UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549

                                    FORM 10-Q

|X| QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE
    ACT OF 1934


                For the Quarterly Period Ended September 30, 2009
                                       or

|_| TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE
    ACT OF 1934

                         Commission file number: 1-12471

                        INTEGRATED SURGICAL SYSTEMS, INC.
                        ---------------------------------
             (Exact name of registrant as specified in its charter)

            Delaware                                            68-0232575
            --------                                            ----------
(State or Other Jurisdiction of                               (IRS Employer
Incorporation or Organization)                              Identification No.)

            401 Wilshire Blvd., Suite 1020
               Santa Monica, California                            90401
               ------------------------                            -----
       (Address of Principal Executive Offices)                 (Zip Code)

                                 (310) 526-5000
                                 --------------
              (Registrant's Telephone Number, Including Area Code)

Indicate by check mark whether the registrant: (1) has filed all reports
required to be filed by Section 13 or 15(d) of the Securities Exchange Act of
1934 during the preceding 12 months (or for such shorter period that the
registrant was required to file such reports), and (2) has been subject to such
filing requirements for the past 90 days. YES |X| NO |_|

Indicate by check mark whether the registrant is a large accelerated filer, an
accelerated filer, a non-accelerated filer, or a smaller reporting company. See
definitions of "large accelerated filer," "accelerated filer" and "smaller
reporting company" in Rule 12b-2 of the Exchange Act. (Check one):


Large accelerated filer |_|              Accelerated filer |_|
Non-accelerated filer   |_|              Smaller reporting company |X|
(Do not check if a smaller reporting company)

Indicate by check mark whether the registrant is a shell company (as defined in
Rule 12b-2 of the Act). YES |X| NO|_|

As of November 10, 2009 there were 7,658,154 shares of the registrant's common
stock outstanding.

Integrated Surgical Systems, Inc. Form 10-Q Table of Contents Page Part I. Financial Information Item 1. Financial Statements 2 Balance Sheets at September 30, 2009 (unaudited) and December 31, 2008 (audited) 2 Statements of Operations (unaudited) for the nine months ended September 30, 2009 3 and 2008 Statements of Operations (unaudited) for the three months ended September 30, 2009 4 and 2008 Statements of Cash Flows (unaudited) for the nine months ended September 30, 2009 5 and 2008 Notes to Financial Statements (unaudited) 6 Item 2. Management's Discussion and Analysis of Financial Condition and Results of 14 Operations Item 3. Quantitative and Qualitative Disclosures About Market Risk 17 Item 4T. Controls and Procedures 17 Part II. Other Information Item 1. Legal Proceedings 18 Item 6. Exhibits 18 Signatures 20 Certifications 1

Part I. FINANCIAL INFORMATION Item 1. Financial Statements. Integrated Surgical Systems, Inc. Balance Sheets Assets September 30, December 31, 2009 2008 (Unaudited) (Audited) ---------------------------------- Current assets: Cash $ 662,893 $ 3,322,358 Investment in available-for-sale securities 3,580,590 1,116,151 Other current assets 66,963 62,822 ---------------------------------- Total current assets 4,310,446 4,501,331 ---------------------------------- Total assets $ 4,310,446 $ 4,501,331 ================================== Liabilities and stockholders' equity Current liabilities: Accounts payable $ 5,513 % 4,951 Accrued liabilities -- 3,000 Accrued stock compensation 12,500 34,066 Income taxes payable -- 800 Deferred rent - current portion 23,160 22,379 ---------------------------------- Total current liabilities 41,173 65,196 Rent deposit 8,175 8,175 Deferred rent - noncurrent 5,716 23,185 ---------------------------------- Total liabilities 55,064 96,556 Convertible preferred stock, $0.01 par value, 1,000,000 shares authorized; 168 shares issued and outstanding ($168,496 aggregate liquidation value) 168,496 168,496 Stockholders' equity: Common stock, $0.01 par value, 100,000,000 shares authorized; 7,658,154 shares issued and outstanding 76,581 74,749 Additional paid-in capital 64,177,507 64,101,448 Accumulated deficit (60,169,762) (59,943,265) Accumulated other comprehensive income 2,560 3,347 ---------------------------------- Total stockholders' equity 4,086,886 4,236,279 ---------------------------------- Total liabilities and stockholders' equity $ 4,310,446 $ 4,501,331 ================================== See accompanying notes to financial statements. 2

Integrated Surgical Systems, Inc. Statements of Operations (Unaudited) Nine Months ended September 30, 2009 2008 ----------- ----------- General and administrative expenses $ 269,170 $ 173,655 ----------- ----------- Loss from operations (269,170) (173,655) Other income Interest income, net 38,724 56,918 Realized gain on available-for-sale securities 4,749 -- ----------- ----------- Loss before income taxes (225,697) (116,737) Income taxes 800 -- ----------- ----------- Net Loss $ (226,497) $ (116,737) =========== =========== Basic net loss per common share $ (0.03) $ (0.02) =========== =========== Diluted net loss per common share $ (0.03) $ (0.02) =========== =========== Weighted average number of shares outstanding: Basic 7,513,623 6,248,683 =========== =========== Diluted 7,513,623 6,248,683 =========== =========== Other Comprehensive Income $ (787) $ -- =========== =========== See accompanying notes to financial statements. 3

Integrated Surgical Systems, Inc. Statements of Operations (Unaudited) Three Months ended September 30, 2009 2008 ----------- ----------- General and administrative expenses $ 52,977 $ 133,912 ----------- ----------- Loss from operations (52,977) (133,912) Other income Interest income, net 14,444 21,723 Realized gain on available-for-sale securities 2,496 -- ----------- ----------- Loss before income taxes (36,037) (112,189) Income taxes -- -- ----------- ----------- Net loss $ (36,037) $ (112,189) =========== =========== Basic net loss per common share $ (0.00) $ (0.02) =========== =========== Diluted net loss per common share $ (0.00) $ (0.02) =========== =========== Weighted average number of shares outstanding: Basic 7,589,819 7,474,894 =========== =========== Diluted 7,589,819 7,474,894 =========== =========== Other Comprehensive Income $ 1,454 $ -- =========== =========== See accompanying notes to financial statements. 4

