SECURITIES AND EXCHANGE COMMISSION

                             Washington, D.C. 20549


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                                  F O R M 8 - K

                                 CURRENT REPORT

                         Pursuant to Section 13 or 15(d)
                         of the Securities Exchange Act
                                     of 1934


Date of Report (Date of earliest event reported)          February 14, 2001


                        INTEGRATED SURGICAL SYSTEMS, INC.
               (Exact name of registrant as specified in charter)


        Delaware                       1-12471                   168-0232575
(State or other jurisdiction        (Commission                 (IRS Employer
     of incorporation)               File Number)            Identification No.)


    1850 Research Park Drive, Davis, California                   95616-4884
     (Address of principal executive offices)                     (Zip Code)



        Registrant's telephone number, including area code (530) 792-2600


                                      N/A
         (Former name or former address, if changed since last report.)







Item 5. Other Events.

     On February 14, 2001,  the  Registrant's securities  were delisted from the
Nasdaq  SmallCap  Market for  failure of its  Common  Stock to satisfy  Nasdaq's
minimum bid price requirement for continued listing.  The Company's Common Stock
and  Warrants  are now traded in the  over-the-counter  market and quoted on the
NASD's OTC Bulletin Board under the symbols RDOC and RDOCW, respectively.

     The Company also has received and is reviewing a letter dated  February 14,
2001 from EASDAQ  notifying the Company that trading in its  securities has been
suspended  pending the outcome of disciplinary  proceedings  against the Company
for  violations  of  EASDAQ's  Continuing   Requirements  for  Listed  Financial
Instruments.


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                                   SIGNATURES

         Pursuant to the requirements of the Securities Exchange Act of 1934,
the Registrant has duly caused this report to be signed on its behalf by the
undersigned thereunto duly authorized.

                                               INTEGRATED SURGICAL SYSTEMS, INC.

Dated:   February 14, 2001                     By:  /s/ Ramesh C. Trivedi
         -----------------                          ----------------------------
         Davis, California                          Ramesh C. Trivedi
                                                    Chief Executive Officer
                                                    and President


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