compute earnings per share and to restate all prior periods. Under the
new requirements for calculating primary earnings per share, the dilutive effect
of stock options will be excluded. The impact of Statement 128 on the Company's
calculation of earnings per share is not expected to be material.

CUSTOMERS AND FOREIGN SALES

     Approximately 99% of the Company's revenues were from two customers in
France during the year ended December 31, 1996 and approximately 95% of the
Company's revenues during the six months ended June 30, 1997 were from a
different customer in Japan.

3.  PROPERTY AND EQUIPMENT
 
     Property and equipment consists of the following:

                                                         DECEMBER 31, 1996     JUNE 30, 1997
                                                         -----------------     -------------
                                                                                (UNAUDITED)
                                                                         
        NEUROMATE System equipment.....................      $  72,560           $ 194,207
        Other equipment................................         92,768             135,751
        Furniture and fixtures.........................         35,820              36,725
        Leasehold improvements.........................         61,247              55,953
                                                              --------            --------
                                                               262,395             422,636
        Less accumulated depreciation..................       (137,284)           (164,268)
                                                              --------            --------
        Total property and equipment...................      $ 125,111           $ 258,368
                                                              ========            ========

4.  ACCOUNTS PAYABLE TO AFFILIATES

     Accounts payable to affiliates consists of the following:

   

                                                     AT DECEMBER 31, 1996
                                                     --------------------     AT JUNE 30, 1997
                                                                              ----------------
                                                                                (UNAUDITED)
                                                                        
        Accounts payable for purchases of
          materials................................        $ 12,918               $ 63,909
        Wages and salaries due to stockholders.....          33,992                 31,142
        Accrued interest on convertible debt.......           6,405                 10,187
                                                            -------               --------
        Total accounts payable to affiliates.......        $ 53,315               $105,238
                                                            =======               ========

 
   
     Purchases for substantially all of the mechanical components of the robot
are made from an affiliate. Total purchases from this company for the years
ended December 31, 1995 and 1996 and the six months ended June 30, 1996 and 1997
were $286,805, $157,334, $37,013 and $36,927 respectively.

     Certain stockholders who are also employees have elected to defer payment
of their wages and salaries in order to provide short-term financing for the
Company. These accounts payable bear interest at 6%.
 
                                      F-23
   88
 
                INNOVATIVE MEDICAL MACHINES INTERNATIONAL, S.A.
 
           NOTES TO CONSOLIDATED FINANCIAL STATEMENTS -- (CONTINUED)
 
5.  LONG-TERM DEBT
 
BANK LOANS
 
     Bank loans consist of the following :

                                                                 DECEMBER 31, 1996
                                                                 -----------------     JUNE 30, 1997
                                                                                       -------------
                                                                                        (UNAUDITED)
                                                                                 
Revolving line of credit established in July 1996 for five
  years with an available amount of $386,347 at a fixed rate of
  interest of 7.15%. The amount available decreases quarterly
  by 5% of the original amount, beginning October 1996.........      $  95,474           $ 290,146
Bank term loan with monthly principal and interest payments
  over three years from May 1997 at a fixed rate of interest of
  5.75%........................................................             --              56,575
Bank term loan with monthly principal and interest payments
  through October 1997 at a fixed rate of interest of 8%.......         12,492               4,547
                                                                     ---------           ---------
                                                                       107,966             351,268
Less current portion...........................................       (107,966)           (313,620)
                                                                     ---------           ---------
Total long-term bank loans.....................................      $      --           $  37,648
                                                                     =========           =========

 
   
     The revolving line of credit is under a single agreement with the Company's
two banks in France. During 1996 and the six months ended June 30, 1997 the
proceeds under this line of credit were obtained equally from each bank. Half of
the credit line was secured by the Company's common stock. On September 5, 1997
the banks waived their security interests in order to enable the sale of the
Company's common stock to Integrated Surgical Systems, Inc., as more fully
described in Note 10. At December 31, 1996, $267,328, of the line of credit was
unused. At June 30, 1997 no amounts were unused by the Company.

     The bank term loans are secured by substantially all of the Company's
assets.
 
CONVERTIBLE DEBT
 
     In May 1996, the Company sold 2,143 units of convertible debt at $67.42 per
unit which may be converted into common stock at a rate of one unit of
convertible debt for one share of common stock between January 1, 1999 and
December 31, 1999. The convertible debt earns interest at 5% which is payable at
December 31 each year.
 
     If the convertible debt is not converted into common stock, it will be
repayable at 102% of the original offering price on December 31, 1999. In
agreement with the convertible debt holders no interest was paid in 1996. The
amount due for interest is accrued and shown in the balance sheet as accounts
payable to affiliates.
 
     On May 31, 1996, the Company sold 1,057 warrants to purchase its common
stock at $28.41 per share for approximately $0.19 per warrant in conjunction
with the convertible debt offering. These warrants expire on December 31, 1999.
 
NOTE PAYABLE

     The Company received an interest free loan of $152,561 from a grant
organization for the development of a new system. In the case of the failure of
the project, the contractual agreement is that the grant organization may decide
to forgive all or part of the repayments.

   
     If the Company sells either a license for technology, the prototype
developed, or articles manufactured specifically for the research project, 50%
of the revenue must be paid to the grant body in the subsequent year up to the
balance of the loan amount outstanding. According to the contract, any such
payments would be

                                      F-24
   89
 
                INNOVATIVE MEDICAL MACHINES INTERNATIONAL, S.A.
 
           NOTES TO CONSOLIDATED FINANCIAL STATEMENTS -- (CONTINUED)

considered to be an advance repayment of the loan. The Company has not made any
sales of this type through June 30, 1997.

FUTURE PRINCIPAL PAYMENTS
 
     As of December 31, 1996, future principal payments by year on long-term
debt are due as follows :

                                                                    AT DECEMBER 31,
                                                                    ---------------
                                                                 
            1997..................................................     $ 107,966
            1998..................................................            --
            1999..................................................       184,435
            2000..................................................        41,214
            2001 and thereafter...................................        82,428
                                                                       ---------
                                                                         416,043
            Less current portion..................................      (107,966)
                                                                       ---------
            Total long-term debt..................................     $ 308,077
                                                                       =========

     Interest payments on total long-term debt during the years ended December
31, 1995 and 1996 and the six months ended June 30, 1996 and 1997 were $800,
$14,813, $8,104 and $12,858, respectively.
 
6.  STOCKHOLDERS' EQUITY (DEFICIT)
 
COMMON STOCK
 
     As of December 31, 1996 pursuant to warrants and convertible debt
outstanding, a total of 4,789 and 2,143 shares of common stock would be issued
upon conversion or exercise of the warrants and convertible debt, respectively.
As the Company's authorized common stock is fully issued the Company will need
to increase authorized common stock prior to any issuance or conversion related
to the warrants or the convertible debt.
 
     During 1995 the Company increased par value from $18.71 to $54.44 resulting
in a reclassification of additional paid in capital to common stock. The Company
subsequently decreased the par value to $28.41 in 1996 resulting in a further
reclassification from common stock to additional paid in capital.
 
COMMON STOCK WARRANTS
 
     On May 31, 1996, the Company sold to an executive officer 3,732 warrants to
purchase its common stock at $28.41 per share for approximately $0.19 per
warrant. These warrants expire on December 31, 1999.
 
     The Company has elected to follow Accounting Principles Board Opinion No.
25, "Accounting for Stock Issued to Employees" and related Interpretations in
accounting for these warrants because, as discussed below, the alternative fair
value accounting provided for under FASB Statement No. 123, "Accounting for
Stock-Based Compensation" ("SFAS No. 123") requires use of valuation models that
were not developed for use in valuing employee common stock warrants.
 
     Pro forma information regarding net income (loss) and earnings (loss) per
share is required by SFAS No. 123, which also requires that the information be
determined as if the Company has accounted for warrants granted to the employees
subsequent to December 31, 1994 under the fair value method of that Statement.
The fair value for these warrants was estimated at the date of the grant using
the minimum value pricing model with the following assumptions: risk-free
interest rate of 5.5%; a dividend yield of 0%; and an expected life of the
warrants of 3.5 years. As determined by the minimum value pricing model using
the above assumptions, the fair value of the warrants on the grant date was
$4.97 per warrant.
 
                                      F-25
   90
 
                INNOVATIVE MEDICAL MACHINES INTERNATIONAL, S.A.
 
           NOTES TO CONSOLIDATED FINANCIAL STATEMENTS -- (CONTINUED)
 
     Valuation models require the input of highly subjective assumptions.
Because the Company's warrants granted to its President have characteristics
significantly different from those of traded warrants and because changes in the
subjective input assumptions can materially affect the fair value estimate, in
management's opinion, the existing models do not necessarily provide a reliable
single measure of the fair value of its warrants.
 
     For purposes of pro forma disclosures, the estimated fair value of the
warrants granted to the President is amortized to expense over the vesting
period. The following is the Company's pro forma information for the year ended
December 31, 1996:

                                                                         1996
                                                                       ---------
                                                                    
            Pro forma net loss.....................................    $(913,013)
            Pro forma net loss per share...........................    $  (39.91)

 
7.  INCOME TAXES
 
     Deferred taxes result from temporary differences in the recognition of
revenue and expense items for income tax and financial reporting.
 
     The significant components of the Company's deferred taxes as of December
31, 1996 are as follows:

                                                                    
            Net operating loss carryover.............................  $ 376,830
            Income recognition.......................................    155,582
            Research and development.................................     38,803
            Other....................................................     23,643
                                                                       ---------
                                                                         594,858
            Less: valuation allowance................................   (594,858)
                                                                       ---------
            Net deferred taxes.......................................  $      --
                                                                       =========

     The principal reasons for the difference between the effective income tax
and the statutory income tax rate are as follows:

                                                                YEARS ENDED DECEMBER
                                                                         31,
                                                               -----------------------
                                                                 1995          1996
                                                               ---------     ---------
                                                                       
        Income tax benefit expected at statutory rates.......  $(244,678)    $(328,268)
        Net operating loss with no current benefit...........    244,678       328,268
        Net research tax credit..............................    (73,940)           --
                                                               ---------     ---------
                                                               $ (73,940)    $      --
                                                               =========     =========

     The research tax credit is allowable based on the increase in research
expenditures in the fiscal year as compared to the average of the two prior
fiscal years. The research tax credit is subject to a review by the tax
authorities up to three years after the credit is claimed. The research tax
credit is payable by tax authorities after the third year following the year in
which it arose. Management has recorded an allowance against a portion of the
research tax credit. At December 31, 1996 and June 30, 1997 the total tax
research credit due for payment between 1998 and 2000 and the related allowance
are as follows:

                                                                               JUNE 30, 1997
                                                           DECEMBER 31, 1996   -------------
                                                           -----------------    (UNAUDITED)
                                                                         
        Research tax credit receivable...................      $ 235,496         $ 210,101
        Allowance........................................       (125,232)         (111,728)
                                                               ---------         ---------
                                                               $ 110,264         $  98,373
                                                               =========         =========

                                      F-26
   91
 
                INNOVATIVE MEDICAL MACHINES INTERNATIONAL, S.A.
 
           NOTES TO CONSOLIDATED FINANCIAL STATEMENTS -- (CONTINUED)
 
     The Company has at December 31, 1996 a net operating loss carryforward of
approximately $610,300 which expires between 1999 and 2002, and a net operating
loss carryforward which does not expire of $141,189 for statutory income taxes.
 
8.  COMMITMENTS
 
LEASES
 
     Through December 31, 1996, the Company leased its facilities under a 9 year
operating lease, cancelable every 3 years. The Company relocated in January
1997. Future lease payments of $33,080 which are due until the end of the
current three year period are accrued in other current liabilities and charged
to operations at December 31, 1996 because the Company no longer uses the
premises. An additional amortization of leasehold improvements of $42,375 was
also recorded during 1996 because of early termination of the lease.
 
     The aggregate annual rental expense under this lease amounted to $22,598
and $22,054 during 1995 and 1996.
 
     In January 1997, the Company obtained an 18 month operating lease of its
facilities from a university in Lyon. This lease is given free of charge by the
University and the local council, as part of a program to encourage the
relocation of new technical companies to Lyon.
 
     Future minimum payments under non-cancelable equipment operating leases are
$12,000 per year through the year ended December 31, 1998. Rental expense for
these non-cancelable leases during the years ended December 31, 1995 and 1996
and the six months ended June 30, 1997 was approximately $12,000, $12,000 and
$6,000, respectively.
 
SALE OF RECEIVABLES WITH RECOURSE
 
     In May 1997 a note for $173,595 was sold to the bank with recourse. No gain
or loss was recognized on this transaction; however, the Company has an
obligation to pay the bank interest on all amounts outstanding on the note at
10.70% until the bank is paid in full. The full amount remained unpaid as of
June 30, 1997.
 
9.  ANVAR GRANT
 
     During 1996, the Company received notification it was awarded a $222,492
grant from the French agency Agence Nationale de Valorisation de la Recherche
("ANVAR") which is a French national agency set up to aid research and
development projects. The grant is to fund the clinical tests to be performed at
two university hospitals on the NeuroMate system over a period of one year. The
project and related ANVAR grant began in March 1997 and will last for one year.
The Company received $173,595 in proceeds (Note 8) under this grant during the
period ended June 30, 1997, of which $59,787 has been recognized as income and
the remainder has been recorded as deferred grant income to be recognized as
income over the period of the project.

10.  SUBSEQUENT EVENT

   
     Effective September 5, 1997, Integrated Surgical Systems, Inc. ("ISS")
acquired all of the Company's issued and outstanding capital stock, stock
warrants and convertible debt in a transaction accounted for as a purchase. The
purchase price consisted of 619,355 shares of ISS common stock with a fair
market value of approximately $3.9 million and the assumption of approximately
$1 million of the Company's liabilities. The purchase agreement places certain
restrictions for a period of eighteen months on the future sale of the ISS stock
issued in connection with the purchase.

                                      F-27
   92
 
          UNAUDITED PRO FORMA COMBINED CONDENSED FINANCIAL STATEMENTS
 
     The following unaudited Pro Forma Combined Condensed Financial Statements,
including the notes thereto, are qualified in their entirety by reference to and
should be read in conjunction with the historical Consolidated Financial
Statements of Integrated Surgical Systems, Inc., ("ISS") and Innovative Medical
Machines International, S.A., ("IMMI"), including the notes thereto, included
herein.
 
     The unaudited Pro Forma Combined Condensed Balance Sheet as of June 30,
1997 and the unaudited Pro Forma Combined Condensed Statements of Operations for
the year ended December 31, 1996 and the six months ended June 30, 1997, give
effect to the business combination involving Integrated Surgical Systems, Inc.
and Innovative Medical Machines International, S.A. accounted for using the
purchase method of accounting. The Pro Forma Combined Condensed Balance Sheet is
presented as if the business combination had occurred on June 30, 1997, and the
Pro Forma Combined Condensed Statements of Operations are presented as if the
business combination had occurred as of January 1, 1996. The pro forma
information is presented for illustrative purposes only and may not be
indicative of the results that would have been obtained had the transaction
actually occurred on the dates assumed nor is it necessarily indicative of the
future combined results of operations. ISS has retained independent valuation
professionals to assist in the final determination of the value to be assigned
to the individual assets acquired including the intangibles and in-process
research and development. The results of the preliminary valuation have been
included in the pro forma adjustments to the combined condensed financial
statements; however, results of the final valuation could differ from those
reflected herein.
 
                                      F-28
   93
 
              UNAUDITED PRO FORMA COMBINED CONDENSED BALANCE SHEET
 
                                 JUNE 30, 1997

                                                                                PRO FORMA
                                                                      -----------------------------
                                          ISS            IMMI         ADJUSTMENTS        COMBINED
                                      -----------     -----------     -----------       -----------
                                                                            
                                              ASSETS
Current assets:
  Cash and cash equivalents.........  $ 3,685,731     $    91,285     $        --       $ 3,777,016
  Accounts receivable...............      655,023         198,401              --           853,424
  Inventory.........................    1,790,371         134,572              --         1,924,943
  Other current assets..............      245,405         140,316              --           385,721
                                      ------------    -----------     -----------       -----------
Total current assets................    6,376,530         564,574              --         6,941,104
Net property and equipment..........      269,658         258,368              --           528,026
Other assets........................       17,169              --              --            17,169
Intangible assets...................           --              --       3,844,242(a)      3,844,242
                                      ------------    -----------     -----------       -----------
                                      $ 6,663,357     $   822,942     $ 3,844,242       $11,330,541
                                      ============    ===========     ===========       ===========
 
                               LIABILITIES AND STOCKHOLDERS' EQUITY
Current liabilities:
  Accounts payable to affiliates....  $        --     $   105,238     $        --       $   105,238
  Accounts payable..................    1,046,771         242,797              --         1,289,568
  Value added taxes payable.........      270,289              --              --           270,289
  Accrued payroll and related
     expenses.......................      103,673          84,078              --           187,751
  Current portion of long-term bank
     loans..........................           --         313,620              --           313,620
  Customer deposits.................      257,172              --              --           257,172
  Accrued product retrofit costs....      135,348              --              --           135,348
  Deferred grant income.............           --          94,110              --            94,110
  Other current liabilities.........      195,592          61,611              --           257,203
                                      ------------    -----------     -----------       -----------
Total current liabilities...........    2,008,845         901,454              --         2,910,299
 
Long-term bank loans................           --          37,648              --            37,648
Convertible debt....................           --         127,777        (127,777)(b)            --
Note payable........................           --         147,079              --           147,079
 
Stockholders' equity (deficit)
  Common stock......................       33,669         716,578        (710,384)(a)        39,863
  Additional paid-in capital........   25,775,656         466,932       3,416,423(a)     29,659,011
  Deferred stock compensation.......     (336,417)             --              --          (336,417)
  Accumulated translation
     adjustment.....................      (29,994)         30,165         (30,165)(a)       (29,994)
  Accumulated deficit...............  (20,788,402)     (1,604,691)      1,296,145(a)    (21,096,948)
                                      ------------    -----------     -----------       -----------
Total stockholders' equity
  (deficit).........................    4,654,512        (391,016)      3,972,019         8,235,515
                                      ------------    -----------     -----------       -----------
                                      $ 6,663,357     $   822,942     $ 3,844,242       $11,330,541
                                      ============    ===========     ===========       ===========

 
   See accompanying notes to unaudited pro forma combined condensed financial
                                  statements.
 
                                      F-29
   94
 
         UNAUDITED PRO FORMA COMBINED CONDENSED STATEMENT OF OPERATIONS
 
                          YEAR ENDED DECEMBER 31, 1996

                                                                                  PRO FORMA
                                                                         ---------------------------
                                              ISS            IMMI        ADJUSTMENTS      COMBINED
                                          -----------     ----------     -----------     -----------
                                                                             
Net sales...............................  $ 2,280,311     $  447,310     $        --     $ 2,727,621
Cost of sales...........................      884,152        200,882              --       1,085,034
                                          -----------     ----------      ----------      ----------
                                            1,396,159        246,428              --       1,642,587
Operating expenses:
  Selling, general and administrative...    2,066,236        600,466         780,276(c)    3,446,978
  Research and development..............    2,468,535        545,823              --       3,014,358
  Stock compensation....................      357,249             --              --         357,249
                                          -----------     ----------      ----------      ----------
                                            4,892,020      1,146,289         780,276       6,818,585
Other income (expense):
  Interest income.......................       87,933            567              --          88,500
  Interest expense......................           --        (10,625)          4,584(d)       (6,041)
  Other.................................      (30,635)            --              --         (30,635)
                                          -----------     ----------      ----------      ----------
Loss before provision for income
  taxes.................................   (3,438,563)      (909,919)       (775,692)     (5,124,174)
Provision for income taxes..............       10,266             --              --          10,266
                                          -----------     ----------      ----------      ----------
Net loss................................  $(3,448,829)    $ (909,919)    $  (775,692)    $(5,134,440)
                                          ===========     ==========      ==========      ==========
Net loss per share......................  $     (0.79)    $   (39.77)                    $     (1.03)
                                          ===========     ==========                      ==========
Shares used in per share calculations...    4,373,947         22,879                       4,993,302
                                          ===========     ==========                      ==========

 
   See accompanying notes to unaudited pro forma combined condensed financial
                                  statements.
 
                                      F-30
   95
 
         UNAUDITED PRO FORMA COMBINED CONDENSED STATEMENT OF OPERATIONS
 
                         SIX MONTHS ENDED JUNE 30, 1997

                                                                                 PRO FORMA
                                                                        ---------------------------
                                               ISS           IMMI       ADJUSTMENTS      COMBINED
                                           -----------     --------     -----------     -----------
                                                                            
Net sales................................  $ 1,379,696     $617,580     $        --     $ 1,997,276
Cost of sales............................      531,693      285,120              --         816,813
                                            ----------     --------                        --------
                                               848,003      332,460              --       1,180,463
Operating expenses:
  Selling, general and administrative....    1,383,596      295,865         390,138(c)    2,069,599
  Research and development...............    1,183,519      107,739              --       1,291,258
  Stock compensation.....................       90,000           --              --          90,000
                                            ----------     --------                        --------
                                             2,657,115      403,604         390,138       3,450,857
Other income (expense):
  Interest income........................      125,147           --              --         125,147
  Interest expense.......................           --      (16,038)          3,066(d)      (12,972)
  Other..................................       14,374       59,787              --          74,161
                                            ----------     --------                        --------
Loss before provision for income taxes...   (1,669,591)     (27,395)       (387,072)     (2,084,058)
Provision for income taxes...............       18,000           --              --          18,000
                                            ----------     --------                        --------
Net loss.................................  $(1,687,591)    $(27,395)    $  (387,072)    $(2,102,058)
                                            ==========     ========                        ========
Net loss per share.......................  $     (0.50)    $  (1.09)                    $     (0.53)
                                            ==========     ========                        ========
Shares used in per share calculations....    3,364,567       25,225                       3,983,922
                                            ==========     ========                        ========

 
   See accompanying notes to unaudited pro forma combined condensed financial
                                  statements.
 
                                      F-31
   96
 
      NOTES TO UNAUDITED PRO FORMA COMBINED CONDENSED FINANCIAL STATEMENTS
 
1.  INTEGRATED SURGICAL SYSTEMS, INC. ACQUISITION OF INNOVATIVE MEDICAL MACHINES
INTERNATIONAL, S.A.

     Effective September 5, 1997, ISS acquired all of IMMI's issued and
outstanding capital stock, stock warrants and convertible debt in a transaction
accounted for as a purchase. The purchase price consisted of 619,355 shares of
ISS common stock with a fair market value of approximately $3.9 million. The
purchase agreement places certain restrictions on the future sale of the ISS
stock issued in connection with the purchase for a period of eighteen months.

   

The estimated purchase price consists of the following:
 
          619,355 shares of ISS common stock.....................................  $3,889,549
 
          Liabilities assumed....................................................   1,086,181
                                                                                   ----------
 
                                                                                   $4,975,730
                                                                                    =========
Certain items affecting the purchase price remain unresolved at this time. A
  summary of management's preliminary allocation of purchase price is as follows:
 
          Tangible assets acquired...............................................  $  822,942
 
          Identified intangible assets...........................................   3,844,242
 
          In-process research and development....................................     308,546
                                                                                   ----------
 
                                                                                   $4,975,730
                                                                                    =========

 
2.  INTANGIBLE ASSETS

     Intangible assets include developed technology and assembled work force.
The estimated useful lives are expected to range from 3 to 5 years. ISS
management does not believe that technological feasibility of the acquired
in-process research and development has been established. Further, ISS
management believes the acquired in-process research and development has no
alternative future uses. Therefore, the amount allocated to in-process research
and development is required to be immediately expensed under generally accepted
accounting principles. Such amount is a nonrecurring charge related to the
acquisition and as such is not reflected in the Pro Forma Statements of
Operations pursuant to Regulation S-B.

3.  PRO FORMA ADJUSTMENTS
 
     Adjustments to the Proforma Combined Condensed Balance Sheet were made:
 
          (a) To record ISS' acquisition of IMMI

          (b) To eliminate convertible debt that will not be assumed.

     Adjustments to the Pro Forma Combined Condensed Statements of Operations
were made:

          (c) To record the amortization of the intangible assets acquired in
     ISS' acquisition of IMMI.

   
          (d) To eliminate interest expense accrued on convertible debt.

                                      F-32
   97
 
                                    PART II
 
                     INFORMATION NOT REQUIRED IN PROSPECTUS
 
ITEM 24.  INDEMNIFICATION OF DIRECTORS AND OFFICERS
 
     Article VI of the Registrant's by-laws provides that a director or officer
shall be indemnified against expenses (including attorneys' fees), judgments,
fines and amounts paid in settlement (provided such settlement is approved in
advance by the Registrant) in connection with certain actions, suits or
proceedings, whether civil, criminal, administrative or investigative (other
than an action by or in the right of the corporation -- a "derivative action")
if he acted in good faith and in a manner he reasonably believed to be in or not
opposed to the best interests of the corporation, and, with respect to any
criminal action or proceeding, had no reasonable cause to believe his conduct
was unlawful. A similar standard of care is applicable in the case of derivative
actions, except that indemnification only extends to expenses (including
attorneys' fees) incurred in connection with the defense or settlement of such
an action, except that no person who has been adjudged to be liable to the
Registrant shall be entitled to indemnification unless a court determines that
despite such adjudication of liability but in view of all of the circumstances
of the case, the person seeking indemnification is fairly and reasonably
entitled to be indemnified for such expenses as the court deems proper.
 
