UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION

                              Washington, DC 20549

                                   FORM 10-QSB

[X]    Quarterly Report under Section 13 or 15(d) of the Securities Exchange
       Act of 1934 For the quarterly period ended September 30, 2007

[ ]    Transition Report under Section 13 or 15(d) of the Securities Exchange
       Act of 1934

       For the transition period from _______ to ________

                         Commission file number: 1-12471

                        INTEGRATED SURGICAL SYSTEMS, INC.
         ---------------------------------------------------------------
        (Exact name of small business issuer as specified in its charter)

                Delaware                                         68-0232575
                --------                                         ----------
       (State or other jurisdiction of                         (IRS Employer
       incorporation or organization)                        Identification No.)

                  1433 N. Market Blvd. #1, Sacramento, CA 95834
                  ---------------------------------------------
                    (Address of principal executive offices)

                                 (916) 285-9943
                                 --------------
                           (Issuer's telephone number)

Check whether the issuer (1) filed all reports required to be filed by Section
13 or 15(d) of the Securities Exchange Act of 1934 during the past 12 months (or
for such shorter period that the registrant was required to file such reports),
and (2) has been subject to such filing requirements for the past 90 days.
Yes [ X ] No [   ]

Indicate by check mark whether the registrant is a shell company (as defined in
Rule 12b-2 of the exchange Act). Yes [X ] No [ ]

The number of shares of common stock, $0.01, par value, outstanding on November
16, 2007 was 4,578,500 Transitional Small Business Disclosure format (check
one). Yes [ ] No [ X ]


Integrated Surgical Systems, Inc. Form 10-QSB for the quarter ended September 30, 2007 Table of Contents Page ---- Part I. Financial Information Item 1. Financial Statements 2 Balance Sheet (unaudited) at September 30, 2007 2 Statements of Operations (unaudited) for the nine months ended September 30, 2007 and 2006 3 Statements of Operations (unaudited) for the three months ended September 30, 2007 and 2006 4 Statements of Cash Flows (unaudited) for the nine months ended September 30, 2007 and 2006 5 Notes to Financial Statements (unaudited) 6 Item 2. Management's Discussion and Analysis 8 Item 3 Controls and Procedures 10 Part II. Other Information Item 1. Legal Proceedings 11 Item 6. Exhibits 11 Signature 12 Certifications 13

Part I. Financial Information Item 1. Financial Statements (unaudited) Integrated Surgical Systems, Inc. Balance Sheet September 30, 2007 (Unaudited) Assets Current assets: Cash $ 3,290,823 Other current assets 79,589 ------------ Total assets $ 3,370,412 ============ Liabilities and stockholders' equity Current liabilities: Accounts payable $ 19,004 Accrued liabilities 55,322 Other current liabilities 495,188 ------------ Total current liabilities 569,514 Convertible preferred stock, $0.01 par value, 1,000,000 shares authorized; 168 shares issued and outstanding ($168,496 aggregate liquidation value) 168,496 ------------ Total liabilities 738,010 ------------ Stockholders' equity: Common stock, $0.01 par value, 100,000,000 shares authorized; 4,578,500 shares issued and outstanding 45,785 Additional paid-in capital 62,427,375 Deferred compensation (13,431) Retained deficit (59,827,327) ------------ Total stockholders' equity 2,632,402 ------------ $ 3,370,412 ============ See accompanying notes to financial statements. 2

Integrated Surgical Systems, Inc. Statements of Operations (Unaudited) Nine months ended September 30, ------------------------------------- 2007 2006 ----------- ------------- Continuing operations General and administrative expenses $ 115,394 $ -- ----------- ------------- Operating (loss) (115,394) -- Interest income - net 26,630 -- ----------- ------------- Loss from continuing operations (88,764) -- ----------- ------------- Discontinued Operations (Loss) gain from operations of discontinued business segment (net of taxes of $50,478 in 2007) (1,219,725) 2,322,094 Net gain on sale of assets 6,176,137 -- ----------- ------------- 4,956,412 2,322,094 ----------- ------------- Net Income $ 4,867,648 $ 2,322,094 =========== ============= Basic net income (loss) per share Continuing $ (0.02) $ -- Discontinued 1.08 0.51 ----------- ------------- Net income $ 1.06 $ 0.51 =========== ============= Diluted net income (loss) per share Continuing $ (0.02) $ -- Discontinued 0.97 0.28 ----------- ------------- Net income $ 0.95 $ 0.28 Shares used in computing basic net income per share 4,578,500 4,516,614 =========== ============= Shares used in computing diluted net income per share 5,127,705 8,314,306 =========== ============= See accompanying notes to financial statements. 3