Integrated Surgical Systems, Inc. Statements of Cash Flows (Unaudited) Nine Months ended September 30, 2009 2008 ----------- ------------ Cash flows from operating activities Net loss $ (226,497) $ (116,737) Adjustments to reconcile net loss to cash used in operating activities: Stock-based compensation 18,825 11,475 Realized gain on available-for-sale securities (4,749) -- Changes in assets and liabilities Other current assets (4,139) (16,300) Accounts payable 562 3,849 Accrued liabilities (3,000) (10,346) Accrued stock compensation 37,500 21,566 Income taxes payable (800) (31,482) Rent deposit received -- 8,175 Deferred rent payable (16,688) (211,790) ----------- ----------- Cash used in operating activities (198,986) (341,590) ----------- ----------- Cash flows from investing activities Purchase of available-for-sale securities (4,750,284) -- Sale of available-for-sale securities 2,289,805 -- ----------- ----------- Cash used in investing activities (2,640,479) -- ----------- ----------- Cash flows from financing activities Proceeds from sale of common stock -- 1,750,000 Offering cost -- (58,258) ----------- ----------- Cash provided by financing activities -- 1,691,742 Net increase (decrease) in cash (2,659,465) 1,350,152 Cash at beginning of period 3,322,358 3,099,199 ----------- ----------- Cash at end of period $ 662,893 $ 4,449,351 =========== =========== Supplemental disclosures of cash flow information: Income taxes paid $ 1,600 $ -- Supplemental disclosures for non-cash transactions Unrealized loss on available-for-sale securities $ (787) $ -- Distribution of common stock for stock compensation $ 59,066 $ -- See accompanying notes to financial statements. 5

Integrated Surgical Systems, Inc. Notes to Financial Statements (unaudited) 1. Organization and Operations Integrated Surgical Systems, Inc. (the "Company") was incorporated in Delaware in 1990 to design, manufacture, sell and service image-directed, computer-controlled robotic software and hardware products for use in orthopedic surgical procedures. The Company's products were authorized to be sold through international distributors to hospitals and clinics in European Union member countries and Australia, Canada, India, Israel, Japan, Korea, New Zealand, Switzerland and South Africa. On June 28, 2007, upon the sale of substantially all of its assets, the Company became inactive. On June 28, 2007, the stockholders approved the future liquidation of the Company if the Company was unable to complete an acquisition or similar transaction within one year of the sale of its assets. At the same time, the Company's stockholders granted the Board of Directors authority to abandon any decision to liquidate without further stockholder action if it determines the liquidation is not in the best interests of the Company or the Company's stockholders. The Board of Directors decided it is in the best interest of the Company and its stockholders to not liquidate. 2. Significant Accounting Policies Basis of presentation The accompanying unaudited financial statements and related notes have been prepared in accordance with accounting principles generally accepted in the United States of America for interim financial statements and with the rules and regulations under Regulation S-X of the Securities and Exchange Commission for Form 10-Q. Accordingly, they do not include all of the information and footnotes required by accounting principles generally accepted in the United States of America for complete financial statements presentation. In the opinion of management, all adjustments (consisting of normal recurring accruals) considered necessary to present fairly the financial position as of September 30, 2009 and results of operations and cash flows for the nine months and three months then ended have been included. These financial statements should be read in conjunction with the financial statements of the Company together with the Company's management discussion and analysis in the Company's Form 10-K for the year ended December 31, 2008. Interim results are not necessarily indicative of the results for a full year. The financial statements include all the accounts of the Company. Estimates The preparation of financial statements in conformity with accounting principles generally accepted in the United States of America requires management to make estimates and assumptions that affect the reported amounts of assets and liabilities and the disclosure of contingent assets and liabilities at the date of the financial statements and revenues and expenses during the reporting period. Actual results could differ from those estimates. Recently Adopted Accounting Pronouncements Effective January 1, 2009, the Company adopted a new accounting standard regarding business combinations. As codified under FASB ASC 805 (formerly SFAS No. 141 revised 2007, "Business Combinations"), this update establishes principles and requirements for determining how an enterprise recognizes and measures the fair value of certain assets and liabilities acquired in a business combination, including non-controlling interests, contingent consideration, and certain acquired contingencies. This update also requires acquisition-related transaction expenses and restructuring costs be expensed as incurred rather than capitalized as a component of the business combination. This accounting standard 6

update applies prospectively to business combinations for which the acquisition date is on or after the beginning of the first annual reporting period beginning on or after December 15, 2008. The adoption of this accounting standard did not have any impact on the results of operations and financial conditions of the Company. Effective January 1, 2009, the Company adopted an accounting standard which establishes accounting and reporting standards for the non-controlling interest in a subsidiary (previously referred to as minority interests). FASB ASC 810-10 also requires that a retained non-controlling interest upon the deconsolidation of a subsidiary be initially measured at its fair value, (formerly SFAS No. 160, "Accounting and Reporting on Non-controlling Interest in Consolidated Financial Statements, an Amendment of ARB 51"). This accounting standard requires the Company to report any non-controlling interests as a separate component of stockholders' equity. The Company is also required to present any net income allocable to non-controlling interests and net income attributable to stockholders of the Company separately in its consolidated statements of income. This accounting standard update applies prospectively to interim and annual reporting periods beginning on or after December 15, 2008. The adoption of this accounting standard did not have any impact on the results of operations and financial conditions of the Company. Effective January 1, 2009, adopted an accounting standard which amends and expands the disclosure requirements related to derivative instruments and hedging activities, as codified in FASB ASC 161-10 (formerly SFAS No. 161 "Disclosures about Derivative and Hedging Activities"). This accounting standard requires qualitative disclosures about credit-risk-related contingent features in derivative agreements. The adoption of these accounting updates did not have any impact on the results of operations and financial conditions of the Company. Effective April 1, 2009, the Company adopted new accounting standards for subsequent events, as codified in FASB ASC 855-10 (formerly SFAS No. 165, "Subsequent Events" ). This update establishes standards of accounting and disclosure of events after the balance sheet date but before financial statements are issued and requires disclosure of the date through which subsequent events have been evaluated and the basis for the date. For the period ended September 30, 2009, the subsequent events assessment was performed through November 10, 2009. This was the date on which the Company's board of directors approved the accompanying financial statements. Recently Issued Accounting Pronouncements Effective July 1, 2009, the Company adopted the "FASB Accounting Standards Codification" and the Hierarchy of Generally Accepted Accounting Principles, FASB ASC 105, (formerly SFAS No. 168, "Accounting Standards Codification and the Hierarchy of Generally Accepted Accounting Principles") This standard does not change generally accepted accounting principles ("GAAP"). Rather, it defines the accounting standards codification which became the source of authoritative U.S. GAAP to be applied by nongovernmental entities. The Company began using the new guidelines and numbering system prescribed by the Codification when referring to GAAP for the period ended September 30, 2009. As the Codification was not intended to change of alter existing GAAP, it did not have any impact on the Company's financial statements. In August 2009, the FASB issued Accounting Standards Update ("ASU") No. 2009-05, "Fair Value Measurements and Disclosures", an update to FASB ASC 820-10 "Fair Value Measurements and Disclosures-Overall". This update provides clarification that in circumstances in which a quoted price in an active market for the 7