     Article 6.5 of the Registrant's by-laws further provides that directors and
officers are entitled to be paid by the Registrant the expenses incurred in
defending the proceedings specified above in advance of their final disposition,
provided that such payment will only be made upon delivery to the Registrant by
the indemnified party of an undertaking to repay all amounts so advanced if it
is ultimately determined that the person receiving such payments is not entitled
to be indemnified.
 
     Article 6.4 of the Registrant's by-laws provides that a person indemnified
under Article VI of the by-laws may contest any determination that a director,
officer, employee or agent has not met the applicable standard of conduct set
forth in the by-laws by petitioning a court of competent jurisdiction.
 
     Article 6.6 of the Registrant's by-laws provides that the right to
indemnification and the payment of expenses incurred in defending a proceeding
in advance of its final disposition conferred in the Article will not be
exclusive of any other right which any person may have or acquire under the
by-laws, or any statute or agreement, or otherwise.
 
     Finally, Article 6.7 of the Registrant's by-laws provides that the
Registrant may maintain insurance, at its expense, to reimburse itself and
directors and officers of the Registrant and of its direct and indirect
subsidiaries against any expense, liability or loss, whether or not the
Registrant would have the power to indemnify such persons against such expense,
liability or loss under the provisions of Article VI of the by-laws. The
Registrant has applied for such insurance, and expects to have such insurance in
effect on the date this Registration Statement is declared effective by the
Securities and Exchange Commission.
 
     Article 11 of the Registrant's certificate of incorporation eliminates the
personal liability of the Registrant's directors to the Registrant or its
stockholders for monetary damages for breach of their fiduciary duties as a
director to the fullest extent provided by Delaware law. Section 102(b)(7) of
the DGCL provides for the elimination off such personal liability, except for
liability (i) for any breach of the director's duty of loyalty to the Registrant
or its stockholders, (ii) for acts or omissions not in good faith or which
involve intentional misconduct or a knowing violation of law, (iii) under
Section 174 of the DGCL or (iv) for any transaction from which the director
derived any improper personal benefit.

     Insofar as indemnification for liabilities arising under the Securities Act
of 1933 (the "Securities Act") may be permitted to directors, officers or
persons controlling the Registrant pursuant to the foregoing provisions, the
Registrant has been informed that in the opinion of the Securities and Exchange
Commission such indemnification is against public policy as expressed in the
Securities Act and is therefore unenforceable.

                                      II-1
   98
 
ITEM 25.  OTHER EXPENSES OF ISSUANCE AND DISTRIBUTION

     The following table sets forth the expenses (other than underwriting
discounts and commissions, and the fee payable to the Placement Coordinator)
which will be paid by the Registrant in connection with the issuance and
distribution of the securities being registered hereby. With the exception of
the SEC registration fee and the NASD filing fee, all amounts indicated are
estimates.

   

    SEC Registration fee......................................................  $  9,582
    NASD filing fee...........................................................     4,000
    Easdaq Filing Fee.........................................................    10,000
    Nasdaq Filing Fee.........................................................     7,500
    Pacific Stock Exchange filing fee.........................................     8,125
    Non-accountable expense allowance.........................................   621,468
    Printing expenses (other than stock certificates).........................    95,000
    Printing and engraving of stock and warrant certificates).................     3,000
    Legal fees and expenses (other than blue sky).............................    80,000
    Accounting fees and expenses..............................................   100,000
    Transfer Agent fees and expenses..........................................     5,000
    Miscellaneous.............................................................     1,325
                                                                                --------
              Total...........................................................  $945,000
                                                                                ========

 
ITEM 26.  RECENT SALE OF UNREGISTERED SECURITIES
 
     During the past three years, the Registrant has sold securities to a
limited number of persons, as described below. Except as indicated, there were
no underwriters involved in the transactions and there were no underwriting
discounts or commissions paid in connection therewith. The purchasers of
securities in each such transaction represented their intention to acquire the
securities for investment only and not with a view to or for sale in connection
with any distribution thereof and appropriate legends were affixed to the
certificates for the securities issued in such transactions. All purchasers of
securities in each such transaction had adequate access to information about the
Registrant, and in the case of transactions exempt from registration under
Section 4(2) of the Securities Act, were sophisticated investors.
 
      1. On December 20, 1995, as part of a recapitalization, the Registrant
         issued 30,482 shares of Common Stock to each of Sutter Health and the
         John N. Kapoor Trust (the "Kapoor Trust") upon conversion of the Series
         B Preferred Stock. The issuance of these shares was exempt from
         registration under Section 3(a)(9) of the Securities Act.
 
      2. On December 20, 1995, as part of a recapitalization, the Registrant
         issued 8,955 shares of Common Stock to each of Sutter Health and the
         Kapoor Trust in consideration for the cancellation of all accumulated
         dividends on the Series B Preferred Stock. The issuance of these shares
         was exempt from registration under Section 4(2) of the Securities Act.
 
      3. On December 20, 1995, as part of a recapitalization, the Registrant
         issued 89,604 shares of Common Stock to Sutter Health and 12,801 shares
         of Common Stock to Keystone Financial Corporation ("Keystone") upon
         conversion of the Series C Preferred Stock. The issuance of these
         shares was exempt from registration under Section 3(a)(9) of the
         Securities Act.
 
      4. On December 20, 1995, as part of a recapitalization, the Registrant
         issued 19,512 shares of Common Stock to Sutter Health and 3,169 shares
         of Common Stock to Keystone in consideration for the cancellation of
         all accumulated dividends on the Series C Preferred Stock. The issuance
         of these shares was exempt from registration under Section 4(2) of the
         Securities Act.
 
                                      II-2
   99
 
      5. On December 21, 1995, as part of a recapitalization, the Registrant
         issued a warrant to purchase 126,895 shares of Common Stock, at an
         exercise price of $0.02 per share, to International Business Machines
         Corporation ("IBM") in exchange for the cancellation of the Company's
         promissory note in the principal amount of $3,000,000 and accrued
         interest thereon. The issuance of this warrant was exempt from
         registration under Section 4(2) of the Securities Act.
 
      6. On December 21, 1995, as part of a recapitalization, the Registrant
         issued 693,195 shares of Series D Preferred Stock to EJ Financial
         Investments V, L.P. ("EJ Financial") for an aggregate purchase price of
         $666,667 ($0.96 per share). In addition, EJ Financial received an
         option to purchase an additional 346,597 shares of Series D Preferred
         Stock on the same terms and conditions as it purchased the Series D
         Preferred Stock, which option was exercised on February 19, 1996. The
         issuance of these securities was exempt from registration under Section
         4(2) of the Securities Act.
 
      7. On December 21, 1995, as part of a recapitalization, the Registrant
         issued a warrant to purchase 1,386,390 shares of Series D Preferred
         Stock (the "Series D Warrants") to IBM, at an exercise price of $0.01
         per share, for an aggregate purchase price of $1,333,333 ($0.96 per
         warrant). In addition, IBM received an option to purchase Series D
         Warrants to purchase an additional 693,194 shares of Series D Preferred
         Stock on the same terms and conditions as it purchased the Series D
         Warrants, which option was exercised on February 19, 1996. The issuance
         of these securities was exempt from registration under Section 4(2) of
         the Securities Act.
 
      8. On December 21, 1995, as part of a recapitalization, the Registrant
         issued warrants to purchase 390,888 shares, 11,899 shares and 43,300
         shares of Common Stock to Sutter Health, Sutter Health Venture Partners
         L.P. and Keystone, respectively, at an exercise price of $0.74 per
         share, in consideration for their consent to the terms of the
         recapitalization. The issuance of these warrants was exempt from
         registration under Section 4(2) of the Securities Act.
 
      9. On December 21, 1995, as part of a recapitalization, the Registrant
         issued warrants to purchase 121,686 shares, 3,705 shares and 13,481
         shares of Common Stock to Sutter Health, Sutter Health Venture Partners
         L.P. and Keystone, respectively, at an exercise price of $0.74 per
         share, in connection with the exercise of certain options by EJ
         Financial and IBM. The issuance of these warrants was exempt from
         registration under Section 4(2) of the Securities Act.
 
     10. From July 24, 1993 through December 31, 1994, the Registrant granted
         options to purchase an aggregate of 11,415 shares of Common Stock to
         employees of the Registrant pursuant to the Registrant's employee stock
         option plans, at an exercise price of $7.84 per share. The grant of
         these options was exempt from registration under Rule 701 of the
         Securities Act.
 
     11. From January 1, 1995 through December 31, 1995, the Registrant granted
         options to purchase an aggregate of 32,713 shares of Common Stock to
         employees of the Registrant pursuant to the Registrant's employee stock
         option plans, at an exercise price of $4.88 per share. The grant of
         these options was exempt from registration under Rule 701 of the
         Securities Act.
 
     12. From January 1, 1996 through September 30, 1996, the Registrant granted
         options to purchase an aggregate of 941,545 shares of Common Stock to
         employees of the Registrant pursuant to the Registrant's employee stock
         option plans. Of these options, options to purchase 899,637 shares were
         granted at an exercise price of $0.07 per share, options to purchase
         21,631 shares were granted at an exercise price of $2.07 per share, and
         options to purchase 20,277 were granted at an exercise price of $5.92
         per share. The grant of these options was exempt from registration
         under Rule 701 of the Securities Act.
 
     13. From January 1, 1993 through December 31, 1994, the Registrant issued
         and sold an aggregate of 399 shares of Common Stock to two employees of
         the Registrant upon exercise of stock options granted pursuant to the
         Registrant's employee stock option plans. Of such shares, 241 were
         issued at an exercise price of $3.33 per share and 158 were issued at
         an exercise price of $7.84 per share. The issuance and sale of these
         shares was exempt from registration under Rule 701 of the Securities
         Act.
 
                                      II-3
   100
 
     14. From January 1, 1995 through December 31, 1995, the Registrant issued
         and sold an aggregate of 781 shares of Common Stock to three employees
         of the Registrant upon exercise of stock options granted pursuant to
         the Registrant's employee stock option plans, at an exercise price of
         $3.33 per share. The issuance and sale of these shares was exempt from
         registration pursuant to Rule 701 promulgated under the Securities Act.
 
     15. From January 1, 1996 through December 31, 1996, the Registrant issued
         and sold an aggregate of 9,592 shares of Common Stock to three
         employees of the Registrant upon exercise of stock options granted
         pursuant to the Registrant's employee stock option plans. Of such
         shares, 9,537 shares were issued at an exercise price of $0.07 per
         share and 55 shares were issued at an exercise price of $0.31 per
         share. The issuance and sale of these shares was exempt from
         registration pursuant to Rule 701 promulgated under the Securities Act.
 
     16. From January 1, 1997 through June 30, 1997, the Registrant issued and
         sold an aggregate of 5,795 shares of Common Stock to two employees of
         the Registrant upon exercise of Stock options granted pursuant to the
         Registrant's employee stock option plans. Of such shares, 928 were
         issued at an exercise price of $0.07 per share and 4,867 shares were
         issued at an exercise price of $3.33 per share. The issuance and sale
         of these shares were exempt from registration pursuant to Rule 701
         promulgated under the Securities Act.
 
     17. On June 17, 1994, the Registrant issued 390 shares of Common Stock to a
         former employee of the Registrant and 152 shares of Common Stock to his
         attorney, in connection with the termination of the employee's
         employment. These shares were valued at $7.84 per share. The issuance
         of the shares was exempt from registration pursuant to Rule 504
         promulgated under the Securities Act.
 
     18. On November 23, 1994, the Registrant issued 676 shares of Common Stock
         to a supplier of the Registrant in payment of accrued interest on note
         payable. The issuance of the shares was exempt from registration under
         Section 4(2) of the Securities Act.

     19. On August 25, 1996, the Company issued 449,374 and 13,680 shares of
         Common Stock to Sutter Health and Sutter Health Venture Partners,
         respectively, at an exercise price of $0.74 per share. The issuance of
         these securities was exempt from registration under Section 4(2) of the
         Securities Act.

     20. On October 29, 1996, the Company issued 49,777 shares of Common Stock
         to Keystone Financial Corporation at an exercise price of $0.74 per
         share. The issuance of these securities was exempt from registration
         under Section 4(2) of the Securities Act.

     21. On September 5, 1997, the Company issued 619,355 shares of Common Stock
         to the former shareholders of Innovative Medical Machines International
         ("IMMI") in connection with the acquisition of IMMI. The issuance of
         these shares was exempt from registration pursuant to Regulation S and
         Section 4(2) of the Securities Act.

ITEM 27.  EXHIBITS

        
   1.1    --  Form of Purchase Agreement.
   1.2    --  Form of Placement Agreement**
   3.1    --  Form of Certificate of Incorporation of the Company, as amended.*
   3.2    --  By-laws of the Company.*
   4.1    --  Form of Underwriters' Warrants**
   4.2    --  Form of Public Warrant Agreement.*
   4.3    --  Specimen Common Stock Certificate.*
   4.4    --  Specimen Warrant Certificate (included as Exhibit A to Exhibit 4.2 herein).*
   4.6    --  Form of Consulting Agreement between the Company and Rickel & Associates, Inc.*
   4.7    --  Common Stock Purchase Warrant issued by the Company to International Business
              Machines Corporation ("IBM"), dated February 6, 1991, as amended (included as
              Exhibit J to Exhibit 10.5 herein).*

 
                                      II-4
   101

        
   4.8    --  Stockholders' Agreement between the Founders of the Company and IBM, dated
              February 6, 1991, as amended.*
   4.9    --  Common Stock Purchase Warrant issued by the Company to IBM, dated December 21,
              1995 (included as Exhibit I to Exhibit 10.5 herein).*
   4.11   --  Warrant issued by the Company to Sutter Health, Sutter Health Venture Partners
              ("Sutter Health VP") and Keystone Financial Corporation ("Keystone"), dated
              December 21, 1995 (included as Exhibits K, L and M, respectively, to Exhibit 10.5
              herein).*
   4.12   --  Registration Rights Agreement among the Company, IBM, John N. Kapoor Trust
              ("Kapoor"), EJ Financial Investments V, L.P. ("EJ Financial"), Keystone, Sutter
              Health and Sutter Health VP, dated as of December 21, 1995 (included as Exhibit G
              to Exhibit 10.5 herein).*
   4.13   --  1995 Stock Option Plan, as amended.*
   4.15   --  Form of Lock-up Agreement.*
   5.1    --  Opinion of Snow Becker Krauss P.C.
  10.1    --  Loan and Warrant Purchase Agreement between the Company and IBM, dated as of
              February 6, 1991.*
  10.2    --  License Agreement between the Company and IBM, dated February 4, 1991.*
  10.6    --  Investors Agreement among the Company, IBM, Wendy Shelton-Paul Trust, William
              Bargar, Brent Mittelstadt, Peter Kazanzides, Kapoor, Sutter Health, Sutter Health
              VP and EJ Financial, dated as of December 21, 1995 (included as Exhibit F to
              Exhibit 10.5 herein).*
  10.7    --  Employment Agreement between the Company and Ramesh Trivedi, dated December 8,
              1995.*
  10.8    --  License Agreement between the Company and IBM, dated February 4, 1991.*
  10.9    --  Agreement for the Purchase and Use of Sankyo Industrial Products between the
              Company and Sankyo Seiki (American) Inc. dated November 1, 1992. *
  10.10   --  Stock Purchase Agreement dated as of September 5, 1997 between the Company and
              the holders of the outstanding capital stock of Innovative Medical Machines
              International, S.A.
  10.11   --  Registration Rights Agreement dated September 5, 1997 by and among the Company
              and the holders of the outstanding capital stock of Innovative Medical Machines
              International, S.A.
  11.1    --  Statement of computation of earnings per share.
  21.1    --  Subsidiaries of the Company.
  23.1    --  Consent of Snow Becker Krauss P.C. (included in Exhibit 5.1 to this Registration
              Statement).
  23.2    --  Consent of Ernst & Young LLP, independent auditors, is included in Part II of
              this Registration Statement.
  23.3    --  Consent of Ernst & Young Entrepreneurs Department D'Ernst & Young Audit,
              Independent Auditors.
  24.1    --  Power of Attorney (included on the signature page of this Registration
              Statement).
  27.1    --  Financial Data Schedule.

 
     Exhibits filed or incorporated by reference herein bear the same numbers as
used in the Registrant's Registration Statement on Form SB-2 effective November
21, 1996, and therefore are not necessarily sequential.
- ---------------
 * Incorporated by reference to the Company's Form SB-2 Registration Statement
   effective on November 21, 1996
** To be filed by Amendment.
 
                                      II-5
   102
 
   ITEM 28.  UNDERTAKINGS
 
   (A) RULE 415 OFFERING
 
     The undersigned small business issuer hereby undertakes that it will:
 
          (1) File, during any period in which it offers or sells securities, a
     post-effective amendment to this registration statement to:
 
             (i) Include any prospectus required by section 10(a)(3) of the
        Securities Act.
 
             (ii) Reflect in the prospectus any facts or events which,
        individually or together, represent a fundamental change in the
        information set forth in the registrant statement. Notwithstanding the
        foregoing, any increase or decrease in volume of securities offered (if
        the total dollar value of securities offered would not exceed that which
        was registered) and any deviation from the low or high end of the
        estimated maximum offering range may be reflected in the form of
        prospectus filed with the Commission pursuant to Rule 424(b) if, in the
        aggregate, the changes in volume and price represent no more than a 20%
        change in the maximum aggregate offering price set forth in the
        "Calculation of Registration Fee" table in the effective registration
        statement.
 
             (iii) Include any additional or changed material information on the
        plan of distribution.
 
          (2) For determining any liability under the Securities Act, treat each
     post-effective amendment as a new registration statement relating to the
     securities offered, and the offering of such securities at that time to be
     the initial bona fide offering thereof.
 
          (3) File a post-effective amendment to remove from registration any of
     the securities that remain unsold at the end of the offering.
 
(D) EQUITY OFFERINGS BY NON-REPORTING SMALL BUSINESS ISSUERS
 
     The undersigned small business issuer hereby undertakes that it will
provide the Underwriters at the closing specified in the Underwriting Agreement
certificates in such denominations and registered in such names as required by
the Underwriters to permit prompt delivery to each purchaser.
 
(E) REQUEST FOR ACCELERATION OF EFFECTIVE DATE
 
     Insofar as indemnification for liabilities arising under the Securities Act
of 1933 (the "Securities Act") may be permitted to directors, officers and
controlling persons of the small business issuer pursuant to the foregoing
provisions, or otherwise, the small business issuer has been advised that in the
opinion of the Securities and Exchange Commission such indemnification is
against public policy as expressed in the Securities Act and is, therefore,
unenforceable. In the event that a claim for indemnification against such
liabilities (other than the payment by the small business issuer of the expenses
incurred or paid by a director, officer, or controlling person of the small
business issuer in the successful defense of any action, suit or proceeding) is
asserted by such director, officer or controlling person in connection with the
securities being registered, the small business issuer will, unless in the
opinion of its counsel the matter has been settled by controlling precedent,
submit to a court of appropriate jurisdiction the question whether such
indemnification by it is against public policy as expressed in the Securities
Act and will be governed by the final adjudication of such issue.
 
(F) RULE 430A OFFERING
 
          (1) For determining any liability under the Securities Act, treat the
     information omitted from the form of prospectus filed as part of this
     registration statement in reliance upon Rule 430A and contained in a form
     of prospectus filed by the small business issuer under Rule 424(b)(1) or
     (4) or 497(h) under the Securities Act as part of this registration
     statement as of the time the Commission declared it effective.
 
                                      II-6
   103

(G) DEREGISTRATION OF SHARES OF COMMON STOCK NOT SOLD IN THE OFFERING

   
     The Registrant agrees to deregister shares of Common Stock included in this
Registration Statement that are not sold in the Offering.

                                      II-7
   104
 
                                   SIGNATURES

     Pursuant to the requirements of the Securities Act of 1933, the Registrant
certifies that it has reasonable grounds to believe that it meets all of the
requirement for filing on Form SB-2 and has duly caused this Amendment to the
Registration Statement to be signed on its behalf by the undersigned, thereunto
duly authorized, in the City of Sacramento in the State of California on
September 23, 1997.

INTEGRATED SURGICAL SYSTEMS, INC.

                                              
          By: /s/ RAMESH C. TRIVEDI                            By: /s/ MARK WINN
- ---------------------------------------------    ---------------------------------------------
              Ramesh C. Trivedi                                    Mark Winn
    Chief Executive Officer and President                   Chief Financial Officer
        (Principal Executive Officer)            (Principal Financial and Accounting Officer)

 
   
     Pursuant to the requirements of the Securities Act of 1933, this
Registration Statement has been signed by the following persons on September 23,
1997, in the capacities indicated.

   

                  SIGNATURE                                         TITLE
- ---------------------------------------------   ----------------------------------------------

 
            /s/ RAMESH C. TRIVEDI               Chief Executive Officer, President, and
- ---------------------------------------------     Director (Principal Executive Officer)
              Ramesh C. Trivedi
                /s/ MARK WINN                   Chief Financial Officer (Principal Financial
- ---------------------------------------------     and Accounting Officer)
                  Mark Winn
 
                      *                         Chairman of the Board of Directors
- ---------------------------------------------
              James C. McGroddy
 
                      *                         Director
- ---------------------------------------------
               John N. Kapoor
 
                      *                         Director
- ---------------------------------------------
              Paul A.H. Pankow
 
                      *                         Director
- ---------------------------------------------
              Gerald D. Knudson
 
                                                Director
- ---------------------------------------------
              Patrick G. Hayes

 
   
*By: /s/ RAMESH C. TRIVEDI
     -----------------------------------------------------
     Ramesh C. Trivedi
     (Attorney-In-Fact)

                                      II-8
   105
 
                                 EXHIBIT INDEX

                                                                                       SEQUENTIALLY
EXHIBIT                                                                                  NUMBERED
NUMBER                                     DESCRIPTION                                     PAGE
- ------         --------------------------------------------------------------------    ------------
                                                                              
  1.1     --   Form of Purchase Agreement
  1.2     --   Form of Placement Agreement**
  3.1     --   Form of Certificate of Incorporation of the Company, as amended*
  3.2     --   By-laws of the Company*
  4.1     --   Form of Underwriters' Warrants, as revised**
  4.2     --   Form of Public Warrant Agreement*
  4.3     --   Specimen Common Stock Certificate*
  4.4     --   Specimen Warrant Certificate (included as Exhibit A to Exhibit 4.2
               herein)*
  4.6     --   Form of Consulting Agreement between the Company and Rickel &
               Associates, Inc.*
  4.7     --   Common Stock Purchase Warrant issued by the Company to International
               Business Machines Corporation ("IBM"), dated February 6, 1996, as
               amended (included as Exhibit J to Exhibit 10.5 herein)*
  4.8     --   Stockholders' Agreement between the Founders of the Company and IBM,
               dated February 6, 1996, as amended*
  4.9     --   Common Stock Purchase Warrant issued by the Company to IBM, dated
               December 21, 1995 (included as Exhibit I to Exhibit 10.5 herein)*
 4.11     --   Warrant issued by the Company to Sutter Health, Sutter Health
               Venture Partners ("Sutter Health VP") and Keystone Financial
               Corporation ("Keystone"), dated December 21, 1995 (included as
               Exhibits K, L and M, respectively, to Exhibit 10.5 herein)*
 4.12     --   Registration Rights Agreement among the Company, IBM, John N. Kapoor
               Trust ("Kapoor"), EJ Financial Investments V, L.P. ("EJ Financial"),
               Keystone, Sutter Health and Sutter Health VP, dated as of December
               21, 1995 (included as Exhibit G to Exhibit 10.5 herein)*
 4.13     --   1995 Stock Option Plan, as amended*
 4.15     --   Form of Lock-up Agreement*
  5.1     --   Opinion of Snow Becker Krauss P.C
 10.1     --   Loan and Warrant Purchase Agreement between the Company and IBM,
               dated as of February 6, 1991*
 10.2     --   License Agreement between the Company and IBM, dated February 4,
               1991*
 10.6     --   Investors Agreement among the Company, IBM, Wendy Shelton-Paul
               Trust, William Barger, Brent Mittelstadt, Peter Kazanzides, Kapoor,
               Sutter Health, Sutter Health VP and EJ Financial, dated as of
               December 21, 1995 (included as Exhibit F to Exhibit 10.5 herein)*
 10.7     --   Employment Agreement between the Company and Ramesh Trivedi, dated
               December 8, 1995*
 10.8     --   License Agreement between the Company and IBM, dated February 4,
               1991*
 10.9     --   Agreement for the Purchase and Use of Sankyo Industrial Products
               between the Company and Sankyo Seiki (American) Inc. dated November
               1, 1992*
10.10     --   Stock Purchase Agreement dated as of September 5, 1997 between the
               Company and the holders of the outstanding capital stock of
               Innovative Medical Machines International, S.A.
10.11     --   Registration Rights Agreement dated September 5, 1997 by and among
               the Company and the holders of the outstanding capital stock of
               Innovative Medical Machines International, S.A.
 11.1     --   Statement of computation of earnings per share
 21.1     --   Subsidiaries of the Company
 23.1     --   Consent of Snow Becker Krauss P.C. (included in Exhibit 5.1 to this
               Registration Statement)

   106

                                                                                       SEQUENTIALLY
EXHIBIT                                                                                  NUMBERED
NUMBER                                     DESCRIPTION                                     PAGE
- ------         --------------------------------------------------------------------    ------------
                                                                              
 23.2     --   Consent of Ernst & Young LLP, independent auditors, is included in
               Part II of this Registration Statement
 23.3     --   Consent of Ernst & Young Entrepreneurs Department D'Ernst & Young
               Audit, Independent Auditors
 24.1     --   Power of Attorney (included on the signature page of this
               Registration Statement)
 27.1     --   Financial Data Schedule

 
     Exhibits filed or incorporated by reference herein bear the same numbers as
used in the Registrant's Registration Statement on Form SB-2 effective November
21, 1996, and therefore are not necessarily sequential.
- ---------------
 * Incorporated by reference to the Company's Form SB-2 Registration Statement
   effective on November 21, 1996
** To be filed by Amendment.
   1
                                                                 Exhibit 1.1

                                  CONFIDENTIAL

                               PURCHASE AGREEMENT

                                  BY AND AMONG
                        INTEGRATED SURGICAL SYSTEMS, INC.
                    INVESTMENTBANK AUSTRIA AKTIENGESELLSCHAFT

                                            , 1997
                             ---------------
   2
           PURCHASE AGREEMENT, dated *, 1997, (the "Agreement") among Integrated
Surgical System, Inc. (the "Company") and Investmentbank Austria
Aktiengesellschaft ("Investmentbank Austria") and * ("*") (Investmentbank
Austria and * referred to herein, collectively, as the "Managers").