Integrated Surgical Systems, Inc. Statements of Operations (Unaudited) Three months ended September 30, ------------------------------------- 2007 2006 ----------- ------------- Continuing operations General and administrative expenses $ 115,394 $ -- ----------- ------------- Operating (loss) (115,394) -- Interest income - net 26,630 -- ----------- ------------- Loss from continuing operations (88,764) -- ----------- ------------- Discontinued Operations Gain from operations of discontinued business segment 34,000 1,076,681 ----------- ------------- Net (Loss) Income $ (54,764) $ 1,076,681 =========== ============= Basic net (loss) income per share Continuing $ (0.02) $ -- Discontinued 0.01 0.24 ----------- ------------- Net (loss) income $ (0.01) $ 0.24 =========== ============= Diluted net (loss) income per share Continuing $ (0.02) $ -- Discontinued 0.01 $ 0.13 ----------- ------------- Net (loss) income $ (0.01) $ 0.13 =========== ============= Shares used in computing basic net income per share 4,578,500 4,532,757 =========== ============= Shares used in computing diluted net income per share 5,214,814 8,553,757 =========== ============= See accompanying notes to financial statements. 4

Integrated Surgical Systems, Inc. Statements of Cash Flows (Unaudited) Nine months ended September 30, ----------------------------------- 2007 2006 ----------- ---------- Continuing operating Loss from continuing operations $ (88,764) $ -- Adjustments to reconcile net loss from continued operations to cash flow used in continued operations: Stock based compensation-directors and employees 13,215 -- Changes in assets and liabilities Other current assets (79,589) -- Accounts payable (3,435) -- Accrued liabilities 55,322 -- Other current liabilities (6,642) -- ----------- ----------- Net cash (used in) continuing operations (109,893) -- ----------- ----------- Discontinued operations Net cash used in operating activities (2,887,569) (640,865) Net cash provided by investing activities 3,961,017 5,000 Net cash provided by financing activities 1,000,000 2,558,000 ----------- ----------- Net cash provided by discontinued activities 2,073,448 1,922,135 ----------- ----------- Net increase in cash 1,963,555 1,922,135 Cash and cash equivalents at beginning of period 1,327,268 158,789 ----------- ----------- Cash and cash equivalents at end of period $ 3,290,823 $ 2,080,924 =========== =========== See accompanying notes to financial statements. 5