identical liability is not available, a reporting entity is required to measure fair value using certain valuation techniques. This accounting update did not have any impact on the results of operations and financial conditions of the Company. Management does not believe that any other recently issued, but not yet effective accounting pronouncements, if adopted, would have a material effect on the accompanying financial statements. 3. Income (Loss) Per Share Basic income (loss) per share is computed by dividing net income (loss) by the weighted average number of shares of common stock outstanding during the period. Diluted net income (loss) per share is computed by dividing net income (loss) by the weighted average number of shares of common stock outstanding during the period plus dilutive common stock equivalents, using the treasury stock method. Convertible preferred stock of 683,554 shares, a warrant for 30,000 shares and stock options of 159,500 were excluded from the calculation of loss per share for the nine months and three months ended September 30, 2009, because their effect was anti-dilutive. Convertible preferred stock of 639,454 shares, a warrant for 30,000 shares and stock options of 162,500 were excluded from the calculation of loss per share for the nine months and three months ended September 30, 2008, because their effect was anti-dilutive. 4. Investment in Available-for-Sale Securities The following is a summary of the Company's investment in available-for-sale securities as of September 30, 2009: Unrealized Unrealized Cost Gains Losses Fair Value ------------------------------------------------------------------------ U.S. federal agency securities $ 1,264,313 $ 3,503 $ (1,377) $ 1,266,439 Corporate securities 632,691 4,263 (629) 636,325 Certificates of deposit 1,681,026 309 (3,509) 1,677,826 ----------- ----------- ----------- ----------- Total $ 3,578,030 $ 8,075 $ (5,515) $ 3,580,590 =========== =========== =========== =========== The cost and fair value of investment in available-for-sale debt securities, by contractual maturity, as of September 30, 2009, are as follows: Fair Cost Value -------------------------- Due within one year $ 998,279 $ 997,296 Due after one year through three years 1,426,578 1,429,533 Due after three years 1,153,173 1,153,761 ---------- ---------- $3,578,030 $3,580,590 ========== ========== 8

Expected maturities will differ from contractual maturities because the issuers of certain debt securities have the right to call or prepay their obligations without any penalties. The Company intends to be opportunistic with the purchase and sale of its debt securities and expects all the securities to be sold or called during the twelve-months ended September 30, 2010. Therefore, the Company has classified the entire fair value of its investment in available-for-sale debt securities as current assets in the accompanying balance sheets. FASB ASC 820 "Fair Value Measurements and Disclosures" (formerly SFAS No. 157) clarifies that fair value is an exit price, representing the amount that would be received to sell an asset or paid to transfer a liability in an orderly transaction between market participants. As such, fair value is a market-based measurement that is determined based on assumptions that market participants would use in pricing an asset or a liability. As a basis for considering such assumptions, ASC 820 establishes a three-tier value hierarchy, which prioritizes the inputs used in the valuation methodologies in measuring fair value: o Level 1 - Observable inputs that reflect quoted prices (unadjusted) for identical assets or liabilities in active markets. o Level 2 - Include other inputs that are directly or indirectly observable in the marketplace. o Level 3 - Unobservable inputs which are supported by little or no market activity. The fair value hierarchy also requires an entity to maximize the use of observable inputs and minimize the use of unobservable inputs when measuring fair value. In accordance with FASB ASC 820, we measure our cash and investments in available-for-sale securities at fair value. Our cash and investments in available-for-sale securities are classified within Level 1 by using quoted market prices utilizing market observable inputs. 5. Common Stock On April 25, 2008, the Company sold an aggregate of 2,896,394 shares of common stock at $0.6042 per share, for an aggregate purchase price of $1,750,000. The Company incurred $58,258 of expenses in connection with the offering. Certain of the investors are affiliated with the Company's advisory services firm that is currently providing investment banking services. On July 29, 2009 and August 19, 2009 the Company issued 68,480 and 23,150, respectively, shares of common stock as compensation to each of two of directors (Note 7). Both directors are affiliated with the Company's advisory services firm that is currently providing investment banking services. 6. Convertible Preferred Stock The Company's Certificates of Incorporation authorized 1,000,000 shares of undesignated, serial preferred stock. Preferred stock may be issued from time to time in one or more series. The Board of Directors is authorized to determine the rights, preferences, privileges, and restrictions granted to and imposed upon any wholly unissued series of preferred stock and designation of any such series without any further vote or action by the Company's stockholders. As of September 30, 2009 and December 31, 2008, the Company's only outstanding series of convertible preferred stock is the Series G Convertible Preferred Stock ("Series G"). 9

The Series G stock has a stated value of $1,000 per share, and is convertible into common stock at conversion price equal to 85% of the lowest sale price of the common stock on its listed market over the five trading days preceding the date of conversion ("Beneficial Conversion Feature"), subject to a maximum conversion price. The number of shares of common stock that may be converted is determined by dividing the stated value of the number of shares of convertible preferred stock to be converted by the conversion price. The Company may elect to pay the Series G holder in cash at the current market price multiplied by the number of shares issuable upon conversion. The value that had been assigned to the Beneficial Conversion feature of the Series G was based on the difference between the maximum conversion price and quoted market price of the common stock on the date that the Series G was sold (the "Discount"). The Discount was accreted using the straight-line method over the conversion period. The Series G does not entitle holders to dividends or voting rights, unless required by law. For the nine months ended September 30, 2009 and the year ended December 31, 2008, no shares of Series G were converted into shares of common stock. At September 30, 2009 and December 31, 2008, the outstanding Series G shares could have been converted into a minimum of 683,554 and 707,966 shares of common stock, respectively. Upon a change in control, sale of or similar transaction, as defined, each holder of the Series G has the option to deem such transaction as a liquidation and may redeem their shares at the liquidation value of $1,000, per share, for an aggregate amount of $168,496. As such redemption is not in control of the Company, the Series G preferred stock has been accounted for as if they were redeemable preferred stock and are classified on the balance sheet between liabilities and stockholders' equity. 7. Stock-based compensation The Company currently has a stock option plan to attract, motivate and retain selected officers, employees, directors and consultants under which incentive or non-incentive options may be granted, generally for a term of ten years from the date of grant. Exercise prices of incentive stock options may not be less than 100% and exercise prices of non-statutory stock options may not be less than 85% of the fair market value of the common stock on the date of the grant. For persons owning 10% or greater of the voting power of all classes of the Company's stock, the exercise price of the incentive or the non-qualified stock options may not be less than 110% of the fair market value of the common stock on the date of the grant. The plan is administered by the Company's board of directors. FASB ASC 718 "Compensation-Stock Compensation" (formerly SFAS 123(R)) requires entities to estimate the number of forfeitures expected to occur and record expense based upon the number of awards expected to vest. Prior to adoption of FASB ASC 718, the Company accounted for forfeitures as they occurred, as permitted under FASB ASC 718. The cumulative effect of adopting the method change of estimating forfeitures is not material to the Company's financial statements for the nine months and three months ended September 30, 2009. The 1998 Stock Option Plan (1998 Plan) was established to grant up to 85,000 non-qualified options through May 12, 2008 to employees and other individuals providing services to the Company. Options under the 1998 Plan vest variably from one year to four years from the date grant and must be exercised within 30 days of employee termination. As of September 30, 2009 the plan had expired; therefore, no options were available for future grant. 10

