UNITED STATES SECURITIES AND EXCHANGE COMMISSION
                              Washington, DC 20549

                                    FORM 8-K

                                 CURRENT REPORT

     Pursuant to Section 13 or 15(d) of The Securities Exchange Act of 1934

       Date of report (Date of earliest event reported): February 9, 2005

                        Integrated Surgical Systems, Inc.
                        ---------------------------------
               (Exact name of registrant as specified in charter)

     Delaware                           1-12471               68-0232575
     --------                           -------               ----------
(State or other jurisdiction           (Commission            (IRS Employer
     of incorporation)                  File Number)        Iden tification No.)


     1850 Research Park Drive
          Davis, California                                      95616-4884
          -----------------                                      ----------
(Address of principal executive offices)                         (Zip Code)

Registrant's telephone number, including area code:  (530) 792-2600

                                 Not Applicable
                                 --------------
          (Former name or former address, if changed since last report)

     Check the appropriate box below if the Form 8-K filing is intended to
simultaneously satisfy the filing obligation of the registrant under any of the
following provisions: G Written communications pursuant to Rule 425 under the
Securities Act (17 CFR 230.425) G Soliciting material pursuant to Rule 14a-12
under the Exchange Act (17 CFR 240.14a-12) G Pre-commencement communications
pursuant to Rule 14d-2(b) under the Exchange Act (17 CFR 240.14d-2(b)) G
Pre-commencement communications pursuant to Rule 13e-4(c) under the Exchange Act
(17 CFR 240.13e-4(c))

Item 8. Other Events. On February 9, 2005, we, Integrated Surgical Systems, Inc., reached an agreement with the holder of our 6-3/4% Convertible Debenture which we issued on June 9, 2004. This agreement provides that (a) the "conversion price" set forth in section 3.1(a) of the debenture be amended to be the lesser of: (i) $0.025 or (ii) 75% of the average of the five lowest volume weighted average prices during the twenty days prior to the holder's election to convert the amount outstanding under the debenture; and (b) the date by which we are required to cause a registration statement to be declared effective by the Securities and Exchange Commission, with respect to the shares issuable upon conversion of the debenture and exercise of the warrants issued together with the debenture, be extended to April 30, 2005. The conversion price originally was set at the lesser of: (i) $0.025 or (ii) 80% of the average of the five lowest volume weighted average prices during the twenty days prior to the holder's election to convert the amount outstanding under the debenture. Further, the original terms of the debenture and warrants required that the registration statement for the underlying shares be declared effective by the SEC by November 6, 2004. The debenture was attached as exhibit 10.1 to our Quarterly Report on Form 10-QSB for the quarter ended June 30, 2004, filed with the SEC on November 24, 2004. The warrant certificate evidencing the warrants was attached as exhibit 10.2 to such Form 10-QSB. Item 9.01. Financial Statements and Exhibits. Set forth below are all exhibits applicable to this Current Report on Form 8-K. Exhibit Number Description - ------ ----------- 10.1 Addendum to Convertible Debenture and Warrant to Purchase Common Stock, dated February 9, 2005, between Integrated Surgical Systems, Inc. and Golden Gate Investors, Inc.

SIGNATURES Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned hereunto duly authorized. Integrated Surgical Systems, Inc. Dated: February 15, 2005 By: /s/ RAMISH TRIVEDI ---------------------------------------- Ramesh Trivedi, Chief Executive Officer

                                                                    Exhibit 10.1


                      ADDENDUM TO CONVERTIBLE DEBENTURE AND
                        WARRANT TO PURCHASE COMMON STOCK

This addendum to Convertible Debenture and Warrant to Purchase Common Stock
("Addendum") is entered into as of the 9th day of February 2005 by and between
Integrated Surgical Systems, Inc., a Delaware corporation ("Integrated"), and
Golden Gate Investors, Inc., a California corporation ("GGI").

WHEREAS, GGI and Integrated are parties to that certain 6 3/4% Convertible
Debenture dated as of June 9, 2004 ("Debenture"); and

WHEREAS, GGI and Integrated are parties to that certain Warrant to Purchase
Common Stock dated June 9, 2004 ("Warrant"); and

WHEREAS, the parties desire to amend the Debenture and Warrant in certain
respects.

NOW, THEREFORE, in consideration of the mutual promises and covenants contained
herein, and for other good and valuable consideration, the receipt and
sufficiency of which are hereby acknowledged, Integrated and GGI agree as
follows:

     1.   All terms used herein and not otherwise defined herein shall have the
          definitions set forth in the debenture.

     2.   The Deadline is hereby changed to be April 30, 2005.

     3.   The Conversion Price set forth in section 3.1(a) of the Debenture is
          hereby changed to be the lesser of: (i) $0.25, or (ii) seventy-five
          percent (75%) of the average of the five lowest Volume Weighted
          Average Prices during the 20 Trading Days prior to GGI's election to
          convert (a "Discount Multiplier").

     4.   Except as specifically amended herein, all other terms and conditions
          of the Debenture and Warrant shall remain in full force and effect.

IN WITNESS WHEREOF, Integrated and GGI have caused this Addendum to be signed by
its duly authorized officers on the date first set forth above.


Integrated Surgical Systems, Inc.           Golden Gate Investors, Inc.
/s/  RAMESH  TRIVEDI                        /s/  TRAVIS HUFF
- ---------------------------------           ------------------------------------
Ramesh Trivedi                              Travis Huff
President/CEO                               Portfolio Manager