Integrated Surgical Systems, Inc. Notes to Financial Statements (unaudited) 1. Organization and Operations Integrated Surgical Systems, Inc. (Company) was incorporated in Delaware in 1990 to design, manufacture, sell and service image-directed, computer-controlled robotic software and hardware products for use in orthopedic surgical procedures. The Company's products are authorized to be sold through international distributors to hospitals and clinics in European Union member countries and Australia, Canada, India, Israel, Japan, Korea, New Zealand, Switzerland and South Africa. On June 28, 2007, upon the sale of substantially all of its assets, the Company became inactive. As a result, all the Company's operations through June 28, 2007 have been classified as discontinued operations. On June 28, 2007, the stockholders approved the future liquidation of the Company if the Company is unable to complete an acquisition or similar transaction within one year from the sale of the assets (Note 3). 2. Significant Accounting Policies Basis of presentation The accompanying unaudited financial statements and related notes have been prepared in accordance with accounting principles generally accepted in the United States for interim financial statements and with the rules and regulations under Regulation SB of the Securities and Exchange Commission for Form 10-QSB. Accordingly, they do not include all of the information and footnotes required by accounting principles generally accepted in the United States for complete financial statements presentation. In the opinion of management, all adjustments (consisting of normal recurring accruals) considered necessary to present fairly the financial position as of September 30, 2007 and results of operations and cash flows for the nine months then ended have been included. These financial statements should be read in conjunction with the financial statements of the Company together with the Company's management discussion and analysis in the Company's Form 10-KSB for the year ended December 31, 2006. Interim results are not necessarily indicative of the results for a full year. Certain amounts for prior years have been reclassified to conform to 2007 financial statement presentations. The financial statements include all the accounts of the Company. Estimates The preparation of financial statements in conformity with accounting principles generally accepted in the United States requires management to make estimates and assumptions that affect the reported amounts of assets and liabilities and the disclosure of contingent assets and liabilities at the date of the financial statements and revenues and expenses during the reporting period. Actual results could differ from those estimates. Significant estimates made by management include revenue recognition, allowances for inventory and warranty liability. New Accounting Pronouncement Management does not believe that any recently issued, but not yet effective accounting pronouncements, if adopted, would have a material effect on the accompanying financial statements. 3. Gain on Sale of Assets On June 28, 2007, the Company sold substantially all of its assets in exchange for $4,000,000 in cash, plus the cancellation of a note payable in the amount of $3,700,000 and accrued interest thereon of $234,462. The gain on sale of assets consisted of the following: 6

Proceeds Cash $ 4,000,000 Cancellation of indebtedness 3,934,462 ----------- Total proceeds 7,934,462 Net book value of assets sold (1,001,007) Employee retention incentives (486,385) Present value of net future lease payments (250,376) Legal expenses (20,557) ----------- Gain on sale of assets $ 6,176,137 =========== In connection with the sale: (a) Certain employees of the Company received payments to remain with the Company until the closing date to effect an orderly transfer of assets to the purchaser. (b) The purchaser has agreed to sublease the Company's space for one year. The Company has accrued the present value of the rent for the balance of the lease term, net of the rent to be received under the sublease. After the utilization of the Company's net operating loss carryforwards for Federal and State purposes, the Company's income taxes on the gain were approximately $39,000. 4. Common Stock Effective July 26, 2007, the Company declared a 1-for-10 reverse stock split of its outstanding shares of common stock. All share and per share amounts have been restated for the split. During the third quarter of 2007, the Company issued options to purchase 50,000 shares of common stock to the directors valued at $13,215. The options to purchase the shares of common stock are exercisable at $0.328 per share, through August 12, 2012. 5. Income Taxes Effective January 1, 2007, the Company adopted the provisions of Financial Accounting Standards Board (FASB) Interpretation No. 48, "Accounting for Uncertainty in Income Taxes, an interpretation of FASB Statement No. 109" (FIN 48). FIN 48 clarifies the accounting for uncertainty in income taxes recognized in the Company's financial statements in accordance with FASB Statement 109, "Accounting for Income Taxes", and prescribes a recognition threshold and measurement process for financial statement recognition and measurement of a tax position taken or expected to be taken in a tax return. FIN 48 also provides guidance on derecognition, classification, interest and penalties, accounting in interim periods, disclosure and transition. Management has evaluated and concluded that there are no significant uncertain tax positions requiring recognition in the Company's financial statements as of January 1, 2007 and September 30, 2007. The Company's policy is to classify assessments, if any, for tax related interest as interest expenses and penalties as general and administrative expenses. 6. Subsequent Event On November 13, 2007 the Company settled a liability to a customer of $195,000 by a payment of $97,500. The Company will recognize a gain on settlement of $97,500, which will be included in discontinued operations during the fourth quarter of 2007. 7