The 2000 Stock Award Plan (2000 Plan) was established to grant up to 100,000 incentive options through December 11, 2010 to employees, excluding officers and directors, and other individuals providing services to the Company. Options under the 2000 Plan vest variably from one year to four years from the date grant and must be exercised within three months of employee termination. As of September 30, 2009 and December 31, 2008, the 2000 plan had 98,046 options available for future grant. Under both plans, exercised, forfeited/expired or cancelled shares may be reissued. Options outstanding or options forfeited/expired may be from expired plans. For the nine months ended September 30, 2009, option activity was as follows: Remaining Weighted-Average Contractual Aggregate Fair Shares Exercise Price Term Value ----------------------------------------------------------- ------------------- Outstanding at beginning of period 161,000 $ 0.97 Granted - $ - Expired and forfeited 1,500 $ 36.04 Exercised - $ - ------------------------------------------------------------------------------- Outstanding at end of period 159,500 $ 0.64 3.44 $43,335 Exercisable at September 30, 2009 159,500 $ 0.64 3.44 $43,335 All of the Company's granted and outstanding options were vested at September 30, 2009. The Company recorded stock-based compensation expense, related to its stock options, which is included in general and administrative expenses, for the nine months ended September 30, 2009 and 2008, of $18,825 and $11,475 respectively, and for the three months ended September 30, 2009 and 2008, of $3,765 and $4,866 respectively. The Company's stock options have no intrinsic value as of September 30, 2009. As of September 30, 2009 a summary of options outstanding under the plans was as follows: Range of Weighted-Average Number Weighted-Average Number Weighted-Average Exercise Price Remaining Contractual Outstanding at Exercise Price Exercisable at Exercise Price Life (Years) 9/30/09 9/30/09 - ------------------------------------------------------------------------------------------------------------------- 0.00-9.99 3.5 158,000 $0.36 158,000 $0.36 10.00-30.00 0.3 1,500 29.17 1,500 29.17 - ------------------------------------------------------------------------------------------------------------------- 3.4 159,500 $0.64 159,500 $0.64 === ======= ======= ===== The following is a summary of the status of the Company's non-vested options as of September 30, 2009, and changes during the nine month period ended September 30, 2009: Weighted-Average Grant-Date Non-vested Shares Shares Fair Value - -------------------------------------------------------------------------------- Non-vested at beginning of period 100,000 $0.30 Granted - - Expired and Forfeited - - Vested 100,000 $0.30 - -------------------------------------------------------------------------------- Non-vested at end of period - $ - 11

During 2008, the Company agreed to compensate two of its directors with common stock in lieu of cash cash compensation and accrued $34,066 as of December 31, 2008. The number of shares was to be determined based upon the equivalent cash compensation accrued divided by the closing stock price on March 31, 2009. The closing stock price on March 31, 2009 was $0.34 resulting in compensation of 68,480 shares to each of the two directors. These shares were issued on July 29, 2009. The two directors also chose to be compensated with common stock for the periods April 1 to June 30, 2009 and July 1 to September 30, 2009. The number of shares was to be determined based upon the cash compensation accrued divided by the closing stock price on June 30, 2009 and September 30, 2009, respectively. The closing stock price on June 30, 2009 was $0.27 resulting in compensation of 23,150 shares to each of the two directors. These shares were issued on August 19, 2009. The closing stock price on September 30, 3009 was $0.29 resulting in compensation of 21,555 shares to each of the two directors. These shares have not been issued as of the date of these financial statements. The Company recorded stock-based compensation related to the common stock earned for the nine months and three months ended September 30, 2009 of $37,500 and $12,500, respectively. 8. Income Taxes Effective January 1, 2007, the Company adopted the provisions of FASB ASC 740 "Income Taxes" (formerly Financial Accounting Standards Board (FASB) Interpretation No. 48, "Accounting for Uncertainty in Income Taxes, an interpretation of FASB Statement No. 109"). FASB ASC 740 clarifies the accounting for uncertainty in income taxes recognized in the Company's financial statements and prescribes a recognition threshold and measurement process for financial statement recognition and measurement of a tax position taken or expected to be taken in a tax return. FASB ASC 740 also provides guidance under recognition, classification, interest and penalties, accounting in interim periods, disclosure and transition. Federal and state income tax returns for the years ended December 31, 2008, 2007 and 2006 are subject to review by the taxing authorities. The Company's policy is to classify assessments, if any, for tax related interest as interest expenses and penalties as general and administrative expenses. The Company has evaluated and concluded that there are no uncertain tax positions requiring recognition in the Company's financial statements for the nine months ended September 30, 2009. 9. Related Party Transactions In July, 2008, the Company retained an accounting firm in which an officer and director is a partner to perform accounting and administrative services. During the nine months and three months ended September 30, 2009, the Company paid this firm $30,901 and $11,438, respectively. 12