                                 P R E A M B L E

           The Company is a corporation incorporated and organized under the
laws of the State of Delaware, United States of America. The Company's shares of
common stock with a par value of U.S $0.01 per share are referred to herein as
the "Shares of Common Stock".

           On *, 1997, the Board of Directors of the Company approved the
issuance of * new Shares of Common Stock with a par value of U.S$0.01 each (the
"New Shares") and with an aggregate par value of U.S$*.

           Investmentbank Austria and *, acting severally but not jointly,
shall, pursuant to the terms and conditions of this Agreement, purchase
themselves such * New Shares.

           Pursuant to this Agreement, the Company is granting to Investmentbank
Austria an option (the "Over-allotment Option") to acquire, upon the terms end
conditions set forth in Section 2 hereof, up to * additional issued and
outstanding Shares of Common Stock (the "Option Shares") solely to cover 
over-allotments in the offering, if any. Any offering of the Option Shares 
will be deemed to be part of the offering. The New Shares and the Option 
Shares are referred to herein, collectively, as the "Offer Shares".

           The offering of the Offer Shares (the "Offering"), comprises private
placements and offerings utilizing other exemptions from public offering
registration requirements in Europe. The Offer Shares will be offered outside 
the United States in reliance on Regulation S ("Regulation S") under the 
United States Securities Act of 1933, as amended (the "1933 Act").

           Value Management & Research GmbH ("VMR"), a German limited
liability company which entered, together with Investmentbank Austria, into an
agreement with the Company (the "Restated Placement Agreement"). Such Restated
Placement Agreement provides, inter alia, that VMR will act as Placement 
Coordinator in connection with the Offering and the listing of Shares of 
Common Stock of the Company on the European Association of Securities Dealers 
Automated Quotation System ("EASDAQ"). The Restated Placement Agreement 
provides that the Company has an obligation to pay to VMR (i) a fee (the 
"Aggregate VMR Fee") in an amount equal to 3.5% of the Aggregate Offer
Price (as defined in Section 2(c)) and (ii) a non-accountable expense allowance
(the "Aggregate VMR Non-accountable Expense Allowance") for costs and expenses
incurred by VMR in connection with the Offering in an amount equalt to 0.75% 
of the Aggregate Offer Price.

           The terms and conditions of the Shares of Common Stock are set forth
in the Preliminary Prospectus dated *, 1997 and the Final Prospectus dated *,
1997. The Preliminary Prospectus together with the Final Prospectus, as any of
such documents may be amended or supplemented from time to time, are referred to
herein as the "Offering Documents".

             NOW; THEREFORE, the parties hereto agree as follows:

                                      2
   3
            Section 1. Representations and Warranties.

                 The Company represents and warrants to and agrees with each 
Manager that:

                        (i) A registration statement on Form SB-2 (File No.
      333-31481) with respect to the Offer Shares and such Shares of Common
      Stock issued upon exercise of such warrants are being sold to
      Investmentbank Austria and VMR pursuant to the Restated Placement
      Agreement has been filed by the Company with the U.S. Securities and
      Exchange Commission (the "Commission") under the 1933 Act, and *
      amendments to that registration statement have been so filed and such
      registration statement has been declared effective on or before the date
      hereof. No stop order suspending the effectiveness of the registration
      statement has been issued under the 1933 Act and no proceedings for that
      purpose have been instituted or are pending or, to the knowledge of the
      Company, are contemplated by the Commission, and any request on the part
      of the Commission for additional information has been complied with.
      Copies of such registration statement and of each amendment hereto filed
      by the Company with the Commission have been delivered to Investmentbank
      Austria and EASDAQ. Such copies of the Registration Statement are
      identical to the electronically transmitted copies thereof filed with the
      Commission pursuant to its Electronic Gathering, Analysis and Retrieval
      system ("EDGAR"). As used in this Agreement, the term "Registration
      Statement" means the registration statement referred to above, as amended
      at the time it was declared effective, and any amendment thereto that was
      or is thereafter declared effective, including all financial schedules
      and exhibits thereto. For purposes of this Agreement, all references to
      the Registration Statement shall be deemed to include the copy filed with
      the Commission pursuant to EDGAR.

                        (ii) When the Registration Statement was declared 
      effective, it (A) contained all statements required to be stated therein 
      in accordance with, and complied in all materal respects with the 
      requirements of the 1933 Act and the rules and regulations of the 
      Commission thereunder and (B) did not and does not contain any untrue 
      statement of a material fact or omit to state any material fact required
      to be stated therein or necessary in order to make the statements
      therein, in the light of the circumstances under which they were made, 
      not misleading.

                        (iii) The Offering Documents as of their date and as of
      the date hereof did not and do not contain any untrue statement of a
      material fact or omit to state any material fact necessary in order to
      make the statements therein, in the light of the circumstances under which
      they were made, not misleading.

                        (iv) The auditors who audited, certified and reviewed 
      the financial statements and supporting schedules included in the
      Registration Statement and the Offering Documents are independent 
      certified public accountants as required by the 1933 Act and the rules
      and regulations of the Commission thereunder with respect to the Company,
      its consolidated subsidiaries (each a "Consolidated Subsidiary" and 
      together the "Consolidated Subsidiaries") and Innovative Medical Machines
      International, S.A. ("IMMI"). IMMI and the Consolidated Subsidiaries are
      referred to herein as the "Subsidiaries". The Company and the Subsidiaries
      are herein referred to as the "Group".

                        (v) The audited consolidated balance sheets of the
      Company and its Consolidated Subsidiaries for the years ended December 31,
      1996, 1995 and 1994 and the related consolidated statements of operations,
      stockholders' equity and cash flow for the years ended December 31, 1996,
      1995 and 1994 (together the "Consolidated Financial Statements"), the
      unaudited consolidated balance sheets of the Company and its Consolidated
      Subsidiaries for the six months periods ended at June 30, 1997 and 1996
      and the related consolidated statements of operations, stockholders'
      equity and cash flow for the six months periods ended at June 30,

                                        3
   4
1997 and 1996 (together the "Consolidated Interim Financial Statements"), and
the audited financial statements of IMMI for the years ended December 31, 1996
and 1995 (together the "IMMI Financial Statements") and the unaudited financial
statements of IMMI for the six months period ended at June 30, 1997 and 1996
(together the "IMMI Interim Financial Statements") included in the Registration
Statement and the Offering Documents, together with the related schedules and
notes, present fairly the financial position of the Company and its Consolidated
Subsidiaries and IMMI as at the dates indicated and the results of its
operations, stockholders' equity and its cash flows for the periods specified.
The Consolidated Financial Statements, the Consolidated Interim Financial
Statements, the IMMI Financial Statements and the IMMI Interim Financial
Statements are referred to herein as the "Financial Statements". The audited
Consolidated Financial Statements for the years ended December 31, 1996, 1995
and 1994 and the unaudited Consolidated Interim Financial Statements for the six
months periods ended at June 30, 1997 and 1996 have been prepared in accordance
and conformity with generally accepted accounting principles in the United
States ("US GAAP") applied on a consistent basis throughout the periods
involved. The audited IMMI Financial Statements for the years ended December 31,
1990 and 1995 and the unaudited IMMI Interim Financial Statements for the six
months periods ended at June 30, 1997 and 1996 have been prepared in accordance
with generally accepted accounting principles in France ("French GAAP") and have
been reconciled from French GAAP to US GAAP. All financial data included in the
Registration Statement and the Offering Documents present fairly the information
shown therein and are accurate in all material respects, and have been compiled
on a basis consistent with that of the audited or unaudited Financial
Statements, as the case may be, included in the Registration Statement and the
Offering Documents.

                  (vi) The Company has been duly organized and is validly
existing as a corporation in good standing under the laws of the State of
Delaware, United States of America. The Company has full corporate power and
authority to own, lease and operate its properties and to conduct its business
as described in the Offering Documents and to enter into and perform its
obligations under this Agreement. The Company is duly qualified as a foreign
corporation to transact business and is in good standing in all jurisdictions in
which such qualification is required, whether by reason of its ownership or
lease of property or the conduct of its business, except where the failure to do
so would not have a Material Adverse Effect (as hereinafter defined).

                  (vii) The authorized, issued and outstanding capital stock of
the Company, the authorized and non-issued capital stock of the Company and all
warrants issued and sold by the Company conform to all statements relating
thereto set forth in the Offering Documents and such description conforms to the
rights set forth in the instruments defining the same.

                  (viii) All of the issued and outstanding Shares of Common
Stock of the Company (including the * New Shares and the * Option Shares) have
been duly authorized for issuance and are fully paid and non-assessable. No
holder of the Offer Shares will be subject to personal liability by reason of
being such a holder. The issuance of the Offer Shares in not subject to
preemptive rights, subscription rights or similar rights of any securityholder
of the Company. The holders of the Offer Shares will receive good and marketable
title, free and clear of any  pledges, liens, security interests, claims,
restrictions or encumbrances of any kind or right of a third party, including,
without limitation, preemptive rights, subscription rights or similar rights 
of any securityholder of the Company (each a "Lien"). The Offer
Shares have been duly authorized, and when such * Offer Shares have been issued,
delivered and paid for in accordance with this Agreement, all the then issued
and outstanding * Shares of Common Stock of the Company will have been validly
issued, fully paid and non-assessable and the holders thereof will receive good
and marketable title free of any Lien. None of the issued and outstanding Shares
of Common Stock of the Company was, or will be prior to the completion of the
Offering, issued in violation of statutory subscription rights. Other than as
set forth in the Offering Documents, there are no valid or enforceable
outstanding options, warrants, contractual subscription rights or similar
arrangements or preemptive rights granted or issued by the

                                        4
   5
  Company with respect to any unissued shares of capital stock of the Company.
  There are no restrictions on transfers of the Offer Shares except as set forth
  in the Offering Documents under 2.2.3 - "Transferability" and 2.5.4 -
  "Underwriting Selling Restrictions" and no person other than the Managers has
  as of the date hereof any right, contingent or otherwise, to purchase or
  acquire, or to be offered for purchase or acquisition, the Offer Shares.
  Except as disclosed in the Offering Documents, there are no contracts,
  agreements or understandings between the Company or any other person that
  would give rise to a valid claim against the Company or any Manager for a
  brokerage commission, finders fee or similar type payment. Since the
  inception of the Company, no compensation was paid to or on behalf of any
  member of the National Association of Securities Dealers, Inc. ("NASD"), or
  any affiliate or employee thereof, in connection with any offering since
  October 1, 1990, except as previously disclosed in writing to
  Investmentbank Austria.

                 (ix) All of the Company's partly or wholly-owned Consolidated
Subsidiaries are set forth in Exhibit 21.1 to the Registration Statement. Each
of the Company's Subsidiaries is a corporation duly organized, validly existing
and in good standing under the laws of the jurisdiction of its incorporation or
formation, as the case may be, with full power and authority (corporate or
otherwise) to own, lease, and operate its properties and to conduct the business
in which it is engaged as described in the Offering Documents. Each Subsidiary
is duly qualified to do business as a corporation in good standing in all
jurisdictions in which its ownership or lease of property or the conduct of its
business requires such qualification, except where the failure to so qualify
would not result in a material adverse change in the condition, financial or
otherwise, or in the earnings, business affairs or business prospects of the
Group (a "Material Adverse Effect"). All of the issued and outstanding capital
stock of each of the Subsidiaries has been duly authorized and validly issued,
is fully paid and non-assessable. The capital stock of the Subsidiaries is owned
by the Company, directly or indirectly, and is free and clear of any Lien. There
are no outstanding options, preemptive rights, warrants or similar arrangements
with respect to any unissued shares of any of the Subsidiaries.

                    (x) Since the respective dates as of which information is
  given in the Offering Documents, except an otherwise stated therein, (A) there
  has been no Material Adverse Effect, whether or not arising in the ordinary
  course of business, (B) there have been no transactions entered into by the
  Company or any of the Subsidiaries other than those in the ordinary course of
  business, that are material with respect to the Company or the Group, (C)
  there has been no material increase in the long-term debt of the Company, no
  material reduction in total assets of the Company, no change in the percentage
  ownership of a Subsidiary and no dividend or distribution of any kind paid or
  made by the Company on its capital stock, and (D) there has been no change in
  the authorized, issued and outstanding capital stock of the Company.

                    (xi)Except as disclosed in the Offering Documents, neither
  the Company nor any of the Subsidiaries is in violation of its charter (or
  similar constitutional documents) or any law, ordinance, rule, regulation,
  decision or order of any court or governmental, administrative or regulatory
  agency or body, domestic or foreign, to which it may be subject, or has failed
  to obtain, or has received any notice of proceeding relating to the revocation
  or modification of, or is in violation

                                        5
   6
of, any license, permit, certificate, franchise or other governmental,
administrative or regulatory authorization (collectively, "Authorizations")
necessary to the lease or ownership of its property or the conduct of its
business as operated by them, except for those Authorizations the failure to
comply with will not have individually or in the aggregate a Material
Adverse Effect, or is in default in the performance or observance of any
obligation, agreement, covenant or condition contained in any contract or other
understanding (whether written or oral) to which it is a party or by which it
may be bound, or to which any of its properties or assets may be subject except
for those violations, failures, notices or defaults that do not or will not,
individually or in the aggregate, result in a Material Adverse Effect. All
products sold by the Company have received all competent approvals and
permissions from all required regulatory authorities in all jurisdictions where
such products have been or are currently being marketed.

                  (xii) The execution, delivery and performance of this
Agreement, the issuance and sale of the Offer Shares and the consummation of the
transactions contemplated herein and compliance by the Company with its
obligations hereunder (A) have been duly authorized by the Company and all
necessary corporate and other action to authorize and approve the same has been
taken, (B) will not conflict with or constitute a breach of, or default under,
or result in the creation or imposition of a Lien upon, any property or assets
of the Company or any of the Subsidiaries pursuant to, or trigger any
change-in-control provision contained in, any material contract or other
material agreement to which the Company or any of the Subsidiaries is a party or
by which it or any of them may be bound, or to which any of the property or
assets of the Company or any of the Subsidiaries is subject, and (C) will not
result in any violation of any provision of the certificate of incorporation or
by-laws of the Company or any relevant applicable law, ordinance, rule,
regulation, decision or order of any court or governmental, administrative or
regulatory body. This Agreement, duly executed and delivered by the Company and,
assuming due authorization, execution and delivery by the other parties hereto,
is a legal, valid and binding obligation of the Company, enforceable against the
Company in accordance with its terms.

                 (xiii) No labor dispute with the employees of the Company or
any of the Subsidiaries, such as strikes or other labor unrest, exists or is
imminent. There is no existing or imminent labor disturbance by the employees of
any of its Subsidiaries' principal suppliers, manufacturers,
customers or contractors, which, in any case, may reasonably be expected to
result in a Material Adverse Effect.

                 (xiv) Except as disclosed in the Offering Documents, there are
no actions, suits, proceedings or investigations, including, without limitation,
personal injury and product liability actions, before or by any court or
governmental, administrative or regulatory agency or body, domestic or foreign,
now pending, or, to the best knowledge of the Company, threatened, against or
affecting any of the Company or any of the Subsidiaries that could, individually
or in the aggregate, (A) materially affect the performance by the Company of its
obligations under this Agreement or the transactions contemplated by the
Offering Documents, (B) reasonably be expected to result in any Material Adverse
Effect, or (C) reasonably be expected to materially and adversely affect the
material properties or assets of the Company or any of the Subsidiaries. Section
4.10 - "Government Regulation" of the Offering Documents as of their date and as
of the date hereof provides an accurate and complete description of the status
of the approvals under the U.S. Federal Food, Drug and Cosmetic Act for the
Company's or its Subsidiaries' products or the Company's or its Subsidiaries'
products under development. Such Section 4.10 does not include any untrue
statement of a material fact or omit to state any material fact necessary to
make the statements therein not misleading.

                                        6
   7
                  (xv) The Company and its Subsidiaries have filed all
applicable tax returns (in all relevant jurisdictions) that are required to be
filed or have duly requested extensions thereof and have paid all taxes required
to be paid by any of them and any related assessments, fines or penalties,
except for any such tax, assessment, fine or penalty that is being contested in
good faith and by appropriate proceedings; and adequate charges, accruals and
reserves have been provided for in the Financial Statements referred to in
paragraph (v) above in respect of all taxes for all periods and to which the tax
liability of the Company or any of its Subsidiaries has not been finally
determined or remains open to examination by applicable taxing authorities,
except for those filings, requests of extensions, payments or charges, accruals
and reserves that could not reasonably be expected to result, individually or in
the aggregate, in a Material Adverse Effect.

                  (xvi) The Company and its Subsidiaries own, or have a license
to use on reasonable terms, the material patents, patent rights, licenses,
inventions, copyrights, know-how (including trade-secrets and other unpatented
and/or unpatentable proprietary or confidential information, systems or
procedures), trade-marks, service marks and trade names (collectively, "Patent
and Proprietary Rights") presently employed by them and that are necessary to
the businesses now operated by them, and neither the Company nor any of the
Subsidiaries has received any notice or is otherwise aware of any infringement
of or conflict with asserted rights of others with respect to any Patent and
Proprietary Rights, or of any facts that would render any Patent and Proprietary
Rights invalid or inadequate to protect the interests of the Company or any of
the Subsidiaries therein, and which infringement or conflict (if the subject of
any unfavorable decision, ruling or finding) or invalidity or inadequacy,
individually or in the aggregate, would result in any Material Adverse Effect.

                  (xvii) Except as disclosed in the Offering Documents, neither
the Company nor any of the Subsidiaries is in violation of any statute or any
law, ordinance, rule, regulation, decision or order of any court or
governmental, administrative or regulatory agency or body, domestic or foreign
(each, an "Environmental Law"), relating to the use, disposal or release of
hazardous or toxic substances or to the protection or restoration of the
environment, including, without limitation, the remediation or clean-up of any
past or present contamination, or to human exposure to hazardous or toxic
substances, operates any real property contaminated with any substance that is
expected to become subject to any clean-up or other remediation action pursuant
to any Environmental Law, is liable or expects to become liable for any clean-up
or other remediation action pursuant to any Environmental Law with respect to
any off-site disposal or contamination, or is subject to any (or has knowledge
of any threatened) claim, order or decree relating to any Environmental Law,
which violations, contaminations, liabilities, claims, orders or decrees, would,
individually or in the aggregate, result in a Material Adverse Effect. The
Company and its Subsidiaries have all permits, authorizations and approvals
required under any applicable Environmental Laws and are each in compliance with
their requirements. There are no pending or threatened administrative,
regulatory or judicial actions, suits, demands, demand letters, claims, liens,
notices of noncompliance or violation, investigations or proceedings relating to
any Environmental Law against the Company or any of its Subsidiaries. There are
no events or circumstances that might reasonably be expected to form the basis
of an order for clean-up or remediation, or an action, suit or proceeding by any
private

                                        7
   8
party or governmental body or agency against or affecting the Company or any of
its Subsidiaries relating to any Environmental Laws.

                  (xviii) Except as disclosed in the Offering Documents, the
Company and the Subsidiaries have good and marketable title to all real
properties and all other properties and assets owned by them that are material
to the businesses of the Group, in each case free from Liens that would
materially interfere with the use made or to be made thereof by them; and except
as disclosed in the Offering Documents, the Company and the Subsidiaries hold
any leased real or personal property under valid and enforceable leases with no
exceptions that could reasonably be expected to result in a Material Adverse
Effect.

                  (xix) The Company and its Subsidiaries are insured by insurers
of recognized financial responsibility against such losses and risks and in such
amounts as are prudent and customary" in the businesses in which the Group is
engaged. The Company and its Subsidiaries have not been refused any insurance
coverage sought or applied for and the Company and its Subsidiaries have no
reason to believe that they will not be able to renew their existing insurance
coverage as and when such coverage expires or to obtain similar cost that would
not materially and adversely affect the condition (financial or otherwise),
business, prospects, net worth or results of operations of the Company and its
Subsidiaries, except as described in or contemplated by the Offering Documents.

                  (xx) All of the Shares of Common Stock of the Company
(including the Offer Shares) and the warrants sold by the Company in its initial
public offering in November 1996 are currently listed on the NASDAQ SmallCap
Market and the Pacific Stock Exchange Incorporated and the Company is in
compliance in all respects with the requirements of such exchanges.

                  (xxi) Except as set forth in the Offering Documents, the
Company has not entered into any contractual arrangement with respect to the
offer, purchase, sale and distribution of any of the Shares of Common Stock or
other securities of the Company, including, without limitation, other types of
stock, options or warrants.

                  (xxii) Neither the Company or their respective affiliates nor
any person acting on any of their behalfs has engaged or will, prior to
completion of the Offering, engage in any activity including, without
limitation, any offer, subscription, sale or delivery, directly or indirectly,
of any of the Shares of Common Stock or other securities of the Company,
including, without limitation, other types of stock, options or warrants or
distribution or publication of the Offering Documents or any other offering
material in or from any jurisdiction, except under circumstances that will
result in compliance with all applicable laws and regulations.

                  (xxiii) All previous offerings by the Company of securities in
the United States were valid and in accordance with the 1933 Act.

                                        8
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           Section 2. Purchase, Sale and Delivery to Managers; Closing;
                      Over-allotment Option.

                  (a) On the basis of the representations and warranties herein
contained and subject to the terms and conditions hereof, the Company agrees to
sell to each Manager, severally and not jointly, and each Manager, severally and
not jointly, agrees to purchase for itself from the Company at the Closing Date
(as defined in Section 2 (d) hereof) the number of New Shares set forth in
Schedule A opposite to the name of such Manager with the obligation to offer
such New Shares at the Offer Price (as defined in paragraph (c) below) (plus
customary bank charges and transfer or other taxes, if any) in the Offering.

                  (b) The Company shall deliver the share certificates
representing the aggregate number of New Shares to be said by the Company
pursuant to paragraph (a) to [*](1) no later then five (5) business days prior
to the Closing Date.

                  (c) The aggregate purchase price for the New Shares (the
"Aggregate Purchase Price") shall consist of an amount (payable in German marks)
equal to the product of (i) DM * Per New Share (the "Offer Price"), less (x)
commissions of DM * per New Share and (y) a Non-accountable Expense Allowance
(as defined in Section 4 hereof) of DM * per New Share for costs and expenses
incurred by Investmentbank Austria in connection with the Offering, and (ii) the
number of New Shares to be purchased by the Managers pursuant to this Agreement.
The product of (i) the Offer Price per New Share, and (ii) the number of New
Shares to be purchased by the Managers pursuant to this Agreement is herein
referred to as the "Aggregate New Shares Offer Price". The product of (i) the
Offer Price per Option Share, and (ii) the number of Option Shares purchased by
the Managers pursuant to this Agreement is herein referred to as the "Aggregate
Option Shares Offer Price". The total amount of the Aggregate New Shares Offer
Price and the Aggregate Option Shares Offer Price is herein referred to as the
Aggregate Offer Price.

                  (d) Payment of the Aggregate Purchase Price for the New Shares
sold by the Company less (x) the Aggregate VMR Placement Coordinator Fee for the
New Shares, and (y) the Aggregate VMR Non-accountable Expense Allowance for the
New Shares which will, pursuant to the terms and conditions of the Placement
Agreement, be paid directly from Investmentbank Austria to VMR, shall be made by
the Managers to the Company by direct bank transfer to the account of the
Company, account number; *, at * no later than ten business days after the
Closing Date, as defined herein. November *, 1997 shall be referred to herein as
the "Closing Date". The Closing Date may be varied by agreement between the
Managers and the Company. lnvestmentbank Austria shall have the right to deduct
costs and expenses to be paid by the Company pursuant to Section 4 (B) hereof
from the Aggregate Purchase Price; provided that such costs and expenses have
been paid by Investmentbank Austria on behalf of the Company.