Item 2. Management's Discussion and Analysis Forward-Looking Statements The discussion in this Quarterly Report on Form 10-QSB contains forward-looking statements that have been made pursuant to the provisions of the Private Securities Litigation Reform Act of 1995. Such forward-looking statements are based on current expectations, estimates and projections about the software industry and certain assumptions made by the Company's management. Words such as "anticipates," "expects," "intends," "plans," "believes," "seeks," "estimates," "could," "would," "may" and variations of such words and similar expressions are intended to identify such forward-looking statements. These statements are not guarantees of future performance and are subject to certain risks, uncertainties and assumptions that are difficult to predict; therefore, actual results may differ materially from those expressed or forecasted in any such forward-looking statements. Unless required by law, the Company undertakes no obligation to update publicly any forward-looking statements, whether as a result of new information, future events or otherwise. However, readers should carefully review the risk factors set forth in other reports or documents the Company files from time to time with the SEC, particularly the Company's Annual Report on Form 10-KSB, Quarterly Reports on Form 10-QSB and any Current Reports on Form 8-K. The following discussion should be read in conjunction with the unaudited financial statements and notes thereto in Part I, Item 1 of this Quarterly Report on Form 10-QSB and with the audited Financial Statements and Notes thereto, together with Management's Discussion and Analysis of Financial Condition and Results of Operations, which are included in the Company's Annual Report on Form 10-KSB for the fiscal year ended December 31, 2006 as filed with the SEC. Overview We were incorporated in Delaware in 1990 to design, manufacture, sell and service image-directed, computer-controlled robotic software and hardware products for use in orthopedic surgical procedures. Although we had not received clearance to market the ROBODOC(R) System (ROBODOC) in the U.S., we were permitted to export the system provided certain requirements were met. Products approved for use by European Union member countries and Australia, Canada, India, Israel, Japan, Korea, New Zealand, Switzerland and South Africa, do not require U.S. FDA export approval. We had sold our robotic systems to international distributors, who in turn resold the product in their territories. Our international distributors were KTEC in Japan, ROCOM Frontier in Korea and Paramount Impex in India. Description of the sales transaction On August 4, 2006, we entered into an Asset Purchase Agreement with Novatrix Biomedical, Inc. ("Novatrix"), as amended, pursuant to which we agreed to sell substantially all of our assets to Novatrix (the "Asset Purchase Agreement"). As consideration for the sale, Novatrix would pay $4,000,000 for the assets. The Loan Agreement provided that upon entering into the Asset Purchase Agreement, Novatrix will meet its obligations to us by providing the balance of any loans due to us to fund our working capital in equal amounts for the purpose of developing the ROBODOC and ORTHODOC products. In addition, the Loan Agreement provided that upon the approval by our stockholders of the asset sale, all of our obligations owing under the Loan Agreement shall be forgiven. On June 28, 2007, the Company completed the sale of substantially all of its assets in exchange for $4,000,000 in cash, plus the cancellation of the note payable in the amount of $3,700,000 and accrued interest thereon of $234,462. The gain on sale of assets consisted of: 8

Proceeds Cash $ 4,000,000 Cancellation of indebtedness 3,934,462 ----------- Total proceeds 7,934,462 Net book value of assets sold (1,001,007) Employee retention incentives (486,385) Present value of net future lease payments (250,376) Legal expenses (20,557) ----------- Gain on sale of assets $ 6,176,137 =========== Revenues Product revenue had consisted of sales of our principal orthopedic product, the ROBODOC(R) Surgical Assistant System ("ROBODOC"), which integrated the ORTHODOC(R) Presurgical Planner ("ORTHODOC") with a computer-controlled robot for use in joint replacement surgeries. We had developed specialized operating software for several implant manufacturing companies. These implant manufacturers' contracted with us for the development of software for particular lines of new prosthesis to be used with the ROBODOC system. Results of operations We generated a net loss for the third quarter of 2007 of $54,800 or $0.02 loss per basic and $0.01 loss per dilutive share, compared to net income of $1,076,700 or $0.24 per basic share and $0.13 per dilutive share for the third quarter of 2006. We generated net income for the first nine months of 2007 of $4,867,600 or $1.06 per basic and $0.95 per dilutive share, compared to net income for the first nine months of 2006 of $2,322,100 or $0.51 per basic and $0.28 per dilutive share. Continuing operations For the three month and nine month periods ending September 30, 2007 we recorded a net loss of $88,800 or $0.02 loss per basic and $0.01 loss per dilutive share. These results consisted of $115,400 in general and administrative expenses partially offset by $26,600 in net interest income. General and administrative expense of $115,400 primarily consisted of $43,900 of legal fees, $18,200 of professional accounting fees, $25,000 of consulting and outside services involved in keeping the company current on regulatory matters, $8,200 of insurance expense, $13,700 of directors' fees and expenses, and $6,400 of printing supplies and other miscellaneous operational expenses. Interest income - net results from $30,900 interest income partially offset by $4,300 in interest expense. Discontinued operations For the three month ending September 30, 2007 we recognized $34,000 of discontinued operations. For the first nine month period of 2007 the Company recorded a loss from the discontinued business operations before the sale of assets to Novatrix of $1,219,700, $0.27 and $0.24 loss per basic and dilutive shares, respectively, as compared to a gain of $2,322,100, $0.51 and $0.28 income per basic and dilutive shares, respectively, for the same nine month period of 2006. The gain in 2006 was primarily the result of the sale of two ROBODOC Systems while there were no comparative sales in 2007. For the nine month period of 2007 the Company recorded a gain on sale of assets of $6,176,100, $1.35 and $1.20 gain per basic and dilutive shares, respectively. The total gain on discontinued operations for the nine months ended September 30, 2007 was $4,956,400 ($1.08 and $0.96 gain per basic and dilutive shares, respectively) as compared to the same nine month period of 2006 of $2,322,100 ($0.51 and $0.28 gain per basic and dilutive shares, respectively). 9