The Company entered into an Investment Banking Advisory Services agreement in November 2007. The Company extended this agreement indefinitely in April 2009. The agreement as modified may be terminated by either party upon 30-days written notice. The Company advanced $25,000 to the Investment Banking firm in December 2007 for its expenses. The remaining $9,878 was repaid to the Company in April 2009. The Company recorded for the nine months and three months ended September 30, 2009 general and administrative expense of $15,122 and $0, respectively, for legal expenses presented against this advance. There have been no other payments or fees earned as a result of this agreement. The Company also has a money market account with this Investment Banking Firm and invested in short-term federal securities, with a balance of $443,238 at September 30, 2009. This Investment Banking firm manages the available-for-sale investments for the Company, a total of $3,580,590 at September 30, 2009.The Chief Executive Officer and director of the Company is the Chief Executive Officer and a director of the Investment Banking firm. Another officer and director of the Company is a managing director of the same Investment Banking firm. 10. Fair Value of Financial Instruments FASB ASC 820 "Fair Value Measurements and Disclosures", (formerly No. 157, "Fair Value Measurements"), which defines the fair value, establishes a framework for measuring fair value and expands disclosures about fair value measurements. This standard is effective for financial statements issued for fiscal years beginning after November 15, 2008, and interim periods within those fiscal years. Our adoption of FASB ASC 820 on January 1, 2008 did not have a material impact on the Company's financial position, results of operations or cash flows. The carrying value of accounts receivable, cash accounts, other current assets, accounts payable, deferred rent, and accrued liabilities are considered to be representative of their respective fair values because of the short-term nature of those instruments. FASB ASC 825 "Financial Instruments" (formerly SFAS No. 159, "The Fair Value Option for Financial Assets and Financial Liabilities"), permits entities to choose to measure at fair value many financial instruments and certain other items that had previously not been required to be measured at fair value. Subsequent changes in fair value for designated items are required to be reported in earnings in the current period. FASB ASC 825 also establishes presentation and disclosure requirements for similar types of assets and liabilities measured at fair value. As permitted by FASB ASC 825, we have elected not to use the fair value option to measure our available-for-sale securities and will continue to report under FASB ASC 320, "Investments-Debt and Equity Securities". We have made this election because the nature of our financial assets and liabilities are not of such complexity that they would benefit from a change in valuation to fair value. 11. Commitments and Contingencies Lease As of September 30, 2009, the Company was committed for future minimum rent under the lease for its former manufacturing, warehouse and administrative space, net of sublease income, plus subsidy payments by the Company to the sublessor, through December 31, 2010. The present value of the future minimum rent under the lease, net of sublease income, was charged to general and administrative expenses in connection with the Company's continuing operations. The minimum payments are as follows: Sublease net of sublease subsidy Lease payments Net ------------------------------------------------ October 1 through December 31, 2009 $ 23,850 $ 17,850 $ 6,000 2010 97,875 73,875 24,000 ----------------------------------------------- $121,725 $ 91,725 $ 30,000 ================================================ 13

Other On January 8, 2009, a complaint was filed in Superior Court of California, County of Sacramento in which the Company was named as a co-defendant in a matter involving an automobile accident. The plaintiffs are seeking damages for pain & suffering, emotional distress, past and future medical expenses and past and future loss of earnings totaling approximately $30,000,000. The Company believes the demands are without merit and intends to vigorously defend the complaint. To the best of the Company's knowledge, there are no other proceedings or litigation currently threatened or proceeding against us or threatening us. From time to time, the Company may be party to other claims and litigation arising in the ordinary course of business. The Company does not believe that any adverse final outcome of any of these matters, whether or not covered by insurance, would have a material adverse effect on the Company. The Company is subject to various legal proceedings and claims arising in the ordinary course of business. There are no current proceedings or litigation involving us that we believe if judgment were rendered against us would have a material adverse impact on our financial position, results of operation or cash flows. 12. Subsequent Event For the period ended September 30, 2009, the subsequent events assessment was performed through November 10, 2009. This was the date on which the Company's board of directors approved the accompanying financial statements. Item 2. Management's Discussion and Analysis of Financial Condition and Results of Operations Forward-Looking Statements The discussion in this Quarterly Report on Form 10-Q contains forward-looking statements that have been made pursuant to the provisions of the Private Securities Litigation Reform Act of 1995. Such forward-looking statements are based on current expectations, estimates and projections about the software industry and certain assumptions made by the Company's management. Words such as "anticipates," "expects," "intends," "plans," "believes," "seeks," "estimates," "could," "would," "may," "on target," "envisions," and variations of such words and similar expressions are intended to identify such forward-looking statements. These statements are not guarantees of future performance and are subject to certain risks, uncertainties and assumptions that are difficult to predict; therefore, actual results may differ materially from those expressed or forecasted in any such forward-looking statements. Unless required by law, the Company undertakes no obligation to update publicly any forward-looking statements, whether as a result of new information, future events or otherwise. 14

However, readers should carefully review the risk factors set forth in other reports or documents the Company files from time to time with the SEC, particularly the Company's Annual Report on Form 10-K, Quarterly Reports on Form 10-Q and any Current Reports on Form 8-K. The following discussion should be read in conjunction with the unaudited financial statements and notes thereto in Part I, Item 1 of this Quarterly Report on Form 10-Q and with the audited Financial Statements and Notes thereto, together with Management's Discussion and Analysis of Financial Condition and Results of Operations, which are included in the Company's Annual Report on Form 10-K for the fiscal year ended December 31, 2008 as filed with the SEC. Overview We were incorporated in Delaware in 1990 to design, manufacture, sell and service image-directed, computer-controlled robotic software and hardware products for use in orthopedic surgical procedures. Although we had not received clearance to market the ROBODOC(R) System (ROBODOC) in the U.S., we were permitted to export the system provided certain requirements were met. Products approved for use by European Union member countries and Australia, Canada, India, Israel, Japan, Korea, New Zealand, Switzerland and South Africa, do not require U.S. FDA export approval. We had sold our robotic systems to international distributors, who in turn resold the product in their territories. Our international distributors were KTEC in Japan, ROCOM Frontier in Korea and Paramount Impex in India. After the sale of substantially all of our assets on June 28, 2007, the Company became inactive. The Company has no employees and all services are provided by contracted personnel. Our operations are limited to raising additional funds to be used to maintain our public company status and for a business combination if a suitable candidate is located. Our stockholders approved the future liquidation of the Company if we were unable to complete an acquisition or similar transaction by June 28, 2008. Our stockholders also granted the Board of Directors authority to abandon any decision to liquidate without further stockholder action if it determined the liquidation was not in the best interests of the Company or our stockholders. The Board of Directors has decided it is in the best interest of the Company and its stockholders to not liquidate. For the nine months and three months ended September 30, 2009, our general and administrative expenses consisted primarily of our continuing expenses to maintain our public company status, the cost to maintain a lease agreement for the facility we used while we were an operating company offset by a sublease for the same space. We retained the lease obligation as part of the sale of substantially all of our assets. The sublease agreement provides for the sublessee to pay our lessor each month for the rent owed by us under our lease through December 31, 2010, the duration of the lease term. As an incentive to agree to the sublease, we have agreed to pay the sublessor $2,000 each month our rent is paid. Results of Operations Nine Months Ended September 30, 2009 and 2008 For the nine months ended September 30, 2009 and 2008 we had a net loss of $226,497 and $116,737, respectively. General and administrative expenses were $269,170 and $173,655 for the nine months ended September 30, 2009 and 2008, respectively. General and administrative expenses were offset for the nine months ended September 30, 2008 by the effect of an approximately $212,000 reduction in deferred rent from a sublease agreement with a company to lease office space from us. Legal fees decreased by approximately $81,000 from the nine months ended September 30, 2008 to September 30, 2009 due to an effort to control our costs. Business insurance decreased approximately $22,000 from the nine months ended September 30, 2008 to September 30, 2009 due to a change in an insurance policy in an effort to control our costs. Stock-based compensation increased by approximately $16,000 for the nine months ended September 30, 2008 to September 30, 2009 due to the addition of two board members in April 2008 with compensation beginning when they became members. State tax expense decreased approximately $14,000 from the nine months ended September 30, 2008 to 15