                  (e) The Company hereby grants to Investmentbank Austria the
Over-allotment Option to require the Company to sell some or all of the Option
Shares to Investmentbank Austria in accordance with the terms of this Section 2.
The Over-allotment Option may be exercised by Investmentbank Austria at any time
after the date hereof and will expire 30 days after the Closing Date, and may be
exercised, in whole or from time to time in part, only for the purpose of
covering over-allotments that may be made in connection with the Offering, only
upon written notice by Investmentbank Austria to the Company stating the number
of Option Shares as to which Investmentbank Austria is exercising the
Over-allotment Option, and the time and date of payment 

                                        9
   10
and delivery thereof (an "Option Closing Date"), a copy of such notice is to be
forwarded from IBA to VMR. The relevant Option Closing Date, which may be the
Closing Date, shall be determined by Investmentbank Austria but shall not be
later than seven business days after the exercise of the Over-allotment Option.
If the Over-allotment Option is exercised as to all or any part of the Option
Shares, the Option Shares as to which the Over-allotment Option is exercised
shall be purchased by Investmentbank Austria. The aggregate purchase price for
the Option Shares (the "Aggregate Option Shares Purchase Price") to be paid by
Investmentbank shall consist of an amount (payable in German marks) equal to the
product of (i) the Offer Price, less (x) commissions of DM * per Option Share
and (y) a nonaccountable expense allowance of DM * per Option Share for costs
and expenses incurred by Investmentbank Austria in connection with the Offering,
and (ii) the number of Option Shares with respect to which an Over-allotment
Option has been exercised. Such Aggregate Option Shares Purchase Price less (x)
the Aggregate VMR Fee for the Option Shares, and (y) the Aggregate VMR
Non-accountable Expense Allowance for the Option Shares shall be paid in the
same manner as set forth in paragraph (d) above. The share certificates
representing the Option Shares shall be delivered by the Company to [*] no later
than on the Closing Date and Investmentbank Austria on behalf of the Company
shall release the share certificates representing the number of Option Shares as
to which Investmentbank Austria exercised the Over-allotment Option on each
Option Closing Date. The obligations of Investmentbank Austria to purchase and
pay for Option Shares as to which an Over-allotment Option has been exercised
are subject to satisfaction of the conditions set forth in Section 5(a) (as if
the references therein to the Closing Date were references to the relevant
Option Closing Date).

                  (f) The Company will bear and pay and hold the Managers and
any initial purchaser harmless against any transfer tax, issuance tax or other
tax, duties or fees imposed by the United States, the State of Delaware or the
Republic of Austria, including any interest and penalties, on or in connection
with the sale, offering, transfer, purchase and delivery of the Offer Shares in
accordance with the terms of this Agreement and on the execution and delivery of
this Agreement, which are or may be required to be paid, and against any value
added or similar taxes ("VAT") payable in connection with commissions and other
amounts payable or allowable by the Company and otherwise in connection with the
transactions contemplated by this Agreement.

              Section 3. Covenants of the Company.

                      The Company covenants with each Manager as follows:

                           (i)  The Company will advise Investmentbank Austria,
        promptly after receiving notice or obtaining knowledge thereof, and
        confirm the notice in writing, of (A) the issuance by the Commission of
        any stop order suspending the effectiveness of the Registration
        Statement, (B) the suspension of the qualification of any Shares of
        Common Stock for offering or sale in any jurisdiction or (C) the
        institution, threat or contemplation of any proceeding for any such
        purpose. The Company will make every reasonable effort to prevent the
        issuance of any such stop order and, if any such stop order is issued,
        to obtain the withdrawal thereof at the earliest possible moment.

                           (ii) The Company shall promptly notify Investmentbank
        Austria, on behalf of the Managers, of any material change affecting any
        of the representations and warranties set forth in Section 1 hereof at
        any time before the Closing Date (for Option Closing Date, as
        applicable), and the Company will take all actions

                                       10
   11
that may be reasonably requested by Investmentbank Austria to remedy such
material change. In the event it is necessary, in the reasonable opinion of any
of the Company, or Investmentbank Austria, to amend or supplement any of the
Offering Documents in order that the Offering Documents do not include any
untrue statement of a material fact or omit to state a material fact necessary
in order to make the statements therein not misleading in the light of the
circumstances then existing, the Company will forthwith amend or supplement the
Offering Documents by preparing and furnishing without charge to each Manager an
amendment or amendments of, or a supplement or supplements to, the Offering
Documents (in form and substance satisfactory in the reasonable opinion of
Investmentbank Austria so that, as so amended or supplemented, the Offering
Documents will not include an untrue statement of a material fact or omit to
state a material fact necessary in order to make the statements therein, in the
light of the circumstances existing at the time it is delivered, not
misleading). Neither Investmentbank Austria's consent to, nor the Managers'
delivery to offerees or investors of any amendment or supplement to the Offering
Documents shall constitute a waiver of any of the conditions set forth in
Section 5 hereof.

                    (iii) The Company shall use its best efforts to qualify the
Offer Shares for offering and sale in each jurisdiction that Investmentbank
Austria, on behalf of the Managers, shall designate and the Company shall
maintain such qualifications in effect for such period, not in excess of six
months from the date of this Agreement, as Investmentbank Austria, on behalf of
the Managers, may reasonably request in order to complete the placement of the
Offer Shares; provided, however, that the Company shall not be obligated to file
any general consent to service of process or to qualify as a foreign corporation
or as a securities dealer in any jurisdiction or to subject themselves to
taxation in respect of doing business in any jurisdiction in which they are not
otherwise so subject.

                    (iv)  Subject to requirements of applicable law and
regulations, prior to the Closing Date, the Company shall not, without prior
consent (such consent not to be unreasonably withheld) of Investmentbank
Austria, make any information relating to the Offering publicly available and
will not take any action that will result in their being obliged under listing
requirements or other obligations to shareholders generally to make available to
the public any information that may be material to a purchaser of the Offer
Shares prior to the expiration of three (3) months following the Closing Date.

                    (v) For a period of six (6) months after the Closing Date,
the Company shall not (A) except as otherwise required by applicable law, issue
any announcement in the Republic of Austria, Belgium, the United States or
elsewhere that could be material in the context of the Offering of the Offer
Shares without informing Investmentbank Austria within a reasonable period of
time prior to such announcement, or (B) issue, sell, offer or contract to issue,
sell, grant any option for the issuance or sale of, or otherwise dispose of
directly or indirectly, any interest in securities of the same class as the
Offer Shares or any securities convertible into, exchangeable for, or
representing the right to receive, any such securities of the same class as the
Offer Shares or other instruments representing interests in securities of the
same class as the Offer Shares without, in any such case, the prior written
consent of Investmentbank Austria, such consent not to be unreasonably withheld.

                                       11
   12
                      (vi) The Company shall deliver one copy of each Offering
Document to Investmentbank Austria, on behalf of the Managers, and of each
amendment or supplement thereto, signed by duly authorized members of the Board
of Directors of the Company.

                      (vii) The Company has made an application for all Shares
of Common Stock of the Company (including the Offer Shares) to be listed on
EASDAQ. In connection with the application, the Company will endeavor to obtain
the listing as promptly as practicable and will furnish any and all documents,
instruments, information and undertakings that may be necessary in order to
obtain such listing, and the Company shall use reasonable endeavors to cause
such listing to be continued so long as any of the Shares of Common Stock of the
Company remain outstanding; provided, however, that if such listing can no
longer be reasonably maintained, so long as any of the Shares of Common Stock of
the Company remain outstanding, the Company will use reasonable endeavors to
obtain and maintain a listing of the Shares of Common Stock on another stock
exchange as agreed by the Company and Investmentbank Austria on behalf of the
Managers.

                      (viii) For so long as Investmentbank Austria is acting as
a market maker or sponsor for the Company in connection with the listing of the
Company's Shares of Common Stock on EASDAQ, in any case, however, for a period
of 18 months following the Closing Date, the Company shall promptly provide
Investmentbank Austria with sufficient copies of its annual report, interim
financial statements, if any, press releases and other public announcements, any
other documents that the Company is, pursuant to the Continuing Obligations of
Companies Admitted to Trading on EASDAQ, required to file with and obliged to
disclose to EASDAQ in connection with the listing of the Company's Shares of
Common Stock on EASDAQ, and other documents or information as Investmentbank
Austria determines necessary to maintain such listing on EASDAQ. All fees and
expenses in connection with such listing shall be borne by the Company.

                      (ix) The Company will further, for a period of three (3)
years following the Closing Date, furnish to Investmentbank Austria, as soon as
practicable, copies of each document required to be filed by the Company with
any other stock exchange or stock exchanges, including without limitation,
NASDAQ, where the Offer Shares may have been listed, and copies of financial
statements and other periodic reports that the Company may furnish generally to
holders of its public debt securities or to its equity securities and, from time
to time, such other information concerning the Company as Investmentbank Austria
may reasonably request.

                      (x) The Company shall, for a period of three (3) years
after the Closing Date, furnish to Investmentbank Austria (and, upon request, to
each of the other Managers), as soon as practicable, copies of each document
required to be delivered by the Company pursuant to the reporting requirements
under the Securities and Exchange Act of 1934, as amended (the "1934 Act").

                                       12
   13
                      (xi) During the period of three (3) years after the
Closing Date, the Company shall not be or become an open-end investment company,
unit investment trust or face-amount certificate company that is required to be
registered under Section 8 of the 1940 Act, and is not, and will not be or
become, a closed-end investment company required to be registered under the 1940
Act.

            Section 4. Expenses.

           (A) The Company agrees to pay to Investmentbank Austria a
non-accountable expense allowance for costs and expenses incurred by
Investmentbank Austria in connection with the Offering (the "Non-Accountable
Expense Allowance") which shall consist of an amount (payable in German marks)
equal to the product of (i) * per Offer Share, and (ii) the Number of Offer
Shares to be purchased by the Managers pursuant to this Agreement. The
Non-Accountable Expense Allowance includes the following:         

           (a) all costs, expenses, fees, stamp or other duties or taxes
(including transfer taxes and issuance taxes, if any) in connection with the
issuance, purchase and delivery of the Offer Shares in Europe; (b) all fees and
expenses of Investmentbank Austria's legal advisers; (c) all costs, expenses,
fees, duties or taxes in connection with the printing and delivery of (x) the
Offering Documents and (y) Investmentbank Austria's research report regarding
the Company; (d) all costs and expenses incurred by Investmentbank Austria in
connection with press conferences, roadshows and any other public relations
activities; and (a) all travelling, accommodation, telex, telephone, facsimile,
postage and other out-of-pocket costs and expenses incurred by Investmentbank
Austria in connection with the Offering.

           (B) The Non-Accountable Expense Allowance does not include the
following costs and expenses, which the Company agrees to pay:

           (a) all costs, expenses, fees, duties or taxes in connection with the
admission and listing of the Shares of Common Stock to trading on EASDAQ,
including any costs, expenses and fees charged by the Belgian Banking and
Finance Commission ("BFC"); (b) all fees and expenses of the Company's
accountants, legal advisers and any other advisers; (c) all costs and expenses
incurred by the Company in connection with press conferences, roadshows and any
other public relations activities; (d) all fees, costs, expenses, stamp or other
duties related to the preparation, printing and filing of the Registration
Statement and any amendments thereto in the United States, including, without
limitation, filing of the Registration Statement with the Commission.

           (C) If this Agreement is terminated by Investmentbank Austria in
accordance with the provisions of Section 5(b) or Section 8(a) hereof, the
Company shall remain liable to pay to Investmentbank Austria all actual costs
and expenses incurred in connection with the contemplated Offering including,
without limitation, fees and expenses of Investmentbank Austria's legal
advisers, costs and expenses related to the printing and delivery of the
Offering Documents and research reports prepared by Investmentbank Austria
and costs and expenses in connection with roadshows.

            Section 5. Conditions of the Obligations of the Managers.

                 (a) The obligations of each Manager to purchase for itself
and pay for the Offer Shares that it has agreed to purchase hereunder are
subject to the following further conditions:

                                     13
   14
                  (A) At the Closing Date the Company shall have complied with
all agreements and satisfied all conditions on its part to be performed or
satisfied under this Agreement at or prior to the Closing Date.

                  (B) The representations and warranties of the Company set
forth in Section 1 hereof shall be accurate as though expressly made at and as
of the Closing Date. The Managers shall have received certificates of officers
of the Company to this respect, dated as of the Closing Date, in form and
substance satisfactory to Investmentbank Austria, on behalf of the Managers.

                  (C) No stop order suspending the effectiveness of the
Registration Statement shall have been issued, and no proceedings for that
purpose shall have been instituted or threatened or, to the knowledge of the
Company or Investmentbank Austria, shall be contemplated by the Commission and
the Company shall have complied with any request of the Commission for
additional information.

                  (D) The Offering Documents shall have been filed, approved and
published in accordance with applicable Belgian law and regulations.

                  (E) All Notices concerning the Offering required to be filed
under applicable law, regulations or listing requirements shall have been filed
with EASDAQ and the BFC and any publications and announcements required by
applicable laws and regulations shall have been made.

                  (F) All Shares of Common Stock (including the Offer Shares)
shall have been admitted to trading an EASDAQ.

                  (G) The Managers shall have received an opinion of Snow Becker
Krauss P.C., Counsel to the Company, dated as of the Closing Date, in form and
substance satisfactory to Investmentbank Austria, on behalf of the Managers,
with respect to legal matters relating to the Offer Shares and the Registration
Statement.

                  (H) The Managers shall have received an opinion of Hogan &
Hartson LLP, U.S. regulatory counsel to the Company, dated as of the Closing
Date, in form and substance satisfactory to Investmentbank Austria, on behalf of
the Managers, with respect to U.S. Federal Food, Drug and Cosmetics Act
regulatory matters relating to the Company. 

                  (I) The Managers shall have received an opinion of De Bandt,
Van Hecke & Lagae, Belgian Counsel to the Managers, dated as of the Closing
Date, in form and substance satisfactory to Investmentbank Austria, on behalf of
the Managers, with respect to Belgian legal matters relating to the Offering.

                  (J) The Company shall have furnished to Investmentbank
Austria, an behalf of the Managers, (x) on the date hereof, a letter of Ernst &
Young LLP as to the Company and its Subsidiaries, dated as of the date hereof
and in the form previously furnished to the Managers confirming that they are
Independent auditors with respect to the Company, consenting to the use of the
Financial Statements in the Offering Documents and commenting upon the Financial
Statements and their reports thereon and other information in the Offering
Documents, and (y) at the Closing Date, a letter of Ernst & Young LLP, dated as
of the date thereof, in form and substance satisfactory to Investmentbank
Austria, on behalf of the Managers, which shall confirm in all material
respects, as of the date of such letter (or, with respect to matters involving
changes or developments since the respective dates as of which specified
financial information is given in the Offering Documents, as of a date not more
than five days prior to the date of such letter), the conclusions and findings
of Ernst & Young LLP with respect to the financial information and other matters
covered in the letters previously delivered to the Managers.

                  (K) All corporate proceedings and other legal matters incident
to the authorization, form and validity of this Agreement and the Offer Shares
and the form of the Offering Doc-

                                       14
   15
uments, other then financial statements and other financial data, and all other
legal matters relating to this Agreement and the transactions contemplated
herein shall be reasonably satisfactory in all respects to Investmentbank
Austria, on behalf of the Managers.

                 (b) If any condition specified in this Section 5 shall not
have been fulfilled when and as required to be fulfilled, Investmentbank
Austria, on behalf of the Managers, has the right to terminate this. Agreement
by notice to the Company at any time at or prior to the Closing Date, and such
termination shall be without liability of any party to any other party except as
provided in Section 4(C) and except that Sections 7, 8, 10, 11 and 12 shall
remain in full force and effect.

            Section 6. Obligations of the Managers.

                 (a) Each Manager represents that it has observed and undertakes
that it will observe the following restrictions on offers and sales of the Offer
Shares and the distribution of documents relating to the Offer Shares:

                       (i) Each Manager represents and agrees that (A) it has
    not offered or sold and, prior to the expiry of six months from the Closing
    Date, it will not offer or sell any Offer Shares to persons in the United
    Kingdom, except to persons whose ordinary activities Involve them In
    acquiring, holding, managing or disposing of investments (as principal or
    agent) for the purposes of their businesses or otherwise in circumstances
    which do not constitute an offer to the public in the United Kingdom within
    the meaning of the Public Offers of Securities Regulations 1995 (the
    "Regulations"), (B) it has complied and will comply with all applicable
    provisions of the Financial Services Act 1986 and the Regulations with
    respect to anything done by it in relation to the Offer Shares in, from or
    otherwise involving the United Kingdom, and (C) it has only issued or passed
    on and will only issue or pass on to any person in the United Kingdom any
    document received by it in connection with the offer and sale of the Offer
    Shares if that person is of a kind described in Article 11 (3) of the
    Financial Services Act 1986 (Investment Advertisements) (Exemptions) Order
    1995 or is a person to whom such document may otherwise lawfully be issued
    or passed on.

                       (ii) Each Manager will comply with all applicable laws
    and regulations in each jurisdiction in which it acquires, offers, sells or
    delivers Offer Shares or has in its possession or distributes any Offering
    Documents or any other offering material. Each Manager understands that no
    action has been or will be taken in any jurisdiction that would permit a
    public offering of the Offer Shares or distribution of any Offering
    Documents or any other offering material, in any country or jurisdiction
    where action for that purpose is required. Each Manager agrees that it will
    not make any representation or use any information in connection with the
    offering, sale, delivery or resale of the Offer Shares other than as
    contained in the Offering Documents.

                 (b) Investmentbank Austria agrees to act as market maker and
sponsor for the Company in connection with the listing of the Company's Shares
of Common Stock on EASDAQ, provided that no material adverse change in the
condition, financial situation or otherwise, or in the earnings, business
affairs or business prospects of the Company occurs. Investmentbank Austria
agrees not to charge a fee for the first year of its market maker and sponsor
activities. For the following years Investmentbank Austria and the Company shall
endeavor

                                       15
   16
to agree on a reasonable annual fee, provided that if the parties do not reach a
agreement on such annual fee Investmentbank Austria shall have no further
obligation to act as a market maker and/or sponsor for the Company.

      Section 7. Indemnification.

                 (a) The Company will indemnify and hold harmless each Manager
and each person, if any, who controls any Manager within the meaning of the 1933
Act or the 1934 Act or other applicable laws against any losses, claims, damages
or liabilities, joint or several, to which such Manager may become subject,
under the 1933 Act or the 1934 Act or other applicable laws, insofar as such
losses, claims, damages or liabilities (or actions in respect thereof) arise out
of or are based upon any breach of any of the representations, warranties or
obligations of the Company contained herein or any untrue statement or alleged
untrue statement of any material fact contained in the Offering Documents or the
Registration Statement, or arise out of or upon the omission or alleged omission
to state in the Offering Documents and Registration Statement a material fact
required to be stated therein or necessary in order to make the statements
therein, in the light of the circumstances under which they were made, not
misleading. In addition, the Company shall reimburse each Manager for any legal
or other expenses reasonably incurred by such Manager in connection with
investigating or defending any such loss, claim, damage, liability or action as
such expenses are incurred.

                 (b) Promptly after receipt by an indemnified party under this
Section 7 of notice of the commencement of any action, such indemnified party
will, if a claim in respect thereof may be made against the indemnifying party
under subsection (a) above, notify the indemnifying party of the commencement
thereof; but the omission to so notify the indemnifying party will not relieve
any indemnifying party from any liability which it may have to any indemnified
party otherwise then under subsections (a) above. In case any such action is
brought against any indemnified party, any indemnifying party will be entitled
to participate therein at its own cost and expense. No indemnifying party shall,
without the prior written consent of the indemnified party, effect any
settlement of any pending or threatened action in respect of which any
indemnified party is or could have been a party and indemnity could have been
sought hereunder by such indemnified party unless such settlement includes an
unconditional release of such indemnified party from all liability on any claims
that are the subject matter of such actions.

                 (c) The obligations of the Company under this Section 7 shall
be in addition to any liability that the Company may otherwise have and shall
extend, upon the same terms and conditions, to each person, if any, who controls
any Manager within the meaning of the 1933 Act or the 1934 Act or other
applicable laws.

      Section 8.  Termination.

                 (a) Investmentbank Austria, on behalf of the Managers, has the
right to terminate this Agreement, after prior consultation with the Company to
the extent practicable, by notice given to the Company at any time at or prior
to the Closing Date, if, in the opinion of Investmentbank Austria, on behalf of
the Managers:

                        (i) there has been, since the date hereof or since the
     respective, dates as of which information is given in the Offering
     Documents, any material adverse change in the condition, financial or
     otherwise, or in the earnings, business

                                       16
   17
      affairs or business prospects of the Company and its Subsidiaries
      considered as one enterprise, whether or not arising in the ordinary
      course of business; or

                          (ii) there has occurred any material adverse change in
      the financial markets in the United States, the Republic of Austria or any
      other European Union market, or any outbreak of hostilities or escalation
      thereof or other calamity or crisis or any change or development involving
      a prospective change in national or international political, financial or
      economic conditions, in each case the effect of which is such as to make
      it, in the judgment of Investmentbank Austria, impracticable to market the
      Offer Shares or to enforce contracts for the sale of the Offer Shares; or

                         (iii) trading in any securities of the Company has been
      suspended or limited by NASDAQ or the Pacific Stock Exchange Incorporated
      or if trading generally on EASDAQ, NASDAQ or the New York Stock Exchange
      shall have been suspended, or maximum ranges for prices for securities
      have been required, or minimum or maximum prices for trading have been
      fixed, by said exchange or by order of any governmental authority; or

                          (iv) trading in the Shares of Common Stock or other
      securities of the Company have been suspended by the Commission or the
      NASD; or

                          (v) a banking moratorium shall have been declared or
      exchange controls imposed by either U.S. federal or New York authorities
      or by the relevant authorities in the Republic of Austria or in any other
      country of the European Union.

                 (b) If this Agreement is terminated pursuant to this Section 8,
such termination shall be without liability of any party to any other party,
except as provided in Section 4(C) hereof and except that Sections 7, 8, 10, 11
and 12 shall remain in full force and effect.

      Section 9. Stabilization.

     Investmentbank Austria may, to the extent permitted by applicable laws,
effect transactions in any over-the-counter market or otherwise in connection
with the distribution of the Offer Shares with a view to stabilizing or
maintaining the market price of the Shares of Common Stock at levels other than
those that might otherwise prevail in the open market but in doing so
Investmentbank Austria shall act as principal and not as agent of the Company
and any loss resulting from such stabilization will be borne, and any profit
arising from it shall be retained, by Investmentbank Austria.

                                       17
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Section 10. Notice and Authority.

                 (a) All notices and communications hereunder shall be furnished
to the parties at the addresses listed below. Notices and communications shall
be deemed to have been duly given if in writing and delivered personally against
receipt, or sent by registered or certified mail, return receipt requested,
postage prepaid, or if sent by facsimile transmission with confirmation of
receipt, addressed as follows:

                              (i) to the Managers:

                 Investmentbank Austria
                 Aktiengesellschaft
                 Nibelungengasse 15
                 A-1010 Vienna
                 Austria

                 Facsimile no: +43-1-58884-636
                 Telephone no: +43-1-58884-630
                 Attention:  Corporate Finance

                 __________________
                 __________________
                 __________________

                Facsimile no:  _________________
                Telephone no:  _________________
                Attention:     _________________

                              (ii) to the Company:

                 Integrated Surgical System, Inc.
                 829 West Stadium Lane
                 Sacramento, California 95834
                 USA

                Facsimile no: +1-916 646-4075
                Telephone no: +1-916-646-3437
                Attention: _____________________

                              (iii)  to Value Management & Research GmbH

                 __________________
                 __________________
                 __________________

                Facsimile no:  _________________
                Telephone no:  _________________
                Attention:     _________________

                                       18
   19
or to such other address as shall be furnished in writing by any party to the
other party, and such notice or communication shall be deemed to have been given
as of the date, indicated on the written receipt in the case of personal or
registered or certified mail delivery, or as of the date, indicated on the
confirmation in the case of facsimile transmission.

                 (b) Investmentbank Austria is hereby authorized by each Manager
to act on behalf of it as specified herein and in relation to all matters
requiring the consent or agreement of such Manager under this Agreement.

        Section 11. Governing Law and Jurisdiction; Competent Court.

           This Agreement shall be governed by and construed and enforced in
accordance with English law.

           The courts of England are to have jurisdiction to settle any disputes
which may arise out of or in connection with this Agreement and accordingly
any litigation or proceedings arising out of or in connection with this
Agreement (the "Proceedings") may be brought in such courts. Each of the
Company and each of the Managers hereby irrevocably submits itself for all
purposes for or in connection with this Agreement to the jurisdiction of the
courts of England and waives any objection to Proceedings in such courts
whether on the ground of venue or on the ground that the Proceedings have been
brought in an inconvenient forum.
  
           The Company and each of the Managers hereby irrevocably
appoints          (or such other person or persons with an address in England)
as its agent or agents to accept service of process on its behalf in any action
based on this Agreement which may be instituted in England. The Company and
each of the Managers will procure that there shall be in force an appointment
of such a person with an office in England with authority to accept service as
aforesaid on behalf of the Company or each of the Managers, as the case may be.

           Notwithstanding the foregoing, any suit, action or proceeding arising
out of or in connection with this Agreement may be instituted by the Managers in
any competent court in the Republic of Austria or elsewhere.

        Section 12.  Severability; Counterparts; Headings.