Liquidity and Capital Resources The Board has retained two of its outside directors, its Chief Financial Officer, and its Secretary as part time consultants to assist with our continuing obligations under the federal securities laws and to evaluate various merger, acquisition or strategic alliance opportunities We anticipate that it will take up to twelve months to conclude this process. While no assurance can be given that such opportunities will be available, or if available, on favorable terms, we believe there are numerous opportunities. If we are unsuccessful with respect to a suitable opportunity within twelve months of the closing of the Novatrix transaction, we will liquidate the Company and distribute all our remaining assets, primarily cash, to our stockholders. We believe our current cash position is adequate to carry out our plan. At September 30, 2007, our "quick ratio" (cash and accounts receivable divided by current liabilities), a conservative liquidity measure designed to predict our ability to pay bills, was 5.79. Net cash used in continuing operations was $109,900 for the nine months ended September 30, 2007. The primary use of cash was a net loss of $88,800 other current assets of $79,600 and decreases in accounts payable and other liabilities of $10,000 partially offset by increase in accrued liabilities of $55,300 and stock based compensation for directors of $13,200. Net cash used in discontinued operating activities was $2,887,600 for the nine months ended September 30, 2007. Cash flows provided from investing activities were $3,961,000 and resulted primarily from cash received from the sale of assets of $4,000,000. Cash flows provided by financing activities were $1,000,000. We anticipate that we will incur operating losses from continuing operations in the next twelve months. We do not have any material commitments for capital expenditures. We do not have any off-balance sheet arrangements that have or are reasonably likely to have a current or future effect on our financial condition, changes in financial condition, revenues or expenses, liquidity or capital resources that are material to our investors. Critical Accounting Policies and Estimates The preparation of our unaudited financial statements requires us to make estimates and judgments that affect the reported amounts of assets, liabilities, revenue and expenses, and related disclosure of contingent assets and liabilities. On an on-going basis, we evaluate the estimates, including those related to bad debts, inventories, warranties, contingencies and litigation. We base these estimates on historical experience and on other assumptions believed to be reasonable under the circumstances, the results of which form the basis for making judgments about the carrying values of assets and liabilities that are not readily apparent from other sources. We have discussed our critical accounting policies with our independent accountants. Actual results may differ from these estimates under different assumptions or conditions. We believe the following critical accounting policies affected our more significant judgments and estimates used in the preparation of our financial statements: We recognized revenue from sales of our products upon the completion of equipment installation and training at the end-user's site, except when the sales contract requires formal customer acceptance. Equipment sales with contractual customer acceptance provisions were recognized as revenue upon written notification of customer acceptance, which generally occurs after the completion of installation and training. Furthermore, due to business customs in Japan and the interpretation of Japanese law, all equipment sales to Japan were recognized after customer acceptance, which generally occurs after the completion of installation and training. Revenue related to maintenance and service contracts was recognized ratably over the duration of the contracts. 10