September 30, 2009 due to a reduction in the base used for the calculation of Delaware gross receipts tax. Accounting and accounting consulting fees decreased by approximately $23,000 from the nine months ended September 30, 2008 to September 30, 2009, due to a decrease in cost for independent accountant and bookkeeping services. Net interest income was $38,724 and $56,918 for the nine months ended September 30, 2009 and 2008, respectively. The decrease of approximately $18,000 was due to less total funds in interest-bearing cash and securities offset by a higher percentage of funds being invested in bonds yielding a higher return than funds deposited in a savings account. Three Months Ended September 30, 2009 and 2008 For the three months ended September 30, 2009 and 2008 we had a net loss of $36,037 and $112,189, respectively. General and administrative expenses were $52,977 and $133,912 for the three months ended September 30, 2009 and 2008, respectively. Legal fees decreased by approximately $49,000 from the nine months ended September 30, 2008 to September 30, 2009 due to an effort to control our costs and an approximately $11,000 negotiated decrease in an invoice for legal services which had been previously expensed during the three month period ended June 30, 2009. Accounting and accounting consulting fees decreased by approximately $8,000 from the nine months ended September 30, 2008 to September 30, 2009, due to a decrease in cost for independent accountant services. Business insurance decreased approximately $7,000 from the nine months ended September 30, 2008 to September 30, 2009 due to a change in an insurance policy in an effort to control our costs. Net interest income was $14,444 and $21,723 for the three months ended September 30, 2009 and 2008, respectively. The decrease of approximately $7,000 was due to less total funds in interest-bearing cash and securities offset by a higher percentage of funds being invested in bonds yielding a higher return than funds deposited in a savings account. Liquidity and Capital Resources We believe our current cash position is adequate to carry out our plan. At September 30, 2009 and December 31, 2008, our "quick ratio" (cash divided by current liabilities), a conservative liquidity measure designed to predict our ability to pay bills, was 16.10 and 50.96, respectively. The decrease in the "quick ratio" ratio at September 30, 2009 from December 31, 2008 was due to increased investment of cash in available-for-sale investments. This investment results in less cash at September 30, 2009 and more in available-for-sale investments, which is recorded in the accompanying financial statements as a current asset. Our "current ratio" (current assets divided by current liabilities) was 104.69 and 69.04 at September 30, 2009 and December 31, 2008. We anticipate that we will incur operating losses from continuing operations in the next twelve months, until we enter into a business combination or until our liquidation. Cash used in operating activities was $198,986 and $341,590 for the nine months ended September 30, 2009 and 2008, respectively. Cash used in operating activities for the nine months ended September 30, 2009 was due primarily to our net loss of $226,497 and a decrease in deferred rent of $16,688 offset by adding back non-cash expense for stock-based compensation of $18,825 and accrued stock compensation of $37,500. Cash used in operating activities for the nine months ended September 30, 2008 was due primarily to our net loss of $116,737, an increase in other current assets of $16,300 and decreases in deferred rent of $211,790, in income taxes payable of $31,482 and accrued liabilities of $10,346 offset by adding back non-cash expense for stock-based compensation of $11,475 and accrued stock compensation of $21,566. 16

Cash used in investing activities for the nine months ended September 30, 2009 of $2,460,479 was from the purchase of available-for-sale securities of $4,750,284 offset by the sale of available-for-sale securities of $2,289,805. Cash provided by financing activities for the nine months ended September 30, 2008 was $1,691,742 and was due to the net proceeds as a result of the April 2008 sale of common stock. We do not have any material commitments for capital expenditures. We do not have any off-balance sheet arrangements that have or are reasonably likely to have a current or future effect on our financial condition, changes in financial condition, revenues or expenses, liquidity or capital resources that are material to our investors. Critical Accounting Policies and Estimates The Company's discussion and analysis of the financial condition and results of operations are based upon the Company's unaudited financial statements included elsewhere in this Form 10-Q and has been prepared in accordance with accounting principles generally accepted in the United States of America as disclosed in our annual financial statements in our Form 10-K for the year ended December 31, 2008. Interim results are not necessarily indicative of the results for a full year. Estimates The preparation of financial statements in conformity with accounting principles generally accepted in the United States of America requires management to make estimates and assumptions that affect the reported amounts of assets and liabilities and the disclosure of contingent assets and liabilities at the date of the financial statements and revenues and expenses during the reporting period. Actual results could differ from those estimates. Item 3. Quantitative and Qualitative Disclosures about Market Risk Market risk represents the risk of loss that may impact our financial position, operating results or cash flows due to changes in U.S. interest rates. Our exposure to market risk is confined to our cash and available-for-sale investments that we expect to hold less than one year. The goals of our cash investment policy are the security of the principal invested and fulfillment of liquidity needs. We currently do not hedge interest rate exposure. Because of the short-term nature of our investments, we do not believe that an increase in market rates would have any material negative impact on the value of our investment portfolio. As of September 30, 2009, we held $662,893 in money market, savings and checking accounts. The Company has a checking account and savings accounts at one major banking institution with combined balances of $189,655 at September 30, 2009. The Company has a savings account in another major banking institution with a balance of $30,000 at September 30, 2009. These checking and savings accounts are guaranteed by the Federal Deposit Insurance Corporation (FDIC) up to $250,000 per institution. The Company has a money market account in a brokerage account with a third financial institution, invested in fixed-income securities, with a balance of $443,238 at September 30, 2009. The funds in the money market at this institution are guaranteed by the Securities Investor Protection Corporation (SIPC) up to $500,000. The Company had no uninsured funds at September 30, 2009. 17