           If any provision of this Agreement is determined by a court of
competent jurisdiction to be invalid, illegal or unenforceable, the remainder of
the provisions of this Agreement shall remain in full force and effect. Upon
such determination, the parties shall negotiate in good faith to promptly
replace the invalid, illegal or unenforceable provisions with valid provisions
the economic and substantive effect of which shall be as close as possible to
that of the invalid, illegal or unenforceable provisions and the original
intention of the parties.

           This Agreement may be executed in counterparts and, when a
counterpart has been executed by each party, all such counterparts taken
together shall constitute one and the same agreement. The section headings
herein are for convenience only and shall not affect the construction hereof.

                                       19
   20
IN WITNESS WHEREOF, the parties mentioned below have caused this Agreement to be
executed in *, on the date first written above by their respective duly
authorized representatives.

          Integrated Surgical Systems, Inc.

          By:_____________________
          Name:
          Title:

                                       20
   21
                  The foregoing Agreement is hereby accepted in London, England,
as of the date first written above.

Investmentbank Austria Aktiengesellschaft

By:_________________________
Name:
Title:

By:_________________________
Name:
Title:

*

By:_________________________
Name:
Title:

Acknowledged and consented to:

Value Management & Research GmbH

By:_________________________
Name:
Title:

                                       21
   22
                                                                      SCHEDULE A
                                    Offering
                                                                      Number of
Name of Manager                                                       New Shares
- ----------------                                                      ----------

Investmentbank Austria Aktiengesellschaft .......................          *
* ...............................................................
Total Offering ..................................................          *

   1
                                                                     Exhibit 5.1

                             SNOW BECKER KRAUSS P.C.
                                Attorneys at Law
                                605 Third Avenue
                            New York, New York 10158
                                     ------
                                 (212) 687-3860

                                                 September 19, 1996

Board of Directors
Integrated Surgical Systems, Inc.
829 West Stadium Lane
Sacramento, California  95834

Ladies and Gentlemen:

                  You have requested our opinion, as counsel for Integrated
Surgical Systems, Inc., a Delaware corporation (the "Company"), in connection
with the registration statement (the "Registration Statement") on Form SB-2
(Registration No. 333-31481), under the Securities Act of 1933 (the "Act"),
filed by the Company with the Securities and Exchange Commission.

                  The Registration Statement relates to (i) an offering of up to
3,737,500 shares (the "Shares") of common stock, par value $0.01 ("Common
Stock"), of the Company and (ii) warrants (the "Warrants") to purchase up to
325,000 shares of Common Stock (the "Warrant Shares") to be issued to the
managers and certain other persons participating in the distribution of the
Shares.

                  We have examined such records and documents and made such
examinations of law as we have deemed relevant in connection with this opinion.
It is our opinion that when there has been compliance with the Act and the
applicable state securities laws:
   2
Integrated Surgical Systems, Inc.
September 19, 1997
Page 2

         (1)      The Shares have been duly authorized and, when issued,
                  delivered and paid for in the manner described in the form of
                  Purchase Agreement filed as Exhibit 1.1 to the Registration
                  Statement (the "Purchase Agreement"), will be legally issued,
                  fully paid and nonassessable.

         (2)      The Warrants have been duly authorized, and when issued and
                  paid for in the manner described in the Registration
                  Statement, will be legally issued, fully paid and
                  non-assessable, and will constitute valid and legally
                  binding obligations of the Company, except as limited by
                  applicable bankruptcy, insolvency, reorganization, moratorium
                  or other laws of general application relating to the
                  availability of remedies (regardless of whether such
                  enforcement is considered in a proceeding in equity or at
                  law).

         (3)      The Warrant Shares have been duly authorized and, when issued,
                  delivered and paid for in the manner described in the
                  Registration Statement, will be legally issued, fully paid and
                  nonassessable.

                  We hereby consent to the filing of this opinion as an exhibit
to the Registration Statement and to the reference to our firm under the caption
"Legal Matters" in the Registration Statement. In so doing, we do not admit that
we are in the category of persons whose consent is required under Section 7 of
the Act or the rules and regulations of the Securities and Exchange Commission
promulgated thereunder.

                                                     Very truly yours,

                                                     /s/ Snow Becker Krauss P.C.

                                                     SNOW BECKER KRAUSS P.C.
   1

                                                                EXHIBIT 10.10

                            STOCK PURCHASE AGREEMENT

         THIS AGREEMENT is made and entered into this fifth day of September
1997,

By:

INTEGRATED SURGICAL SYSTEMS, Inc., a company registered under the laws of
Delaware, United States of America, having its headquarters at 829, West Stadium
Lane, Sacramento, California, 95834, United States of America, represented by
its President and Chief Executive Officer, Mr. Ramesh Trivedi (hereinafter the
"Buyer"),

                                                             on the one hand,

And:

- - Mrs. Farideh DANEL, a French citizen, residing at Chemin des Bouts, 38330
Saint Ismier, France,

- - Mr. Francois DANEL, a French citizen, residing at Chemin des Bouts, 38330
Saint Ismier, France,

- - Mr. Gerard HASCOET, a French citizen, residing at 10, avenue du Colonel
Bonnet, 75016 Paris, France,

- - Mr. Jerome LEBON, a French citizen, residing at 6, rue Emile Zola, 69002 Lyon,
France

- - Mr. Jean-Luc BOULNOIS, a French citizen, residing at 17 Scott Road, MA 02173
Lexington, USA,

- - Mr. Fernand BADANO, a French citizen, residing at 4, allee Marcel Achard,
69100 Villeurbanne, France,

- - Mr. Pierre WUERGLER, a Swiss citizen, residing at c/o Credit Suisse,
Paradeplatz 8, 8070 Zurich, Switzerland, duly represented by Mr. Georges-Henri
Meylan, pursuant to the power of attorney attached as Annex A,

                                       1
   2
- - Mr. Georges-Henri MEYLAN, a Swiss citizen, residing at Route du Ruisseau 1,
1348 Le Brassus, Switzerland,

- - Mr. Enzo FILIPPINI, a Swiss citizen, residing at 6803 Camignolo, Switzerland,
duly represented by Mr. Georges-Henri Meylan, pursuant to the power of attorney
attached as Annex A,

- - Mr. Pierre Angelo BOTTINELLI, a Swiss citizen, residing at Chemin des
Trembles, 1261 Genolier, Switzerland, duly represented by Mr. Georges-Henri
Meylan, pursuant to the power of attorney attached as Annex A,

- - Mr. Gulio MERLANI, a Swiss citizen, residing at Via Alla Chiesa, 6932
Breganzona, Switzerland, duly represented by Mr. Georges-Henri Meylan, pursuant
to the power of attorney attached as Annex A,

- - Mr. Serge TSCHOPP, a Swiss citizen, residing at avenue des Cerisiers 45, 1009
Pully, Switzerland, duly represented by Mr. Georges-Henri Meylan, pursuant to
the power of attorney attached as Annex A,

- - Mr. Raymond BORNAND, a Swiss citizen, residing at Chemin du Cret 12, 1110
Morges, Switzerland, duly represented by Mr. Georges-Henri Meylan, pursuant to
the power of attorney attached as Annex A,

- - Mr. Jacques-Louis AUDEMARS, a Swiss citizen, residing at Valneige, 1348 Le
Brassus, Switzerland, duly represented by Mr. Georges-Henri Meylan, pursuant to
the power of attorney attached as Annex A,

- - Mr. Mohamed DIAB, a Swiss citizen, residing at 11 Chemin des Pecheurs, Vouvry,
Switzerland,

- - GEMED SA, a Swiss societe anonyme, having its registered address at Route de
France 16, 1348 Le Brassus, Switzerland, with registered capital of 100,000
Swiss francs, and registered with the Commerce Registry under the number 3/173
represented by Mr. Georges-Henri Meylan, Chairman of the board of directors and
by Mr. Pierre Dubois, Director, both duly empowered to enter into this Agreement
pursuant to a decision of the board of directors of August 7,1997

(hereinafter defined as the "Sellers" and in Article 1 as the "Shareholders of
IMMI"),

                                                          on the other hand.

         WHEREAS, the Sellers are the owners of (i) twenty five thousand two
hundred and twenty five (25,225) shares, (ii) four thousand seven hundred and
eighty nine (4,789) warrants ("bons de souscription"), and (iii) two thousand
one hundred and forty three (2,143) convertible debentures ("obligations
convertibles en actions") of IMMI, a French societe anonyme having its
registered office at 

                                       2
   3
Universite Claude Bernard - rue Guillaume Paradin - 69372 Lyon Cedex, with
registered capital of 3,581,950 French francs, and registered at the Register of
Commerce and Companies of Lyon under the number B 392 277 828 (hereinafter the
"Company").

         As of the date of this Agreement, the sole and exclusive owners of all
the shares, warrants and convertible debentures of the Company are the Sellers
listed hereinafter:

- -----------------------------------------------------------------------------------------------
                                                                      NUMBER OF 
                                NUMBER OF          NUMBER OF         CONVERTIBLE          
          SELLERS                 SHARES           WARRANTS          DEBENTURES           TOTAL
- -----------------------------------------------------------------------------------------------
                                                                                
Mme Farideh DANEL                  4187                                                    4187
- -----------------------------------------------------------------------------------------------
M. Francois DANEL                  3279                                                    3279
- -----------------------------------------------------------------------------------------------
M. Gerard HASCOET                  6342              3732                                 10074
- -----------------------------------------------------------------------------------------------
M. Jerome LEBON                    1761                                                    1761
- -----------------------------------------------------------------------------------------------
M. Jean-Luc BOULNOIS               1491                                                    1491
- -----------------------------------------------------------------------------------------------
M. Fernand BADANO                   282                                                     282
- -----------------------------------------------------------------------------------------------
GEMED SA                           4175               565                1144              5884
- -----------------------------------------------------------------------------------------------
M. WUERGLER                         994               135                 273              1402
- -----------------------------------------------------------------------------------------------
M. Georges Henri MEYLAN             457                52                 106               615
- -----------------------------------------------------------------------------------------------
M. Enzo FILIPINI                    386                52                 106               544
- -----------------------------------------------------------------------------------------------
M. P.A. BOTINELLI                   386                52                 106               544
- -----------------------------------------------------------------------------------------------
M. MERLANI                          386                52                 106               544
- -----------------------------------------------------------------------------------------------
M. S. TSCHOPP                       386                52                 106               544
- -----------------------------------------------------------------------------------------------
M. R. BORNAND                       386                52                 106               544
- -----------------------------------------------------------------------------------------------
M. Jacques-Louis                    232                31                  63               326
 AUDEMARS                         
- -----------------------------------------------------------------------------------------------
M. Mohammed DIAB                     95                14                  27               136
- -----------------------------------------------------------------------------------------------
                                 
                  TOTAL           25225              4789                2143             32157
- -----------------------------------------------------------------------------------------------

         The Sellers' shares, warrants and convertible debentures are
hereinafter collectively referred to as the "Shares". The Sellers wish to sell
and the Buyer agrees to buy all of the Shares subject to the terms of this
Agreement.

         NOW, THEREFORE, in consideration of the foregoing and the respective
representations, warranties, covenants, agreements and conditions hereinafter
set forth, and intending to be legally bound hereby, THE PARTIES HERETO AGREE AS
FOLLOWS:

                                       3
   4
                                    ARTICLE 1
                           PURCHASE AND SALE OF SHARES

         1.1. Shares to be Sold. At the Date of Closing (as hereinafter defined)
the Sellers shall sell and transfer all the Shares to Buyer, and Buyer shall
purchase and accept all the Shares from Sellers. At the Date of Closing, the
Shares shall constitute all of the issued and outstanding capital stock of the
Company.

         1.2 Purchase Price for the Shares - Payment. The aggregate purchase
price for the Shares shall be paid by delivery of six hundred nineteen thousand
three hundred and fifty five (619,355) shares of Buyer's common stock, with a
par value of 0,01 US dollars (the "Purchase Price Shares"). The Purchase Price
Shares has been determined based on the quoted price at Nasdaq of the shares of
Buyer's common stock at the close of the trading day on July 10, 1997 of 7.75 US
dollars a share.

         Buyer will issue the Purchase Price Shares to Sellers in an offering to
be made in accordance with the terms of Regulation S promulgated under the
United States Securities Act of 1933, as amended (the "Act") or Section 4(2) of
the Act or other applicable exemptions from registration.

         After issuance of the Purchase Price Shares on the Date of Closing,
they will be immediately freely tradeable outside the United States (subject to
the securities laws of jurisdictions other than the United States) and tradeable
in the United States after the Date of Closing in accordance with the United
States securities laws as provided below.

         The Buyer undertakes to file a Registration Statement on Form S-3 (or
such other form as may be needed in accordance with the applicable rules of the
Securities and Exchange Commission) with the Securities and Exchange Commission
on November 21, 1997, or as soon thereafter as is practicable, for the
registration on behalf of the Sellers of 619,355 shares of capital stock of
Buyer. In addition to the Registration Statement on Form S-3 permitting the
Shareholders of IMMI to sell shares of capital stock of Buyer upon the
effectiveness, said Shareholders of IMMI who are foreign persons may sell shares
of capital stock of Buyer notwithstanding the foregoing, subject to Regulation S
promulgated under the Securities Act of 1933, as amended (the "Act"), which
permits sales for 40 days, provided such sales are not otherwise deemed to
constitute part of a distribution. For a period of eighteen months following the
Date of Closing, the Shareholders of IMMI may only sell shares of capital stock
of Buyer received by said Shareholders of IMMI in the aggregate as follows:

         (i) during the first quarter following the Date of Closing - 50,000
         shares;

         (ii) during the second quarter following the Date of Closing - 50,000
         shares plus 1% of the total shares of capital stock of Buyer traded on
         the Nasdaq Stock Market, during the first quarter;

                                       4
   5
         (iii) during the third quarter following the Date of Closing - 75,000
         shares plus 1% of the total shares of capital stock of Buyer traded on
         the Nasdaq Stock Market during the second quarter;

         (iv) during the fourth quarter following the Date of Closing - 100,000
         shares plus 1% of the total shares of capital stock traded on the
         Nasdaq Stock Market in the third quarter, and

         (v) during the fifth quarter following the Date of Closing - 100,000
         shares plus 1% of the total shares of capital stock traded on the
         Nasdaq Stock Market in the fourth quarter, and

         (vi) during the sixth quarter following the Date of Closing - 100,000
         shares plus 1% of the total shares of capital stock traded on the
         Nasdaq Stock Market in the fifth quarter.

         After the sixth quarter, the Shareholders of IMMI may sell shares of
Buyer subject to Rule 144 of the Act (as in effect as of the date hereof) for a
period of six months thereafter and, after two years from the Date of Closing,
the Shareholders of IMMI may sell the balance of the shares owned by them of
Buyer pursuant to Rule 144(k) of the Act (as in effect as of the date hereof).

         1.3.     Closing. The Closing (the "Closing") shall take place on the
date hereof (the "Date of Closing") at the offices of GEMED, Route de France 16,
1348 Le Brassus, Switzerland.

         1.4.     Deliveries by Sellers. At the Closing, the Sellers shall 
deliver the following to the Buyer:

                  (a) Transfer deed of Shares (the "Ordres de mouvement") signed
         by the Sellers, (including the shares ("actions"), convertible
         debentures ("obligations convertibles") and warrants ("bons de
         souscription"));

                  (b) The minutes of the meeting of the Board of Directors of
         the Company approving this Agreement and the Buyer as transferee of the
         Shares in compliance with article 11.2 of the by-laws of the Company
         (Board minutes of August 11, 1997), and other actions the Buyer may
         reasonably request;

                  (c) The resignation, effective as of the Date of Closing of
         all directors of the Company (save for Mr. Hascoet), and of all
         Directors and Officers of Innovative Medical Machines International,
         Inc., without any payment nor indemnity;

                  (d) A release certificate by Bank San Paolo of any pledge on
         the Shares of Mr. Jerome Lebon;

                                       5
   6
                  (e) A waiver, duly signed by all the Sellers, to all accrued
         interest as of the Date of Closing on all convertible debentures issued
         by the Company;

                  (f) The written agreements of banks "Societe Generale" and
         "Banque Populaire Du Dauphine Et Des Alpes Du Sud" undertaking to
         release the Company of the joint pledge of second rank on the going
         business ("fonds de commerce") of the Company given on July 10, 1996,
         subject to the remittance by the Buyer of the surety agreements
         referred to in Article 1.5.2, and instructing the public notary
         ("notaire") to carry out all legal formalities to effect these
         releases;

                  (g) The written agreement of bank "Societe Generale" releasing
         the Company of the pledge of third rank on the going business ("fonds
         de commerce") of the Company given on March 24, 1997, subject to the
         remittance by the Buyer of the surety agreement referred to in Article
         1.5.2; and instructing the public notary ("notaire") to carry out all
         legal formalities to effect this release;

                  (h) The letter of the Company, sent by registered mail,
         notifying Anvar of the the proposed sale of the Shares of the Company
         to the Buyer;

                  (i) The legal opinion of Counsel of the Sellers in the form
         attached as Annex 1.4 (j);

                  (j) The following financial statements in conformity with
         Regulation S-X promulgated under the Securities Act of 1933, as
         amended: balance sheet at December 31, 1996; statements of income, cash
         flows and changes in stockholders' equity for years ended December 31,
         1996 and December 31, 1995; balance sheet at June 30, 1997; statements
         of income, cash flows and changes in stockholders' equity for the six
         month period ended June 30, 1997;

                  (k) The written agreement between the Sellers terminating any
         shareholders' agreement which may have existed, with effective date of
         termination on the date of Closing;

                  (l) The debt forgiveness agreement duly signed by Mr. Hascoet,
         Mr. Danel;

                  (m) The Registration Rights Agreement dated as of the date of
         this Agreement duly signed and executed by and among the Sellers and
         the Buyer.

                                       6
   7
         1.5. Deliveries by the Buyer.

         1.5.1.   At the Closing, the Buyer shall deliver to the Sellers:

                  (a) The Purchase Price Shares represented by the certificates
         for the 619,355 shares of capital stock of Buyer, bearing appropriate
         restrictive legends, which shall be delivered as follows to the
         Sellers:

                                       Number of shares of           
         Sellers                      common stock of Buyer            Legends
         -------                      ---------------------            -------
                                                                 
- - Mrs. Farideh DANEL                           80,643                   A   C
- - Mr. Francois DANEL                           63,155                   A   C
- - Mr. Gerard HASCOET                          194,028                   A   C
- - Mr. Jerome LEBON                             33,917                   A   C
- - Mr. Jean-Luc BOULNOIS                        28,717                   A   B
- - Mr. Fernand BADANO                            5,431                   A   C
- - Mr. Pierre WUERGLER                          27,003                   A   C
- - Mr. Georges-Henri MEYLAN                     11,845                   A   C
 - Mr. Enzo FILIPINI                           10,478                   A   C
- - Mr. Pierre Angelo BOTTINELLI                 10,478                   A   C
- - Mr. Julio MERLANI                            10,478                   A   C
- - Mr. Serge TSCHOPP                            10,478                   A   C
- - Mr. Raymond BORNAND                          10,478                   A   C
- - Mr. Jacques-Louis AUDEMARS                    6,279                   A   C
- - Mr. Mohamed DIAB                              2,619                   A   C
- - GEMED SA                                    113,328                   A   C
                                                                
                         Total:               619,355           

The certificates evidencing the Purchase Price Shares shall be endorsed with the
following legends:

A: THE SHARES OF COMMON STOCK REPRESENTED BY THIS CERTIFICATE HAVE BEEN ISSUED
PURSUANT TO A STOCK PURCHASE AGREEMENT DATED SEPTEMBER 5, 1997 AND HAVE NOT BEEN
REGISTERED WITH THE SECURITIES AND EXCHANGE COMMISSION UNDER THE SECURITIES ACT
OF 1933, AS AMENDED ("THE ACT") OR THE SECURITIES COMMISSION OF ANY STATE UNDER
ANY STATE SECURITIES LAWS.

B: (FOR PURCHASE PRICE SHARES ISSUED PURSUANT TO THE EXEMPTION PROVIDED BY
SECTION 4(2) AND REGULATION D THEREUNDER:). THE SHARES HAVE BEEN ISSUED PURSUANT
TO THE EXEMPTION FROM THE REGISTRATION REQUIREMENTS OF THE ACT PROVIDED BY
SECTION 4(2) AND REGULATION D PROMULGATED THEREUNDER. THEY MAY NOT BE OFFERED,
SOLD OR OTHERWISE TRANSFERRED WITHOUT REGISTRATION UNDER THE ACT OR AN OPINION
OF COUNSEL TO THE COMPANY THAT AN EXEMPTION FROM THE REGISTRATION REQUIREMENTS
OF THE ACT IS AVAILABLE.

                                       7
   8
C: (FOR PURCHASE PRICE SHARES ISSUED PURSUANT TO REGULATION S:) THE SHARES HAVE
BEEN ISSUED PURSUANT TO THE SAFE HARBOR PROVIDED BY REGULATION S PROMULGATED
UNDER THE ACT. THE SHARES MAY NOT BE OFFERED, SOLD, OR OTHERWISE TRANSFERRED IN
THE UNITED STATES OR TO U.S. PERSONS (AS SUCH TERM IS DEFINED IN REGULATION S)
UNLESS THEY ARE REGISTERED UNDER THE ACT AND APPLICABLE STATE SECURITIES LAWS,
OR SUCH OFFERS, SALES AND TRANSFERS ARE MADE PURSUANT TO AN AVAILABLE EXEMPTION
FROM THE REGISTRATION REQUIREMENTS OF THOSE LAWS.

                  (b) The Registration Rights Agreement dated as of the date of
         this Agreement duly signed and executed by and among the Buyer and the
         Sellers.

                  1.5.2.  At the Closing, the Buyer shall deliver to:

         (a) Bank "Societe Generale" and to Bank "Banque Populaire Du Dauphine
Et Des Alpes Du Sud" two surety agreements ("cautionnement") to guarantee, in
the event of default of the Company occurring after the Date of Closing, the
reimbursement by the Company of two loans agreements each in a respective amount
of FF 1,000,000 entered into by the Company in a single agreement dated July
10,1996.

         (b) Bank "Societe Generale" a a surety agreement ("cautionnement") to
guarantee, in the event of default of the Company occurring after the Date of
Closing, the reimbursement by the Company of a loan agreement in an amount of
FF. 350,000 entered into by the Company on March 24,1997.

                                    ARTICLE 2
                    REPRESENTATIONS AND WARRANTIES OF SELLERS

                  The Sellers hereby jointly and severally make the
representations and warranties set forth in this Article 2. For the purposes
hereof, "knowledge of the Sellers" shall include matters known to any of the
Sellers or the Company. When reference is made to any event, change or effect
having a "Material Adverse Effect", this reference shall mean that this event,
change or effect materially harms or is reasonably likely to materially harm the
business, operations, prospects, assets (including intangible assets), liability
(including contingent liabilities), financial situation or operation profits of
the Company, or that this event, change or effect delays or is reasonably likely
to delay or prevents or is reasonably likely to prevent the consumation of the
transactions contemplated by this Agreement.

                  2.1. Corporate Organization. The Company is a societe anonyme
duly organized and validly existing under French law. It has the corporate power

                                       8
   9
and authority to own or lease its properties and to carry on its business in the
manner in which it is currently conducted. Save for a wholly owned subsidiairy
incorporated under the name Innovative Medical Machines Inc., registered under
the laws of the State of Delaware United States, the Company does not, directly
or indirectly, have any equity interest or other property interest in any
company, joint venture, partnership, association or other entity. Complete and
correct copies of the certificate of incorporation and by-laws (the
"Constitutive Documents") are attached as Annex 2.1. The Company has not stopped
making payments, declared a moratorium on payments of its debts, is not in
bankruptcy or reorganization or liquidation, has not entered into an assignment
for the benefit of its creditors and has not become subject to any
reorganization procedure.

                  2.2. Authorization. The Sellers have the requisite capacity to
enter into this Agreement and the other agreements to be executed and delivered
by the Sellers pursuant hereto (the "Additional Sellers' Documents") and to
carry out the transactions contemplated hereby and thereby. When fully executed
and delivered, this Agreement and each of the Additional Sellers' Documents will
constitute the valid and binding agreements of the Sellers, enforceable against
the Sellers in accordance with their respective terms.

                  2.3. Capitalization. As of the date of this Agreement, the
share capital of the Company is as set forth in the preamble to this Agreement.
All the shares ("actions") have been validly issued and are fully paid,
nonassessable and free of any lien, preemptive rights or other restrictions with
respect thereto (save for the restriction enacted by article 11.2 of the by-laws
of the Company concerning the prior consent of the board of the directors for
the sale of shares "actions" to a non-shareholder). All the warrants and
convertible debentures ("bons de souscription en actions", and "obligations
convertibles an actions") have been validly issued, have not been converted into
shares ("actions") and are nonassessable and free of any lien, preemptive rights
or other restrictions with respect thereto. The Shares are held by the Sellers
as set out in the table in the preamble to this Agreement. There is no agreement
or commitment which could result in the Company having to purchase, amortize,
issue or transfer the Shares of the Company in any manner whatsoever.

                  2.4. Ownership of Shares. On the Date of Closing, the Buyer
will acquire all rights to the Shares free of any liens, pledges, charges or
encumbrances. No Seller has granted any rights to any individual or entity to
purchase any of the Shares.