We periodically evaluated the need for allowances for doubtful accounts for estimated losses resulting from the inability of our customers to make required payments. Item 3. Controls and Procedures (a) Under the supervision and with the participation of management, including our President, Chief Executive Officer and Chief Financial Officer, an evaluation was made of the effectiveness of our disclosure controls and procedures, as such term is defined under Rule 13a-15(e) promulgated under the Securities Exchange Act of 1934, as amended. Based upon that evaluation, our Chief Executive Officer and our Chief Financial Officer concluded that our disclosure controls and procedures were effective as of the end of the period covered by this quarterly report. (b) There has been no significant changes in our internal control over financial reporting during the quarter ended September 30, 2007 that has materially affected, or is reasonably likely to materially affect, our internal control over financial reporting. Part II. Other Information Item 1. Legal Proceedings There were no current proceedings or litigation involving us that we believe if judgment were rendered against us would have a material adverse impact on our financial position, results of operation or cash flows. Item 6. Exhibits (a)Exhibits 31.1 Certification Pursuant to Exchange Act Rule 13a-14(a) of Peter B. Mills 31.2 Certification Pursuant to Exchange Act Rule 13a-14(a) of David H. Adams 32.1 Certification Pursuant to Section 1350 of the Sarbanes-Oxley Act of 2002 of Peter B. Mills 32.2 Certification Pursuant to Section 1350 of the Sarbanes-Oxley Act of 2002 of David H. Adams 11

SIGNATURES In accordance with the requirements of the Exchange Act, the registrant caused this report to be signed on its behalf by the undersigned, thereunto duly authorized. INTEGRATED SURGICAL SYSTEMS, INC. By: /s/ DAVID H. ADAMS ----------------------------------- David H. Adams, Chief Financial Officer November 16, 2007 12


                                                                    Exhibit 31.1


                                 CERTIFICATION


I, Peter B. Mills, certify that:

1.       I have reviewed this quarterly report on Form 10-QSB of Integrated
         Surgical Systems, Inc. (the "registrant");

2.       Based on my knowledge, this report does not contain any untrue
         statement of a material fact or omit to state a material fact necessary
         to make the statements made, in light of the circumstances under which
         such statements were made, not misleading with respect to the period
         covered by this report;

3.       Based on my knowledge, the financial statements, and other financial
         information included in this report, fairly present in all material
         respects the financial condition, results of operations and cash flows
         of the registrant as of and for the periods presented in this report;

4.       The registrant's other certifying officers and I are responsible for
         establishing and maintaining disclosure controls and procedures (as
         defined in Exchange Act Rules 13a-15(e) and 15d-15(e)) and internal
         control over financial reporting (as defined in Exchange Act Rules
         13a-15(f) and 15d-15(f)) for the registrant and have:

a)       Designed such disclosure controls and procedures, or caused such
         disclosure controls and procedures to be designed under our
         supervision, to ensure that material information relating to the
         registrant is made known to us by others within those entities,
         particularly during the period in which this report is being prepared;

b)       Designed such internal control over financial reporting, or caused such
         internal control over financial reporting to be designed under our
         supervision, to provide reasonable assurance regarding the reliability
         of financial reporting and the preparation of financial statements for
         external purposes in accordance with generally accepted accounting
         principles; and

c)       Disclosed in this report any change in the registrant's internal
         control over financial reporting that occurred during the registrant's
         most recent fiscal quarter that has materially affected, or is
         reasonably likely to materially affect, the registrant's internal
         control over financial reporting; and

5.       The registrant's other certifying officers and I have disclosed, based
         on our most recent evaluation of internal control over financial
         reporting, to the registrant's auditors and the audit committee of the
         registrant's board of directors:

a)       All significant deficiencies and material weaknesses in the design or
         operation of internal control over financial reporting which are
         reasonably likely to adversely affect the registrant's ability to
         record, process, summarize and report financial information; and
b)       Any fraud, whether or not material, that involves management or other
         employees who have a significant role in the registrant's internal
         control over financial reporting.