Item 4T. Controls and Procedures (a) Evaluation of Disclosure Controls and Procedures Our management has established and maintains a system of disclosure controls and procedures designed to provide reasonable assurance that information required to be disclosed by us in the reports filed or submitted by us under the Securities Exchange Act of 1934, as amended (the "Exchange Act"), is recorded, processed, summarized and reported within the time periods specified in the SEC's rules and forms, and include controls and procedures designed to provide reasonable assurance that information required to be disclosed by us in those reports is accumulated and communicated to our management, including our Chief Executive Officer and our Chief Financial Officer (our principal executive officer and principal financial officer, respectively), as appropriate to allow timely decisions regarding required disclosure. As of September 30, 2009, our management, including our Chief Executive Officer and our Chief Financial Officer, conducted an evaluation of our disclosure controls and procedures. Based on this evaluation, our Chief Executive Officer and Chief Financial Officer concluded that our disclosure controls and procedures are effective to provide reasonable assurance that the information required to be disclosed by us in the reports we file or submit under the Exchange Act is recorded, processed, summarized and reported within the time periods specified in the SEC's rules and forms. All disclosure control systems, no matter how well designed, have inherent limitations. Therefore, even those systems determined to be effective can provide only reasonable assurance with respect to financial statement preparation and presentation. (b) Changes in Internal Controls There were no changes in internal control during the nine-month period ended September 30, 2009. Management has not identified any matters that constitute material weaknesses (as defined under the Public Company Accounting Oversight Board Auditing Standard) in our internal controls over financial reporting. Part II. OTHER INFORMATION Item 1. Legal Proceedings On January 8, 2009, a complaint was filed in Superior Court of California, County of Sacramento in which the Company was named as a co-defendant in a matter involving an automobile accident. The plaintiffs are seeking damages for pain & suffering, emotional distress, past and future medical expenses and past and future loss of earnings totaling approximately $30,000,000. The Company believes the demands are without merit and intends to vigorously defend the complaint. To the best of the Company's knowledge, there are no other proceedings or litigation currently threatened or proceeding against us or threatening us. From time to time, the Company may be party to other claims and litigation arising in the ordinary course of business. The Company does not believe that any adverse final outcome of any of these matters, whether or not covered by insurance, would have a material adverse effect on the Company. The Company is subject to various legal proceedings and claims arising in the ordinary course of business. There are no current proceedings or litigation involving us that we believe if judgment were rendered against us would have a material adverse impact on our financial position, results of operation or cash flows. Item 6. Exhibits Pursuant to the rules and regulations of the SEC, we have filed certain agreements as exhibits to this Quarterly Report on Form 10-Q. These agreements may contain representations and warranties by the parties. These representations and warranties have been made solely for the benefit of the other party or 18

parties to such agreements and (i) may have been qualified by such disclosures made to such other party or parties, (ii) were made only as of the date of such agreements or such other date(s) as may be specified in such agreements and are subject to more recent developments, which may not be fully reflected in our public disclosure, (iii) may reflect the allocation risk among the parties to such agreements and (iv) may apply materiality standards different from what may be viewed as material to investors. Accordingly, these representations and warranties may not describe our actual state of affairs at the date hereof and should not be relied upon. Exhibit No. Description - ----------- ----------- 3.1 Articles of Incorporation (1) 3.2 By-laws (1) 31.1 Certification Pursuant to Exchange Act Rule 13a-14(a) of Christopher A. Marlett * 31.2 Certification Pursuant to Exchange Act Rule 13a-14(a) of Michael J. Tomczak * 32.1 Certification Pursuant to Section 1350 of the Sarbanes-Oxley Act of 2002 of Christopher A. Marlett * 32.2 Certification Pursuant to Section 1350 of the Sarbanes-Oxley Act of 2002 of Michael J. Tomczak * (1) Incorporated by reference to Form SB-2 filed on July 30, 1996 * Filed herewith 19

SIGNATURES Pursuant to the requirements of the Exchange Act, the registrant has duly caused this report to be signed on its behalf by the undersigned thereunto duly authorized. INTEGRATED SURGICAL SYSTEMS, INC. By: /s/ Michael J. Tomczak ------------------------------------------- Michael J. Tomczak, Chief Financial Officer Dated: November 10, 2009 20


Exhibit 31.1

                            CERTIFICATION PURSUANT TO
                  SECTION 302 OF THE SARBANES-OXLEY ACT OF 2002

     I, Christopher A. Marlett, Chief Executive Officer of Integrated Surgical
Systems, Inc., certify that:

     1.   I have reviewed this Quarterly Report on Form 10-Q for the quarter
          ended September 30, 2009 of Integrated Surgical Systems, Inc. (the
          "registrant");

     2.   Based on my knowledge, this report does not contain any untrue
          statement of a material fact or omit to state a material fact
          necessary to make the statements made, in light of the circumstances
          under which such statements were made, not misleading with respect to
          the period covered by this Quarterly Report;

     3.   Based on my knowledge, the financial statements, and other financial
          information included in this report, fairly present in all material
          respects the financial condition, results of operations and cash flows
          of the registrant as of, and for, the periods presented in this
          Quarterly Report;

     4.   The registrant's other certifying officers and I are responsible for
          establishing and maintaining disclosure controls and procedures (as
          defined in Exchange Act Rules 13a-15(e) and 15d-15(e)) and internal
          control over financial reporting (as defined in Exchange Act Rules
          13a-15(f) and 15d-15(f)) for the registrant and have:

          (a) Designed such disclosure controls and procedures, or caused such
          disclosure controls and procedures to be designed under our
          supervision, to ensure that material information relating to the
          registrant, including its consolidated subsidiaries, is made known to
          me by others within those entities, particularly during the period in
          which this Quarterly Report is being prepared;

          (b) Designed such internal control over financial reporting or caused
          such internal control over financial reporting to be designed under
          our supervision, to provide reasonable assurance regarding the
          reliability of financial reporting and the preparation of financial
          statements for external purposes in accordance with generally accepted
          accounting principles;

          (c) Evaluated the effectiveness of the registrant's disclosure
          controls and procedures and presented in this Quarterly Report, my
          conclusions about the effectiveness of the disclosure controls and
          procedures, as of the end of the period covered by this Quarterly
          Report based on such evaluation; and

          (d) Disclosed in this Quarterly Report any change in the registrant's
          internal control over financial reporting that occurred during the
          registrant's most recent fiscal quarter (the registrant's fourth
          fiscal quarter in the case of an annual report) that has materially
          affected, or is reasonably likely to materially affect, the
          registrant's internal control over financial reporting.