                  2.5. Consents and Approvals; Non-Contravention. Neither the
execution, delivery or performance of this Agreement or of any related
documents, nor the consummation by the Company or the Sellers of the
transactions contemplated hereby or thereby, nor compliance by the Company or
the Sellers with any of the provisions hereof or thereof:

                  (a) violates any provision of the Constitutive Documents or
any applicable law or regulation,

                                       9
   10
                  (b) With the exception of Anvar as provided in Article 1.4(i),
requires on the part of the Sellers any filing with, or permit, authorization,
consent or approval of, any court, trustee in bankruptcy ("administrateur
judiciaire"), administrative or other authority (a "Governmental Entity"),

                  (c) With the exception of Anvar as provided in Article 1.4(i),
require, in accordance with the terms of any contract, lease or other agreement
to which the Sellers or the Company is a party, any consent, approval or
authorization,

                  (d) violate any judicial or arbitral decision, any law or
regulation or contractual provision applicable to the Sellers or the Company, or

                  (e) result in a violation of any agreement or result in the
termination, modification, cancellation, loss of a benefit, or result in the
creation or imposition of any lien upon any of the respective properties or
assets of the Sellers or the Company.

                  2.6. Financial Statements. (i) The balance sheet of the
Company as at March 31, 1997, duly audited and certified by the statutory
auditor of the Company, which has been delivered to Buyer and which is attached
as Annex 2.6 is complete, sincere and true and prepared in accordance with
generally applicable accounting principles in France and accurately reflects the
asset and liability situation of the Company at the date and the period
indicated, and (ii) the interim unaudited balance sheet of the Company as of
June 30, 1997 which has been delivered to Buyer and which is attached as Annex
2.6 is complete, sincere and true and prepared in accordance with United States
generally accepted accounting principles ("GAAP") and accurately reflects the
asset and liability situation of the Company at the date and the period
indicated.

The balance sheet of the Company as at March 31, 1997 and the interim unaudited
balance sheet of the Company as at June 30, 1997 are collectively referred to as
the "Financial Statements".

                  2.7. Interim Change. Since July 1st, 1997, the Company has not
engaged in any business or transaction other than in the ordinary course of
business. In particular (but without this list being exclusive):

                  (a) the Company has not suffered any change, nor has there
arisen any event, having or which could reasonably be expected to have a
Material Adverse Effect;

                  (b) the Company has not forgiven or canceled any debts or
claims or waived, released or relinquished any contract right or any other
rights of its business;

                  (c) the Company has not consented to, or has not had imposed
on it, any liens;

                                       10
   11
                  (d) the Company has not suffered any damage, destruction or
loss of property, whether or not covered by insurance, which had or could
reasonably be expected to have a Material Adverse Effect;

                  (e) the Company has not accelerated the collection of, granted
any discounts with respect to or sold or assigned to third parties any accounts
receivable or delayed the payment of any payables or, other than in the ordinary
course of business and consistent with past practice, had any reason to write
off as uncollectable any accounts receivable or any portion thereof;

                  (f) the Company has not assumed any loan, directly or
indirectly, or incurred or guaranteed any obligation with regards to a loan, or
made any loans, advances or capital contributions to, or investment in, any
other individual, corporation, partnership, joint venture, association,
organization or other entity (a "Person"),

                  (g) pledged or subjected to any lien, sold, assigned or
transferred any asset except for sales of inventory in the ordinary course of
business and consistent with past practice;

                  (h) the Company has not increased in any manner the wages,
salaries, bonuses, pension plans, retirement allocations or other allocations of
any officer, employee or other person,

                  (i) the Company has not entered into any pension plan,
profit-sharing, bonus, severance pay, or other plan, agreement or arrangement
relating to retirement or other benefits,

                  (j) the Company has not entered into any employment or
consulting agreement with any person,

                  (k) the Company has not amended any plan, agreement or
arrangement in effect as of the date hereof;

                  (l) the Company has not been the target of any work stoppage
or other labor difficulty;

                  (m) the Company has not made any investment in any business,
company, partnership, association or other entity.

                  (n) the Company has not entered into any agreement, contract
or commitment, with respect to the manufacture of any product of the Company or
any update or derivative thereof (collectively, the "Products");

                  (o) the Company has not declared, paid or set aside for
payment any dividend or other distribution;

                                       11
   12
                  (p) the Company has not made any change in its accounting
principles or methods, except as may have been required by a change in generally
accepted accounting principles in France;

                  (q) the Company has not issued any share or other securities
other than the Shares.

                  2.8. No Undisclosed Liabilities. Except as and to the extent
of the amounts specifically reflected or reserved against in the Financial
Statements, and obligations under agreements, commitments or contracts entered
into, in the ordinary course of business, the Company has not incurred any
liabilities or obligations of any nature (whether or not accrued).

                  2.9. Litigation. There is no claim, action, suit, inquiry or
investigation by or before any judicial entity pending or, to the knowledge of
the Sellers, threatened against or involving the Company or affecting any of its
assets. There is no basis known to the Sellers for any such claim, action, suit,
inquiry, or investigation.

                  2.10. No Violation.

                  (a) The Sellers and the Company have always been in full
compliance with the by-laws of the Company.

                  (b) The Sellers and the Company have always been in full
compliance with (i) all legal regulations applicable to the Company and (ii) all
judicial decisions related thereto,

                  (c) The Sellers and the Company have not breached any
obligations with regard to any contract or agreement irrespective of its
purpose.

                  (d) The Company has all authorizations (from Governmental
Entities and other authorities) necessary to : (i) enable it conduct its
business as currently conducted and, if necessary (ii) to enter into all
transactions contemplated by this Agreement.

                  2.11. Title to Assets. The Company does not own any real
property assets. With the exception of the liens listed in the two Certificates
of recordation of liens delivered by the Commercial Courts of Lyon and Grenoble,
attached as Annex 2.11, the Company has good and marketable title, free and
clear of all liens, of all assets, rights, trademarks, trade names, licenses and
properties, which are used in the conduct of the business conducted by the
Company (the "Assets"). The Company has valid and enforceable leases or
licenses, as the case may be, with respect to the Assets consisting of property
that is leased or licensed to the Company, and there does not exist any default
on the part of the Company under such leases or licenses. Since inception, the
Company has validly entered into and, as the case may be, has validily and
legally terminated any lease agreement used for carrying on its business
activities.

                                       12
   13
                  2.12. Intellectual and Industrial Property.

                  (a) A true and complete list of all the Company's industrial
and intellectual property rights, including tradenames, trademarks and patents
(collectively, "Intellectual and Industrial Property") owned by, or licensed to
the Company is contained in Annex 2.12. Such Annex 2.12 also provides a copy of
all the certificates of recordations for the Intellectual and Industrial
Property, the States in which these registrations are issued and the States
where applications concerning Intellectual and Industrial Property are pending
on the date hereof. The Intellectual and Industrial Property described in Annex
2.12 constitutes all Intellectual and Industrial Property necessary to operate
the Company's business. The Intellectual and Industrial Property is duly and
validly registered under the Company's name and all fees for recordation or
renewal have been timely paid by the Company.

                  (b) The Company has the sole and exclusive right to use, sell,
license, dispose of or bring actions for the infringement of its rights to the
Intellectual and Industrial Property as utilized in its business; there are no
royalties, honoraria, fees or other payments payable by the Company to any
Person by reason of ownership, use, licensure, sale or disposition of any
Intellectual and Industrial Property.

                  (c) There are no license agreements, commitments or guaranteed
royalty or fee payments with respect to Intellectual and Industrial Property.
The Closing of the transaction contemplated hereby will not in any way impair
the right of the Company to use, sell, license or dispose of, or any portion
thereof, or to bring any action for the infringement of any of such rights to
the Intellectual and Industrial Property.

                  (d) None of the former or present employees or officers of the
Company hold any right, title or interest, directly or indirectly, in whole or
in part, in or to any Intellectual and Industrial Property which the Company
currently owns or which is necessary for the business of the Company; no former
or present employees, officers or directors of the Company or any other third
party has asserted any moral rights claim with respect to the Intellectual and
Industrial Property.

                  (e) There is no pending or threatened claim or litigation
challenging or questioning the validity, ownership or right to use, sell,
license or dispose of any Intellectual and Industrial Property nor, to the
knowledge of the Sellers, is there a valid basis for any such claim, nor has the
Company received any notice asserting that the proposed use, sale, license or
disposition by the Company of any Intellectual and Industrial Property conflicts
or will conflict with the rights of any other party, nor is there, to the
knowledge of the Sellers, a valid basis for any such claim or assertion.

                  (g) There are no allegations by any third party that the
Company has infringed any copyright, patent, trademark, trade name or
misappropriated or misused any invention, patent, trade secret or other
proprietary information 

                                       13
   14
entitled to legal protection, and the Company has not asserted any claim of
infringement, misappropriation or misuse.

                  2.13. Contracts and Commitments.

                  (a) All material contracts and agreements of the Company
(whether written or oral), corresponding to the criteria noted hereinbelow
("Material Contracts") are attached or described in Annex 2.13.

                      (i) all contracts or agreements in an amount greater than
100,000 francs in which the Company is the creditor or the debtor;

                      (ii) all contracts or agreements with a duration greater
than one year (save for employment contracts);

                      (iii) all license and other agreements with respect to any
Intellectual and Industrial Property;

                      (iv) distribution, lease, license, joint venture,
representation or manufacturing agreements that can only be terminated with a
notice period of 30 days or more;

                      (v) any agreement, contract or engagement containing a
non-competition clause;

                      (vi) all agreements, contracts or engagements regarding
the acquisition of real estate or any participation in a company, partnership,
joint venture or any other entity;

                      (vii) contracts or other commitments with any supplier
containing any provision permitting any party other than the Company that is a
party thereto to renegotiate the price or other terms, or containing any payback
or other similar provision, upon the occurrence of a failure by the Company to
meet its obligations under the contract when due or the occurrence of any other
event;

                      (viii) credit agreements, financial obligations,
guarantees of or agreements to acquire any such debt obligation of others or
similar documents relating to indebtedness for borrowed money to which the
Company is a party or by which any assets of the Company is bound, restricted or
encumbered;

                      (ix) all agreements or contracts obliging the Company to
reimburse, in whole or in part, any financial benefit, investment, subsidy
granted by any public agency;

                      (x) all agreements or contracts granting bonuses or
subsidies to the Company either in cash or in kind;

                                       14
   15
                      (xi) all employment, consulting and severance agreements,
and settlement agreements in the case of termination or indemnification of
employment contracts;

                      (xii) any agreement, or group of related agreements with
the same party or any affiliates, under which the Company has leased or has
agreed to lease any property;

                      (xiii) any other contract which is material to the
business, operations or prospects of the Company or any other contract,
instrument, commitment, plan or arrangement which has not been made in the
ordinary course of business.

                  (b) Each Material Contract: (i) is valid and binding on the
other party or parties thereto and is in full force and effect and (ii) after
the Date of Closing shall continue in full force and effect without penalty or
other adverse consequence arising solely from the consummation of the
transactions contemplated by this Agreement. Neither the Company nor, to the
best knowledge of the Sellers, any other party to any Material Contract is in
breach of, or default under, any Material Contract.

                  (c) The Company duly and timely satisfies all the conditions
provided in the agreements entered into with ANVAR on July 10, 1996 (one
agreement) and on March 25, 1997 (two agreements), copies of which are attached
in Annex 2.13 (c).

                  (d) With the exception of a loan agreement entered into with
Banque Populaire on November 3, 1995, a loan agreement entered into with Banque
Populaire and with Societe Generale on July 10, 1996 and a loan agreement
entered into with Societe Generale on April 8, 1997 (all three loans being
attached as Annex 2.13 (d)), the Company has not entered into any credit
agreement or loan agreement with any financial institution or third party.

                  (e) With the exception of two ANVAR agreements of July 10,
1996 and March 24, 1997 and with the exception of a grant from COFACE granted on
October 23, 1995 and attached in Annex 2.13 (e), the Company has not received
any financial benefit, investment or subsidy granted by any public agency.

                  (f) The Company does not have outstanding contracts with
respect to the employment of any officer, individual, employee, agent,
consultant, adviser, salesperson, representative or other person on a full-time,
part-time, contract or consulting basis which differs in any material respect
from the requirements of applicable law including provisions with respect to
termination indemnification. A copy of all the employment contracts of the
employees of the Company as of the date hereof is attached in Annex 2.13 (f).

                  (g) With the exception of a lease agreement for office space
located in Meylan, entered into with SCI Des Buclos (a copy of which is attached
as Annex 2.13 (g)), which shall terminate on June 22, 1998, without indemnity or

                                       15
   16
other responsibility on the part of the Company save for any rent payments which
would be outstanding after the Date of Closing, the Company does not have any
agreement with any of the Sellers or any affiliate of any Seller.

                  (h) Except as required by law, the Company does not have any
pension, profit-sharing, bonus, severance pay, retirement, hospitalization,
insurance, stock purchase, stock option or other benefit with or for the benefit
of any of the Sellers nor with any third party to this Agreement (a "Benefit
Plan").

                  (i) The Company does not have any employee on a fixed-term
employment agreement and the Company has not entered into an agreement for the
secondment of personnel with any of the Sellers or any affiliate of any Seller.

                  (j) the Company does not have any outstanding loan to any
Seller or to any employee.

                  (k) The Company has not guaranteed any obligations of the
Sellers or any other person. The Sellers have not guaranteed any obligations of
the Company which would still be in effect after the Date of Closing.

                  (l) All shareholders agreements, voting agreement, pledge
agreement, or sale-purchase agreements relating to the Shares and which have
been in existence between certain Sellers before the Date of Closing shall
become null and void on the Date of Closing and shall give rise to no claim or
liability whatsoever whether against the Company or the Buyer.

                  (m) Any pledge agreement relating to the Shares and which have
been granted by certain Shareholders of IMMI in favor of a third party shall be
validly terminated on Date of Closing and shall give rise to no claim or
liability whatsoever whether against the Company or the Buyer.

                  (n) The Company does not have any contract which is material
to its business, operations or prospects or any other contract, instrument,
commitment, plan or arrangement which has not been made in the ordinary course
of business.

                  (o) Each Material Contract: (i) is valid and binding on the
other party or parties thereto and is in full force and effect and (ii) after
the Date of Closing of the transaction contemplated by this Agreement, shall
continue in full force and effect without penalty or other adverse consequence
arising solely from the consummation of the transactions contemplated by this
Agreement. Neither the Company nor, to the best knowledge of the Sellers, any
other party to any Material Contract is in breach of, or default under, any
Material Contract.

                  (p) The Company is not restricted by any agreement from
carrying on its business anywhere in the world.

                  2.14. Customers and Suppliers. Annex 2.14 sets forth a list of
the largest customers of the Company in terms of sales for the six months ended

                                       16
   17
June 30, 1997 as well as a list of the ten largest suppliers of goods and
materials to the Company. There has not been any adverse change in the business
relationship of the Company with any customer or supplier since July 1st, 1997.

                  2.15. Insurance. The Company has valid insurance policies
which adequately cover all the risks against which it is normal to insure
considering the activities of the Company. There has not been any failure to
give any notice or present any claim under any such policy in a timely fashion
or in the manner or detail required by the policy . There are no outstanding
past due premiums or claims, and there are no provisions for retroactive or
retrospective premium adjustments. No notice of cancellation or non-renewal with
respect to, or disallowance of any claim under, any such policy has been
received by the Company. Execution of this Agreement shall not entitle any of
the insurers covered by this Article 2.15 to modify the terms of the insurance
policies taken out by or on behalf of the Company.

                  2.16. Environmental Matters. The Company is not in breach of
any environmental laws or regulations. The Company has received all required
environmental approvals and there has been no claim made against the Company
with respect to the violation of any environmental laws or regulations.

                  2.17. Taxes - Social security contributions.

                  (a) All tax and social security returns, declarations,
reports, estimates, information returns, and statements (collectively, "Tax and
Social Security Returns") required to be filed by the Company on or before the
date hereof for all periods ending on or before the Date of Closing have been
timely filed, and all such Tax and Social Security Returns are true, correct and
complete.

                  (b) The Company has timely paid (or accrued in its accounts)
all taxes and social security contributions due or claimed to be due by it by
any taxing or social security authority in respect to periods (or any portion
thereof) ending on or before the Date of Closing, and no failure in this regard
may be attributed to it.

                  (c) No audit or other proceeding by any national or local
court, governmental, regulatory, parafiscal, administrative or similar authority
are presently pending with respect to any taxes or social security contributions
of the Company.

                  (d) The Company is not a party to, or is bound by or has any
obligation under, any tax-consolidation agreement or similar contract or
arrangement.

                  2.18 Research and development tax credit. As of June 30, 1997,
the research and development tax credit of the Company is as follows:

                                       17
   18

FRENCH FRANCS                 1994         1995          1996           TOTAL

Gross tax credit             208,366      516,085       508,842       1,233,293
Allowance                       --       (147,000)     (508,842)       (655,842)
- -------------------------------------------------------------------------------
Net tax credit               208,366      369,085          --           577,451

The net tax credit of FF. 577,451 shall be accepted and paid by the French tax
authorities.

                  2.19 Regulatory Authority. The Company has never been the
subject of any inspection or investigation by a French or foreign regulatory
authority and has never received any notice of deficiency by any regulatory
authority (including but not limited to the French Ministry of Health, the
Federal United States Food And Drug Administration, and the Japanese Ministry of
Health ("Koseisho").

                  2.20 Sale of Neuromate. The Company is authorized to sell
Neuromate product in the European Community, Japan and the United States and
holds all regulatory authorizations to this effect under its own name, save for
the regulatory authorization of Koseisho which has been granted to the exclusive
distributor of the Company in Japan, IMATRON. All such authorizations are
attached in Annex 2.20 to this Agreement. No further action must be taken by the
Company to sell Neuromate product in any of the above jurisdictions or to
maintain its right to sell Neuromate product or any improvements thereof in
those jurisdictions.

                  2.21. Transactions with Affiliates. None of the Sellers has,
directly or indirectly, (i) an interest in any entity which furnished or sold,
or which furnishes or sells, services or products which the Company furnishes or
sells, or proposes to furnish or sell, or (ii) any interest in any Person which
purchases from or sells or furnishes to the Company any goods or services, with
the exception of informal commercial relationships with Audemars Piguet for the
purchases of components by the Company, which purchases are carried on from time
to time at the discretion of the Company and on an arm's length basis.

                  2.22 Accounts Receivable. All receivables of the Company arose
in the ordinary course of business and the aggregate amounts thereof are
collectible (except to the extent reserved against as reflected in the Financial
Statements) and are carried at values determined in accordance with French and
US generally accepted accounting principles. None of the receivables is subject
to any claim of offset, setoff or counterclaim and there are no facts or
circumstances that would give rise to any such claim. No person has any lien,
charge, pledge, security interest or other encumbrance on any of such
receivables and no agreement for deduction or discount has been made with
respect to any of such receivables.

                  2.23 Sellers' former shareholders' accounts ("compte
courant"). As of the Date of Closing, any and all sums which could be due by the
Company to the Sellers, whether or not registered in the shareholders' accounts
("compte

                                       18
   19
courant") have been either reimbursed, set-off or forgiven and there exists no
monies owed by the Company to the Sellers.

                  2.24 Minute Books. The minute books of the Company made
available to counsel for Buyer contain all minutes since the Company's
incorporation as normally kept in conformance with French law.

                  2.25 Entirety of Representations. The above representations
and warranties are true, accurate and complete in all respects and do not
contain any untrue statement of a material fact or omit to state any material
fact necessary in order to make the statements made not misleading.

                  2.26 Regulations Requirements. The Sellers acquiring Purchase
Price Shares pursuant to Regulation S promulgated under the Act represent that
are neither a United States citizen nor a United States resident and that the
offer to acquire the Purchase Price Shares was not made in the United States.

                  2.27 Section 4(2) Requirements. With respect to Mr. Boulnois
only, Mr. Boulnois represents and warrants to the Buyer as follows: (i) Mr.
Boulnois is acquiring the Purchase Price Shares for his own account for
investment and not with a view to, or for sale in connection with, any
distribution thereof, nor with any present intention of distributing or selling
the same, and (ii) Mr. Boulnois has adequate net worth and means to provide for
his current needs and contingencies and the financial capacity to sustain a
complete loss of his investment in the Buyer.

                  2.28 Innovative Medical Machines International, Inc. The
Sellers hereby jointly and severally represent and warrant that (i) the Company
is the owner of two hundred (200) shares of Common Stock, par value $0.01 US
dollars, of Innovative Medical Machines International, Inc., a Delaware
corporation (the "Subsidiary"); (ii) the 200 shares of Subsidiary Common Stock
held by the Company represents the total outstanding stock of the Subsidiary;
(iii) the Subsidiary is a corporation duly organized , validly existing and in
good standing under the laws of the State of Delaware, United States, and has
full corporate power and authority to own, lease and operate its assets,
properties and business and to carry on its business as now being conducted;
(iv) the Subsidiary is duly qualified to do business and is in good standing as
a foreign corporation in the Commonwealth of Massachusetts, (v) the Subsidiary
has applied for and received from the Food & Drug Administration of the United
States Department of Health and Human Services a 510k premarket approval notice
for the Neuromate, a product of the Company, and (iv) to the knowledge of the
Sellers, there does not exist any circumstance or event involving the Subsidiary
as of the Date of Closing that is likely to result in a Material Adverse Effect
to the Company.

                                       19
   20
                                    ARTICLE 3
                         REPRESENTATIONS AND WARRANTIES
                                    OF BUYER

                  The Buyer acknowledges that the Sellers required the Buyer to
make the following representations and warranties as a determining condition of
this Agreement, failing which the Sellers would not have accepted the Purchase
Price Shares. Accordingly, the Buyer hereby represents and warrants to the
Sellers as follows:

                  3.1. Corporate Organization. Buyer is duly organized, validly
existing and in good standing under the laws of the State of Delaware.

                  3.2. Authorization. Buyer has the requisite corporate power
and authority to enter into this Agreement and the other documents and
instruments to be executed and delivered by Buyer pursuant hereto (the
"Additional Buyer's Documents") and to carry out the transactions contemplated
hereby and thereby. When fully executed and delivered, this Agreement and each
of the Additional Buyer's Documents will constitute the valid and binding
agreements of Buyer, enforceable against it in accordance with their respective
terms.

                  3.3. Consents; Due Execution; Delivery and Performance of the
Agreement. The Buyer's execution, delivery and performance of this Agreement (a)
has been duly authorized under Delaware law by all requisite corporate action by
the Buyer, (b) will not violate any law or the Restated Certificate or Restated
By-laws of the Buyer or any other corporation of which the Buyer owns at least
50% of the outstanding voting stock (a "Buyer Subsidiary") or any provision of
any material indenture, mortgage, agreement, contract or other material
instrument to which the Buyer or any Buyer Subsidiary is a party or by which any
of their respective properties or assets is bound as of the Date of Closing or
(c) require any consent by any person under, constitute or result (upon notice
or lapse of time or both) in a breach of any term, condition or provision of, or
constitute a default or give rise to any right of termination or acceleration
under any such indenture, mortgage, agreement, contract or other material
instrument or result in the creation or imposition of any lien, security
interest, mortgage, pledge, charge or other encumbrance, of any material nature
whatsoever, upon any properties or assets of the Buyer or any Buyer Subsidiary.
Upon its execution and delivery, and assuming the valid execution thereof by the
Sellers, the Agreement will constitute a valid and binding obligation of the
Buyer, enforceable against the Buyer in accordance with its terms, except as
enforceability may be limited by applicable bankruptcy, insolvency,
reorganization, moratorium or similar laws affecting creditors' and contracting
parties' rights generally and except as enforceability may be subject to general
principles of equity (regardless of whether such enforceability is considered in
a proceeding in equity or at law).

                  3.4. Authorized Capital Stock. As of the Date of Closing, the
authorized capital stock of the Buyer consists of (a) 15,000,000 shares of
common 

                                       20
   21
stock, $0.01 par value per share, of which on September 5, 1997 3,366,956 shares
were validly issued and outstanding, fully paid and non-assessable, (b)
1,000,000 shares of undesignated preferred stock, $0.01 par value per share,
none of which are issued and outstanding, and (c) 4,332,816 shares of common
stock issuable upon exercise of outstanding warrants at exercise prices ranging
from $0,01 to $8.25 per share, and (iv) 1,052,317 shares of common stock
issuable upon exercise of outstanding options granted pursuant to the Buyer's
stock option plans, at exercise prices ranging from $0.07 to $7.84 per share.

                  3.5. Issuance, Sale and delivery of the Shares. When issued
and paid for, the Purchase Price Shares to be sold hereunder by the Buyer will
be validly issued and outstanding, fully paid and non-assessable.

                  3.6. Exempt Transaction. Subject to the accuracy of the
Sellers representations in Article 1.2 of this Agreement, the issuance of the
Purchase Price Shares will constitute transactions which are not subject to the
registration requirements of Section 5 of the Securities Act of 1933, as amended
(the "Securities Act") in reliance upon Regulation S of the Securities Act and
the regulations promulgated pursuant thereto, with the exception of Mr.
Boulnois. The issuance of the Purchase Price Shares to Mr. Boulnois will
constitute a transaction exempt from the registration requirements of Section 5
of the Securities Act in reliance upon Regulation D of the Securities Act and
the regulations promulgated pursuant thereto, subject to Mr. Boulnois
representations in Article 2.27.

                  3.7. Disclosure. Neither this Agreement, nor any other items
prepared or supplied to the Sellers by or on behalf of the Buyer with respect to
the transactions contemplated hereby contain any untrue statement of a material
fact or omit a material fact necessary to make each statement contained herein
or therein not misleading.