/s/ Peter B. Mills
- ---------------------------------------
Peter B. Mills, Chief Executive Officer

November 16, 2007




                                                                    Exhibit 31.2


                                  CERTIFICATION





I, David H. Adams, certify that:

1.       I have reviewed this quarterly report on Form 10-QSB of Integrated
         Surgical Systems, Inc. (the "registrant");

2.       Based on my knowledge, this report does not contain any untrue
         statement of a material fact or omit to state a material fact necessary
         to make the statements made, in light of the circumstances under which
         such statements were made, not misleading with respect to the period
         covered by this report;

3.       Based on my knowledge, the financial statements, and other financial
         information included in this report, fairly present in all material
         respects the financial condition, results of operations and cash flows
         of the registrant as of and for the periods presented in this report;

4.       The registrant's other certifying officers and I are responsible for
         establishing and maintaining disclosure controls and procedures (as
         defined in Exchange Act Rules 13a-15(e) and 15d-15(e)) and internal
         control over financial reporting (as defined in Exchange Act Rules
         13a-15(f) and 15d-15(f)) for the registrant and have:

a)       Designed such disclosure controls and procedures, or caused such
         disclosure controls and procedures to be designed under our
         supervision, to ensure that material information relating to the
         registrant is made known to us by others within those entities,
         particularly during the period in which this report is being prepared;

b)       Designed such internal control over financial reporting, or caused such
         internal control over financial reporting to be designed under our
         supervision, to provide reasonable assurance regarding the reliability
         of financial reporting and the preparation of financial statements for
         external purposes in accordance with generally accepted accounting
         principles; and

c)       Disclosed in this report any change in the registrant's internal
         control over financial reporting that occurred during the registrant's
         most recent fiscal quarter that has materially affected, or is
         reasonably likely to materially affect, the registrant's internal
         control over financial reporting; and

5.       The registrant's other certifying officers and I have disclosed, based
         on our most recent evaluation of internal control over financial
         reporting, to the registrant's auditors and the audit committee of the
         registrant's board of directors:

a)       All significant deficiencies and material weaknesses in the design or
         operation of internal control over financial reporting which are
         reasonably likely to adversely affect the registrant's ability to
         record, process, summarize and report financial information; and

b)       Any fraud, whether or not material, that involves management or other
         employees who have a significant role in the registrant's internal
         control over financial reporting.




/s/ David H. Adams
- ---------------------------------------
David H. Adams, Chief Financial Officer

November 16, 2007




                                                                    Exhibit 32.1





                                  CERTIFICATION








In connection with the Quarterly Report on Form 10-QSB of Integrated Surgical
Systems, Inc. (the "Company") for the period ended September 30, 2007, as filed
with the Securities and Exchange Commission on the date hereof (the "Report"),
I, Peter B. Mills, Chief Executive Officer of the Company, certify, pursuant to
18 U.S.C. 1350, that:


     (1)  The Report fully complies with the requirements of Section 13(a) or
          15(d) of the Securities Exchange Act of 1934; and

     (2)  The information contained in the Report fairly presents, in all
          material respects, the financial condition and results of operations
          of the Company.






/s/ Peter B. Mills
- ---------------------------------------
Peter B. Mills, Chief Executive Officer

November 16, 2007


                                                                    Exhibit 32.2





                                  CERTIFICATION








In connection with the Quarterly Report on Form 10-QSB of Integrated Surgical
Systems, Inc. (the "Company") for the period ended September 30, 2007, as filed
with the Securities and Exchange Commission on the date hereof (the "Report"),
I, David H. Adams, Chief Financial Officer of the Company, certify, pursuant to
18 U.S.C. 1350, that:


     (1)  The Report fully complies with the requirements of Section 13(a) or
          15(d) of the Securities Exchange Act of 1934; and

     (2)  The information contained in the Report fairly presents, in all
          material respects, the financial condition and results of operations
          of the Company.













/s/ David H. Adams
- ---------------------------------------
David H. Adams, Chief Financial Officer

November 16, 2007