     5.   The registrant's other certifying officer(s) and I have disclosed,
          based on our most recent evaluation of internal control over financial
          reporting, to the registrant's auditors and the audit committee of the
          registrant's board of directors (or persons performing the equivalent
          functions); (a) All significant deficiencies and material weaknesses
          in the design or operation of internal control over financial
          reporting which are reasonably likely to adversely affect the
          registrant's ability to record, process, summarize and report
          financial information; and (b) Any fraud, whether or not material,
          that involves management or other employees who have a significant
          role in the registrant's internal control over financial reporting.


         Dated:  November 10, 2009          By: /s/   Christopher A. Marlett
                                                      -----------------------
                                                      Christopher A. Marlett
                                                      Chief Executive Officer




Exhibit 31.2

                            CERTIFICATION PURSUANT TO
                  SECTION 302 OF THE SARBANES-OXLEY ACT OF 2002

     I, Michael J. Tomczak, Chief Financial Officer of Integrated Surgical
Systems, Inc., certify that:

     1.   I have reviewed this Quarterly Report on Form 10-Q for the quarter
          ended September 30, 2009 of Integrated Surgical Systems, Inc. (the
          "registrant");

     2.   Based on my knowledge, this report does not contain any untrue
          statement of a material fact or omit to state a material fact
          necessary to make the statements made, in light of the circumstances
          under which such statements were made, not misleading with respect to
          the period covered by this Quarterly Report;

     3.   Based on my knowledge, the financial statements, and other financial
          information included in this report, fairly present in all material
          respects the financial condition, results of operations and cash flows
          of the registrant as of, and for, the periods presented in this
          Quarterly Report;

     4.   The registrant's other certifying officers and I are responsible for
          establishing and maintaining disclosure controls and procedures (as
          defined in Exchange Act Rules 13a-15(e) and 15d-15(e)) and internal
          control over financial reporting (as defined in Exchange Act Rules
          13a-15(f) and 15d-15(f)) for the registrant and have:

          (a) Designed such disclosure controls and procedures, or caused such
          disclosure controls and procedures to be designed under our
          supervision, to ensure that material information relating to the
          registrant, including its consolidated subsidiaries, is made known to
          me by others within those entities, particularly during the period in
          which this Quarterly Report is being prepared;

          (b) Designed such internal control over financial reporting or caused
          such internal control over financial reporting to be designed under
          our supervision, to provide reasonable assurance regarding the
          reliability of financial reporting and the preparation of financial
          statements for external purposes in accordance with generally accepted
          accounting principles;

          (c) Evaluated the effectiveness of the registrant's disclosure
          controls and procedures and presented in this Quarterly Report my
          conclusions about the effectiveness of the disclosure controls and
          procedures, as of the end of the period covered by this Quarterly
          Report based on such evaluation; and

          (d) Disclosed in this Quarterly Report any change in the registrant's
          internal control over financial reporting that occurred during the
          registrant's most recent fiscal quarter (the registrant's fourth
          fiscal quarter in the case of an annual report) that has materially
          affected, or is reasonably likely to materially affect, the
          registrant's internal control over financial reporting.

     5.   The registrant's other certifying officer(s) and I have disclosed,
          based on our most recent evaluation of internal control over financial
          reporting, to the registrant's auditors and the audit committee of the
          registrant's board of directors (or persons performing the equivalent
          functions); a) All significant deficiencies and material weaknesses in
          the design or operation of internal control over financial reporting
          which are reasonably likely to adversely affect the registrant's
          ability to record, process, summarize and report financial
          information; and b) Any fraud, whether or not material, that involves
          management or other employees who have a significant role in the
          registrant's internal control over financial reporting.


         Dated: November 10, 2009           By: /s/   Michael J. Tomczak
                                                      -----------------------
                                                      Michael J. Tomczak
                                                      Chief Financial Officer


Exhibit 32.1

                            CERTIFICATION PURSUANT TO
                             18 U.S.C. SECTION 1350,
                             AS ADOPTED PURSUANT TO
                  SECTION 906 OF THE SARBANES-OXLEY ACT OF 2002


I, Christopher A. Marlett, Chief Executive Officer of Integrated Surgical
Systems, Inc. (the "Company"), hereby certify, pursuant to 18 U.S.C. Section
1350, as adopted pursuant to Section 906 of the Sarbanes-Oxley Act of 2002,
that:

     1.   The Quarterly Report on Form 10-Q of the Company for the quarter ended
          September 30, 2009, which this certification accompanies (the
          "Periodic Report"), fully complies with the requirements of Section
          13(a) or 15(d) of the Securities Exchange Act of 1934; and

     2.   The information contained in the Periodic Report fairly presents, in
          all material respects, the financial condition and results of
          operations of the Company.

 Dated: November 10, 2009                         /s/ Christopher A. Marlett
                                                  ----------------------------
                                                     Christopher A. Marlett
                                                     Chief Executive Officer





Exhibit 32.2

                            CERTIFICATION PURSUANT TO
                             18 U.S.C. SECTION 1350,
                             AS ADOPTED PURSUANT TO
                  SECTION 906 OF THE SARBANES-OXLEY ACT OF 2002


I, Michael J. Tomczak, Chief Financial Officer of Integrated Surgical Systems,
Inc. (the "Company"), hereby certify, pursuant to 18 U.S.C. Section 1350, as
adopted pursuant to Section 906 of the Sarbanes-Oxley Act of 2002, that:

     1.   The Quarterly Report on Form 10-Q of the Company for the quarter ended
          September 30, 2009, which this certification accompanies (the
          "Periodic Report"), fully complies with the requirements of Section
          13(a) or 15(d) of the Securities Exchange Act of 1934; and

     2.   The information contained in the Periodic Report fairly presents, in
          all material respects, the financial condition and results of
          operations of the Company.

 Dated: November 10, 2009                      /s/ Michael J. Tomczak
                                               ---------------------------
                                                   Michael J. Tomczak
                                                   Chief Financial Officer