                  3.8. SEC Filings Current and in Compliance. All reports filed
by the Buyer with the Securities and Exchange Commission ("SEC") pursuant to the
reporting requirements of the Securities Exchange Act of 1934, as amended (the
"Exchange Act"), when filed, did not contain any untrue statement of a material
fact or omit to state any material fact required to be stated therein or
necessary to make the statements therein, in light of the circumstances in which
they were made, not misleading. The Buyer has made all filings with the SEC to
file any amendment or supplement to any such filings.

                  3.9. No Material Changes. As of the Date of Closing, there has
been no material adverse change in the financial condition or results of
operations of the Buyer since the filing date of the Buyer's last report with
the SEC pursuant to the reporting requirements of the Exchange Act, except for
losses from continuing operations.

                                       21
   22
                                    ARTICLE 4
                              ADDITIONAL AGREEMENTS

                  4.1. Consents and Approvals. The parties shall, and Sellers
shall cause the Company to, take all reasonable actions necessary to comply
promptly with all legal requirements which may be imposed with respect to the
transactions contemplated hereby (which actions shall include, without
limitation, furnishing all information required in connection with approvals of
or filings with any Governmental Entity) and will promptly cooperate with and
furnish information to each other in connection with any such requirements
imposed on any of them in connection with the transactions contemplated hereby.

                  4.2. Further Assurances. From time to time after the Date of
Closing, the Sellers will use all reasonable efforts to obtain any licenses,
permits, waivers, consents, authorizations, qualifications and orders of
Governmental Entities or other Persons or entities as Buyer shall reasonably
request as necessary to enable the Company to continue to enjoy after the Date
of Closing the rights and benefits presently enjoyed by the Sellers in the
operation of the business conducted by the Company.

                  4.3. Non Competition - Confidentiality.

                  (a) The Sellers, from the present date until the end of a
three year period, shall not, in the European Union, the United States of
America and Canada, directly or indirectly, own any capital stock or other
equity securities of, have any direct or indirect (unless the participation is
less than 1% of the capital of a publicly traded company) equity or ownership
interest in, or serve as a director, officer, employee, consultant or agent of
any individual, partnership, corporation, trust or unincorporated association
which competes with, or conducts a similar business as that of the Company or
the Buyer, namely the designing, manufacturing and sale of equipment for image
guided surgery.

                  (b) The following restrictions shall be applicable to Article
4.3 (a):

                      (i) Mr. Boulnois shall comply with the non-competion
obligation of Article 4.3 (a) for all its duration, with the exception that he
is authorized to act merely as a consultant in the United States for any medical
equipment company;

                      (ii) GEMED shall comply with the non-competion obligation
of Article 4.3 (a) for all its duration subject to the continuation by the
Company of the existing supply agreements for spare parts between the Company
and Audemars Piguet, the parent company of GEMED. GEMED declares that Audemars
Piguet undertakes to supply spare parts to the Company after the Date of Closing
in a manner and with timetable deliveries consistent with current practices, at
reasonable costs, and with the same high level of quality as currently in
effect. The termination of all or part of the supply agreements by GEMED or

                                       22
   23
Audemars Piguet, for any reason whatsoever, shall not cause the anticipated
termination of the non-competition obligation of GEMED.

                  (c) The Sellers, from the present date until the end of a
three year period, shall not, directly or indirectly, hire present employees of
the Company or otherwise induce or encourage them to leave the employment of the
Company.

                  (d) The Sellers shall maintain the confidentiality of all
information which they obtained or may have obtained with respect to the Company
and its business prior to the Date of Closing which is not in the public domain
and which they acquired or had access to due to their position as shareholder or
director or employee of the Company, save for the disclosure of any such
information to which they would be compelled by any Governmental Entity.

                  (e) The Sellers acknowledge and agree that notwithstanding the
provisions of Article 6.2, in the event of a violation by any of the Sellers of
the provisions of this Article 4.3, the Buyer shall be authorized to file any
appropriate judicial action before any court or any tribunal of any jurisdiction
to seek an injuction against any of the Sellers as well as any appropriate
remedy at law.

                  4.4. Compliance with Rule 144. At the written request of the
Sellers at any time and from time to time, the Buyer shall furnish to the
Sellers, within three days after receipt of such request, a written statement
confirming the Buyer's compliance with the filing requirements of the SEC set
forth in SEC Rule 144 as amended from time to time.

                  4.5. Best Efforts to Become S-3 Eligible. The Buyer will use
its best efforts to become eligible to file a registration statement on Form S-3
with respect to the sale of the Purchase Price Shares. The Buyer shall use its
best efforts to make all required filings of all reports with the SEC pursuant
to the Exchange Act.

                                    ARTICLE 5
                          SURVIVAL AND INDEMNIFICATION

                  5.1. Survival. All representations and warranties contained in
this Agreement shall survive for three (3) years after the Date of Closing with
the exception of the representations and warranties of Article 2.17 (fiscal and
labor questions) which will survive for the applicable statutes of limitations.
All representations and warranties shall further survive beyond such three-year
period (or period of the applicable statutes of limitation) for so long as any
claim made during such three-year period (or period of the applicable statutes
of limitation) under this Article 5 are not definitively settled. In addition,
it is specified that the periods thus defined apply to the notification of the
event giving rise to indemnification and not to its judicial or amicable
settlement.

                                       23
   24
                  5.2. Indemnification. The Sellers jointly and severally agree
to indemnify and hold harmless the Buyer and/or the Company for the period
stipulated in Article 5.1 commencing on the Date of Closing (and for any further
period during which a claim for indemnification is pending hereunder) against
and in respect of any Damages (as hereinafter defined in Article 5.6) of which
the cause predates the Date of Closing and incurred or sustained by either of
them as a result of any breach by any Seller of this Agreement, including the
representations, warranties and covenants contained herein or in any agreement,
document or other instrument delivered pursuant hereto or in connection
herewith. No investigation made by or for the Buyer shall affect any
representation or warranty of the Sellers contained in this Agreement or the
indemnification obligation of the Sellers set forth herein. The Sellers may not
be relieved of their indemnification or financial obligations in this agreement
by claiming that they did not have knowledge of the facts in question.

                  5.3. Threshold. As concerns all Damages, the Sellers will not
be held liable under this Article 5 for the indemnification of the Buyer, unless
the total Damages exceed the sum of two hundred thousand (200,000) French
francs, in which case the Sellers will be liable for any sums of Damages
exceeding FF. 200,000.

                  To determine whether this threshold is met, all sums for which
the Sellers are liable pursuant to the provisions of this Agreement shall be
aggregated irrespective of when such sums are claimed from the Sellers within
the guarantee period defined in article 5.1.

                  5.4. Procedure for Indemnification.

                  (a) The Buyer shall give prompt written notice (within 30
days) to the Sellers of any claim or event known to it which does or may give
rise to a claim for indemnification hereunder by the Buyer against the Sellers;
provided that the failure of the Buyer to give notice as provided in this
Agreement shall not relieve the Sellers of their obligations under this Article
5 to the extent that such failure has not prejudiced the Sellers.

                  (b) In the case of any claim for indemnification hereunder
arising out of a claim, action, suit or proceeding brought against the Company
by any Person who is not a party to this Agreement (a "Third Party Claim"), the
Buyer shall also give the Sellers copies of any written claims, process or legal
pleadings with respect to such Third Party Claim promptly after such documents
are received by the Buyer, it being understood that any delay in remitting such
documentation by the Buyer shall not relieve the Sellers of their obligations
under this Article 5 except to the extent that such failure has prejudiced the
Sellers.

                  (c) A Seller may elect to compromise or defend at such
Seller's own expense and with such Seller's own counsel any Third Party Claim.
If a Seller elects to compromise or defend a Third Party Claim, it shall, within
30 days 

                                       24
   25
(or sooner, if the nature of such Third Party Claim so requires), notify the
Buyer of its intent to do so, and the Buyer shall reasonably cooperate in the
compromise of, or defense against, such Third Party Claim.

                  Such Seller shall pay the Buyer's actual out-of-pocket
expenses incurred in connection with such cooperation including the Buyer's
reasonable legal expenses. After notice from a Seller to the Buyer of its
election to assume the defense of a Third Party Claim, such Seller shall not be
liable to the Buyer under this Article 5 for any legal expenses subsequently
incurred by the Buyer in connection with the defense thereof; provided that the
Buyer shall have the right to employ one counsel of its choice in each
applicable jurisdiction (if more than one jurisdiction is involved) to represent
the Buyer if, in the Buyer's reasonable judgment, a conflict of interest between
the Buyer and such Seller exists in respect of such claim. If the Sellers elect
not to compromise or defend against a Third Party Claim, or fail to notify the
Buyer of their election as provided in this Article 5.4, the Buyer may pay,
compromise or defend such Third Party Claim at the expense of the Sellers,
including the Buyer's reasonable legal expenses. No Seller shall consent to
entry of any judgment or enter into any settlement without the written consent
of the Buyer (which consent shall not be unreasonably withheld), unless such
judgment or settlement provides solely for money damages or other money payments
for which the Buyer is entitled to indemnification hereunder and includes as an
unconditional term thereof the giving by the claimant or plaintiff to the Buyer
of a release from all liability in respect of such Third Party Claim. The amount
of the legal expenses of the Buyer payable by the Sellers shall be included in
the maximum indemnification provision set forth in Article 5.6 (b) (vi).

                  (d) If there is a reasonable likelihood that a Third Party
Claim may adversely affect the Buyer, other than as a result of money damages or
other money payments for which the Buyer is entitled to indemnification
hereunder, the Buyer will have the right, after consultation with the Sellers,
to have sole control of the defense and settlement of such Third Party Claim
notwithstanding the provisions of Article 5.4.

                  5.5. Payment of Amounts Due.

                  (a) In case of a claim by the Buyer under the provisions of
this Article 5, the Sellers shall pay the amounts claimed as soon as there is an
agreement between them with respect thereto.

                  (b) The Sellers shall be authorized to pay the indemnification
due to the Buyer either in cash or in shares of common stock of the Buyer. The
value of the shares of common stock of the Buyer shall be determined on the
average of the closing price of the shares of the Buyer over the last twenty
(20) trading days immediately preceding the tendering of the Buyer's shares by
the Sellers and payment of the damages, as such closing price appears on the
Nasdaq stock market or if such shares of common stock of the Buyer are traded on
a national securities exchange, as such closing price appears on such exchange.
If the Sellers elect to pay the indemnification due to the Buyer in cash
(whether in whole or in part), 

                                       25
   26
such payment shall be settled by the Sellers in French francs, using the
currency exchange rate published in the Wall Street Journal on the date before
the Date of Closing (i.e.; USD 1 = FF. 6,1220) .

                  5.6. Definition of Damages - Determination of the Amount of
Damages.

                  (a) For purposes of this Article 5, "Damages" shall mean any
loss, liability, damage, cost, expense or diminution of assets suffered or
incurred by the Company or the Buyer (including, in particular, reasonable
attorneys' fees and expenses incurred or actually disbursed in connection with
any claim, suit or proceeding brought against the Company or the Buyer) that
satisfies the following requirements:

                      (i) Its cause or origin predates the Date of Closing and;

                      (ii) It has not been booked or a provision has not been
made adequately in the Financial Statements of the Company.

                  (b) The aggregate amount of Damages payable by the Sellers
shall be determined on the basis of the following:

                      (i) The aggregate amount due shall be equal to any damages
effectively incurred by the Buyer or the Company, after deduction of any tax
benefit or relief relating to such Damage that can be effectively taken by the
Company or the Buyer;

                      (ii) The amount to which the Buyer or the Company might
otherwise be entitled under the Sellers' indemnification obligation shall be
reduced where and to the extent of the net amount of any indemnity paid under
any insurance policy to the Company or the Buyer in respect of such Damages;

                      (iii) No indemnity shall be due by the Sellers in respect
of any tax audit or claim (other than with respect to penalties or interest
arising therefrom) which only modifies the tax period during which a deductible
charge or amortisation may be taken, or in respect of any amount deductible or
recoverable for VAT, except if such VAT is not deductible or recoverable and
except with respect to penalties, fines or interests arising therefrom;

                      (iv) Any supplement of asset or reduction of liabilities
of the Company originating before the Date of Closing compared to these shown in
the Financial Statements as of June 30, 1997 shall be deducted from the amount
of Damages;

                      (v) Any amount due by the Buyer as a result of the
provisions of Article 3 shall be offset against the amount of the
indemnification payable by the Sellers under this Article 5.

                                       26
   27
                      (vi) The maximum indemnification payable by the Sellers to
the Buyer under this Article 5 shall be limited to 4,800,001.25 US dollars,
which is the Purchase Price Shares as determined based on the quoted price at
Nasdaq of the shares of Buyer's common stock at the close of the trading day on
July 10, 1997 of 7.75 US dollars a share.

                                    ARTICLE 6
                               GENERAL PROVISIONS

                  6.1. Amendment and Waiver. No amendment of any provision of
this Agreement shall in any event be effective, unless the same shall be in
writing and signed by the parties hereto. Any failure of any party to comply
with any obligation, agreement or condition hereunder may only be waived in
writing by the other parties. No failure by any party to take any action against
any breach of this Agreement or default by the other parties shall constitute a
waiver of such party's right to enforce any provision hereof or to take any such
action.

                  6.2. Dispute Resolution.

                  (a) Any dispute, controversy or claim arising out of or in
connection with this Agreement or the breach, termination or validity thereof (a
"Dispute"), shall be finally settled by arbitration in accordance with this
Article 6.2. The arbitration shall be held in Paris, France. The arbitration
proceedings shall be conducted in French and English (documents and testimony
may be provided in either language), and the award shall be rendered in the
French language. The arbitration proceedings and the award shall be kept
confidential unless disclosure is necessary in actions to enforce an arbitral
award and actions seeking interim or other provisional relief in any court of
competent jurisdiction to enforce such award or this Article 6.2.

                  (b) In case of a Dispute, the party deciding to resort to
arbitration, (whether the Sellers on the one hand or the Buyer on the other
hand), shall inform the other party by registered letter return receipt
requested sent to its address set forth in Article 6.5, indicating the name of
the arbitrator designated by it. The other party shall have a period of 15 days
from receipt of the above-mentioned letter to proceed with the nomination of a
second arbitrator. In the event of failure to do so within this time period, the
President of the Commercial Court of Paris will do so at the request of the
first party to so request, ruling as a judge in summary proceedings. The two
arbitrators thus designated shall name a third arbitrator within a period of 15
days from the date of appointment of the second arbitrator. In the event of
failure of the arbitrators to agree upon a third arbitrator, this person will be
named by the President of the Commercial Court of Paris, who will do so at the
request of the first party to so request, ruling as a judge in summary
proceedings. The third arbitrator thus appointed will chair the arbitral panel.
In case an arbitrator withdraws or is otherwise prevented from acting, he will
be replaced following the same method of nomination as that used for the
arbitrator who withdraws or is prevented from acting, and this shall 

                                       27
   28
be done within a period of one month from his being prevented from acting or his
withdrawal. The arbitrators may not be affiliated in any way with the parties or
their respective accountants or legal counsel. Each arbitrator shall be fluent
in English and French.

                  (c) Subject to the provisions of this Article 6.2, the
arbitrators shall conduct the arbitration in accordance with such procedural and
evidentiary rules as they may determine and they shall be entitled to hire such
experts (such as appraisal firms or certified public accountants) as they may
deem appropriate in view of the nature of the dispute submitted to them. The
arbitrators shall give written reasons for their award.

                  (d) The hearing shall be held no later than 120 days following
the appointment of the third arbitrator and the award shall be rendered no later
than 30 days following the close of the hearing, by a majority vote of the
arbitrators who shall not be entitled to decide "ex aequo et bono".

                  (e) The parties hereto hereby waive any rights of application
or appeal to a court tribunal of competent jurisdiction to the fullest extent
permitted by law in connection with any question of law arising in the course of
the arbitration or with respect to any award made, except for actions to enforce
an arbitral award and actions seeking interim or other provisional relief in any
court of competent jurisdiction.

                  (f) The award shall be final and binding upon the parties
hereto, and shall be the sole and exclusive remedy between the parties regarding
any claims, counterclaims, issues, or accounting presented to the arbitrator.
Judgment upon any award may be entered in any court having jurisdiction.

                  (g) Any monetary award shall be made and promptly payable in
U.S. dollars or French francs free of any tax, deduction or offset, and the
arbitrator shall be authorized in its discretion to grant pre-award and
post-award interest at commercial rates. Any costs, fees, or taxes incident to
enforcing the award shall, to the maximum extent permitted by law, be charged
against the party resisting such enforcement.

                  (h) This Agreement and the rights and obligations of the
parties hereto shall remain in full force and effect pending the award in any
arbitration proceeding hereunder.

                  (i) At the request of either party, the arbitrators shall
adopt procedures for the arbitration that permit oral examination and oral
cross-examination of witnesses.

                  (j) All notices by one party hereto to the other in connection
with the arbitration shall be in accordance with the provisions of Article 6.5
hereof.

                                       28
   29
                  (k) This agreement to arbitrate shall be binding upon the
successors and assigns of each party hereto.

                  6.3. Broker's and Finder's Fees. The Sellers hereby represent
and warrant to Buyer, and Buyer hereby represents and warrants to Sellers, that
no Person or entity is entitled to receive any investment banking, brokerage or
finder's fee or fees for financial consulting or advisory services in connection
with this Agreement or the transactions contemplated hereby.

                  6.4 Legal fees. Each party will bear its own legal fees and
expenses in connection with the transactions contemplated by this agreement.

                  6.5. Notices. All notices, requests and other communications
hereunder shall be in writing and shall be deemed given if delivered personally,
facsimiled (which is confirmed) or mailed by registered or certified mail
(postage prepaid, return receipt requested) to the parties at the following
addresses (or at such other address for a party as shall be specified by like
notice):

                  (a)  To the Buyer:
                      
                       INTEGRATED SURGICAL SYSTEMS, Inc.
                       829, West Stadium Lane,
                       Sacramento, California, 95834 USA
                       Attention:  Ramesh TRIVEDI
                       Facsimile NO.:  (916) 646 40 75

                       with a copy to:
                      
                       SNOW BECKER KRAUSS P.C.
                       605 Third Avenue
                       New York, N.Y. 10158-0125
                       Attention: Jack BECKER
                       Facsimile No.: (212) 949 70 52
                     
                  (b)  For purposes of the performance of obligations under this
Agreement, the Sellers designate Mr. Gerard HASCOET and Mr. Georges-Henri MEYLAN
as their sole agents (the "Agents"), authorized to represent the Sellers in any
of the rights or obligations and with capacity to act jointly or individually.
All notices, requests and other communications, in whatever form, pursuant to
this Article, shall be addressed only to the Agents at:

                       Mr. Gerard HASCOET
                       10, avenue du Colonel Bonnet
                       75016 Paris, France,
                       Facsimile No: 33 1 42 30 72 44
                     
                       Mr. Georges-Henri MEYLAN
                       Route du Ruisseau 1,

                                       29
   30
                       1348 Le Brassus, Switzerland,
                       Facsimile No: 41 21 845 14 02
                    
                  6.6. Entire Agreement; Binding Effect. This Agreement and the
documents referred to herein (a) constitute the entire agreement and supersede
all other agreements and understandings, both written and oral, between the
parties with respect to the subject matter hereof and (b) shall not be assigned
by either party (by operation of law or otherwise) without the prior written
consent of the other party, except that Buyer may assign, in its sole
discretion, any of its rights, interests and obligations hereunder to any
affiliate.

                  6.7. Applicable Law. This Agreement shall be governed by and
be construed in accordance with French law without reference to its conflicts of
laws principles except to the extent that French conflicts of laws principles
would apply United States federal and state securities laws and the corporation
law of the State of Delaware to questions regarding the issuance and
registration of the shares of Buyer's common stock.

                  6.8. Severability. In case any term, provision, covenant or
restriction of this Agreement is held to be invalid, illegal or unenforceable in
any jurisdiction, the validity, legality and enforceability of the remaining
terms, provisions, covenants or restrictions, or of such term, provision,
covenant or restriction in any other jurisdiction, shall not in any way be
affected or impaired thereby.

                  IN WITNESS WHEREOF, the parties hereto have signed this
Agreement as of the date first written above.

INTEGRATED SURGICAL SYSTEMS, Inc.

/s/   Ramesh TRIVEDI                          /s/ Farideh DANEL
- --------------------------------              --------------------------------
Name: Ramesh TRIVEDI                          Mrs. Farideh DANEL
Title:   President
and Chief Executive Officer

/s/ Francois DANEL                            /s/ Gerard HASCOET
- --------------------------------              --------------------------------
Mr. Francois DANEL                            Mr. Gerard HASCOET

/s/ Jerome LEBON                              /s/ Jean-Luc BOULNOIS
- --------------------------------              --------------------------------
Mr. Jerome LEBON                              Mr. Jean-Luc BOULNOIS

/s/ Fernand BADANO                            /s/ Pierre WUERGLER
- --------------------------------              --------------------------------
Mr. Fernand BADANO                            Mr. Pierre WUERGLER
                                              (by power of attorney)

                                       30
   31
/s/ Georges-Henri MEYLAN                      /s/ Enzo FILIPPINI
- --------------------------------              --------------------------------
Mr. Georges-Henri MEYLAN                      Mr. Enzo FILIPPINI
                                              (by power of attorney)

/s/ Pierre Angelo BOTTINELLI                  /s/ Gulio MERLANI
- --------------------------------              --------------------------------
Mr. Pierre Angelo BOTTINELLI                  Mr. Gulio MERLANI
(by power of attorney)                        (by power of attorney)

/s/ Serge TSCHOPP                             /s/ Raymond BORNAND
- --------------------------------              --------------------------------
Mr. Serge TSCHOPP                             Mr. Raymond BORNAND
(by power of attorney)                        (by power of attorney)

/s/ Jacques-Louis AUDEMARS                    /s/ Mohamed DIAB
- --------------------------------              --------------------------------
Mr. Jacques-Louis AUDEMARS                    Mr. Mohamed DIAB
(by power of attorney)

GEMED SA

/s/ Georges-Henri MEYLAN
- --------------------------------
Name: Georges-Henri MEYLAN
Title: President Directeur
General

                                       31
   32
                                 LIST OF ANNEXES

Annex A                    Powers of attorney

Annex 1.4 (j)              Legal opinion of Counsel to the Sellers

Annex 2.1                  Constitutive Documents

Annex 2.6                  Financial Statements

Annex 2.11                 Two Certificates of recordation of liens

Annex 2.12                 Intellectual and Industrial Property

Annex 2.13                 Material Contracts

Annex 2.13 (c)             Agreements with ANVAR of July 10, 1996 (one
                           agreement) and March 25, 1997 (two agreements)

Annex 2.13 (d)             Loan agreement with Banque Populaire of November
                           3, 1995, loan agreement with Banque Populaire
                           and with Societe Generale of July 10, 1996
                           and loan agreement with Societe Generale of
                           March 24, 1997

Annex 2.13 (d)             Grant from COFACE dated October 23, 1995

Annex 2.13 (f)             Employment contracts of all the employees of the
                           Company

Annex 2.13 (g)             Lease agreement in Meylan

Annex 2.14                 List of the largest customers of the Company in
                           terms of sales for the six months ended June 30, 1997
                           as well as a list of the ten largest suppliers

Annex 2.20                 Regulatory authorizations

                                       32
   1
                                                                EXHIBIT 10.11

                          REGISTRATION RIGHTS AGREEMENT

         This Rights Agreement dated as of September 5, 1997 (the "Effective
Date") is entered into by and among Integrated Surgical Systems, Inc., a
Delaware corporation (the "Company") and the individuals and entities listed on
Exhibit A hereto (the "Sellers").

         WHEREAS, the Company and the Sellers have entered into a Stock Purchase
Agreement of even date herewith (the "Purchase Agreement"); and

         WHEREAS, the Company and the Sellers desire to provide for certain
rights to the shares of capital stock of the Company has proposed to issue to
the Sellers under the terms of the Purchase Agreement;

         WHEREAS, the Company and the Sellers desire to provide for certain
arrangements with respect to the registration of shares of capital stock of the
Company under the Securities Act of 1933;

         NOW, THEREFORE, in consideration of the mutual promises and covenants
contained in this Agreement, the parties hereto agree as follows:

1.       Certain Definitions. As used in this Agreement, the following terms
shall have the following respective meanings:

              "Commission" means the Securities and Exchange Commission, or any
other Federal agency at the time administering the Securities Act.

              "Common Stock" means the common stock, $.01 par value per share,
of the Company.

              "Exchange Act" means the Securities Exchange Act of 1934, as
amended, or any similar Federal statute, and the rules and regulations of the
Commission issued under such Act, as they each may, from time to time, be in
effect.

              "Registration Statement" means a registration statement filed by
the Company with the Commission for a public offering and sale of Common Stock
(other than a registration statement on Form S-8 or Form S-4, or their
successors, or any other form for a similar limited purpose, or any registration
statement covering only securities proposed to be issued in exchange for
securities or assets of another corporation).

              "Registration Expenses" means the expenses described in Section
2.4.

                                       1
   2
              "Registrable Shares" means (i) the Purchase Price Shares and (ii)
any other shares of Common Stock of the Company issued in respect of the
Purchase Price Shares (because of stock splits, stock dividends,
reclassifications, recapitalizations, or similar events).

              "Securities Act" means the Securities Act of 1933, as amended, or
any similar Federal statute, and the rules and regulations of the Commission
issued under such Act, as they each may, from time to time, be in effect.

              "Purchase Price Shares" shall have the meaning specified in
Section 1.2 of the Purchase Agreement.

              "Stockholders" means the Sellers and any persons or entities to
whom the rights granted under this Agreement are transferred by any Sellers,
their successors or assigns pursuant to Section 3 hereof.

2.       Registration Rights.

         2.1. Required Registration. The Company shall use its best efforts to
become eligible to use Form S-3 (or any successor form relating to resale
registration) on November 21, 1997, or as soon as thereafter as is possible.
Upon becoming S-3 eligible, the Company shall then use its best efforts to
effect the registration on Form S-3, or such successor form, for all Registrable
Shares.

         2.2. Incidental Registrations.

              (a) Whenever the Company proposes to file a Registration Statement
(except for the Registration Statement the Company currently has on file as of
the Effective Date), prior to such filing it shall give written notice to all
Stockholders of its intention to do so, and upon the written request of a
Stockholder or Stockholders given within 20 days after the Company provides such
notice (which request shall state the intended method of disposition of such
Registrable Shares), the Company shall cause all Registrable Shares which the
Company has been requested to register to be registered under the Securities Act
to the extent necessary to permit their sale or other disposition in accordance
with the intended methods of distribution specified in the request of such
Stockholder(s); provided, however, the Stockholders rights under Section 2.2 of
this Agreement shall be subject and subordinate only to the registration rights
held by those certain security holders of the Company pursuant to Section 3 of
the Registration Rights Agreement dated December 21, 1995 (the "Existing Rights
Agreement") by and among the Company and such certain security holders of the
Company ("Existing Rights Holders").

              (b) In connection with any offering under this Section 2.2
involving an underwriting, the Company shall not be required to include any
Registrable Shares in such

                                       2
   3
underwriting unless the holders thereof accept the terms of the underwriting
agreement to be executed in connection with such registration, and then only in
such quantity as will not, in the opinion of the underwriters, jeopardize the
success of the offering by the Company or the Existing Rights Holders, as the
case may be, subject and subordinate only to the rights of the Existing Rights
Holders under Section 3 of the Existing Rights Agreement. If in the opinion of
the managing underwriter the registration of all, or part of, the Registrable
Shares which the Stockholders have requested to be included would materially and
adversely affect such public offering, then the Company shall be required to
include in the underwriting only that number of Registrable Shares, if any,
which the managing underwriter believes may be sold without causing such adverse
effect, subject only to the rights of the Existing Rights Holders under Section
3 of the Existing Rights Agreement. In the event of such a reduction in the
number of shares to be included in the underwriting, all Stockholders of
Registrable Shares who have requested registration shall participate in the
underwriting pro rata based upon their total ownership of Registrable Shares (or
in any other proportion as agreed upon by such Stockholders) and if any such
Stockholders would thus be entitled to include more shares than such
Stockholders requested to be registered, the excess shall be allocated among
such other requesting holders pro rata based on their ownership of Registrable
Shares, subject only to the rights of the Existing Rights Holders under Section
3 of the Existing Rights Agreement. No other securities requested to be included
in a registration for the account of anyone other than the Company or the
Existing Rights Holders, as the case may be, and the Stockholders shall be
included in a registration unless all Registrable Shares requested to be
included in such registration are also included, subject and subordinate only to
the rights of the Existing Rights Holders under Section 3 of the Existing Rights
Agreement.

         2.3. Registration Procedures. If and whenever the Company is required
by the provisions of this Agreement to use its best efforts to effect the
registration of any of the Registrable Shares under the Securities Act, the
Company shall:

              (a) file with the Commission a Registration Statement with respect
to such Registrable Shares and use its best efforts to cause that Registration
Statement to become and remain effective;

              (b) with respect to the Registration Statement filed pursuant to
Section 2.1 of this Agreement, as expeditiously as possible prepare and file
with the Commission any amendments and supplements to the Registration Statement
and the prospectus included in the Registration Statement and use its best
efforts to keep such Registration Statement effective for the lesser of (i) a
period of time necessary to permit the Stockholders to dispose of all of their
Registrable Shares or (ii) September 5, 1999.

              (c) with respect to a Registration Statement filed pursuant to
Section 2.2 of this Agreement, as expeditiously as possible prepare and file
with the Commission any amendments and supplements to such Registration
Statement and the prospectus included in the

                                       3
   4
Registration Statement and use its best efforts to keep such Registration
Statement effective for the lesser of (i) a period of time necessary to permit
the Stockholders to dispose of all of their Registrable Shares or (ii) 90 days
after the effective date of such Registration Statement.

              (d) as expeditiously as possible furnish to each selling
Stockholder such reasonable numbers of copies of the prospectus, including the
preliminary prospectus, in conformity with the requirements of the Securities
Act, and such other documents as the selling Stockholder may reasonably request
in order to facilitate the public sale or other disposition of the Registrable
Shares owned by the selling Stockholder; and

              (e) as expeditiously as possible use its best efforts to register
or qualify the Registrable Shares covered by the Registration Statement under
the securities or Blue Sky laws of such states as the selling Stockholder shall
reasonably request, and do any and all other acts and things that may be
necessary or desirable to enable the selling Stockholder to consummate the
public sale or other disposition of the Registrable Shares owned by the selling
Stockholder in such jurisdictions; provided, however, that the Company shall not
be required in connection with this paragraph (d) to qualify as a foreign
corporation in any jurisdiction.

         If the Company has delivered preliminary or final prospectuses to
selling Stockholders and after having done so the prospectus is amended to
comply with the requirements of the Securities Act, the Company shall promptly
notify the selling Stockholders and, if requested, the selling Stockholders
shall immediately cease making offers of Registrable Shares and shall return all
prospectuses to the Company. The Company shall promptly provide the selling
Stockholders with revised prospectuses and, following receipt of the revised
prospectuses, the selling Stockholder shall be free to resume making offers of
the Registrable Shares.

         2.4. Allocation of Expenses. The Company shall pay the Registration
Expenses for the registrations pursuant to Section 2.1 and Section 2.2. For
purposes of this Section, the term "Registration Expenses" shall mean all
expenses incurred by the Company in complying with this Section 2, including,
without limitation, all registration and filing fees, exchange listing fees,
printing expenses, fees and disbursements of counsel for the Company and one
counsel for the selling Stockholders, out-of-pocket expenses of the Company and
the underwriters, state Blue Sky fees and expenses, and the expense of any
special audits incident to or required by any such registration, but excluding
underwriting discounts and selling commissions and fees of more than one counsel
for the selling Stockholders. Such underwriting discounts and selling
commissions shall be borne pro rata by the selling Stockholders in accordance
with the number of their Registrable Shares included in such registration.

         2.5. Indemnification. In the event of any registration of any of the
Registrable Shares under the Securities Act pursuant to this Agreement, then to
the extent permitted by law the Company shall indemnify and hold harmless the
seller of such Registrable Shares, each

                                       4
   5
underwriter of such Registrable Shares and each other person, if any, who
controls such seller or underwriter within the meaning of the Securities Act or
the Exchange Act against any losses, claims, damages or liabilities, joint or
several, to which such seller, underwriter or controlling person may become
subject under the Securities Act, the Exchange Act, state securities laws or
otherwise, insofar as such losses, claims, damages or liabilities (or actions in
respect thereof) arise out of or are based upon any untrue statement or alleged
untrue statement of any material fact contained in any Registration Statement
under which such Registrable Shares were registered under the Securities Act,
any preliminary prospectus or final prospectus contained in the Registration
Statement, or any amendment or supplement to such Registration Statement, or
arise out of or are based upon the omission or alleged omission to state a
material fact required to be stated therein or necessary to make the statements
therein not misleading; and the Company shall reimburse each such seller,
underwriter and controlling person for reasonable legal or any other expenses
incurred by such seller, underwriter or controlling person in connection with
investigating or defending any such loss, claim, damage, liability or action;
provided, however, that the Company shall not be liable in any such case to the
extent that any such loss, claim, damage or liability arises out of or is based
upon any untrue statement or omission made in such Registration Statement,
preliminary prospectus or final prospectus, or any such amendment or supplement,
in reliance upon and in conformity with information furnished to the Company, in
writing, by or on behalf of such seller, underwriter or controlling person
specifically for use in the preparation thereof.

         In the event of any registration of any of the Registrable Shares under
the Securities Act pursuant to this Agreement, then to the extent permitted by
law, each seller of Registrable Shares, severally and not jointly, shall
indemnify and hold harmless the Company, each of its directors and officers and
each underwriter (if any) and each person, if any, who controls the Company or
any such underwriter within the meaning of the Securities Act or the Exchange
Act, against any losses, claims, damages or liabilities, joint or several, to
which the Company, such directors and officers, underwriter or controlling
person may become subject under the Securities Act, Exchange Act, state
securities laws or otherwise, insofar as such losses, claims, damages or
liabilities (or actions in respect thereof) arise out of or are based upon any
untrue statement or alleged untrue statement of a material fact contained in any
Registration Statement under which such Registrable Shares were registered under
the Securities Act, any preliminary prospectus or final prospectus contained in
the Registration Statement, or any amendment or supplement to the Registration
Statement, or arise out of or are based upon any omission or alleged omission to
state a material fact required to be stated therein or necessary to make the
statements therein not misleading, if the statement or omission was made solely
in reliance upon and in conformity with information furnished in writing to the
Company by or on behalf of such seller, specifically for use in connection with
the preparation of such Registration Statement, prospectus, amendment or
supplement; and such seller shall reimburse the Company for reasonable legal or
other expenses incurred by the Company in connection with investigating or
defending any such loss, claim, damage, liability or action; provided, however,
that the obligations of any seller of Registrable Shares hereunder shall not
exceed an amount

                                       5
   6
equal to the proceeds to such seller of the Registrable Shares sold pursuant to
the Registration Statement.

         An underwriter shall not be entitled to indemnification pursuant to
this subsection in the event that it fails to deliver to any selling Stockholder
any preliminary or final or revised prospectus, as required by the rules and
regulations of the Commission. Finally, no indemnification shall be provided
pursuant to this subsection in the event that any error in a preliminary
prospectus of the Company is subsequently corrected in the final prospectus of
the Company for a particular offering, and such final prospectus is delivered to
all Sellers in the offering prior to the date of purchase of the securities.

         Each party entitled to indemnification under this Section 2.5 (the
"Indemnified Party") shall give notice to the party required to provide
indemnification (the "Indemnifying Party") promptly after such Indemnified Party
has actual knowledge of any claim as to which indemnity may be sought, and shall
permit the Indemnifying Party to assume the defense of any such claim or any
litigation resulting therefrom; provided, that counsel for the Indemnifying
Party, who shall conduct the defense of such claim or litigation, shall be
approved by the Indemnified Party (whose approval shall not be unreasonably
withheld); and, provided, further, that the failure of any Indemnified Party to
give notice as provided herein shall not relieve the Indemnifying Party of its
obligations under this Section 2.5. The Indemnified Party may participate in
such defense at such party's expense; provided, however, that the Indemnifying
Party shall pay such expense if representation of such Indemnified Party by the
counsel retained by the Indemnifying Party would be inappropriate due to actual
or potential differing interests between the Indemnified Party and any other
party represented by such counsel in such proceeding. No Indemnifying Party, in
the defense of any such claim or litigation shall, except with the consent of
each Indemnified Party, consent to entry of any judgment or enter into any
settlement that does not include as an unconditional term thereof the giving by
the claimant or plaintiff to such Indemnified Party of a release from all
liability in respect of such claim or litigation, and no Indemnified Party shall
consent to entry of any judgment or settle such claim or litigation without the
prior written consent of the Indemnifying Party.

         2.6. Indemnification with Respect to Underwritten Offerings. In the
event that Registrable Shares are sold pursuant to a Registration Statement in
an underwritten offering, the Company agrees to enter into an underwriting
agreement containing customary representations and warranties with respect to
the business and operations of an issuer of the securities being registered and
customary covenants and agreements to be performed by such issuer, including
without limitation customary provisions with respect to indemnification by the
Company of the underwriters of such offering.

         2.7. Information by Holder. Each holder of Registrable Shares included
in any registration shall furnish to the Company such information regarding such
holder and the distribution proposed by such holder as the Company may request
in writing and as shall be

                                       6
   7
required in connection with any registration, qualification or compliance
referred to in this Section 2.

         2.8. Rule 144 Requirements. With a view to making available to the
Stockholders the benefits of Rule 144 promulgated under the Securities Act and
any other rule or regulation of the Commission that may at any time permit a
Stockholder to sell securities of the Company to the public without
registration, the Company agrees to use its best efforts to:

              (a) make and keep public information available, as those terms are
understood and defined in Rule 144 under the Securities Act (at any time after
it has become subject to the reporting requirements of the Exchange Act);

              (b) file with the Commission in a timely manner all reports and
other documents required of the Company under the Securities Act and the
Exchange Act (at any time after it has become subject to such reporting
requirements); and

              (c) furnish to any holder of Registrable Shares upon request a
written statement by the Company as to its compliance with the reporting
requirements of said Rule 144 (at any time after 90 days after the closing of
the first sale of securities by the Company pursuant to a Registration
Statement), and of the Securities Act and the Exchange Act (at any time after it
has become subject to such reporting requirements), a copy of the most recent
annual or quarterly report of the Company, and such other reports and documents
of the Company as such holder may reasonably request to avail itself of any
similar rule or regulation of the Commission allowing it to sell any such
securities without registration.

         2.9. Termination. The provisions of this Section 2 shall terminate on
the earlier of (i) the second anniversary of the Effective Date; or (ii) such
time as all the Stockholders shall have disposed of their Registrable Shares.

                                       7
   8
3.       Transfers of Certain Rights.

         3.1. The rights granted to the Sellers may be transferred or succeeded
to only by (i) any general or limited partner, officer or other affiliate of
such Seller, or (ii) another Seller; provided, however, that the Company is
given written notice by the transferee at the time of such transfer stating the
name and address of the transferee and identifying the securities with respect
to which such rights are being assigned; and, provided, further, as a condition
precedent to any such transfer, the transferee agrees in writing to be bound by
and subject to all of the terms and conditions of this Agreement.

         3.2. A transferee to whom rights are transferred pursuant to this
Section 3 may not again transfer such rights to any other person or entity,
other than as provided in paragraph (a) above.

4.       General.

         4.1. Notices. All notices, requests, consents and other communications
under this Agreement shall be in writing and shall be delivered by hand, by
telecopier, by overnight mail or mailed by first class certified or registered
mail, return receipt requested, postage prepaid:

              If to the Company:

              Integrated Surgical Systems, Inc.
              829 West Stadium Lane
              Sacramento, California 95834

(or at such other address as may have been furnished in writing to the Sellers
by the Company) with a copy to:

              Jack Becker, Esq.
              Snow Becker Krauss P.C.
              605 Third Avenue
              New York, New York 10158-0125

              If to a Seller, at its address set forth on Exhibit A to this
Agreement (or at such other address as may have been furnished in writing to the
Company by such Seller) with copy to:

              Michael Lytton, Esq.
              Palmer & Dodge LLP
              One Beacon Street
              Boston, Massachusetts 02108

                                       8
   9
         Notices provided in accordance with this Section 4 shall be deemed
delivered upon personal delivery, receipt by telecopy or overnight mail, or 72
hours after deposit in the mail in accordance with the above.

         4.2. Entire Agreement. This Agreement embodies the entire agreement and
understanding between the parties hereto with respect to the subject matter
hereof and supersedes all prior agreements and understandings relating to such
subject matter.

         4.3. Amendments and Waivers. Except as otherwise expressly set forth in
this Agreement, any term of this Agreement may be amended and the observance of
any term of this Agreement may be waived (either generally or in a particular
instance and either retroactively or prospectively), with the written consent of
the Company and the holders of not less than two-thirds of the Registrable
Shares. No waivers of or exceptions to any term, condition or provision of this
Agreement, in any one or more instances, shall be deemed to be, or construed as,
a further or continuing waiver of any such term, condition or provision.

         4.4. Counterparts. This Agreement may be executed in several
counterparts, each of which shall be deemed an original, but all of which
together shall constitute one and the same instrument.

         4.5. Captions. The captions of the sections, subsections and paragraphs
of this Agreement have been added for convenience only and shall not be deemed
to be a part of this Agreement.

         4.6. Severability. Each provision of this Agreement shall be
interpreted in such manner as to validate and give effect thereto to the fullest
lawful extent, but if any provision of this Agreement is determined by a court
of competent jurisdiction to be invalid or unenforceable under applicable law,
such provision shall be ineffective only to the extent so determined and such
invalidity or unenforceability shall not affect the remainder of such provision
or the remaining provisions of this Agreement.

         4.7. Governing Law. This Agreement shall be governed by and construed
in accordance with the laws of the State of Delaware.

             [The remainder of this page intentionally left blank.]

                                       9
   10
         IN WITNESS WHEREOF, the Company and the Sellers have executed and
delivered this Agreement as an instrument under seal as of the date first above
written.

                                       THE COMPANY:

                                       INTEGRATED SURGICAL SYSTEMS, INC.

                                       By: /s/ Ramesh Trivedi
                                           ------------------------------------
                                       Name:   Ramesh Trivedi
                                       Title:  President and Chief Executive
                                                 Officer

                                       THE SELLERS:

                                       FARIDEH DANEL

                                       By: /s/ Farideh Danel
                                           ------------------------------------

                                       FRANCIOS DANEL

                                       By: /s/ Francois Danel
                                           ------------------------------------

                                       GERARD HASCOET

                                       By: Gerard Hascoet
                                           ------------------------------------

                                       JEROME LEBON

                                       By: /s/ Jerome Lebon
                                           ------------------------------------

                                       10
   11
                                       JEAN-LUC BOULNOIS

                                       By: /s/ Jean-Luc Boulnois
                                           ------------------------------------

                                       FERNAND BADANO

                                       By: /s/ Fernand Badano
                                           ------------------------------------

                                       PIERRE WUERGLER

                                       By: /s/ Pierre Wuergler
                                           ------------------------------------
                                           (By Power of Attorney)

                                       GEORGES-HENRI MEYLAN

                                       By: /s/ Georges-Henri Meylan
                                           ------------------------------------

                                       ENZO FILIPINI

                                       By: /s/ Enzo Filipini
                                           ------------------------------------

                                       PIERRE ANGELO BOTTINELLI

                                       By: /s/ Pierre Angelo Bottinelli
                                           ------------------------------------
                                           (By Power of Attorney)

                                       11
   12
                                       GIULIO MERLANI

                                           /s/ Giulio Merlani
                                       By:____________________________________
                                           (By Power of Attorney)

                                       SERGE TSCHOPP

                                           /s/ Serge Tschopp
                                       By:____________________________________
                                           (By Power of Attorney)

                                       RAYMOND BORNAND

                                           /s/ Raymond Bornand
                                       By:____________________________________
                                           (By Power of Attorney)

                                       JACQUES-LOUIS AUDEMARS

                                           /s/ Jacques-Louis Audemars
                                       By:____________________________________
                                           (By Power of Attorney)

                                       MOHAMMED DIAB

                                           /s/ Mohammed Diab
                                       By:____________________________________

                                       GEMED S.A.

                                           /s/ Georges-Henri Meylan
                                       By:____________________________________
                                       Name:  Georges-Henri Meylan
                                       Title: President Directeur General

                                       12
   13
                                    EXHIBIT A

Seller Name                             Number of
and Address                             Registrable Shares
- -----------                             ------------------

Farideh Danel                            80,643
Chemin des Bouts
38330 SAINT ISMIER
FRANCE

Francios Danel                           63,155
Chemin des Bouts
38330 SAINT ISMIER
FRANCE

Gerard Hascoet                          194,028
10 Avenue du Colonel Bonnet
75016 PARIS
FRANCE

Jerome Lebon                             33,917
6 rue Emile Zola
69002 LYON
FRANCE

Jean-Luc Boulnois                        28,717
17 Scott Road
Lexington, MA 02173
UNITED STATES

Fernand Badano                            5,431
4 allee Marcel Achard
69100 VILLEURBANNE
FRANCE

                                       1
   14

Pierre Wuergler                          27,003
c/o Credit Suisse
Paradeplatz 8
8070 ZURICH
SUISSE

Georges-Henri Meylan                     11,845
Route du Ruisseau 1
1348 LE BRASSUS
SUISSE

Enzo Filipini                            10,478
6803 CAMIGNOLO
SUISSE

Pierre Angelo Bottinelli                 10,478
Chemin des Trembles
1261 GENOLIER
SUISSE

Giulio Merlani                           10,478
Via Alla Chiesa
6932 BREGANZONA
SUISSE

Serge Tschopp                            10,478
Avenue des Cerisiers 45
1009 PULLY
SUISSE

Raymond Bornand                          10,478
Chemin du Cret 12
1110 MORGES
SUISSE

                                       2
   15

Jacques-Lois Audemars                     6,279
Valneige
1348 LE BRASSUS
SUISSE

Mohammed Diab                             2,619
11 Chemin des pecheurs
VOUVRY
SUISSE

GEMED S.A.                              113,328
Route de France 16
1348 LE BRASSUS
SUISSE

TOTAL:                                  619,355

                                       3
   1
                                    EXHIBIT 11.1

                          INTEGRATED SURGICAL SYSTEMS, INC.
                   STATEMENT OF COMPUTATION OF EARNINGS PER SHARE

                                               Years Ended December 31,        Six Months Ended June 30,
                                                  1995           1996              1996          1997
                                                  ----           ----              ----          ----          
                                                                                    
Primary and fully diluted:

Average common shares outstanding ........         75,180        721,657             273,946       3,364,567

Common and common equivalent shares
  issued during the twelve month period
  prior to the initial public offering at
  prices below the assumed public
  offering price in accordance with Staff
  Accounting Bulletin No. 83 ..............     4,103,697      3,652,290           4,103,697         --
                                              -----------    -----------         -----------     -----------
Shares used in per share calculations .....     4,178,877      4,373,947           4,377,643       3,364,567
                                              ===========    ===========         ===========     ===========
Net Loss ..................................   $(4,053,528)   $(3,448,829)        $(1,490,594)    $(1,687,591)
Preferred stock dividends .................      (936,325)       --                   --             --
                                              -----------    -----------         -----------     -----------
Net loss applicable to common
stockholders ..............................   $(4,989,853)   $(3,448,829)        $(1,490,594)    $(1,687,591)
                                              ===========    ===========         ===========     ===========
Net loss per common and common share
equivalent ................................        $(1.19)        $(0.79)             $(0.34)         $(0.50)
                                                   ======         ======              ======          ======

   1
                                                                    Exhibit 21.1

                                  SUBSIDIARIES
                       INTEGRATED SURGICAL SYSTEMS, INC.

                                  Jurisdiction
                                       of
Name                              Incorporation           Ownership
- ----                              -------------           ---------

Integrated Surgical 
  Systems B.V.                    Netherlands                100%

Integrated Surgical
  Systems GmbH                    Germany                    100%

Innovative Medical
  Machines International,
  S.A. ("IMMI")                   France                     100%

Innovative Medical
  Machines International, Inc.    Delaware                   100%*

_____________
* Indirectly owned through IMMI.
   1

                                                                    EXHIBIT 23.2

   
               CONSENT OF ERNST & YOUNG LLP, INDEPENDENT AUDITORS

   
     We consent to the reference to our firm under the captions "Experts" and
"Selected Consolidated Financial Information" and to the use of our report dated
January 31, 1997, except for Note 10, as to which the date is September 5, 1997,
in the Registration Statement (Form SB-2) and related Prospectus of Integrated
Surgical Systems, Inc. for the registration of 4,062,500 shares of its common
stock and warrants to purchase 325,000 shares of its common stock.

   
                                                               ERNST & YOUNG LLP

   
Sacramento, California

   
September 19, 1997
    
   1

                                                                    EXHIBIT 23.3

   
               CONSENT OF ERNST & YOUNG ENTREPRENEURS' DEPARTMENT

   
                  D'ERNST & YOUNG AUDIT, INDEPENDENT AUDITORS

   
     We consent to the reference to our firm under the caption "Experts" and to
the use of our report dated September 10, 1997 with respect to the consolidated
financial statements of Innovative Medical Machines International, S.A. included
in the Registration Statement (Form SB-2) and related Prospectus of Integrated
Surgical Systems, Inc. for the registration 4,062,500 shares of its common stock
and warrants to purchase 325,000 shares of its common stock.

   
                                                   ERNST & YOUNG ENTREPRENEURS

   
                                                   DEPARTMENT D'ERNST & YOUNG
                                                   AUDIT

                                                   Marc Bonhomme

                                                   Partner

   
Villeurbanne, France

   
September 19, 1997

 5

                   YEAR
                          DEC-31-1996
                               JUN-30-1997
                                       3,685,731
                                         0
                                  665,023
                                         0
                                  1,790,371
                             6,376,530
                                       1,358,540
                               1,088,882
                               6,663,357
                        2,008,845
                                              0
                                0
                                          0
                                        33,669
                                   4,620,843
                 6,663,357
                                      1,379,696
                             1,379,696
                                          531,693
                                2,659,115
                             (139,521)
                                     0
                                   0
                            (1,669,591)
                                    18,000
                        (1,687,591)
                                       0
                                      0
                                            0
                               (1,687,591)
                                   (0.50)
                                   (0.50)